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Proc Natl Acad Sci U S A. Sep 1969; 64(1): 161–167.
PMCID: PMC286141

THE RADIOIMMUNOASSAY OF CIRCULATING CARCINOEMBRYONIC ANTIGEN OF THE HUMAN DIGESTIVE SYSTEM*

Abstract

A radioimmunoassay has been developed for determining the serum levels of carcinoembryonic antigen of the human digestive system in patients with cancer of the colon and rectum. The assay is simple to perform and has a high degree of reproducibility and specificity. The test detects a concentration of 2.5 ng of carcinoembryonic antigen per ml of serum and this has provided the first demonstration of a circulating tumor-specific antigen in the sera of cancer patients.

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Selected References

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  • GOLD P, FREEDMAN SO. DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES. J Exp Med. 1965 Mar 1;121:439–462. [PMC free article] [PubMed]
  • Gold P, Freedman SO. Specific carcinoembryonic antigens of the human digestive system. J Exp Med. 1965 Sep 1;122(3):467–481. [PMC free article] [PubMed]
  • Krupey J, Gold P, Freedman SO. Physicochemical studies of the carcinoembryonic antigens of the human digestive system. J Exp Med. 1968 Sep 1;128(3):387–398. [PMC free article] [PubMed]
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  • Hunter WM, Greenwood FC. A radio-immunoelectrophoretic assay for human growth hormone. Biochem J. 1964 Apr;91(1):43–56. [PMC free article] [PubMed]
  • FARR RS. A quantitative immunochemical measure of the primary interaction between I BSA and antibody. J Infect Dis. 1958 Nov-Dec;103(3):239–262. [PubMed]
  • YALOW RS, BERSON SA. Immunoassay of endogenous plasma insulin in man. J Clin Invest. 1960 Jul;39:1157–1175. [PMC free article] [PubMed]

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