Logo of nihpaAbout Author manuscriptsSubmit a manuscriptNIH Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
Schizophr Res. Author manuscript; available in PMC Sep 1, 2010.
Published in final edited form as:
PMCID: PMC2825750
NIHMSID: NIHMS134244

Symptoms as mediators of the relationship between neurocognition and functional outcome in schizophrenia: A meta-analysis[star]

Abstract

Background

Neurocognitive functioning in schizophrenia has received considerable attention because of its robust prediction of functional outcome. Psychiatric symptoms, in particular negative symptoms, have also been shown to predict functional outcome, but have garnered much less attention. The high degree of intercorrelation among all of these variables leaves unclear whether neurocognition has a direct effect on functional outcome or whether that relationship to functional outcome is partially mediated by symptoms.

Methods

A meta-analysis of 73 published English language studies (total n = 6519) was conducted to determine the magnitude of the relationship between neurocognition and symptoms, and between symptoms and functional outcome. A model was tested in which symptoms mediate the relationship between neurocognition and functional outcome. Functional outcome involved measures of social relationships, school and work functioning, and laboratory assessments of social skill.

Results

Although negative symptoms were found to be significantly related to neurocognitive functioning (p < .01) positive symptoms were not (p = .97). The relationship was moderate for negative symptoms (r=−.24, n = 4757, 53 studies), but positive symptoms were not at all related to neurocogniton (r = .00, n= 1297, 25 studies). Negative symptoms were significantly correlated with functional outcome (r =−.42, p<.01), and again the correlation was higher than for positive symptoms (r = −.03, p = .55). Furthermore, our findings support a model in which negative symptoms significantly mediate the relationship between neurocognition and functional outcome (Sobel test p <.01).

Conclusions

Although neurocognition and negative symptoms are both predictors of functional outcome, negative symptoms might at least partially mediate the relationship between neurocognition and outcome.

Keywords: Meta-analysis, Schizophrenia, Neurocognition, Positive symptoms, Negative symptoms, Mediation model, Sobel test, Functional outcome

1. Introduction

Perhaps one of the most contemporary and compelling issues in schizophrenia research today is the understanding of the relative contribution of neurocognitive deficits and psychiatric symptoms to functional outcome. Neurocognitive deficits continue to be widely accepted as a core feature of the disorder (Green et al., 2004; Bellack et al., 2007; Harvey et al., 2006) because they are present not only in chronic patients when they are acutely ill, but also during periods of symptom remission. Similar deficits have also been found in first episode patients (Saykin et al., 1994; Albus et al., 1996; Bilder et al., 2000; Hoff and Kremen, 2003; Hoff et al., 2005). Several literature reviews that have included cross-sectional and longitudinal data demonstrate that neurocognitive functioning is a strong predictor of community functioning, such as social functioning, work performance, and social skills (Green, 1996; Green et al., 2000). In general, these studies conclude that neurocognitive functioning more robustly predicts functional outcome than do symptoms, especially positive symptoms (reality distortion). In contrast to the recent emphasis of the impact of neurocognitive deficits on functional outcomes in schizophrenia, psychiatric symptoms have received relatively less attention as predictors but are nonetheless significantly associated with community outcomes.

Several cross-sectional studies have suggested that performance on neurocognitive tests is correlated with at least one of the three of the major symptom factors, positive, negative, or disorganization (Roy and DeVriendt, 1994; Davidson and McGlashan, 1997; Rund et al., 1997; Addington and Addington, 1999, 2000; Brazo et al., 2002, 2005). Most of the studies seem to have found a stronger cross-sectional relationship with negative symptoms than with positive symptoms, non-disorganizing type (Harvey et al., 1998; Heaton et al., 1994; Corrigan and Toomey, 1995; Harvey et al., 2006; Keefe et al., 2006a,b). A substantial body of literature suggests that symptoms of disorganization, when reported as a separate factor, are also strongly related to neurocognition and warrant a separate empirical study. In particular, attentional deficits and poor performance in verbal fluency have been linked to severity of negative symptoms (Nuechterlein et al., 1986; Kerns et al., 1999; Howanitz et al., 2000). In addition, there is some evidence to suggest that negative symptoms or deficit syndrome patients have particular impairments in reasoning and problem solving (executive functioning) and on tests of motor functions as compared to memory functions (Cuesta et al., 1995; Berman et al., 1997; Zakzanis, 1998; Bryson et al., 2001; Bozikas et al., 2004); (Brazo et al., 2005). One study linked the severity of negative symptoms to IQ (Carlsson et al., 2006) while contradictory results of other studies show that this finding is not consistent (Simon et al., 2003; Brazo et al., 2002; Bozikas et al., 2004). Some have argued that schizophrenia patients with the greatest cognitive impairments have the most prominent negative symptoms (Brazo et al., 2005; Villalta-Gil et al., 2006). Thus, at least on a cross-sectional basis, neurocognition is linked to psychiatric symptoms (Harvey et al., 2006).

Although psychiatric symptoms have received relatively less emphasis recently as predictors of functioning, they are nonetheless significantly associated with community outcomes (Addington and Addington, 1999; Dickerson et al., 1999a,b; Norman et al., 1999; Addington and Addington, 2000; Suslow et al., 2000; Smith et al., 2002; Dickinson and Coursey, 2002; Malla et al., 2002; Hoffmann et al., 2003; McGurk et al., 2003; Lysaker and Davis, 2004; Milev, 2005; Pencer et al., 2005; Hofer et al., 2006; Bowie et al., 2006; Bozikas et al., 2006). Interestingly, positive (non-disorganizing) symptoms appear to interfere less with social and work functioning than do negative symptoms, yet both symptom groups appear to make independent contributions to community functioning (Pogue-Geile and Harrow, 1984; Breier et al., 1991; Herbener and Harrow, 2004). For instance, negative symptoms have predicted deficits in community functioning for up to two years following baseline assessments (Breier et al., 1991; Beng-Choon et al., 1998; McGlashan and Fenton, 1992; Herbener and Harrow, 2004). Despite the number of theorists who conclude that neurocognitive deficits should take center stage in predicting functional outcomes, there are compelling arguments and data suggesting that the importance of symptoms, in particular negative symptoms, should not be overlooked (Brekke et al., 2005; Harvey et al., 2006). The consistency of the cross-sectional association between negative symptoms and neurocognitive functioning, combined with the results of studies that examine symptoms as predictors of functional outcome, warrants further investigation of these complex relationships. This line of research raises the question of whether negative symptoms might mediate some of the associations observed between neurocognitive performance and functional outcome in schizophrenia.

