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Antimicrob Agents Chemother. 1994 February; 38(2): 400–402. | PMCID: PMC284468 |
Reduction of matrix metalloproteinase 8-neutrophil collagenase levels during long-term doxycycline treatment of reactive arthritis. A Lauhio, Y T Konttinen, H Tschesche, D Nordström, T Salo, J Lähdevirta, L M Golub, and T Sorsa Department of Internal Medicine, Aurora Hospital, Helsinki, Finland. Abstract The aim of this work was to determine whether human polymorphonuclear neutrophilic interstitial collagenase (matrix metalloproteinase 8 [MMP-8]) levels are reduced during long-term doxycycline treatment in humans with reactive arthritis. Serum MMP-8 levels were reduced (mean +/- standard error of the mean, 678.9 +/- 185.6 versus 491.2 +/- 144.8 ng of MMP-8 per ml), but not statistically significantly. However, the reduction of salivary MMP-8 levels was statistically significant (3,729 +/- 1,905.3 versus 1,866 +/- 780.0 ng of MMP-8 per ml, P < 0.05). This study demonstrated that a 2-month regimen of doxycycline can reduce MMP-8 levels in serum and especially in body fluids (i.e., saliva) containing inflammatory exudates and thus may contribute to reduced tissue destruction. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (525K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - Bergmann U, Michaelis J, Oberhoff R, Knäuper V, Beckmann R, Tschesche H. Enzyme linked immunosorbent assays (ELISA) for the quantitative determination of human leukocyte collagenase and gelatinase. J Clin Chem Clin Biochem. 1989 Jun;27(6):351–359. [PubMed]
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