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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptNIH Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
Arch Dermatol. Author manuscript; available in PMC Apr 5, 2010.
Published in final edited form as:
PMCID: PMC2849106
NIHMSID: NIHMS148511

Psoriasis and the risk of diabetes and hypertension – A prospective Study of US female nurses

Abrar Qureshi, MD, MPH,1,2 Hyon K. Choi, MD, DrPH,1 Arathi R. Setty, MD, MPH,1 and Gary C. Curhan, MD, ScD1,3

Abstract

Context

Psoriasis has been associated with diabetes and hypertension in previous cross-sectional studies

Objective

To evaluate prospectively the independent association between psoriasis and risk of diabetes and hypertension

Design

A prospective study of female nurses followed from 1991-2005

Setting

Nurses' Health Study II, a cohort of 116,671 US women aged 27 - 44 in 1991

Participants

78,061 women who responded to a question about life-time history of physician-diagnosed psoriasis in 2005; women reporting a diagnosis of diabetes or hypertension at baseline were excluded

Main outcome measure

New diagnosis of diabetes or hypertension, obtained from biennial questionnaires.

Results

Among the 78,061 women, 1,813 (2.3%) reported a diagnosis of psoriasis. During the 14 years of follow-up, we documented a total of 1,560 (2%) incident cases of diabetes and 15,724 (20%) incident cases of hypertension. The multivariate-adjusted relative risk (RR) of diabetes in women with psoriasis compared to women without was 1.63 (95% CI, 1.25-2.12). Women with psoriasis were also at an increased risk for developing hypertension (multivariate RR 1.17; 95% CI, 1.06-1.30). Age, body mass index and smoking did not significantly modify the association between psoriasis and risk of diabetes or hypertension (p values for interaction ≥0.07).

Conclusions

In this prospective analysis, psoriasis was independently associated with an increased risk of diabetes and hypertension. Future studies are needed to examine if psoriasis treatment will reduce the risk of diabetes and hypertension.

Introduction

Psoriasis is a chronic inflammatory skin disease that affects between 1-3% of the population [1] and poses a lifelong burden [2]. Recent studies indicate that psoriasis is associated with an increased risk of comorbidity [3] and mortality compared to the general population [4]. Systemic inflammation in psoriasis and an increased prevalence of unhealthy life style factors have been independently associated with obesity, insulin resistance and an unfavorable cardiovascular risk profile [5].

Diabetes and hypertension are responsible for major morbidity and mortality in the United States [6-9]. Previous cross-sectional studies have demonstrated that individuals with psoriasis have a higher prevalence of obesity, diabetes and hypertension [10, 11]. Participants with mild psoriasis had a slightly, but significantly higher adjusted (for age, sex, and BMI) odds of diabetes 1.13 and hypertension 1.03 [12]. In a case-control study from Israel, the risk of diabetes 1.27 was significantly higher in individuals with psoriasis [13]. In a group of psoriatic individuals from Italy, diabetes mellitus occurred more frequently in those under 50 years age [14]. Individuals with psoriasis were more likely to have cardiovascular risk factors including hypertension [12] and myocardial infarctions at a younger age [15].

More than 80% of individuals with diabetes develop hypertension, and about 20% of individuals with hypertension develop diabetes [16]. In patients with hypertension and diabetes, the pathophysiology of cardiovascular disease is multifactorial, but recent evidence points toward the presence of a low-grade inflammatory process [16]. Inflammatory markers (e.g. C-reactive protein) have been shown to predict development of diabetes [17-19], and hypertension [20].

No previous studies have prospectively evaluated the link between psoriasis and diabetes or hypertension; therefore we examined this in a cohort of US women.

Methods

Study Population

The Nurses Health Study II (NHS II) is an ongoing longitudinal study of 116,671 female registered nurses from fifteen states in the US who were between the ages of 25 and 42 when they completed and returned a baseline questionnaire in 1989. The cohort is followed with biennial questionnaires and the follow-up rate exceeded 90% for each two-year period.

