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J Bacteriol. Jun 1963; 85(6): 1274–1279.
PMCID: PMC278328

NEISSERIA GONORRHOEAE I.

Virulence Genetically Linked to Clonal Variation

Abstract

Kellogg, Douglas S., Jr. (Communicable Disease Center, Atlanta, Ga.), William L. Peacock, Jr., W. E. Deacon, L. Brown, and Carl I. Pirkle. Neisseria gonorrhoeae. I. Virulence genetically linked to clonal variation. J. Bacteriol. 85:1274–1279. 1963.—One type, obtained from the purulent exudate of acute gonorrhea was maintained by 69 selective in vitro passages, at which point the organisms produced infections in human volunteers. A predominance of clonal types found in laboratory strains and a lack of ability to infect human volunteers resulted from 69 nonselective in vitro passages. Physiological and serological characteristics of the clonal types are compared. We are now in a position to study Neisseria gonorrhoeae organisms in their virulent form.

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Selected References

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  • DEACON WE, PEACOCK WL, Jr, FREEMAN EM, HARRIS A. Identification of Neisseria gonorrhoeae by means of fluorescent antibodies. Proc Soc Exp Biol Med. 1959 Jun;101(2):322–325. [PubMed]
  • Morton HE, Shoemaker J. The Identification of Neisseria gonorrhoeae by Means of Bacterial Variation and the Detection of Small Colony Forms in Clinical Material. J Bacteriol. 1945 Nov;50(5):585–587. [PMC free article] [PubMed]
  • SCHERP HW. Neisseria and neisserial infections. Annu Rev Microbiol. 1955;9:319–334. [PubMed]

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