This meta-analysis was conducted to determine if the relationship between neurocognitive functioning and functional outcome is mediated by the extent of positive (non-disorganizing) or negative symptoms in patients with schizophrenia. We hypothesized that the meta-analysis would support a mediation hypothesis for negative symptoms based on the strength of the relationship between neurocognition and negative symptoms, and negative symptoms and outcome.

2. Methods

2.1. Review procedures

A literature search was conducted in scientific journals covering the period from 1977 to December 31, 2006. The following databases were used in the literature search: PsychInfo, PsychAbstracts, EBSCOhost, PubMed, and Social Sciences Citation index. Searches were restricted to articles published in the English language. The following key search terms in schizophrenia were used (some terms were combined): neurocognition, neuropsychology, working memory, verbal learning and memory, executive functions, problem solving, attention/vigilance, symptoms, skills assessment, social functioning, work performance, and functional outcome. The reference lists of published articles were also searched to locate additional studies that were relevant. We cannot be certain that we were able to locate all of the published English language papers that met our inclusion criteria, but we were able to obtain a sufficiently representative number of relevant papers for empirical analysis.

Using these methods, over 200 articles were identified as potentially relevant to this topic. The inclusion criteria were as follows: (1) study must have used empirical methods and been published in a peer reviewed journal; (2) contained descriptions of study measures and operational definitions of variables; (3) used structured assessments of symptoms with established scales or standardized methods of symptom assessment; (4) neurocognitive functioning was assessed using standardized batteries; (5) all participants in the study must have been diagnosed with schizophrenia or schizoaffective disorder according to DSM criteria (6) statistics reported must have been correlation coefficients or other statistics that could be converted into correlations (e.g. F-statistic, t-statistic) so that an effect size and z score could be calculated, and (7) sample data from a study were not included or published previously in another paper.

One hundred and eleven articles were eliminated due to not meeting these criteria. An additional 26 were excluded because the statistics they reported could not be converted into effect sizes or correlations for statistical analyses. A total of 73 studies met all the criteria (Table 1) which included 6519 patients. There were three primary categories of studies (see Table 1), those that examined (1) the relationship between neurocognition and symptoms, (2) the relationship between symptoms and functional outcome, and (3) interrelationships of all three. Studies of both inpatients and outpatients were included. If a study included cross-sectional and longitudinal analyses, we included only the cross-sectional data into our meta-analysis. We considered an interval between observations of less than 90 days to be cross-sectional. For each of the 73 studies a record was created that included (1) a description of the neuropsychological tests, e.g., Wisconsin Card Sorting Test (WCST), California Verbal Learning Test (CVLT), (2) symptom measures, e.g., Scale for the Assessment of Positive Symptoms (SAPS), Scale for the Assessment of Negative Symptoms (SANS), (3) measures of functional outcome, e.g., QOL, (4) study statistics, e.g., correlation coefficients, and (5) study characteristics, such as gender ratio, patient status, diagnosis, location.

Table 1
Studies included in meta-analysis, domains of interest, and number and type of subjects.

2.2. Defining neurocognition, positive and negative symptoms, and functional outcome

For the current study, neurocognition was operationally defined as cognitive processes that are measurable with structured neuropsychological tests, such as verbal learning and memory (Table 2). Selection of neurocognitive domains for analysis was guided by the MATRICS initiative (Nuechterlein et al., 2004). The current study included 6 of the 7 MATRICS domains of cognitive functioning: speed of processing, attention/vigilance, working memory, verbal learning visual learning, and reasoning and problem solving, but not social cognition. Because social cognition may itself be a mediator between neurocognition and functional outcome (Brekke et al., 2005; Sergi et al., 2006), we excluded it from this examination of symptom mediators between neurocognition and functional outcome.

Table 2
Neurocognitive domains, symptom assessments, and functional outcome measures.

The construct of symptoms included positive and negative symptom dimensions as measured by structured instruments (Table 2). Positive symptoms consisted of hallucinations and delusions (reality distortion) which were considered conceptually different from symptoms of disorganization (Dibben et al., 2009; Nieuwenstein et al., 2001). For the current analysis, we considered only the relationship between reality distortion and neurocognition, and reality distortion and functional outcome. We excluded a separate consideration of the relationship between symptoms of disorganization and neurocognition because this topic warrants an independent investigation. Therefore, studies or analyses were excluded that had combined disorganization with positive symptoms (reality distortion), e.g., the PANSS positive symptom factor which includes delusions, hallucinations, and conceptual disorganization, the total score from the SAPS which combined reality distortion, bizarre behavior, and formal thought disorder. For the definition of negative symptoms, we considered only those scales which measured negative symptoms, e.g., SANS, or had negative symptom items that were clustered together or were created through factor analysis, e.g., PANSS negative symptom factor.

The construct of functional outcome was divided into community functioning, skills assessment, and functional capacity (Table 2). Community functioning included work or school performance, social functioning, independent living, and quality of life. Social skill was measured in the laboratory using structured measures, e.g., a role-play test such as the Assessment of Interpersonal Problem-Solving Skills (AIPSS), and functional capacity, e.g., the University of San Diego Performance-Based Skills Assessment. Social skills and functional capacity are considered intermediate variables rather than direct measures functional outcome.