Ascertainment of psoriasis

In 2005, NHS II participants were asked if they had ever received a physician diagnosis of psoriasis and if so, the date of diagnosis. Of the 84,039 women who responded to the psoriasis question in 2005, a total of 2,169 women reported a physician-diagnosis of psoriasis. After excluding women with diabetes or hypertension at baseline in 1991, 78,061 women remained in the analysis of whom 1,813 women reported psoriasis. Hence we excluded 356 women with psoriasis because of baseline diabetes or hypertension. For this study, we started follow-up in 1991 as this is the first year for which we have corresponding information on smoking and alcohol status.

Ascertainment of diabetes and hypertension

Self-reported incident hypertension and incident diabetes cases were recorded from 1991 to 2005. We excluded women who first reported concomitant diabetes and hypertension on the same questionnaire during follow-up so that diabetes and hypertension could be evaluated as independent outcomes. Previously, medical record review confirmed a documented blood pressure >140/90 in 100% of women in the Nurses' Health Study I reporting hypertension; additionally, self-reported hypertension was predictive of subsequent cardiovascular events [21].

Covariates

Date of birth and height were reported on the 1989 questionnaire. Participants reported their current weight on the biennial mailed questionnaires. Body mass index was calculated by dividing weight in kilograms by the square of height in meters. The baseline and biennial follow up questionnaires inquired about smoking status and alcohol intake. Physical activity was assessed as the number of metabolic equivalent hours (MET-hrs) per week, the time invested in an activity every week multiplied by the energy expenditure required by the activity.

Statistical Analysis

Women accrued person-time from the return of the 1991 questionnaire until they reported a diagnosis of diabetes or hypertension or were censored at the end of the follow-up period in 2005. New psoriasis diagnoses were updated every 2 years. We used Cox proportion hazards modeling to estimate the age-adjusted and multivariate relative risks of incident diabetes and hypertension in women who had reported a physician diagnosis of psoriasis compared with those who did not. We categorized body mass index at baseline and at each questionnaire cycle into six categories: <21 kg/m2, 21-22.9 kg/m2, 23-24.9 kg/m2, 25-29.9 kg/m2, 30-34.9 kg/m2 and ≥35 kg/m2. To minimize residual confounding by BMI in categories, we also considered BMI as a continuous variable. Smoking was categorized (never, current, past), as was alcohol intake (1-4, 5-9, 10-14, 15-29, ≥30 grams per week). Physical activity was categorized in quintiles of metabolic equivalents (METS) per week. We explored potential interactions by age (<45 versus ≥45 years), BMI (<25 versus ≥25 kg/m2) and smoking (never, current, past) by testing the significance of interaction terms added to our final multivariate models. For all rate ratios, we calculated 95% confidence intervals. All statistical analyses were performed using SAS software, version 9.1 (SAS Institute Inc, Cary, NC). The Partners Health Care System institutional review board approved this study.

Results

Over the 14-year follow-up, 1,560 incident cases of diabetes and 15,724 incident cases of hypertension occurred. There was no substantial difference in mean age between women with and without psoriasis (Table 1). Mean BMI, alcohol intake and the proportions of current smoking and past smokers were higher in the psoriasis group.

Table 1
Baseline characteristics of women who self-reported a diagnosis of psoriasis between 1991 and 2005

Among women with psoriasis, there were 60 (3.3%) incident cases of diabetes. Compared to women without psoriasis, the age-adjusted relative risk of diabetes in women with psoriasis was 2.08 (95% confidence interval [CI], 1.60-2.69) (Table 2). This remained significantly elevated (RR 1.63; 95% CI, 1.25-2.12) after further adjusting for BMI, smoking, alcohol intake and physical activity. None of the 60 women who reported psoriasis and diabetes had type I diabetes.

Table 2
Age-adjusted and multivariate relative risks for development of diabetes and hypertension among women with psoriasis

Among women with psoriasis, a total of 386 (21.3%) women developed incident hypertension. This represented an increased risk of hypertension in women with psoriasis (age-adjusted RR 1.32; 95% CI, 1.19-1.45) that was attenuated but remained significant after multivariate adjustment (RR 1.17; 95% CI, 1.06-1.30).

