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J Clin Invest. 1972 August; 51(8): 2040–2046. doi: 10.1172/JCI107010. | PMCID: PMC292360 |
Circadian rhythm in serum parathyroid hormone concentration in human subjects: correlation with serum calcium, phosphate, albumin, and growth hormone levels William Jubiz, Janet M. Canterbury, Eric Reiss, and Frank H. Tyler Laboratory for the Study of Hereditary and Metabolic Disorders and Clinical Research Center, Department of Medicine, University of Utah College of Medicine, and the Veterans Administration Hospital, Salt Lake City, Utah 84113 Department of Medicine, Michael Reese Hospital and Medical Center and the University of Chicago Pritzger School of Medicine, Chicago, Illinois 60616 Abstract A circadian variation in serum calcium, albumin and PTH concentration in normal subjects has been demonstrated. The levels of the three blood constituents were remarkably constant during the day, but striking night and early morning changes occurred. Serum calcium levels were highest at 8:00 p.m. and reached a nadir between 2:00 and 4:00 a.m. Serum albumin levels were parallel to those of serum calcium. PTH levels began to rise after 8:00 p.m., reached the highest levels between 2:00 and 4:00 a.m., and fell to baseline values by 8:00 a.m. The nocturnal fall in serum calcium levels appears to be secondary to dilution of serum proteins by increasing blood volume. The nocturnal rise in PTH levels appears to be independent of serum calcium levels within the normal range but it can be abolished by induced hypercalcemia. Serum phosphate levels were lowest between 8:00 a.m. and 10:00 a.m. and highest between 2:00 a.m. and 4:00 a.m. The data presented suggest that circadian changes in serum phosphate levels are not mediated in toto by parathyroid hormone but they are exaggerated when the secretion of this hormone is inhibited. They are independent of growth hormone levels and activity but they are greatly modified during a prolonged fast. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (920K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - Mills JN. Human circadian rhythms. Physiol Rev. 1966 Jan;46(1):128–171. [PubMed]
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