2.3. Data analysis procedures

For the main analysis we combined all 6 domains of neurocognitive functioning and created one composite neurocognitive variable to represent neurocognition. There were a sufficient number of studies for analysis in each of the separate domains that examined the relationship between neurocognition and symptoms, and also between symptoms with functional outcome. The relationship between neurocognition and functional outcome (estimated r =.30) was based on the meta-analysis by Green et al. (2000). Correlation matrices were constructed based on aggregated estimates of neurocognition, positive and negative symptoms, and functional outcomes. These 3 by 3 correlation matrices were derived by first transforming the observed (published) correlations in each study using Fisher’s r-to-z transformation. Where indicated, multiple results were averaged from the same domain, e.g., several tests of working memory were combined into a single observation for that study. The correlation coefficients were then combined into a single estimate of the population correlation by averaging them weighted by sample size (Hedges and Olkin, 1984). Based on these combined correlation coefficients, the studies were then tested for homogeneity by calculating a Q-statistic. Every neurocognitive domain proved to be heterogeneous at the .05% level. Some of the studies that contained multiple measures of the same neurocognitive variables showed evidence that the measures were heterogeneous even within studies. However, there were not enough examples of each particular test from different studies to conduct a random effects model controlling for both study and within-study measurement effects. As heterogeneity of measures is a known problem in the field, and because of the fact that the question of the adequate multivariate alpha level of a multi-Z study is not yet solved (Hafdahl, 2007), the decision was made to continue the analysis using all studies in our sample. Although the significance of the reported p-values may be exaggerated, the data presented here can at least be considered a preliminary analysis of the relationship between the variables of interest. The estimated correlation coefficients were then combined into the 3 by 3 correlation matrices of interest using the multi-Z method, and these combined meta-analytic correlation matrices are the basis of the reported correlations and follow-up analyses.

2.4. Testing mediation

For testing mediation, we followed the well-established procedures and conceptual understanding provided by Baron and Kenny (1986) (Fig. 1). The Sobel test (Preacher and Hayes, 2004) determines the significance of the indirect effect through the mediator by testing the hypothesis of no difference between the total effect (path c; neurocognition and functional outcome) and the indirect effect (path c′; neurocognition and symptoms, symptoms and outcome). The indirect effect of the mediator is the product of paths a and b; which is equivalent to (c–c′). As such a significant result of the Sobel test is evidence of partial mediation and does not make any claims about the absence or presence of complete mediation. The regression coefficients for the multiple regression predicting functional outcome from both neurocognitive variables and symptom ratings can be estimated from the pairwise correlation coefficients used to evaluate the strength of the indirect effect.

b=ryx1ryx2rx1x21rx1x22

Deriving the estimate of the conditional correlations directly from the pairwise correlations makes it easier to account for different sample sizes underlying the different elements of the covariance matrix. This is done by calculating the standard error of the estimate of the regression coefficients based on the number of observations of a particular estimate. This approach is more straightforward than trying to determine the correct sample size of a structural equation model that has been fitted to data that are derived from a combined correlation matrix. Because of the lack of homogeneity of the neuropsychological tests (described above), three neurocognitive domains were chosen with the highest correlations for tests of indirect effects. These neurocognitive domains would most likely represent true effects in the population despite the fact that the significance of test statistics for these variables is potentially exaggerated. Even under conservative assumptions, such as assuming that the significance is 10 fold increased, a number of the results are still significant.

Fig. 1
Typical mediation model.

3. Results

To provide a foundation for examining the variables of interest, we examined separately the relationship between neurocognition and symptoms, and the relationship between symptoms and functional outcomes. As the severity of illness might influence the functional relationship between these variables, we tested if these relationships differ between inpatient samples and out-patient samples. We considered the patient status as a proxy for severity of illness because we assume in-patient samples are in an acute phase of illness, while outpatients in general are stable. The results were identical for both types of patients in that negative symptoms were a significant mediator for both inpatients and outpatients. Therefore, all of the following results are presented for the combined sample which included both types of patients.

The cross-sectional relationship between neurocognition and positive symptoms (reality distortion) was not statistically significant (r=−.00, p = .97) as was the relationship between positive symptoms and community functioning (r =−.03, p = .55). Therefore, no test of mediation was performed (Table 3). In contrast, the effect size of the correlation between neurocognition and negative symptoms was moderate (r=−.24, p <.01) (Table 3). Negative symptoms were significantly related to functional outcome (r=−.42, p<.01) defined as community functioning and with skills assessment (r = −.28, p<.01)(Table 4). These significant relationships between neurocognition and negative symptoms, and between negative symptoms and functional outcome formed the basis for examining the mediation hypothesis.

Table 3
The magnitude of relationships between neurocognition with symptoms, and symptoms with outcome is examined using average correlations across studies.
Table 4
The indirect effects of neurocognition on functioning mediated through negative symptoms were examined using a Sobel test of mediation.

Using the Sobel test for indirect effects, we examined the estimated strength of the indirect effect from independent variable to the dependent variable through the mediator, and the p-value to determine the level of significance (Table 4). We found support for the hypothesis that the relationship between neurocognition and community functioning and skills assessment was partially mediated by negative symptoms (Sobel test for indirect effects: z= 133.20, p<.01 and z = 4.33, p<.01, respectively). The relationship between neurocognitive domains and functional outcome (i.e., community functioning and skill assessment) was also partially mediated by negative symptoms (Table 4). As expected, and despite using the same methodology in calculating effect sizes, the estimated effect of negative symptoms on community functioning (estimated r=−.42) is much stronger than the estimated effect of positive symptoms (estimated r=−.03).

4. Discussion

We examined models that included neurocognition, positive symptoms, and negative symptoms as predictors of community-based functional outcomes and social skills in schizophrenia. Our meta-analyses showed there was strong cross-sectional evidence indicating that negative symptoms are related to community-based functional outcome and skill assessment. Using meta-analytic techniques, such as the Sobel test of mediation, yielded fairly strong evidence indicating that the relationship between neurocognition and functional outcome is at least partially mediated by negative symptoms. In this model, neurocognition is still a primary causal variable that influences outcome. However, we found that the total effects of neurocognition on outcome were at least partially mediated via an indirect path through negative symptoms. Therefore, neurocognition is proposed to have both direct and indirect effects on functional outcome.

