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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptNIH Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
FEMS Microbiol Lett. Author manuscript; available in PMC Jul 1, 2011.
Published in final edited form as:
PMCID: PMC2925232

Discovery of novel Vibrio cholerae VSP II genomic islands using comparative genomic analysis


This report describes Vibrio Seventh Pandemic Island II (VSP-II) and three novel variants revealed by comparative genomics of 23Vibrio cholerae strains and their presence among a large and diverse collection of V. cholerae isolates. Three VSP-II variants were previously reported and our results demonstrate the presence of three novel VSP-II in clinical and environmental V. cholerae marked by major deletions and genetic rearrangements. A new VSP-II cluster was found in the seven pandemic V. cholerae O1 El Tor strain CIRS101, which is dominant (95%) among recent (2004-2007) seven pandemic V. cholerae O1 El Tor isolates from two endemic sites, but was not found in older strains from the same region. Two other variants were found in V. cholerae TMA21 and RC385, two environmental strains from coastal Brazil and the Chesapeake Bay, respectively, the latter being prevalent among environmental V. cholerae non-O1/non-O139 and V. mimicus. Results of this study indicate that the VSP-II island has undergone significant rearrangement through a complex evolutionary pathway in V. cholerae. Interestingly, one of the new VSP-II revealed the presence of “old” and “new” V. cholerae O1 El Tor pandemic clones circulating in some of the areas where cholera is endemic.

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