We also evaluated possible effect modification by age, BMI and smoking in multivariate models. The association between psoriasis and risk was not modified by BMI for diabetes (p = 0.65) or hypertension (p = 0.07). There was also no effect modification by smoking for diabetes or hypertension (p ≥ 0.50).

Because women with psoriasis may be more likely to see a physician and therefore diagnosed with diabetes or hypertension, we performed additional analyses after limiting the population to those women who had at least one physical examination during the follow-up. There was no material change in the results.

Discussion

This prospective study demonstrated an increased risk of diabetes and hypertension in women with psoriasis, even after adjusting for age, BMI, alcohol intake and smoking. Hence, our study advances previous findings from cross-sectional studies and emphasizes the need to better understand the mechanisms that underlie these associations.

The risk of diabetes among individuals with psoriasis has been shown in cross-sectional studies to be elevated with RR between 1.27 and 2.48 [4, 10, 13, 14, 22-25], consistent with our prospective study. Although obesity and the metabolic syndrome had been proposed as an explanation for this increased risk [5], we found that the risk of diabetes was independent of BMI. Inflammation could be a biologically plausible mechanism underlying this association; insulin resistance has been attributed to inflammation previously [26, 27] and elevated C-reactive protein levels are predictive of diabetes [17, 18]. Alternatively, therapy for psoriasis may promote development of diabetes, especially if patients were treated with systemic steroids. In our study, information on psoriasis-related therapy is not available. Nonetheless, systemic steroids are not the standard of care for psoriasis in the United States and are typically avoided in psoriasis patients due to the potential for disease worsening [28]. Topical steroids often used in psoriasis may be systemically absorbed if used on large body surface areas for extended periods of time [29]. This could explain the observed increase in risk for diabetes, although adherence with long-term topical steroids use is generally low [30, 31].

An increased risk of hypertension of 1.2 to 2-fold has been reported in cross-sectional studies. In our study, individuals with psoriasis were at slightly increased risk for hypertension. Although psoriasis and hypertension share common risk factors such as smoking and obesity, we observed an independent association between psoriasis and hypertension after adjusting for smoking and BMI. Potential explanations for this association include systemic inflammation and psoriasis treatment. As mentioned above, psoriasis is a chronic inflammatory disease [32], and inflammation is a risk factor for hypertension [5, 11, 12]. In one study, although the risk for other cardiovascular risk factors was higher in severe psoriasis, a similar association between psoriasis severity and risk of hypertension was not found [12]. Previous work has shown that elevated levels of C-reactive protein were associated with a 52% increase in the risk of developing hypertension in women [33]. Systemic therapy for psoriasis with medications such as cyclosporine may increase risk of hypertension directly, albeit this risk is low [34]; we did not have data on therapy in our study but long-term cyclosporine use in psoriasis is not common [35]. Individuals with psoriasis may also be less likely to exercise due to physical or social discomfort [36], hence increasing their risk for hypertension. In our study, we controlled for physical activity and found no material change in risk for hypertension.

Our study was restricted to predominantly Caucasian women. Hence we cannot generalize these results to men or other racial groups. Our study was observational; thus, we cannot rule out the possibility that unmeasured factors might contribute to the observed associations. While we observed no material change in the results that excluded those with at least one physical examination during the follow-up, we cannot eliminate potentially increased ascertainment of our outcomes among women with psoriasis. A major strength of the study was detailed collection of information on body mass index, smoking and alcohol. Similar to other epidemiologic studies of psoriasis [37-40], we did not confirm the nurses' self-reported physician-diagnosis of psoriasis clinically with an examination by a dermatologist. Previous validation studies in the Nurses Health Study I for another skin condition, i.e. basal cell carcinoma, found self-reports to be >90% accurate [21, 41]. While we expect the overall accuracy of self-reported physician-diagnosis of psoriasis to be high among registered nurses, the corresponding accuracy against a dermatologist's examination is not available. Confirming our results using more specific case definitions of psoriasis and evaluating for various psoriasis subtypes, severity, and treatment effects would be valuable.

