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Journal List > Proc Natl Acad Sci U S A > v.85(5); Mar 1988

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Proc Natl Acad Sci U S A. 1988 March; 85(5): 1672–1676.
PMCID: PMC279836
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Enhancement of synaptic potentials in rabbit CA1 pyramidal neurons following classical conditioning.
J L LoTurco, D A Coulter, and D L Alkon
Section on Neural Systems, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
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Abstract
A synaptic potential elicited by high-frequency stimulation of the Schaffer collaterals was enhanced in hippocampal CA1 pyramidal cells from rabbits that were classically conditioned relative to cells from control rabbits. In addition, confirming previous reports, the after-hyperpolarization was reduced in cells from conditioned animals. We suggest that reduced after-hyperpolarization and enhanced synaptic responsiveness in cells from conditioned animals work in concert to contribute to the functioning of hippocampal CA1 pyramidal cells during classical conditioning.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • Alkon DL. Calcium-mediated reduction of ionic currents: a biophysical memory trace. Science. 1984 Nov 30;226(4678):1037–1045. [PubMed]
  • Alkon DL, Lederhendler I, Shoukimas JJ. Primary changes of membrane currents during retention of associative learning. Science. 1982 Feb 5;215(4533):693–695. [PubMed]
  • Alkon DL, Sakakibara M, Forman R, Harrigan J, Lederhendler I, Farley J. Reduction of two voltage-dependent K+ currents mediates retention of a learned association. Behav Neural Biol. 1985 Sep;44(2):278–300. [PubMed]
  • Brons JF, Woody CD. Long-term changes in excitability of cortical neurons after Pavlovian conditioning and extinction. J Neurophysiol. 1980 Sep;44(3):605–615. [PubMed]
  • Disterhoft JF, Coulter DA, Alkon DL. Conditioning-specific membrane changes of rabbit hippocampal neurons measured in vitro. Proc Natl Acad Sci U S A. 1986 Apr;83(8):2733–2737. [PubMed]
  • SCOVILLE WB, MILNER B. Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry. 1957 Feb;20(1):11–21. [PubMed]
  • Isaacson RL. Hippocampal destruction in man and other animals. Neuropsychologia. 1972 Apr;10(1):47–64. [PubMed]
  • Port RL, Mikhail AA, Patterson MM. Differential effects of hippocampectomy on classically conditioned rabbit nictitating membrane response related to interstimulus interval. Behav Neurosci. 1985 Apr;99(2):200–208. [PubMed]
  • Solomon PR, Vander Schaaf ER, Thompson RF, Weisz DJ. Hippocampus and trace conditioning of the rabbit's classically conditioned nictitating membrane response. Behav Neurosci. 1986 Oct;100(5):729–744. [PubMed]
  • Solomon PR, Moore JW. Latent inhibition and stimulus generalization of the classically conditioned nictitating membrane response in rabbits (Oryctolagus cuniculus) following dorsal hippocampal ablation. J Comp Physiol Psychol. 1975 Dec;89(10):1192–1203. [PubMed]
  • Port RL, Patterson MM. Fimbrial lesions and sensory preconditioning. Behav Neurosci. 1984 Aug;98(4):584–589. [PubMed]
  • Solomon PR. Role of the hippocampus in blocking and conditioned inhibition of the rabbit's nictitating membrane response. J Comp Physiol Psychol. 1977 Apr;91(2):407–417. [PubMed]
  • Berger TW, Orr WB. Hippocampectomy selectively disrupts discrimination reversal conditioning of the rabbit nictitating membrane response. Behav Brain Res. 1983 Apr;8(1):49–68. [PubMed]
  • Berger TW, Rinaldi PC, Weisz DJ, Thompson RF. Single-unit analysis of different hippocampal cell types during classical conditioning of rabbit nictitating membrane response. J Neurophysiol. 1983 Nov;50(5):1197–1219. [PubMed]
  • Berger TW, Alger B, Thompson RF. Neuronal substrate of classical conditioning in the hippocampus. Science. 1976 Apr 30;192(4238):483–485. [PubMed]
  • Mamounas LA, Thompson RF, Lynch G, Baudry M. Classical conditioning of the rabbit eyelid response increases glutamate receptor binding in hippocampal synaptic membranes. Proc Natl Acad Sci U S A. 1984 Apr;81(8):2548–2552. [PubMed]
  • Baraban JM, Snyder SH, Alger BE. Protein kinase C regulates ionic conductance in hippocampal pyramidal neurons: electrophysiological effects of phorbol esters. Proc Natl Acad Sci U S A. 1985 Apr;82(8):2538–2542. [PubMed]
  • Malenka RC, Madison DV, Andrade R, Nicoll RA. Phorbol esters mimic some cholinergic actions in hippocampal pyramidal neurons. J Neurosci. 1986 Feb;6(2):475–480. [PubMed]
  • Hawkins RD, Abrams TW, Carew TJ, Kandel ER. A cellular mechanism of classical conditioning in Aplysia: activity-dependent amplification of presynaptic facilitation. Science. 1983 Jan 28;219(4583):400–405. [PubMed]
  • Walters ET, Byrne JH. Associative conditioning of single sensory neurons suggests a cellular mechanism for learning. Science. 1983 Jan 28;219(4583):405–408. [PubMed]
  • Barrionuevo G, Brown TH. Associative long-term potentiation in hippocampal slices. Proc Natl Acad Sci U S A. 1983 Dec;80(23):7347–7351. [PubMed]
  • Weisz DJ, Clark GA, Thompson RF. Increased responsivity of dentate granule cells during nictitating membrane response conditioning in rabbit. Behav Brain Res. 1984 May;12(2):145–154. [PubMed]
  • Morris RG, Anderson E, Lynch GS, Baudry M. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature. 319(6056):774–776. [PubMed]
  • Collingridge GL, Kehl SJ, McLennan H. Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus. J Physiol. 1983 Jan;334:33–46. [PubMed]
  • Stelzer A, Slater NT, ten Bruggencate G. Activation of NMDA receptors blocks GABAergic inhibition in an in vitro model of epilepsy. Nature. 326(6114):698–701. [PubMed]
  • Mody I, Heinemann U. NMDA receptors of dentate gyrus granule cells participate in synaptic transmission following kindling. Nature. 326(6114):701–704. [PubMed]
  • Madison DV, Malenka RC, Nicoll RA. Phorbol esters block a voltage-sensitive chloride current in hippocampal pyramidal cells. Nature. 1986 Jun 12;321(6071):695–697. [PubMed]
  • Jahr CE, Stevens CF. Glutamate activates multiple single channel conductances in hippocampal neurons. Nature. 325(6104):522–525. [PubMed]
  • Nowak L, Bregestovski P, Ascher P, Herbet A, Prochiantz A. Magnesium gates glutamate-activated channels in mouse central neurones. Nature. 307(5950):462–465. [PubMed]
  • Mayer ML, Westbrook GL, Guthrie PB. Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones. Nature. 309(5965):261–263. [PubMed]
  • Malenka RC, Ayoub GS, Nicoll RA. Phorbol esters enhance transmitter release in rat hippocampal slices. Brain Res. 1987 Feb 10;403(1):198–203. [PubMed]
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