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Emerg Infect Dis. 2001 Sep-Oct; 7(5): 812–819.
PMCID: PMC2631888

Factors contributing to the emergence of Escherichia coli O157 in Africa.

Abstract

In 1992, a large outbreak of bloody diarrhea caused by Escherichia coli O157 infections occurred in southern Africa. In Swaziland, 40,912 physician visits for diarrhea in persons ages >5 years were reported during October through November 1992. This was a sevenfold increase over the same period during 1990-91. The attack rate was 42% among 778 residents we surveyed. Female gender and consuming beef and untreated water were significant risks for illness. E. coli O157:NM was recovered from seven affected foci in Swaziland and South Africa; 27 of 31 patient and environmental isolates had indistinguishable pulsed-field gel electrophoresis patterns. Compared with previous years, a fivefold increase in cattle deaths occurred in October 1992. The first heavy rains fell that same month (36 mm), following 3 months of drought. Drought, carriage of E. coli O157 by cattle, and heavy rains with contamination of surface water appear to be important factors contributing to this outbreak.

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Selected References

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  • Isaäcson M, Canter PH, Effler P, Arntzen L, Bomans P, Heenan R. Haemorrhagic colitis epidemic in Africa. Lancet. 1993 Apr 10;341(8850):961–961. [PubMed]
  • Browning NG, Botha JR, Sacho H, Moore PJ. Escherichia coli O157:H7 haemorrhagic colitis. Report of the first South African case. S Afr J Surg. 1990 Mar;28(1):28–29. [PubMed]
  • Olsvik O, Rimstad E, Hornes E, Strockbine N, Wasteson Y, Lund A, Wachsmuth K. A nested PCR followed by magnetic separation of amplified fragments for detection of Escherichia coli Shiga-like toxin genes. Mol Cell Probes. 1991 Dec;5(6):429–435. [PubMed]
  • Cebula TA, Payne WL, Feng P. Simultaneous identification of strains of Escherichia coli serotype O157:H7 and their Shiga-like toxin type by mismatch amplification mutation assay-multiplex PCR. J Clin Microbiol. 1995 Jan;33(1):248–250. [PMC free article] [PubMed]
  • Barrett TJ, Lior H, Green JH, Khakhria R, Wells JG, Bell BP, Greene KD, Lewis J, Griffin PM. Laboratory investigation of a multistate food-borne outbreak of Escherichia coli O157:H7 by using pulsed-field gel electrophoresis and phage typing. J Clin Microbiol. 1994 Dec;32(12):3013–3017. [PMC free article] [PubMed]
  • Fields PI, Blom K, Hughes HJ, Helsel LO, Feng P, Swaminathan B. Molecular characterization of the gene encoding H antigen in Escherichia coli and development of a PCR-restriction fragment length polymorphism test for identification of E. coli O157:H7 and O157:NM. J Clin Microbiol. 1997 May;35(5):1066–1070. [PMC free article] [PubMed]
  • Boyce TG, Swerdlow DL, Griffin PM. Escherichia coli O157:H7 and the hemolytic-uremic syndrome. N Engl J Med. 1995 Aug 10;333(6):364–368. [PubMed]
  • Griffin PM, Ostroff SM, Tauxe RV, Greene KD, Wells JG, Lewis JH, Blake PA. Illnesses associated with Escherichia coli O157:H7 infections. A broad clinical spectrum. Ann Intern Med. 1988 Nov 1;109(9):705–712. [PubMed]
  • Mead PS, Griffin PM. Escherichia coli O157:H7. Lancet. 1998 Oct 10;352(9135):1207–1212. [PubMed]
  • Griffin PM, Tauxe RV. The epidemiology of infections caused by Escherichia coli O157:H7, other enterohemorrhagic E. coli, and the associated hemolytic uremic syndrome. Epidemiol Rev. 1991;13:60–98. [PubMed]
  • Rodrigue DC, Mast EE, Greene KD, Davis JP, Hutchinson MA, Wells JG, Barrett TJ, Griffin PM. A university outbreak of Escherichia coli O157:H7 infections associated with roast beef and an unusually benign clinical course. J Infect Dis. 1995 Oct;172(4):1122–1125. [PubMed]
  • Swerdlow DL, Woodruff BA, Brady RC, Griffin PM, Tippen S, Donnell HD, Jr, Geldreich E, Payne BJ, Meyer A, Jr, Wells JG, et al. A waterborne outbreak in Missouri of Escherichia coli O157:H7 associated with bloody diarrhea and death. Ann Intern Med. 1992 Nov 15;117(10):812–819. [PubMed]
  • Paquet C, Perea W, Grimont F, Collin M, Guillod M. Aetiology of haemorrhagic colitis epidemic in Africa. Lancet. 1993 Jul 17;342(8864):175–175. [PubMed]