Previous research has linked neurocognition to symptoms and symptoms to functional outcome, but in separate studies. In fact, there is a consistent and moderately strong relationship between neurocognition and negative symptoms. Harvey et al. (2006) suggested that cognitive deficits and negative symptoms share many features in common and are correlated, at least cross-sectionally. They point out that cognitive deficits and negative symptoms can have a similar type of onset, course, and are correlated with other aspects of schizophrenia, e.g., functional outcome. However, as far as we are aware, no prior meta-analysis has empirically tested a mediation model using the Sobel test to examine whether negative symptoms mediate between neurocognition and functional domains. The current results indicate that the relationship of negative symptoms to community-based functioning is relatively strong, but the relationship of positive symptoms to community-based functioning is relatively weak. Thus, positive symptoms (non-disorganizing type), such as hallucinations and delusions, do not consistently interfere with a person's ability to socialize or to perform at work. Patients might learn to compensate for positive symptom deficits in various ways, e.g., ignoring beliefs about aliens while working in retail clothing store. However, the data suggest that negative symptoms might be more closely linked to impairments in daily performance or skill acquisition. This relationship seems to hold for both inpatients and outpatients with schizophrenia.

Heterogeneity in the measurement of neurocognition was very evident in the studies included in this meta-analysis. Some neurocognitive tests were used very frequently, e.g., WCST. The constructs of executive functions, working memory, and attentional processes appeared to be oversampled as compared to constructs such as visual and spatial learning and memory. In addition, even within one domain of neurocognition, such as working memory, several tests were used, e.g., digit span measured auditory processing of working memory while spatial span tests measured visual working memory. In some cases, the same tests were classified in different studies as assessing different domains, probably because the tests demanded several different cognitive processes. For the current meta-analysis, we used the MATRICS classification scheme and definitions of domains (Nuechterlein et al., 2004) to place measures in domains based on the predominant cognitive process required.

There are several limitations to this study that warrant mention, some of which are common to all meta-analytic investigations (for a discussion, see: Rosenthal, 1991; Lipsey and Wilson, 2001). First, the study sample was not randomly selected. Additionally, neurocognition is not a homogenous concept and its measurement was influenced by how common a particular set of neurocognitive tests appear in the published literature. Therefore, the p-values that were averaged across studies are certainly not precise. The relationships in the studies in this meta-analysis are cross-sectional rather than longitudinal in design. For all of these reasons, and more, one cannot use meta-analysis or any correlational data, to infer causality. Further, the selection of which variables to place as predictors and which to test as a mediator was somewhat arbitrary. A theory driven approach was used to decide the direction that neurocognition is likely an underlying “causal” factor for the severity of negative symptoms. We do not believe that there is strong evidence suggesting that negative symptoms cause neurocognitive deficits. Similarly, the severity of symptoms most likely contributes to poor outcomes, but poor outcomes could conceivably contribute to a worsening of symptoms. In addition, we note the possibility of measurement overlap resulting in an inflated correlation between negative symptoms and outcome. With the SANS, there are definitions and anchor points for rating domains such as avolition at work or school that overlap with definitions of functional outcome. Despite the fact that each of these study limitations suggest that caution should be used in interpreting the results of the current study, our findings still provide some direction for future research on potential contributors to outcome. While we believe that this study can inform future outcomes research, we want to emphasize that a meta-analysis cannot replace focused empirical research.

The model of mediation that was tested in this study would benefit from further examination because it would, if validated through longitudinal observational and experimental designs, have implications for intervention. Considering the central role that neurocognitive deficits play in relationship to daily functioning in schizophrenia, it is not surprising that cognitive deficits have emerged as important targets for new treatments (Green and Nuechterlein, 1999; Carpenter and Gold, 2002; Carpenter, 2004; Gold, 2004). If the relationship between neurocognition and functional outcome is partially mediated by negative symptoms, then perhaps negative symptoms should be an additional treatment target as a means to improve functional outcome.

Acknowledgement

The authors wish to thank Lisa Guzik, B.A. for her contribution to the preparation of this manuscript

Footnotes

[star]The findings from this meta-analysis were presented in part at the 10th bi-annual meeting of the International Congress on Schizophrenia Research, Colorado Springs, Colorado, March 28–April 1, 2007; Ventura, J., Hellemann, G.S., Thames, A.D, Koellner, V., and Nuechterlein, K.H. Negative Symptoms as a Mediator of the Relationship Between Neurocognition and Functional Outcome: A meta-analysis.

Role of funding source

There was no funding source.

Contributors

Joseph Ventura conceived the study design, data analysis plan, conducted literature searches, supervised the conduct of the study, and wrote the manuscript Dr. Hellemann conducted the data analysis and commented on all drafts of the manuscript. Ms. Thames performed literature searches, created tables, and commented on all drafts of the manuscript. Ms. Koeller conducted literature searches and organized study papers. Dr. Nuechterlein provided consultation of concepts we addressed and edited the final manuscript. All authors have contributed to and approved the final manuscript.

Conflict of interest

None of the authors has a financial conflict of interest.

