Logo of pnasPNASInfo for AuthorsSubscriptionsAboutThis Article
Proc Natl Acad Sci U S A. 1970 Apr; 65(4): 905–910.
PMCID: PMC283002

Surface Movements during the Growth of Single Explanted Neurons*


The processes of isolated rat sympathetic neurons growing in culture were marked with glass or carmine particles and observed with timelapse microphotography. Particles on the processes moved with the cell in relation to the dish and underwent continual small jerky movements. They did not, however, show any over-all distal motion and for long periods, during which the growth cone progressed more than 100 μ, the particles remained at about the same distance from the cell body. The most obvious explanation for this result is that new fiber surface, and perhaps the plasma membrane, is deposited in the region of the growing tip.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.5M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • HUGHES A. The growth of embryonic neurites; a study of cultures of chick neural tissues. J Anat. 1953 Apr;87(2):150–162. [PMC free article] [PubMed]
  • Varon S, Nomura J, Shooter EM. Subunit structure of a high-molecular-weight form of the nerve growth factor from mouse submaxillary gland. Proc Natl Acad Sci U S A. 1967 Jun;57(6):1782–1789. [PMC free article] [PubMed]
  • LEVI-MONTALCINI R, ANGELETTI PU. Essential role of the nerve growth factor in the survival and maintenance of dissociated sensory and sympathetic embryonic nerve cells in vitro. Dev Biol. 1963 Mar;6:653–659. [PubMed]
  • Ingram VM. A side view of moving fibroblasts. Nature. 1969 May 17;222(5194):641–644. [PubMed]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences


Save items

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...