• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of jcmPermissionsJournals.ASM.orgJournalJCM ArticleJournal InfoAuthorsReviewers
J Clin Microbiol. Aug 1986; 24(2): 288–293.
PMCID: PMC268891

Cutoff levels of immunoglobulin M antibody against viral core antigen for differentiation of acute, chronic, and past hepatitis B virus infections.

Abstract

The titer of antibody against core antigen of hepatitis B virus in the immunoglobulin M class (IgM anti-HBc) was determined by an IgM capture assay of reduced sensitivity (30 arbitrary units). The distribution of titers among 235 acute hepatitis patients who were hepatitis B surface antigen (HBsAg) positive suggested that 600 U forms a lower cutoff value for acute hepatitis B. Clinically apparent cases of acute hepatitis with high IgM anti-HBc and without HBsAg were rare (2.6%). Acute, non-B hepatitis in HBsAg carriers was more frequent (9.4%). In chronic hepatitis B, 39% of 174 biopsy-proven cases had moderate titers of 30 to 600 U, whereas healthy HBsAg carriers were rarely (4/84) positive. In mild or inapparent infections without HBsAg, titers were between 50 and 400 U. Thus, sufficiently accurate and sensitive quantitation of IgM anti-HBc allows for differentiation of acute and nonacute hepatitis B virus infection in acute hepatitis, partial differentiation between clinically symptomatic and asymptomatic chronic infections, and identification of recent subclinical infections.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.0M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Aldershvile J, Roggendorf M, Kryger P, Tage-Jensen U, Deinhardt F, Frösner GG, Hardt F, Nielsen JO. Anti-HBc of IgM-class, HBeAg and anti-HBe in acute and chronic hepatitis B. Liver. 1981 Dec;1(4):290–297. [PubMed]
  • Angarano G, Monno L, Santantonio TA, Pastore G. New principle for the simultaneous detection of total and immunoglobulin M antibodies applied to the measurement of antibody to hepatitis B core antigen. J Clin Microbiol. 1984 Jun;19(6):905–910. [PMC free article] [PubMed]
  • Bänninger P, Altorfer J, Frösner GG, Pirovino M, Gudat F, Bianchi L, Grob PJ, Schmid M. Prevalence and significance of anti-HBc IgM (radioimmunoassay) in acute and chronic hepatitis B and in blood donors. Hepatology. 1983 May-Jun;3(3):337–342. [PubMed]
  • Briantais MJ, Grangeot-Keros L, Pillot J. Specificity and sensitivity of the IgM capture immunoassay: studies of possible factors inducing false positive or false negative results. J Virol Methods. 1984 Aug;9(1):15–26. [PubMed]
  • Cappel R, Van Beers D, Maes F, Toppet M, Cadranel S. Significance of persisting IgM anti-HBc antibodies in hepatitis B virus infection. J Med Virol. 1981;8(3):201–205. [PubMed]
  • Chau KH, Hargie MP, Decker RH, Mushahwar IK, Overby LR. Serodiagnosis of recent hepatitis B infection by IgM class anti-HBc. Hepatology. 1983 Mar-Apr;3(2):142–149. [PubMed]
  • Cohen BJ. The IgM antibody responses to the core antigen of hepatitis B virus. J Med Virol. 1978;3(2):141–149. [PubMed]
  • Cohen BJ, Litton PA, Mortimer PP, Simmons P. Hepatitis B core antigen synthesised in Escherichia coli: its use for antibody screening in patients attending a clinic for sexually transmitted diseases. J Hyg (Lond) 1984 Oct;93(2):225–232. [PMC free article] [PubMed]
  • Coltorti M, Del Vecchio-Blanco C, Iannelli F, Lavarini C, Caporaso N. The role of IgM anti-HBc in the etiologic diagnosis of HBsAg-positive acute and chronic hepatitis. Ric Clin Lab. 1984 Jan-Mar;14(1):89–94. [PubMed]
  • Dromeyer HH, Arnold W, Kryger P, Nielsen JO, Meyer zum Büschenfelde KH. IgM antibody to hepatitis B core antigen (anti-HBc IgM) in "healthy" HBsAg carriers: a longitudinal study of 75 cases. Klin Wochenschr. 1981 Jun 15;59(12):675–678. [PubMed]
  • Feuerhake A, Wille E, Müller R. Klinische Bedeutung der Immunglobulin-M-Antikörperfraktion gegen das Hepatitis-B-core-Antigen (anti-HBc-IgM). Dtsch Med Wochenschr. 1982 Jul 2;107(26):1012–1014. [PubMed]
  • Gerlich WH, Biswas RM, Stamm B, Thomssen R. The diagnostical significance of antibodies against hepatitis B core antigen. Klin Wochenschr. 1977 Nov 1;55(21):1051–1056. [PubMed]