References

  • Addington J, Addington D. Facial affect recognition and information processing in schizophrenia and bipolar disorder. Schizophrenia Research. 1998a;32(3):171–181. [PubMed]
  • Addington J, Addington D. Visual attention and symptoms in schizophrenia: a 1-year follow-up. Schizophrenia Research. 1998b;34(1–2):95–99. [PubMed]
  • Addington J, Addington D. Neurocognitive and social functioning in schizophrenia. Schizophrenia Bulletin. 1999;25(1):173–182. [PubMed]
  • Addington J, Addington D. Neurocognitive and social functioning in schizophrenia: a 2.5 year follow-up study. Schizophrenia Research. 2000;44:47–56. [PubMed]
  • Addington J, Addington D, Maticka-Tyndale E. Cognitive functioning and positive and negative symptoms in schizophrenia. Schizophr Res. 1991;5(2):123–134. [PubMed]
  • Addington J, Addington D, Gasbarre L. Distractibility and symptoms in schizophrenia. Journal of Psychiatry & Neuroscience. 1997;22(3):180–184. [PMC free article] [PubMed]
  • Addington J, van Mastrigt S, Addington D. Patterns of premorbid functioning in first-episode psychosis: initial presentation. Schizophrenia Research. 2003;62:23–30. [PubMed]
  • Aghevli MA, Blanchard JJ, Horan WP. The expression and experience of emotion in schizophrenia: a study of social interactions. Psychiatry Research. 2003;119(3):261–270. [PubMed]
  • Albus M, Hubmann W, Wahlheim C, Sobizack N, Franz U, Mohr F. Contrasts in neuropsychological test profile between outpatients with first-episode schizophrenia. Acta Psychiutr Scand. 1996;94:87–93. [PubMed]
  • Baron RM, Kenny DA. The moderator–mediator variable distinction in social psychological research: conceptual, strategic and statistical considerations. Journal of Personality and Social Psychology. 1986;51:1173–1182. [PubMed]
  • Basso MR, Nasrallah HA, Olson SC, Bornstein RA. Neuropsychological correlates of negative, disorganized and psychotic symptoms in schizophrenia. Schizophrenia Research. 1998;31(2–3):99–111. [PubMed]
  • Bell MD, Mishara AL. Does negative symptom change relate to neurocognitive change in schizophrenia? Implications for targeted treatments. Schizophrenia Research. 2006;81(1):17–27. [PubMed]
  • Bellack AS, Green MF, Cook JA, et al. Assessment of community functioning in people with schizophrenia and other severe mental illnesses: a white paper based on an NIMH-sponsored workshop. Schizophrenia Bulletin. 2007;33(3):805. [PMC free article] [PubMed]
  • Beng-Choon H, Nopoulos P, Flaum M, Arndt S, Andreasen NC. Two-year outcome in first-episode schizophrenia: predictive value of symptoms for quality of life. American Journal of Psychiatry. 1998;155:1196–1201. [PubMed]
  • Berman I, Viegner B, Merson A, Allan E, Pappas D, Green AI. Differential relationships between positive and negative symptoms and neuropsychological deficits in schizophrenia. Schizophrenia Research. 1997;25(1):1–10. [PubMed]
  • Bilder RM, Goldman RS, Robinson D, et al. Neuropsychology of first-episode schizophrenia: initial characterization and clinical correlates. American Journal of Psychiatry. 2000;157:549–559. [PubMed]
  • Bowie CR, Harvey PD, Moriarty PJ, Parrella M, White L, Davis KL. A comprehensive analysis of verbal fluency deficit in geriatric schizophrenia. Archives of Clinical Neuropsychology. 2004;19(2):289–303. [PubMed]
  • Bowie CR, Reichenberg A, Patterson TL, Heaton RK, Harvey PD. Determinants of real-world functional performance in schizophrenia subjects: correlations with cognition, functional capacity, and symptoms. American Journal of Psychiatry. 2006;163(3):418. [PubMed]
  • Bozikas VP, Kosmidis MH, Anezoulaki D, Giannakou M, Karavatos A. Relationship of affect recognition with psychopathology and cognitive performance in schizophrenia. Journal of the International Neuropsychological Society. 2004 Jul;10(4):549–558. [PubMed]
  • Bozikas VP, Kosmidis MH, Kafantari A, Gamvrula K, Vasiliadou E, Petrikis P, Fokas K, Karavatos A. Community dysfunction in schizophrenia: rate-limiting factors. Progress in Neuropsychopharmacology & Biological Psychiatry. 2006;30(3):463–470. [PubMed]
  • Brazo P, Marié RM, Halbecq L, et al. Cognitive patterns in subtypes of schizophrenia. European Psychiatry. 2002;17(3):155–162. [PubMed]
  • Brazo P, Delamillieure P, Morello R, Halbecq L, Marié RM, Dollfus S. Impairments of executive/attentional functions in schizophrenia with primary and secondary negative symptoms. Psychiatry Research. 2005;133(1):45–55. [PubMed]
  • Brebion G, Smith MJ, Amador X, Malaspina D, Gorman JM. Clinical correlates of memory in schizophrenia: differential links between depression, positive and negative symptoms, and two types of memory impairment. American Journal of Psychiatry. 1997;154(11):1538–1543. [PubMed]
  • Breier I, Schreiber JL, Dyer J, Pickar D. National Institute of Mental Health longitudinal study of chronic schizophrenia: prognosis and predictors of outcome. Archives of General Psychiatry. 1991;48:239–246. [PubMed]
  • Brekke JS, Raine A, Thomson C. Cognitive and psychophysiological correlates of positive, negative, and disorganized symptoms in the schizophrenia spectrum. Psychiatry Research. 1995;57:241–250. [PubMed]
  • Brekke J, Kay DD, Lee KS, Green MF. Biosocial pathways to functional outcome in schizophrenia. Schizophrenia Research. 2005;80(2–3):213–225. [PubMed]
  • Bryson G, Whelahan HA, Bell M. Memory and executive function impairments in deficit syndrome schizophrenia. Psychiatry Research. 2001;102(1):29–37. [PubMed]
  • Caligiuri MP, Hellige JB, Cherry BJ, Kwok W, Lulow LL, Lohr JB. Lateralized cognitive dysfunction and psychotic symptoms in schizophrenia. Schizophrenia Research. 2005;80(2–3):151–161. [PubMed]
  • Cameron AM, Oram J, Geffen GM, Kavanagh DJ, McGrath JJ, Geffen LB. Working memory correlates of three symptom clusters in schizophrenia. Psychiatry Research. 2002;110(1):49–61. [PubMed]
