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Proc Natl Acad Sci U S A. Jun 1989; 86(12): 4559–4563.
PMCID: PMC287310

cricklet: A locus regulating a number of adult functions of Drosophila melanogaster


During a screen for mutations in trans-acting genes regulating yolk protein synthesis in Drosophila melanogaster, we have isolated a mutant (cricklet, clt) that is defective in yolk protein synthesis, histolysis of the larval fat body, vitellogenesis, and synthesis of larval serum protein 2 in the adult, larval synthesis occurring normally. Larval serum protein 2 was previously thought to be synthesized only in the third-instar larva. We suggest that the clt locus may encode a protein essential for mediating the response of adult tissues to juvenile hormone.

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