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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptNIH Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
Eur Psychiatry. Author manuscript; available in PMC Jun 1, 2011.
Published in final edited form as:
PMCID: PMC2896004
NIHMSID: NIHMS205362

Stress, genetics and epigenetic effects on the neurobiology of suicidal behavior and depression

Abstract

Alterations in a number of neurobiological systems have been associated with suicidal behavior including the serotonergic and noradrenergic systems and the hypothalamic-pituitary-adrenal axis. Altered functioning of these systems may stem from both genetic and developmental causes. Adversity in early-life has developmental consequences on these systems that persist into adulthood. Genetic differences may also contribute to alterations in functioning of neurobiological systems. Moreover, the interaction of early- life experiences of adversity and genetic vulnerability is increasing thought to play a role, including via epigenetic mechanisms.

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