  • Carlsson R, Nyman H, Ganse G, Cullberg J. Neuropsychological functions predict 1 and 3-year outcome in first-episode psychosis. Acta Psychiatric Scandanavia. 2006;113:102–111. [PubMed]
  • Carpenter WT. Clinical constructs and therapeutic discovery. Schizophrenia Research. 2004;72(1):69–73. [PubMed]
  • Carpenter WT, Gold JM. Another view of therapy for cognition in schizophrenia. Biological Psychiatry. 2002;51(12):969–971. [PubMed]
  • Carter C, Robertson L, Nordahl T, Chaderjian M, Kraft L, O'Shora-Celaya L. Spatial working memory deficits and their relationship to negative symptoms in unmedicated schizophrenia patients. Biological Psychiatry. 1996;40(9):930–932. [PubMed]
  • Corrigan PW, Toomey R. Interpersonal problem solving and information processing in schizophrenia. Schizophrenia Bulletin. 1995;21(3):395–403. [PubMed]
  • Cuesta MJ, Peralta V. Cognitive disorders in the positive, negative, and disorganization syndromes of schizophrenia. Psychiatry Research. 1995;58(3):227–235. [PubMed]
  • Cuesta MJ, Peralta V, Caro E, Leon J. Is poor insight in psychotic disorders associated with poor performance on the Wisconsin Card Sorting Test? American Journal of Psychiatry. 1995;152(9):1380–1382. [PubMed]
  • Daban C, Amado I, Bayle F, et al. Correlation between clinical syndromes and neuropsychological tasks in unmedicated patients with recent onset schizophrenia. Psychiatry Res. 2002 Dec 15;113(1–2):83–92. [PubMed]
  • Davidson L, McGlashan TH. The varied outcomes of schizophrenia. Canadian Journal of Psychiatry. 1997;42:34–43. [PubMed]
  • Dibben CR, Rice C, Laws K, McKenna PJ. Is executive impairment associated with schizophrenic syndromes? A meta-analysis. Psychol Med. 2009 Mar;39(3):381–392. [PubMed]
  • Dickerson E, Boronow JJ, Ringel N, Parente E. Social functioning and neurocognitive deficits in outpatients with schizophrenia: a 2-year follow-up. Schizophrenia Research. 1999a;37(1):13–20. [PubMed]
  • Dickerson FB, Ringel N, Parente F. Predictors of residential independence among outpatients with schizophrenia. Psychiatr Serv. 1999b;50:515–519. [PubMed]
  • Dickinson D, Coursey RD. Independence and overlap among neurocognitive correlates of community functioning in schizophrenia. Schizophrenia Research. 2002 Jul;56(1–2):161–170. [PubMed]
  • Evans JD, Bond GR, Meyer PS, Kim HW, Lysaker PH, Gibson PJ, Tunis S. Cognitive and clinical predictors of success in vocational rehabilitation in schizophrenia. Schizophrenia Research. 2004;70(2–3):331–342. [PubMed]
  • Franke P, Maier W, Hain C, Klingler T. Wisconsin Card Sorting Test: an indicator of vulnerability to schizophrenia? Schizophrenia Research. 1992;6(3):243–249. [PubMed]
  • Friedman JI, Harvey PD, McGurk SR, et al. Correlates of change in functional status of institutionalized geriatric schizophrenic patients: focus on medical comorbidity. American Journal of Psychiatry. 2002;159:1388–1394. [PubMed]
  • Gold JM. Cognitive deficits as treatment targets in schizophrenia. Schizophrenia Research. 2004 Dec 15;72(1):21–28. [PubMed]
  • Gooding DC, Tallent KA. Nonverbal working memory deficits in schizophrenia patients: evidence of a supramodal executive processing deficit. Schizophrenia Research. 2004;68(2–3):189–201. [PubMed]
  • Green MF. What are the functional consequences of neurocognitive deficits in schizophrenia? American Journal of Psychiatry. 1996;153(3):321–330. [PubMed]
  • Green MF, Nuechterlein KH. Should schizophrenia be treated as a neurocognitive disorder? Schizophrenia Bulletin. 1999;25:309–318. [PubMed]
  • Green MF, Kern RS, Braff DL, Mintz J. Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the “right stuff”? Schizophrenia Bulletin. 2000;26(1):119–136. [PubMed]
  • Green MF, Kern RS, Heaton RK. Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS. Schizophrenia Research. 2004 Dec 15;72(1):41–51. [PubMed]
  • Guillem F, Bicu M, Bloom D, Wolf MA, Desautels R, Lalinec M, Kraus D, Debruille JB. Neuropsychological impairments in the syndromes of schizophrenia: a comparison between different dimensional models. Brain and Cognition. 2001;46(1–2):153–159. [PubMed]
  • Hafdahl AR. Combining correlation matrices: simulation analysis of improved fixed-effects methods. Journal of Educational and Behavioral Statistics. 2007;32(2):180.
  • Hammer MA, Katsanis J, Iacono WG. The relationship between negative symptoms and neuropsychological performance. Biological Psychiatry. 1995;37(11):828–830. [PubMed]
  • Harvey PD, Howanitz E, Parrella M, White L, Davidson M, Mohs RC, Hoblyn J, Davis KL. Symptoms, cognitive functioning, and adaptive skills in geriatric patients with lifelong schizophrenia: a comparison across treatment sites. American Journal of Psychiatry. 1998;155:1080–1086. [PubMed]
  • Harvey PD, Green MF, Bowie C, Loebel A. The dimensions of clinical and cognitive change in schizophrenia: evidence for independence of improvements. Psychopharmacology. 2006;187(3):356–363. [PubMed]
  • Heaton R, Paulsen JS, McAdams LA, Kuck J, Zisook S, Braff D, Harris MJ, Jeste DV. Neuropsychological deficits in schizophrenics: relationship to age, chronicity, and dementia. Archives of General Psychiatry. 1994;51:469–476. [PubMed]
  • Hedges LV, Olkin I. Nonparametric estimators of effect size in metaanalysis. Psychological Bulletin. 1984;96(3):573–580.
  • Herbener ES, Harrow M. Are negative symptoms associated with functioning deficits in both schizophrenia and nonschizophrenia patients? A 10-year longitudinal analysis. Schizophrenia Bulletin. 2004;30(4):813. [PubMed]
  • Hofer A, Rettenbacher MA, Widschwendter CG, Kemmler G, Hummer M, Fleischhacker WW. Correlates of subjective and functional outcomes in outpatient clinic attendees with schizophrenia and schizoaffective disorder. European Archives of Psychiatry and Clinical Neuroscience. 2006;256(4):246–255. [PubMed]