In conclusion, our prospective study indicates that women with psoriasis have an increased risk of diabetes and hypertension, confirming the findings from previous cross-sectional studies. These data illustrate the importance of considering psoriasis a systemic disorder rather than simply a skin disease. Further research is needed to better understand the mechanisms underlying these associations and whether psoriasis therapy can reduce risk for diabetes and hypertension.

Acknowledgments

We are indebted to Elaine Coughlan-Gifford for her assistance with data analysis and programming

Funding: This work was partly supported by K07CA108978/NCI (AAQ) and CA050385/NCI

Footnotes

Conflict of Interest: Dr. Qureshi has been a consultant/speaker for Abbott, Amgen and Genentech

References

1. Christophers E. Psoriasis--epidemiology and clinical spectrum. Clinical & Experimental Dermatology. 2001;26(4):314–20. [PubMed]
2. Kimball AB, et al. The psychosocial burden of psoriasis. American Journal of Clinical Dermatology. 2005;6(6):383–92. [PubMed]
3. Pearce DJ, et al. The comorbid state of psoriasis patients in a university dermatology practice. Journal of Dermatological Treatment. 2005;16(5-6):319–23. [PubMed]
4. Mallbris L, Ritchlin CT, Stahle M. Metabolic disorders in patients with psoriasis and psoriatic arthritis. Current Rheumatology Reports. 2006;8(5):355–63. [PubMed]
5. Wakkee M, et al. Unfavorable cardiovascular risk profiles in untreated and treated psoriasis patients. Atherosclerosis. 2007;190(1):1–9. [PubMed]
6. Nakagami T, et al. Screen-detected diabetes, hypertension and hypercholesterolemia as predictors of cardiovascular mortality in five populations of Asian origin: the DECODA study. European Journal of Cardiovascular Prevention & Rehabilitation. 2006;13(4):555–61. [PubMed]
7. Hu G, et al. The impact of history of hypertension and type 2 diabetes at baseline on the incidence of stroke and stroke mortality. [see comment] Stroke. 2005;36(12):2538–43. [PubMed]
8. Livingston EH, Ko CY. Effect of diabetes and hypertension on obesity-related mortality. Surgery. 2005;137(1):16–25. [PubMed]
9. Ravipati G, et al. Incidence of new stroke or new myocardial infarction or death at 39-month follow-up in patients with diabetes mellitus, hypertension or both with and without microalbuminuria. Cardiology. 2008;109(1):62–5. [PubMed]
10. Gibson SH, Perry HO. Diabetes and psoriasis. A M A Archives of Dermatology. 1956;74(5):487–8. [PubMed]
11. Cohen AD, et al. Association between psoriasis and the metabolic syndrome. A cross-sectional study. Dermatology. 2008;216(2):152–5. [PubMed]
12. Neimann AL, et al. Prevalence of cardiovascular risk factors in patients with psoriasis. Journal of the American Academy of Dermatology. 2006;55(5):829–35. [PubMed]
13. Shapiro J, et al. The association between psoriasis, diabetes mellitus, and atherosclerosis in Israel: a case-control study. Journal of the American Academy of Dermatology. 2007;56(4):629–34. [PubMed]
14. Binazzi M, Calandra P, Lisi P. Statistical association between psoriasis and diabetes: further results. Archives for Dermatological Research - Archiv fur Dermatologische Forschung. 1975;254(1):43–8. [PubMed]
15. Gelfand JM, et al. Risk of myocardial infarction in patients with psoriasis. JAMA. 2006;296(14):1735–41. [PubMed]
16. Savoia C, Schiffrin EL. Vascular inflammation in hypertension and diabetes: molecular mechanisms and therapeutic interventions. Clinical Science. 2007;112(7):375–84. [PubMed]
17. Pradhan AD, et al. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. [see comment] JAMA. 2001;286(3):327–34. [PubMed]
18. Yuan G, et al. Serum CRP levels are equally elevated in newly diagnosed type 2 diabetes and impaired glucose tolerance and related to adiponectin levels and insulin sensitivity. Diabetes Research & Clinical Practice. 2006;72(3):244–50. [PubMed]