  • Calundungo R, Maddau G, Rappelli P, Cappuccinelli P, Leite F, Francisco M, Colombo M. Escherichia coli and enteritis in Angola. Lancet. 1994 Aug 20;344(8921):538–539. [PubMed]
  • Armstrong GL, Hollingsworth J, Morris JG., Jr Emerging foodborne pathogens: Escherichia coli O157:H7 as a model of entry of a new pathogen into the food supply of the developed world. Epidemiol Rev. 1996;18(1):29–51. [PubMed]
  • Cunin P, Tedjouka E, Germani Y, Ncharre C, Bercion R, Morvan J, Martin PM. An epidemic of bloody diarrhea: Escherichia coli O157 emerging in Cameroon? Emerg Infect Dis. 1999 Mar-Apr;5(2):285–290. [PMC free article] [PubMed]
  • Germani Y, Soro B, Vohito M, Morel O, Morvan J. Enterohaemorrhagic Escherichia coli in Central African Republic. Lancet. 1997 Jun 7;349(9066):1670–1670. [PubMed]
  • Sang WK, Saidi SM, Yamamoto H, Ezaki T, Iida T, Yoh M, Honda T. Haemorrhagic colitis due to Escherichia coli O157:H7 in Kenya. J Trop Pediatr. 1996 Apr;42(2):118–119. [PubMed]
  • Akinyemi KO, Oyefolu AO, Opere B, Otunba-Payne VA, Oworu AO. Escherichia coli in patients with acute gastroenteritis in Lagos, Nigeria. East Afr Med J. 1998 Sep;75(9):512–515. [PubMed]
  • Dadié A, Karou T, Adom N, Kétté A, Dosso M. Isolement d'agents pathogènes entériques en Côte d'Ivoire: Escherichia coli O157:H7 et E. coli entéroagrégant. Bull Soc Pathol Exot. 2000 Apr;93(2):95–96. [PubMed]
  • Germani Y, Minssart P, Vohito M, Yassibanda S, Glaziou P, Hocquet D, Berthélémy P, Morvan J. Etiologies of acute, persistent, and dysenteric diarrheas in adults in Bangui, Central African Republic, in relation to human immunodeficiency virus serostatus. Am J Trop Med Hyg. 1998 Dec;59(6):1008–1014. [PubMed]
  • Abdul-Raouf UM, Ammar MS, Beuchat LR. Isolation of Escherichia coli O157:H7 from some Egyptian foods. Int J Food Microbiol. 1996 Apr;29(2-3):423–426. [PubMed]
  • Wittenberg DF. Emerging and re-emerging diseases--epidemic enterohaemorrhagic infections 100 years after Shiga. S Afr Med J. 1999 Jul;89(7):750–752. [PubMed]
  • Aragón M, Barreto A, Chambule J, Noya A, Tallarico M. Shigellosis in Mozambique: the 1993 outbreak rehabilitation--a follow-up study. Trop Doct. 1995 Oct;25(4):159–162. [PubMed]
  • Malakooti MA, Alaii J, Shanks GD, Phillips-Howard PA. Epidemic dysentery in western Kenya. Trans R Soc Trop Med Hyg. 1997 Sep-Oct;91(5):541–543. [PubMed]
  • Wong CS, Jelacic S, Habeeb RL, Watkins SL, Tarr PI. The risk of the hemolytic-uremic syndrome after antibiotic treatment of Escherichia coli O157:H7 infections. N Engl J Med. 2000 Jun 29;342(26):1930–1936. [PMC free article] [PubMed]
  • Mintz ED, Reiff FM, Tauxe RV. Safe water treatment and storage in the home. A practical new strategy to prevent waterborne disease. JAMA. 1995 Mar 22;273(12):948–953. [PubMed]
  • Reiff FM, Roses M, Venczel L, Quick R, Witt VM. Low-cost safe water for the world: a practical interim solution. J Public Health Policy. 1996;17(4):389–408. [PubMed]
  • Quick RE, Venczel LV, Mintz ED, Soleto L, Aparicio J, Gironaz M, Hutwagner L, Greene K, Bopp C, Maloney K, et al. Diarrhoea prevention in Bolivia through point-of-use water treatment and safe storage: a promising new strategy. Epidemiol Infect. 1999 Feb;122(1):83–90. [PMC free article] [PubMed]
  • Morse SS. Factors in the emergence of infectious diseases. Emerg Infect Dis. 1995 Jan-Mar;1(1):7–15. [PMC free article] [PubMed]
  • Colwell R, Epstein P, Gubler D, Hall M, Reiter P, Shukla J, Sprigg W, Takafuji E, Trtanj J. Global climate change and infectious diseases. Emerg Infect Dis. 1998 Jul-Sep;4(3):451–452. [PMC free article] [PubMed]
  • Engelthaler DM, Mosley DG, Cheek JE, Levy CE, Komatsu KK, Ettestad P, Davis T, Tanda DT, Miller L, Frampton JW, et al. Climatic and environmental patterns associated with hantavirus pulmonary syndrome, Four Corners region, United States. Emerg Infect Dis. 1999 Jan-Feb;5(1):87–94. [PMC free article] [PubMed]
  • Feldbaum H. Forging new perspectives on disease surveillance. Emerg Infect Dis. 1998 Apr-Jun;4(2):337–338. [PMC free article] [PubMed]

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