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# Benchmarks for identification of ordinary differential equations from time series data

^{1}Department of Mathematical Sciences, University of Göteborg, SE-412 96 Göteborg,

^{2}Department of Mathematics, Uppsala University, SE-751 06 Uppsala and

^{3}Department of Computer Science and Engineering, Chalmers University of Technology, SE-412 96 Göteborg, Sweden

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

## Abstract

**Motivation:** In recent years, the biological literature has seen a significant increase of reported methods for identifying both structure and parameters of ordinary differential equations (ODEs) from time series data. A natural way to evaluate the performance of such methods is to try them on a sufficient number of realistic test cases. However, weak practices in specifying identification problems and lack of commonly accepted benchmark problems makes it difficult to evaluate and compare different methods.

**Results:** To enable better evaluation and comparisons between different methods, we propose how to specify identification problems as optimization problems with a model space of allowed reactions (e.g. reaction kinetics like Michaelis–Menten or S-systems), ranges for the parameters, time series data and an error function. We also define a file format for such problems.

We then present a collection of more than 40 benchmark problems for ODE model identification of cellular systems. The collection includes realistic problems of different levels of difficulty w.r.t. size and quality of data. We consider both problems with simulated data from known systems, and problems with real data. Finally, we present results based on our identification algorithm for all benchmark problems. In comparison with publications on which we have based some of the benchmark problems, our approach allows all problems to be solved without the use of supercomputing.

**Availability:** The benchmark problems are available at www.odeidentification.org

**Contact:** es.sremlahc@gretep

**Supplementary information:** Supplementary data are available at *Bioinformatics* online.

## 1 INTRODUCTION

We consider the problem of identifying both the structure and the parameters of an ordinary differential equation (ODE) system from time series data. In recent years, there has been a significant increase in the number of reported methods approaching this problem in the biological literature (see Table 1 and the references).

For systems of realistic size and with realistic amount and quality of data this is a hard problem and heuristic algorithms are therefore typically employed. Such algorithms cannot guarantee that they give the best answer to a given problem. An established way to evaluate the performance of heuristic algorithms is to try them on a sufficient number of realistic test cases. However, lack of well defined and commonly accepted benchmark problems makes it difficult to evaluate and compare different methods:

- Problems are often incompletely and/or ambiguously specified, and personal communication is required to reconstruct essential aspects of the problems.
- Very few test problems are usually considered. This serves the purpose of demonstrating feasibility, but says little about general performance.
- Even when problems originate from the same system, different papers typically consider slight modifications of the original problem, which make direct comparisons difficult. An example is a test problem from Kikuchi
*et al.*, 2003. Several recent publications (Cho*et al.*, 2006; Daisuke and Horton, 2006; Gennemark and Wedelin, 2007; Kimura*et al.*, 2005; Liu and Wang, 2008; Tsai and Wang, 2005; Tucker and Moulton, 2006) consider the same system, but usually with a more informative dataset.

To a considerable degree, the lack of benchmark problems is caused by a more fundamental underlying difficulty in how to specify such *identification problems* mathematically, and how to conveniently represent them in files. This is much more complex when both structure and parameters are unknown, compared with the well known case of parameter estimation in a given structure.

In particular, it is not sufficient to give only data from one or several experiments, or a *source model* from which such data can be simulated, see Figure 1A. In addition to the data, a model space must be defined, to specify the possible forms of the right-hand side of the ODEs and appropriate parameter ranges. Clearly, if we allow few possible reactions and narrow parameter ranges we obtain a simpler identification problem, and if we allow many possible reactions and wide parameter ranges we obtain a more difficult problem. Furthermore, known prior information about parts of the model may be given. Finally, we must define an objective function that also includes some notion of model complexity. This is needed since we are searching among different structures, and a simple maximum likelihood criterion is not sufficient and will lead to over-fitting. Together, this defines the identification problem mathematically as an *optimization problem*, the *solution* of which is a model. An illustration of an identification problem is shown in Figure 1B, and the solution model is shown in Figure 1C.

