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Proc Natl Acad Sci U S A. Apr 1970; 65(4): 905–910.
PMCID: PMC283002

Surface Movements during the Growth of Single Explanted Neurons*

Abstract

The processes of isolated rat sympathetic neurons growing in culture were marked with glass or carmine particles and observed with timelapse microphotography. Particles on the processes moved with the cell in relation to the dish and underwent continual small jerky movements. They did not, however, show any over-all distal motion and for long periods, during which the growth cone progressed more than 100 μ, the particles remained at about the same distance from the cell body. The most obvious explanation for this result is that new fiber surface, and perhaps the plasma membrane, is deposited in the region of the growing tip.

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Selected References

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  • HUGHES A. The growth of embryonic neurites; a study of cultures of chick neural tissues. J Anat. 1953 Apr;87(2):150–162. [PMC free article] [PubMed]
  • Varon S, Nomura J, Shooter EM. Subunit structure of a high-molecular-weight form of the nerve growth factor from mouse submaxillary gland. Proc Natl Acad Sci U S A. 1967 Jun;57(6):1782–1789. [PMC free article] [PubMed]
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  • Ingram VM. A side view of moving fibroblasts. Nature. 1969 May 17;222(5194):641–644. [PubMed]

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