• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of jcmPermissionsJournals.ASM.orgJournalJCM ArticleJournal InfoAuthorsReviewers
J Clin Microbiol. Oct 1984; 20(4): 605–607.
PMCID: PMC271393

Onset and duration of urinary antigen excretion in Legionnaires disease.


The purposes of this study were to determine whether antigen is excreted by patients with Legionnaires disease early enough after the onset of symptoms to be useful for making therapeutic decisions and whether antigen excretion ends when successful treatment is concluded. Specific antigen was detected in the urine of 14 (88%) of 16 patients with Legionnaires disease during days 1 to 3 of symptoms, 33 (80%) of 41 patients during days 4 to 7, 25 (89%) of 28 patients during days 8 to 14, and 11 of 11 patients after day 14, by solid-phase immunoassays for serogroup 1 Legionella pneumophila antigen. Antigen excretion persisted for 42 days or longer after the onset of treatment in at least 15 patients. The longest documented duration of excretion was 326 days. We conclude that antigen can be detected approximately as often early after symptoms begin as later, allowing meaningful therapeutic decisions to be made, but that prolonged antigen excretion may negate the diagnostic value of urinary antigen detection for relapsing or recurrent L. pneumophila pneumonia.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (565K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Barrett TJ, Snyder JD, Blake PA, Feeley JC. Enzyme-linked immunosorbent assay for detection of Salmonella typhi Vi antigen in urine from typhoid patients. J Clin Microbiol. 1982 Feb;15(2):235–237. [PMC free article] [PubMed]
  • Eng R, Chmel H, Corrado M, Smith SM. The course of cryptococcal capsular polysaccharide antigenemia/human cryptococcal polysaccharide elimination kinetics. Infection. 1983 May-Jun;11(3):132–136. [PubMed]
  • FELTON LD, PRESCOTT B, KAUFFMANN G, OTTINGER B. Pneumococcal antigenic polysaccharide substances from animal tissues. J Immunol. 1955 Mar;74(3):205–213. [PubMed]
  • Klaucke DN, Vogt RL, LaRue D, Witherell LE, Orciari LA, Spitalny KC, Pelletier R, Cherry WB, Novick LF. Legionnaires' disease: the epidemiology of two outbreaks in Burlington, Vermont, 1980. Am J Epidemiol. 1984 Mar;119(3):382–391. [PubMed]
  • Kohler RB, Sathapatayavongs B. Recent advances in the diagnosis of serogroup 1 L. pneumophila pneumonia by detection of urinary antigen. Zentralbl Bakteriol Mikrobiol Hyg A. 1983 Jul;255(1):102–107. [PubMed]
  • Kohler R, Wheat LJ. Rapid diagnosis of pneumonia due to Legionella pneumophila serogroup 1. J Infect Dis. 1982 Sep;146(3):444–444. [PubMed]
  • Kohler RB, Zimmerman SE, Wilson E, Allen SD, Edelstein PH, Wheat LJ, White A. Rapid radioimmunoassay diagnosis of Legionnaires' disease: detection and partial characterization of urinary antigen. Ann Intern Med. 1981 May;94(5):601–605. [PubMed]
  • O'Reilly RJ, Anderson P, Ingram DL, Peter G, Smith DH. Circulating polyribophosphate in Hemophilus influenzae, type b meningitis. Correlation with clinical course and antibody response. J Clin Invest. 1975 Oct;56(4):1012–1022. [PMC free article] [PubMed]
  • Sathapatayavongs B, Kohler RB, Wheat LJ, White A, Winn WC., Jr Rapid diagnosis of Legionnaires' disease by latex agglutination. Am Rev Respir Dis. 1983 May;127(5):559–562. [PubMed]
  • Sathapatayavongs B, Kohler RB, Wheat LJ, White A, Winn WC, Jr, Girod JC, Edelstein PH. Rapid diagnosis of Legionnaires' disease by urinary antigen detection. Comparison of ELISA and radioimmunoassay. Am J Med. 1982 Apr;72(4):576–582. [PubMed]
  • STARK OK. Studies on pneumococcal polysaccharide. II. Mechanism involved in production of immunological paralysis by type I pneumococcal polysaccharide. J Immunol. 1955 Feb;74(2):130–133. [PubMed]

Articles from Journal of Clinical Microbiology are provided here courtesy of American Society for Microbiology (ASM)


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...