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Proc Natl Acad Sci U S A. May 1989; 86(10): 3748–3752.
PMCID: PMC287217

Induction of diapause in Drosophila melanogaster: photoperiodic regulation and the impact of arrhythmic clock mutations on time measurement.


The fruit fly Drosophila melanogaster displays an ovarian diapause that is regulated by photoperiod. Newly eclosed female flies (Canton-S wild type) exposed to short days (less than 14 hr of light per day) at 12 degrees C (or 10 degrees C) enter a fairly shallow reproductive diapause. Females exposed to long days (16 hr of light per day) at the same low temperature undergo ovarian maturation. The short day induced diapause continues for 6-7 weeks under a 10:14 light/dark cycle at 12 degrees C but is terminated rapidly after a transfer to higher temperature (18 or 25 degrees C) or to long days (18:6 light/dark cycle). Females from three strains homozygous for alleles of the period (per) locus, reportedly arrhythmic for behavioral circadian rhythms, and females that possessed two overlapping deletions of per were also capable of discriminating between long and short days, although, when compared with the wild-type flies, the critical day length was shifted to shorter values by approximately 2 hr. It is concluded that the period locus is not causally involved in photoperiod time measurement.

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Selected References

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  • Pittendrigh CS. Circadian surfaces and the diversity of possible roles of circadian organization in photoperiodic induction. Proc Natl Acad Sci U S A. 1972 Sep;69(9):2734–2737. [PMC free article] [PubMed]
  • Tyshchenko VP, Goryshin NI, Azarian AG. Rol' tsirkadnykh protsessov v fotoperiodizme nasekomykh. Zh Obshch Biol. 1972 Jan-Feb;33(1):21–31. [PubMed]
  • Lumme J, Oikarinen A, Lakovaara S, Alatalo R. The environmental regulation of adult diapause in Drosophila littoralis. J Insect Physiol. 1974 Oct;20(10):2023–2033. [PubMed]
  • Pittendrigh CS, Takamura T. Temperature dependence and evolutionary adjustment of critical night length in insect photoperiodism. Proc Natl Acad Sci U S A. 1987 Oct;84(20):7169–7173. [PMC free article] [PubMed]
  • Konopka RJ, Benzer S. Clock mutants of Drosophila melanogaster. Proc Natl Acad Sci U S A. 1971 Sep;68(9):2112–2116. [PMC free article] [PubMed]
  • Bargiello TA, Young MW. Molecular genetics of a biological clock in Drosophila. Proc Natl Acad Sci U S A. 1984 Apr;81(7):2142–2146. [PMC free article] [PubMed]
  • Zehring WA, Wheeler DA, Reddy P, Konopka RJ, Kyriacou CP, Rosbash M, Hall JC. P-element transformation with period locus DNA restores rhythmicity to mutant, arrhythmic Drosophila melanogaster. Cell. 1984 Dec;39(2 Pt 1):369–376. [PubMed]
  • Hall JC, Rosbash M. Genetic and molecular analysis of biological rhythms. J Biol Rhythms. 1987 Fall;2(3):153–178. [PubMed]
  • Smith RF, Konopka RJ. Circadian clock phenotypes of chromosome aberrations with a breakpoint at the per locus. Mol Gen Genet. 1981;183(2):243–251. [PubMed]
  • KING RC, RUBINSON AC, SMITH RF. Oogenesis in adult Drosophila melanogaster. Growth. 1956 Jun;20(2):121–157. [PubMed]
  • Dowse HB, Hall JC, Ringo JM. Circadian and ultradian rhythms in period mutants of Drosophila melanogaster. Behav Genet. 1987 Jan;17(1):19–35. [PubMed]
  • Helfrich C, Engelmann W. Evidences for circadian rhythmicity in the per0 mutant of Drosophila melanogaster. Z Naturforsch C. 1987 Nov-Dec;42(11-12):1335–1338. [PubMed]

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