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J Clin Microbiol. 1992 Mar; 30(3): 561–563.
PMCID: PMC265109

Modified indirect hemagglutination test for detection of treponemal antibodies in finger-prick blood.


A modified indirect hemagglutination test for the detection of treponemal antibodies was developed for use with finger-prick blood. By using paired serum and absorbed finger-prick blood from 58 patients from an area previously endemic for yaws and 12 patients without yaws, the modified hemagglutination test was compared with a hemagglutination test for Treponema pallidum and the fluorescent treponemal antibody absorption test. The modified hemagglutination test showed 100% specificity and an overall agreement of 96.5% with the hemagglutination test for T. pallidum and 94.8% with the fluorescent treponemal antibody test. The modified hemagglutination test appears to be a simple and economical test that is suitable for use in large epidemiological surveys for yaws.

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Selected References

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  • Garner MF, Backhouse JL, Daskalopoulos G, Walsh JL. Treponema pallidum haemagglutination test for yaws. Comparison with the TPI and FTA-ABS tests. Br J Vener Dis. 1972 Dec;48(6):479–482. [PMC free article] [PubMed]
  • Geizer I. Yaws in the Western Pacific region: an overview. Southeast Asian J Trop Med Public Health. 1986 Dec;17(4 Suppl):8–13. [PubMed]
  • Hopkins DR. Fluorescent treponemal antibody absorption (FTA-ABS) tests using blood samples collected on filter paper. Am J Trop Med Hyg. 1977 Jan;26(1):188–189. [PubMed]
  • Martin PM, Gonzalez JP, Martin MH, Georges-Courbot MC, Palisson MJ, Georges AJ. Clinical aspects and usefulness of indirect absorbed immunofluorescence for diagnosis of yaws in Central Africa. J Clin Microbiol. 1988 Nov;26(11):2432–2433. [PMC free article] [PubMed]

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