  • Hoff AL, Kremen WS. Neuropsychology in schizophrenia: an update. Current Opinion in Psychiatry. 2003;16:149–155.
  • Hoff A, Svetina LC, Maurizio AM, Crow TJ, Spokes K. Familial cognitive deficits in schizophrenia. American Journal of Medical Genetics. 2005;133(5B) [PubMed]
  • Hoffmann H, Kupper Z, Zbinden M, Hirsbrunner HP. Predicting vocational functioning and outcome in schizophrenia outpatients attending a vocational rehabilitation program. Social Psychiatry and Psychiatric Epidemiology. 2003;38(2):76–82. [PubMed]
  • Howanitz E, Cicalese C, Harvey PD. Verbal fluency and psychiatric symptoms in geriatric schizophrenia. Schizophrenia Research. 2000;42(3):167–169. [PubMed]
  • Keefe RS, Bilder RM, Harvey PD, et al. Baseline neurocognitive deficits in the CATIE schizophrenia trial. Neuropsychopharmacology. 2006a Apr 19; [PubMed]
  • Keefe RS, Seidman LJ, Christensen BK, et al. Long-term neurocognitive effects of olanzapine or low-dose haloperidol in first-episode psychosis. Biological Psychiatry. 2006b Jan 15;59(2):97–105. [PubMed]
  • Kerns JG, Berenbaum H, Barch DM, Banich MT, Stolar N. Word production in schizophrenia and its relationship to positive symptoms. Psychiatry Research. 1999;87(1):29–37. [PubMed]
  • Klingberg S, Wittorf A, Wiedemann G. Disorganization and cognitive impairment in schizophrenia: independent symptom dimensions? European Archives of Psychiatry and Clinical Neuroscience. 2006;256(8):532–540. [PubMed]
  • Liddle PF, Morris DL. Schizophrenic syndromes and frontal lobe performance. Br J Psychiatry. 1991 Mar;158:340–345. [PubMed]
  • Lipsey MW, Wilson DB. Practical Meta-analysis. Sage Pubns; 2001.
  • Lysaker PH, Davis LW. Social function in schizophrenia and schizoaffective disorder: associations with personality, symptoms and neurocognition. Health Quality Life Outcomes. 2004;2:15. [PMC free article] [PubMed]
  • Malla AK, Norman RMG, Manchanda R, Townsend L. Symptoms, cognition, treatment adherence and functional outcome in first-episode psychosis. Psychological Medicine. 2002;32:1109–1119. [PubMed]
  • McDaniel WF, Heindel CS, Harris DW. Verbal memory and negative symptoms of schizophrenia revisited. Schizophrenia Research. 2000;41(3):473–475. [PubMed]
  • McGlashan TH, Fenton WS. The positive–negative distinction in schizophrenia: review of natural history validators. Archives of General Psychiatry. 1992;49:63–72. [PubMed]
  • McGurk SR, Moriarty PJ, Harvey PD, Parrella M, White L, Davis KL. The longitudinal relationship of clinical symptoms, cognitive functioning, and adaptive life in geriatric schizophrenia. Schizophrenia Research. 2000;42(1):47–55. [PubMed]
  • McGurk SR, Mueser KT, Harvey PD, LaPuglia R, Marder J. Cognitive and symptom predictors of work outcomes for clients with schizophrenia in supported employment. Psychiatric Services. 2003;54(8):1129–1135. [PubMed]
  • Milev P. Predictive values of neurocognition and negative symptoms on functional outcome in schizophrenia: a longitudinal first-episode study with 7-year follow-up. American Journal of Psychiatry. 2005;162(3):495–506. [PubMed]
  • Minzenberg M, Poole J, Vinogradov S, Shenaut G, Ober B. Slowed lexical access is uniquely associated with positive and disorganised symptoms in schizophrenia. Cognitive Neuropsychiatry. 2003;8(2):107–127. [PubMed]
  • Moore DJ, Savla GN, Woods SP, Jeste DV, Palmer BW. Verbal fluency impairments among middle-aged and older outpatients with schizophrenia are characterized by deficient switching. Schizophrenia Research. 2006;87(1–3):254–260. [PubMed]
  • Moritz S, Andresen B, Jacobsen D, Mersmann K, Wilke U, Lambert M, Naber D, Krausz M. Neuropsychological correlates of schizophrenic syndromes in patients treated with atypical neuroleptics. European Psychiatry. 2001a;16(6):354–361. [PubMed]
  • Moritz S, Heeren D, Andresen B, Krausz M. An analysis of the specificity and the syndromal correlates of verbal memory impairments in schizophrenia. Psychiatry Research. 2001b;101(1):23–31. [PubMed]
  • Müller BW, Sartory G, Bender S. Neuropsychological deficits and concomitant clinical symptoms in schizophrenia. European Psychologist. 2004;9(2):96–106.
  • Nieuwenstein MR, Aleman A, de Haan EH. Relationship between symptom dimensions and neurocognitive functioning in schizophrenia: a meta-analysis of WCST and CPT studies. Wisconsin Card Sorting Test Continuous Performance Test. Journal of Psychiatric Research. 2001 Mar–Apr;35(2):119–125. [PubMed]
  • Norman RMG, Malla AK, Cortese L, et al. Symptoms and cognition as predictors of community functioning: a prospective analysis. American Journal of Psychiatry. 1999;156(3):400–405. [PubMed]
  • Nuechterlein KH, Edell WS, Norris M, Dawson ME. Attentional vulnerability indicators, thought disorder, and negative symptoms. Schizophrenia Bulletin. 1986;12:408–426. [PubMed]
  • Nuechterlein KH, Barch DM, Gold JM, Goldberg TE, Green MF, Heaton RK. Identification of separable cognitive factors in schizophrenia. Schizophrenia Research. 2004 Dec 15;72(1):29–39. [PubMed]
  • Pantelis C, Harvey CA, Plant G, et al. Relationship of behavioural and symptomatic syndromes in schizophrenia to spatial working memory and attentional set-shifting ability. Psychological Medicine. 2004;34(04):693–703. [PubMed]
  • Park S, Püschel J, Sauter BH, Rentsch M, Hell D. Spatial working memory deficits and clinical symptoms in schizophrenia: a 4-month follow-up study. Biological Psychiatry. 1999;46(3):392–400. [PubMed]
  • Park S, Püschel J, Sauter BH, Rentsch M, Hell D. Spatial selective attention and inhibition in schizophrenia patients during acute psychosis and at 4-month follow-up. Biological Psychiatry. 2002;51(6):498–506. [PubMed]