**A**) An identification problem can be specified with real or simulated data from one or several experiments, a model space of allowed reactions occurring on the right-hand side of the ODEs, an initial model representing prior

**...**

Based on these considerations, we present a collection of more than 40 fully specified and publicly available benchmark problems for ODE system identification. The problems have mainly been collected and translated from recent publications, but we have also included new and carefully designed problems.

The collection includes both simple problems suitable for initial testing, and more complex problems with realistic size and quality of data. Most problems are based on simulated data from a known source model, which is important for evaluation purposes. However, several problems are also based on real data.

The collection consists of problems of two different kinds. The first kind are problems whose solutions are models based on traditional chemical rate equations like unimolecular mass action and Michaelis–Menten's kinetics. An example of such a system with three variables is shown in Figure 1C. Typically for systems of this kind, the rate equations are composed as linear combinations of known reaction types that can be non-linear in both the parameters and in the state variables.

The other kind of problem is where the solutions are defined on a fixed form, like S-systems which is currently the most popular form for identification. The S-system formalism (Savageau, 1976; Voit, 2000) is based on approximating kinetic laws with multivariate power-law functions. A model consists of *n* non-linear ODEs and the generic form of equation *i* reads

where *X* is a vector (length *n*) of dependent variables, α and β are vectors (length *n*) of non-negative rate constants and *g* and *h* are matrices (*n* × *n*) of kinetic orders, that can be negative as well as positive. The structure of the system is defined by the non-zero elements of *g* and *h*, and for realistic models most of these parameters are zero.

To our knowledge, this is the first article to address how to best represent this kind of identification problems as optimization problems and to define a suitable file format. As far as we know, this is also the first collection of benchmark problems for ODE system identification, where both structure and parameters are unknown.

Another paper that recognizes the importance of systematic evaluation of identification algorithms, is Mendes *et al.* (2003), which presents a system for generating realistic artificial gene networks and simulated data, and a large number of problems generated by this system. In comparison, our benchmark problems are typically smaller and address the more specific need of evaluating algorithms identifying both structure and parameters, fully specifying problems as optimization problems. For parameter estimation only, several benchmark problems are publicly available, e.g. in the data base EASY-FIT (Schittkowski, 2002).

The two kinds of systems we consider, chemical rate equations and S-systems, have previously been used for identification of ODE models as indicated by references in Table 1. In addition to these kinds of systems, other fixed forms have been considered in the literature. One example is Generalized Mass Action (GMA) models (Tucker *et al.*, 2007; Voit, 2000), and another is linear dynamical models with non-linear transfer functions of sigmoid type (D'haeseleer, 2000; Nelander *et al.*, 2008; Wahde and Hertz, 2000). However, at this stage, we have chosen to focus on the more frequently used S-systems as one representative fixed form system.

We finally note that identification of ODEs where more basic operands and operators are used as structural components have been considered (Bongard and Lipson, 2007).

## 2 SPECIFYING IDENTIFICATION PROBLEMS AS OPTIMIZATION PROBLEMS

We now outline how we define identification problems mathematically. Our first and most important concern has been that an identification problem must be defined unambiguously as an optimization problem. This ensures that a problem has a well defined solution independently of any method for solving it, and that the task of *modelling* identification problems is separated from the algorithmic task of *solving* given problems. It is to be noted that if we fail to explicitly specify the entire problem, missing parts have to be supplied by the user or be implicitly defined by the algorithm, resulting in confusion and lack of reproducibility.

Our second concern has been to find a reasonably simple standard form that can still represent a wide range of identification problems. We have then chosen the following way to structure and specify our problems.

