• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of jcinvestThe Journal of Clinical InvestigationCurrent IssueArchiveSubscriptionAbout the Journal
J Clin Invest. Jul 1961; 40(7): 1304–1314.
PMCID: PMC290843


Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.9M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • BENEDICT JD, FORSHAM PH, STETTEN D., Jr The metabolism of uric acid in the normal and gouty human studied with the aid of isotopic uric acid. J Biol Chem. 1949 Nov;181(1):183–193. [PubMed]
  • BISHOP C, GARNER W, TALBOTT JH. Pool size, turnover rate, and rapidity of equilibration of injected isotopic uric acid in normal and pathological subjects. J Clin Invest. 1951 Aug;30(8):879–888. [PMC free article] [PubMed]
  • BENEDICT JD, ROCHE M, YU TF, BIEN EJ, GUTMAN AB, STETTEN D., Jr Incorporation of glycine nitrogen into uric acid in normal and gouty man. Metabolism. 1952 Jan;1(1):3–12. [PubMed]
  • BENEDICT JD, YU TF, BIEN EJ, GUTMAN AB, STETTEN D., Jr A further study of the utilization of dietary glycine nitrogen for uric acid synthesis in gout. J Clin Invest. 1953 Aug;32(8):775–777. [PMC free article] [PubMed]
  • WYNGAARDEN JB. Overproduction of uric acid as the cause of hyperuricemia in primary gout. J Clin Invest. 1957 Oct;36(10):1508–1515. [PMC free article] [PubMed]
  • SEEGMILLER JE, LASTER L, LIDDLE LV. Failure to detect consistent overincorporation of glycine-1-C14 into uric acid in primary gout. Metabolism. 1958 Jul;7(4 Pt 1):376–377. [PubMed]
  • WYNGAARDEN JB. Normal glycine-C14-incorporation into uric acid in primary gout. Metabolism. 1958 Jul;7(4 Pt 1):374–375. [PubMed]
  • GUTMAN AB, YU TF, BLACK H, YALOW RS, BERSON SA. Incorporation of glycine-1-C14, glycine-2-C14 and glycine-N15 into uric acid in normal and gouty subjects. Am J Med. 1958 Dec;25(6):917–932. [PubMed]
  • LIDDLE L, SEEGMILLER JE, LASTER L. The enzymatic spectrophotometric method for determination of uric acid. J Lab Clin Med. 1959 Dec;54:903–913. [PubMed]
  • GRAYZEL AI, SEEGMILLER JE, LOVE E. Suppression of uric acid synthesis in the gouty human by the use of 6-diazo-5-oxo-L-norleucine. J Clin Invest. 1960 Mar;39:447–454. [PMC free article] [PubMed]
  • GUTMAN AB, YU TF. Renal function in gout; with a commentary on the renal regulation of urate excretion, and the role of the kidney in the pathogenesis of gout. Am J Med. 1957 Oct;23(4):600–622. [PubMed]
  • BENEDICT JD, FORSHAM PH, ROCHE M, SOLOWAY S, STETTEN D., Jr The effect of salicylates and adrenocorticotropic hormone upon the miscible pool of uric acid in gout. J Clin Invest. 1950 Aug;29(8):1104–1111. [PMC free article] [PubMed]
  • BENEDICT JD, KALINSKY HJ, SCARRONE LA, WERTBEIM AR, STETTEN D., Jr The origin of urinary creatine in progressive muscular dystrophy. J Clin Invest. 1955 Jan;34(1):141–145. [PMC free article] [PubMed]
  • WATTS RW, CRAWHALL JC. The first glycine metabolic pool in man. Biochem J. 1959 Oct;73:277–286. [PMC free article] [PubMed]
  • BIEN EJ, ZUCKER M. Uricolysis in normal and gouty individuals. Ann Rheum Dis. 1955 Dec;14(4):409–411. [PMC free article] [PubMed]
  • SORENSEN LB. Degradation of uric acid in man. Metabolism. 1959 Sep;8:687–703. [PubMed]
  • NUGENT CA, TYLER FH. The renal excretion of uric acid in patients with gout and in nongouty subjects. J Clin Invest. 1959 Nov;38:1890–1898. [PMC free article] [PubMed]
  • OREN BG, RICH M, BELLE MS. Chlorothiazide (diuril) as a hyperuricaci'emic agent. J Am Med Assoc. 1958 Dec 20;168(16):2128–2129. [PubMed]
  • ARONOFF A. Acute gouty arthritis precipitated by chlorothiazide. N Engl J Med. 1960 Apr 14;262:767–769. [PubMed]
  • HEALEY LA, MAGID GJ, DECKER JL. Uric acid retention due to hydrochlorothiazide. N Engl J Med. 1959 Dec 31;261:1358–1362. [PubMed]
  • CULLEN JH, LEVINE M, FIORE JM. Studies of hyperuricemia produced by pyrazinamide. Am J Med. 1957 Oct;23(4):587–595. [PubMed]
  • SHAPIRO M, HYDE L. Hyperuricemia due to pyrazinamide. Am J Med. 1957 Oct;23(4):596–599. [PubMed]
  • YU TF, SIROTA JH, BERGER L, HALPERN M, GUTMAN AB. Effect of sodium lactate infusion on urate clearance in man. Proc Soc Exp Biol Med. 1957 Dec;96(3):809–813. [PubMed]
  • HANDLER JS. The role of lactic acid in the reduced excretion of uric acid in toxemia of pregnancy. J Clin Invest. 1960 Oct;39:1526–1532. [PMC free article] [PubMed]

Articles from The Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • Compound
    PubChem Compound links
  • PubMed
    PubMed citations for these articles
  • Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...