  • Gerlich WH, Lüer W. Selective detection of IgM-antibody against core antigen of the hepatitis B virus by a modified enzyme immune assay. J Med Virol. 1979;4(3):227–238. [PubMed]
  • Gerlich WH, Lüer W, Thomssen R. Diagnosis of acute and inapparent hepatitis B virus infections by measurement of IgM antibody to hepatitis B core antigen. J Infect Dis. 1980 Jul;142(1):95–101. [PubMed]
  • Gitnick G. Immunoglobulin M hepatitis B core antibody: to titer or not to titer? to use or not to use? Gastroenterology. 1983 Mar;84(3):653–655. [PubMed]
  • Gordon SC, Jeffers LJ, De Medina MD, Reddy KR, Schiff ER. Immunoglobulin M antibody to hepatitis B core antigen and fulminant hepatitis B. Ann Intern Med. 1985 Mar;102(3):415–416. [PubMed]
  • Hasche G, Stecher J, Gmelin K, Doerr HW. Use of hepatitis B core antigen produced in Escherichia coli to detect immunoglobulin M specific antibodies in an enzyme-linked immunosorbent assay. Eur J Clin Microbiol. 1984 Feb;3(1):30–34. [PubMed]
  • Kryger P. Significance of anti-HBc IgM in the differential diagnosis of viral hepatitis. J Virol Methods. 1985 Apr;10(4):283–289. [PubMed]
  • Lavarini C, Farci P, Chiaberge E, Veglio V, Giacobbi D, Bedarida G, Susani G, Toti M, Almi P, Caporaso N, et al. IgM antibody against hepatitis B core antigen (IgM anti-HBc): diagnostic and prognostic significance in acute HBsAg positive hepatitis. Br Med J (Clin Res Ed) 1983 Oct 29;287(6401):1254–1256. [PMC free article] [PubMed]
  • Lemon SM, Gates NL, Simms TE, Bancroft WH. IgM antibody to hepatitis B core antigen as a diagnostic parameter of acute infection with hepatitis B virus. J Infect Dis. 1981 Jun;143(6):803–809. [PubMed]
  • Mortimer PP, Vandervelde EM, Parry JV, Cohen BJ, Tedder RS. The anti-HBc IgM response in the acute and convalescent phases of acute hepatitis. J Infect. 1981 Dec;3(4):339–347. [PubMed]
  • Niermeijer P, Gips CH, Huizenga JR, Houthoff HJ, Snijder JA. Anti-HBc titers and anti-HBc immunoglobulin (M/G) classes in acute, chronic and resolved hepatitis B. Hepatogastroenterology. 1980 Aug;27(4):271–276. [PubMed]
  • Papaevangelou G, Roumeliotou-Karayannis A, Tassopoulos N, Stathopoulou P. Diagnostic value of anti-HBc IgM in high HBV prevalence areas. J Med Virol. 1984;13(4):393–399. [PubMed]
  • Perrillo RP, Chau KH, Overby LR, Decker RH. Anti-hepatitis B core immunoglobulin M in the serologic evaluation of hepatitis B virus infection and simultaneous infection with type B, delta agent, and non-A, non-B viruses. Gastroenterology. 1983 Jul;85(1):163–167. [PubMed]
  • Roggendorf M, Deinhardt F, Frösner GG, Scheid R, Bayerl B, Zachoval R. Immunoglobulin M antibodies to hepatitis B core antigen: evaluation of enzyme immunoassay for diagnosis of hepatitis B virus infection. J Clin Microbiol. 1981 Apr;13(4):618–626. [PMC free article] [PubMed]
  • Sampliner RE, Schable CA. Predominance of immunoglobulin M antibody to hepatitis B core antigen in chronic carriers of hepatitis B surface antigen. Am J Clin Pathol. 1984 Jan;81(1):88–90. [PubMed]
  • Shimizu M, Ohyama M, Takahashi Y, Udo K, Kojima M, Kametani M, Tsuda F, Takai E, Miyakawa Y, Mayumi M. Immunoglobulin M antibody against hepatitis B core antigen for the diagnosis of fulminant type B hepatitis. Gastroenterology. 1983 Mar;84(3):604–610. [PubMed]
  • Sjogren M, Hoofnagle JH. Immunoglobulin M antibody to hepatitis B core antigen in patients with chronic type B hepatitis. Gastroenterology. 1985 Aug;89(2):252–258. [PubMed]
  • Tedder RS, Wilson-Croome R. IgM-antibody response to the hepatitis B core antigen in acute and chronic hepatitis B. J Hyg (Lond) 1981 Apr;86(2):163–172. [PMC free article] [PubMed]
  • Wang AX, Coulepis AG, Hui Z, Gust ID. Immunoglobulin M antibodies against hepatitis B core antigen in patients with chronic hepatitis B infection. Pathology. 1984 Jan;16(1):83–85. [PubMed]

Articles from Journal of Clinical Microbiology are provided here courtesy of American Society for Microbiology (ASM)

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...