*Data*. Time series data for one or several experiments. In the case of several experiments, they may differ with respect to initial values of the variables and/or input functions. For each data-point, the standard deviation is also given in the problem specification.*Model space*. The model space determines the allowed form of the right-hand side of the ODEs.For models based on traditional chemical rate equations, each ODE in the model is assumed to be a sum of a number of reactions. The possible reactions must belong to a subset of predefined reaction types, where each allowed reaction type is specified by its name, a subset of possible input variables and ranges of allowed parameter values. The allowed reaction types can be specified individually for each state variable. As an example, in Figure 1B, the allowed reactions types are a unimolecular mass action reaction, a Michaelis–Menten reaction, and a simplified Hill equation. For reactions having multiple input variables, e.g. a bimolecular mass action reaction with equation*k*_{1}*X*_{i}*X*_{j}, it is implicitly assumed that*i*and*j*are not equal (to consider equality as in problem osc1 and osc2, we define an additional reaction type*k*_{1}*X*_{i}^{2}).The model space of an S-system is simply defined by lower and upper bounds for each element in the parameter vectors (α and β) and matrices (*g*and*h*). Sometimes, additional constraints are required. For example, three of the benchmark problems include an additional constraint of type {*g*_{i,j}∈[−3, 3],*g*_{i,j}≠0} (there is an interaction between variable*i*and*j*but the direction is unknown).Finally, we also define lower and upper bounds for the initial data-point in each time series. For noisy data, these bounds were set to ±2 SDs. Hence, for noisy data there is one additional parameter for each time series, but these parameters are typically bound tighter compared with the model parameters.*Initial model*. It is convenient to allow definition of an initial model, corresponding to prior knowledge of the system. The initial model is described as known reactions (terms) on the right-hand side of the ODEs. Also reactions from outside the model space can be included in the initial model.In principle, one can also think of prior information in the form of starting points for iterative algorithms and thus not technically a part of the defined problem. No such information is assumed known in our current problems.*Error function*. We have chosen to minimize(2)The first term is the negative log-likelihood of the experimental data, and the second term is a term that penalizes structural complexity of the model. This kind of error function is common, and is related to several different proposed methods for handling model complexity (Crampin*et al.*, 2004).In detail,*L*is the log-likelihood, denotes the experimental data,*k*is a vector of parameters, λ is a constant and*K*is the number of parameters. By assuming independent and normally distributed measurement errors and disregarding constant terms we can express the log-likelihood for one time series aswhere(3)*i*indexes the measurement points, and where*X*_{j}, and σ_{j}denotes simulated data, experimental data and SD for variable*j*, respectively. The total log-likelihood is defined by summing over all variables and all experiments.For models based on chemical rate equations,*K*is simply the total number of parameters on the right-hand side of the ODEs. For S-systems, it is natural to define*K*as the total number of non-zero elements in*g*and*h*plus the number of parameters in α and β.

To establish the relationship with standard optimization terminology, the model space and and the initial model define the *feasible set*, and the data together with the error function define the *objective function*.

### 2.1 File format for identification problems

In order to work with identification problems and to provide them as input to identification algorithms, we also need to represent such problems in files, and it is highly desirable that an entire problem can be represented in a single file. Since an identification problem is an optimization problem and not a model, common model formats such as SBML are not applicable, and no existing format known to us can be used for this purpose. However, the output of an identification algorithm is a model and can be represented in SBML. Also, if a partially known initial model is available in SBML, an identification algorithm can input that part in SBML and the rest of the identification problem in our format.

The file format we have designed for the identification problems can be seen as a special case of a more general format that is currently developed as a separate project. The format attempts to be self documenting and easy to read both by the human and the computer. Compared with a typical XML-equivalent, more structure is explicit and it is easier to read. It bears some resemblance to how data structures are built in a computer programme, but without the explicit use of pointers. An extract of the format is given below:

This particular extract describes first some variables and then a possible reaction in the model space. Finally, a sample from the first experiment is given.

The format can also be used to specify a parameter estimation problem only. Method specific parameters (like random seed) can be defined in the same file or separately. Finally, we can easily extend the format to describe new classes of problems, for example with compartment modelling and system modifications like gene deletions.

We anticipate that the exact mathematical form of the identification problems, as well as the file format, will be extended over time. Up-to-date information and detailed documentation is therefore available on the web site, as well as a simple parser for the file format.

## 3 THE COLLECTION OF BENCHMARK PROBLEMS

An overview of the collection of benchmark problems is presented in Table 1. The problems have different sources, and in most cases several different problems are given for each system.

The number of variables in combination with the amount of data and noise level, give a rough indication of the difficulty of each problem. The first problem for each system generally has a lower level of difficulty than the subsequent problems, and is hence a good starting point when evaluating new methods.