  • Pencer A, Addington J, Addington D. Outcome of a first episode of psychosis in adolescence: a 2-year follow-up. Psychiatry Research. 2005;133(1):35–43. [PubMed]
  • Pogue-Geile ME, Harrow M. Negative and positive symptoms in schizophrenia and depression: a followup. Schizophrenia Bulletin. 1984;10(3):371–387. [PubMed]
  • Preacher KJ, Hayes AF. SPSS and SAS procedures for estimating indirect effects in simple mediation models. Behavior Research Methods, Instruments, & Computers. 2004;36(4):717–731. [PubMed]
  • Ragland JD, Censits DM, Gur RC, Glahn DC, Gallacher F, Gur RE. Assessing declarative memory in schizophrenia using Wisconsin Card Sorting Test stimuli: the Paired Associate Recognition Test. Psychiatry Res. 1996 Mar 29;60(2–3):135–145. [PubMed]
  • Rhinewine JP, Lencz T, Thaden EP, et al. Neurocognitive profile in adolescents with early-onset schizophrenia: clinical correlates. Biological Psychiatry. 2005;58(9):705–712. [PubMed]
  • Robert PH, Lafont V, Medecin I, Berthet L, Thauby S, Baudu C, Darcourt GUY. Clustering and switching strategies in verbal fluency tasks: comparison between schizophrenics and healthy adults. Journal of the International Neuropsychological Society. 1998;4(06):539–546. [PubMed]
  • Rocca P, Bellino S, Calvarese P, Marchiaro L, Patria L, Rasetti R, Bogetto F. Depressive and negative symptoms in schizophrenia: different effects on clinical features. Comprehensive Psychiatry. 2005;46(4):304–310. [PubMed]
  • Rocca P, Castagna E, Marchiaro L, Rasetti R, Rivoira E, Bogetto E. Neuropsychological correlates of reality distortion in schizophrenic patients. Psychiatry Research. 2006;145(1):49–60. [PubMed]
  • Rosenthal R. Meta-analytic Procedures for Social Research. Sage Pubns; 1991.
  • Roy MA, DeVriendt X. Positive and negative symptoms in schizophrenia: a current overview. Canadian Journal of Psychiatry. 1994;39(7):407–414. [PubMed]
  • Rund BR, Melle I, Friis S, Larsen TK, Midbøe LJ, Opjordsmoen S, Simonsen E, Vaglum P, McGlashan T. Neurocognitive dysfunction in first-episode psychosis: correlates with symptoms, premorbid adjustment, and duration of untreated psychosis. American Journal of Psychiatry. 2004 Mar;61(3):466–472. [PubMed]
  • Rund BR, Landro NI, Orbeck AL. Stability in cognitive dysfunctions in schizophrenic patients. Psychiatry Research. 1997;69:131–141. [PubMed]
  • Salem JE, Kring AM. Flat affect and social skills in schizophrenia: evidence for their independence. Psychiatry Research. 1999;87(2–3):159–167. [PubMed]
  • Salokangas RK. Living situation, social network and outcome in schizophrenia: a five-year prospective follow-up study. Acta Psychiatrica Scandinavica. 1997;96(6):459–468. [PubMed]
  • Saykin AJ, Shtasel DL, Gur RE, Kester DB, Mozley LH, Stafiniak P, Gur RC. Neuropsychological deficits in neuroleptic naive patients with first episode schizophrenia. Archives of General Psychiatry. 1994;51:124–131. [PubMed]
  • Schuepbach D, Keshavan MS, Kmiec JA, Sweeney JA. Negative symptom resolution and improvements in specific cognitive deficits after acute treatment in first-episode schizophrenia. Schizophrenia Research. 2002;53(3):249–261. [PubMed]
  • Sergi MJ, Rassovsky Y, Nuechterlein KH, Green ME. Social perception as a mediator of the influence of early visual processing on functional status in schizophrenia. American Journal of Psychiatry. 2006 Mar;163(3):448–454. [PubMed]
  • Silver H, Shlomo N. Perception of facial emotions in chronic schizophrenia does not correlate with negative symptoms but correlates with cognitive and motor dysfunction. Schizophrenia Research. 2001;52(3):265–273. [PubMed]
  • Simon AE, Giacomini V, Ferrera E, Mohr S. Is executive function associated with symptom severity in schizophrenia? European Archives Psychiatry and Clinical Neuroscience. 2003;253:216–218. [PubMed]
  • Shean G, Burnett T, Eckman FS. Symptoms of schizophrenia and neurocognitive test performance. J Clin Psychol. 2002;58(7):723–731. [PubMed]
  • Smith TE, Hull JW, Huppert JD, Silverstein SM. Recovery from psychosis in schizophrenia and schizoaffective disorder: symptoms and neurocognitive rate-limiters for the development of social behavior skills. Schizophrenia Research. 2002;55:229–237. [PubMed]
  • Startup M, Jackson MC, Bendix S. The concurrent validity of the Global Assessment of Functioning (GAF) British Journal of Clinical Psychology. 2002;41(4):417–422. [PubMed]
  • Stratta P, Daneluzzo E, Bustini M, Prosperini P, Rossi A. Processing of context information in schizophrenia: relation to clinical symptoms and WCST performance. Schizophrenia Research. 2000;44(1):57–67. [PubMed]
  • Suslow T, Schonauer K, Ohrmann P, Eikelmann B, Reker T. Prediction of work performance by clinical symptoms and cognitive skills in schizophrenic outpatients. Journal of Nervous and Mental Disease. 2000;188:116–118. [PubMed]
  • Van der Does AJW, Dingemans P, Linszen DH, Nugter MA, Scholte WF. Symptoms, cognitive and social functioning in recent-onset schizophrenia: a longitudinal study. Schizophrenia Research. 1996;19(1):61–71. [PubMed]
  • Villalta-Gil V, Vilaplana M, Ochoa S, Haro JM, Dolz M, Usall J, Cervilla J. Neurocognitive performance and negative symptoms: are they equal in explaining disability in schizophrenia outpatients? Schizophrenia Research. 2006;87(1–3):246–253. [PubMed]
  • Wegener S, Redoblado-Hodge MA, Lucas S, Fitzgerald D, Harris A, Brennan J. Relative contributions of psychiatric symptoms and neuropsychological functioning to quality of life in first-episode psychosis. Australian and New Zealand Journal of Psychiatry. 2005;39(6):487–492. [PubMed]
  • Zakzanis KK. Neuropsychological correlates of positive vs. negative schizophrenic symptomatology. Schizophrenia Research. 1998;29(3):227–233. [PubMed]
PubReader format: click here to try

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...