19. Dehghan A, et al. Risk of type 2 diabetes attributable to C-reactive protein and other risk factors. Diabetes Care. 2007;30(10):2695–9. [PubMed]
20. Corrado E, et al. Association of elevated fibrinogen and C-reactive protein levels with carotid lesions in patients with newly diagnosed hypertension or type II diabetes. Archives of Medical Research. 2006;37(8):1004–9. [PubMed]
21. Colditz GA, et al. Validation of questionnaire information on risk factors and disease outcomes in a prospective cohort study of women. American Journal of Epidemiology. 1986;123(5):894–900. [PubMed]
22. Brownstein MH. Psoriasis and diabetes mellitus. Archives of Dermatology. 1966;93(6):654–5. [PubMed]
23. Reeds RE, Jr, Fusaro RM, Fisher I. Psoriasis Vulgaris. I. a Clinical Survey of the Association with Diabetes Mellitus. Archives of Dermatology. 1964;89:205–8. [PubMed]
24. Ollendorff-Curth H. Psoriasis und Diabetes mellitus. Archiv fur Klinische und Experimentelle Dermatologie. 1966;227(1):240–7. [PubMed]
25. Sommer DM, et al. Increased prevalence of the metabolic syndrome in patients with moderate to severe psoriasis. Archives of Dermatological Research. 2006;298(7):321–8. [PubMed]
26. Duncan BB, et al. Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes. 2003;52(7):1799–805. [PubMed]
27. Syrenicz A, et al. Low-grade systemic inflammation and the risk of type 2 diabetes in obese children and adolescents. Neuroendocrinology Letters. 2006;27(4):453–8. [PubMed]
28. Brodell RT, Williams L. A corticosteroid-induced flare of psoriasis. How to control or, better yet, avoid. Postgraduate Medicine. 1999;106(7):31–2. [PubMed]
29. Garden JM, Freinkel RK. Systemic absorption of topical steroids. Metabolic effects as an index of mild hypercortisolism. Archives of Dermatology. 1986;122(9):1007–10. [PubMed]
30. Chu T. Better patient compliance in psoriasis. Practitioner. 2000;244(1608):238–42. [PubMed]
31. Zaghloul SS, Goodfield MJ. Objective assessment of compliance with psoriasis treatment. Archives of Dermatology. 2004;140(4):408–14. [PubMed]
32. Fitch E, et al. Pathophysiology of psoriasis: recent advances on IL-23 and Th17 cytokines. Current Rheumatology Reports. 2007;9(6):461–7. [PMC free article] [PubMed]
33. Women's high CRP levels can predict hypertension. Healthcare Benchmarks & Quality Improvement. 2004;11(2):20–1. [PubMed]
34. Ho VC. The use of ciclosporin in psoriasis: a clinical review. British Journal of Dermatology. 2004;150 67:1–10. [PubMed]
35. Grossman RM, et al. Long-term safety of cyclosporine in the treatment of psoriasis. [see comment] Archives of Dermatology. 1996;132(6):623–9. [PubMed]
36. Mease PJ, Menter MA. Quality-of-life issues in psoriasis and psoriatic arthritis: outcome measures and therapies from a dermatological perspective. Journal of the American Academy of Dermatology. 2006;54(4):685–704. [PubMed]
37. Gelfand JM, et al. Risk of myocardial infarction in patients with psoriasis. [see comment] JAMA. 2006;296(14):1735–41. [PubMed]
38. Gelfand JM, et al. The prevalence of psoriasis in African Americans: results from a population-based study. Journal of the American Academy of Dermatology. 2005;52(1):23–6. [PubMed]
39. Nijsten T, et al. Traditional systemic treatments have not fully met the needs of psoriasis patients: results from a national survey. Journal of the American Academy of Dermatology. 2005;52(3 Pt 1):434–44. [PubMed]
40. Krueger G, et al. The impact of psoriasis on quality of life: results of a 1998 National Psoriasis Foundation patient-membership survey. [see comment] Archives of Dermatology. 2001;137(3):280–4. [PubMed]
41. Hunter DJ, et al. Diet and risk of basal cell carcinoma of the skin in a prospective cohort of women. Annals of Epidemiology. 1992;2(3):231–9. [PubMed]

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