A part of the collection is based on identification problems considered in the literature, which is dominated by problems based on S-systems, probably because these are relatively easy to represent. By including translations of these problems that were previously not easily accessible, the collection has an immediate value for those actively developing algorithms in this area. However, we balance the S-system dominance by also defining new problems based on traditional chemical reactions that are more frequently used in the biological modelling community. We note that research in this area is in an early stage, and in our experience identification algorithms for S-systems can relatively easily be modified for other kinds of models. Our proposed way of specifying identification problems can then facilitate and contribute to a more widespread use of problems based on other kinds of models.

For problems that have been collected and translated from another publication, we have taken care to match the original problem as closely as available information and the standardization to our formalism allow, see the Supplementary Material for details. We have replaced some non-standard objective functions with our simple function, and relaxed a few unusual constraints. Noisy data have been simulated from random distributions, and in one case we have also reduced an excessive and unrealistic number of data-points in the original problem. However, the solutions in the next section confirm that the changes have not negatively affected the quality of the solutions when compared directly with the source models. We note that our problems never have more data or a smaller model space, so they are in this sense at least as difficult as the original problems.

### 3.1 Best known solutions

In Table 2 we report the best known solutions for all benchmark problems, and we will now describe the detailed information in the table. The solutions have been found using our own identification algorithm (Gennemark and Wedelin, 2007). All solution models as well as source models are available in SBML on our web site.

For problems with noisy or otherwise insufficient data, an optimal solution has slightly different parameter values and sometimes also different structure than the source model. To clarify this for our solutions, Table 2 gives the error of the source model from which data was simulated. We can see that for all problems based on simulated data the found solutions have approximately equal or lower error than that of the source model. We also give the number of FP and FN interactions, to indicate if the found structure is the same as the source model. If the structure is the same as for the source model, we also give the largest deviation (LD) in percent for any parameter compared with the source model. For the problems based on real data, no source model is available, and no such comparisons can be made.

For our algorithm, as well as for most algorithms in the literature, the results may differ between runs depending on a random seed. With our approach, the main difference between runs is that sometimes the best structure is not found due to the heuristic nature of the search algorithm. However, for two solutions with the same structure, the difference in the parameters is negligible for all tested problems. To indicate the stability of the algorithm, we therefore report the proportion of runs where the best structure was found. Note, however, the fact that solutions are stable does not generally imply that they are optimal.

Computation times are reported as the average computation time for runs with different random seeds, scaled to a 1 GHz processor (the actual runs were performed on a Pentium IV, 2.13 GHz). The times can be improved by adjusting the method parameters for individual problems, but we report the computation time using our standard settings, see the Supplementary Material.

For the benchmark problems that have been adapted from problems in the literature, the final columns report available results for these original problems.

In addition to the numerical details, Table 2 allows us to draw the following qualitative conclusions about the benchmark problems.

- Every problem with data from a known source model is well formulated in the sense that the solution model is similar to the source model, in terms of the FP/FN/LD values.
- Every solution model is at least as similar to the source model as any previously reported solution. This confirms that the translation to our standard format works well, and also that our solutions are indeed the best known solutions to the benchmark problems.
- Every problem can be solved within hours on an ordinary computer with our approach, so there is no need for supercomputing. This was not previously established since some previous results for the original problems required running times of several months if run on a single processor.

## 4 CONCLUSIONS

We have proposed a way to unambiguously specify ODE identification problems as mathematical optimization problems, and have also defined a file format making it easy to document and exchange such problems.

The benchmark problems include translations of problems that have been frequently used in the development of algorithms, as well as new problems based on chemical rate equations. The problems, their best solutions and the source models from which problem data was simulated are all available on our web site. This makes it easy for everyone to evaluate and compare algorithms in a reproducible way. To maintain a useful collection of problems of various types, we intend to extend the collection, and are interested in contributions and feedback from others, see the web site.

Finally, our own solutions show that all the benchmark problems can be solved in reasonable time, in contrast to results for some of the original problems where supercomputing was required.

## ACKNOWLEDGEMENTS

Thanks to Sven Nelander (MSKCC) and the reviewers for valuable comments.

*Funding*: Chalmers Bioscience Program and Göteborg Mathematical Modelling Centre.

*Conflict of Interest*: none declared.

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