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Emerg Infect Dis. 2001 Mar-Apr; 7(2): 178–182.
PMCID: PMC2631711

The changing epidemiology of Staphylococcus aureus?


Strains of methicillin-resistant Staphylococcus aureus (MRSA), which had been largely confined to hospitals and long-term care facilities, are emerging in the community. The changing epidemiology of MRSA bears striking similarity to the emergence of penicillinase-mediated resistance in S. aureus decades ago. Even though the origin (hospital or the community) of the emerging MRSA strains is not known, the prevalence of these strains in the community seems likely to increase substantially.

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Selected References

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  • Herold BC, Immergluck LC, Maranan MC, Lauderdale DS, Gaskin RE, Boyle-Vavra S, Leitch CD, Daum RS. Community-acquired methicillin-resistant Staphylococcus aureus in children with no identified predisposing risk. JAMA. 1998 Feb 25;279(8):593–598. [PubMed]
  • Boyce JM. Are the epidemiology and microbiology of methicillin-resistant Staphylococcus aureus changing? JAMA. 1998 Feb 25;279(8):623–624. [PubMed]
  • Thompson RL, Cabezudo I, Wenzel RP. Epidemiology of nosocomial infections caused by methicillin-resistant Staphylococcus aureus. Ann Intern Med. 1982 Sep;97(3):309–317. [PubMed]
  • Boyce JM. Methicillin-resistant Staphylococcus aureus. Detection, epidemiology, and control measures. Infect Dis Clin North Am. 1989 Dec;3(4):901–913. [PubMed]
  • Payne MC, Wood HF, Karakawa W, Gluck L. A prospective study of staphylococcal colonization and infections in newborns and their families. Am J Epidemiol. 1965 Nov;82(3):305–316. [PubMed]
  • Ross S, Rodriguez W, Controni G, Khan W. Staphylococcal susceptibility to penicillin G. The changing pattern among community strains. JAMA. 1974 Aug 19;229(8):1075–1077. [PubMed]
  • Adcock PM, Pastor P, Medley F, Patterson JE, Murphy TV. Methicillin-resistant Staphylococcus aureus in two child care centers. J Infect Dis. 1998 Aug;178(2):577–580. [PubMed]
  • Sanford MD, Widmer AF, Bale MJ, Jones RN, Wenzel RP. Efficient detection and long-term persistence of the carriage of methicillin-resistant Staphylococcus aureus. Clin Infect Dis. 1994 Dec;19(6):1123–1128. [PubMed]
  • Gross-Schulman S, Dassey D, Mascola L, Anaya C. Community-acquired methicillin-resistant Staphylococcus aureus. JAMA. 1998 Aug 5;280(5):421–422. [PubMed]
  • L'Hériteau F, Lucet JC, Scanvic A, Bouvet E. Community-acquired methicillin-resistant Staphylococcus aureus and familial transmission. JAMA. 1999 Sep 15;282(11):1038–1039. [PubMed]
  • Saravolatz LD, Pohlod DJ, Arking LM. Community-acquired methicillin-resistant Staphylococcus aureus infections: a new source for nosocomial outbreaks. Ann Intern Med. 1982 Sep;97(3):325–329. [PubMed]
  • Saravolatz LD, Markowitz N, Arking L, Pohlod D, Fisher E. Methicillin-resistant Staphylococcus aureus. Epidemiologic observations during a community-acquired outbreak. Ann Intern Med. 1982 Jan;96(1):11–16. [PubMed]
  • Crossley K, Landesman B, Zaske D. An outbreak of infections caused by strains of Staphylococcus aureus resistant to methicillin and aminoglycosides. II. Epidemiologic studies. J Infect Dis. 1979 Mar;139(3):280–287. [PubMed]
  • BARBER M, ROZWADOWSKA-DOWZENKO M. Infection by penicillin-resistant staphylococci. Lancet. 1948 Oct 23;2(6530):641–644. [PubMed]
  • Jessen O, Rosendal K, Bülow P, Faber V, Eriksen KR. Changing staphylococci and staphylococcal infections. A ten-year study of bacteria and cases of bacteremia. N Engl J Med. 1969 Sep 18;281(12):627–635. [PubMed]
  • Hughes GB, Chidi CC, Macon WL. Staphylococci in community-acquired infections: Increased resistance to penicillin. Ann Surg. 1976 Apr;183(4):355–357. [PMC free article] [PubMed]
  • Hahn DL, Baker WA. Penicillin G susceptibility of "rural" staphylococcus aureus. J Fam Pract. 1980 Jul;11(1):43–46. [PubMed]
  • GOULD JC, CRUIKSHANK JD. Staphylococcal infection in general practice. Lancet. 1957 Dec 7;273(7006):1157–1161. [PubMed]
  • Harris DM, Wise PJ. Penicillinase-producing staphylococci in general practice and their control by cloxacillin. Practitioner. 1969 Aug;203(214):207–211. [PubMed]
  • Layton MC, Hierholzer WJ, Jr, Patterson JE. The evolving epidemiology of methicillin-resistant Staphylococcus aureus at a university hospital. Infect Control Hosp Epidemiol. 1995 Jan;16(1):12–17. [PubMed]
  • Kreiswirth B, Kornblum J, Arbeit RD, Eisner W, Maslow JN, McGeer A, Low DE, Novick RP. Evidence for a clonal origin of methicillin resistance in Staphylococcus aureus. Science. 1993 Jan 8;259(5092):227–230. [PubMed]
  • Hiramatsu K. Molecular evolution of MRSA. Microbiol Immunol. 1995;39(8):531–543. [PubMed]
  • Katayama Y, Ito T, Hiramatsu K. A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus. Antimicrob Agents Chemother. 2000 Jun;44(6):1549–1555. [PMC free article] [PubMed]
  • Small PM, Chambers HF. Vancomycin for Staphylococcus aureus endocarditis in intravenous drug users. Antimicrob Agents Chemother. 1990 Jun;34(6):1227–1231. [PMC free article] [PubMed]
  • Levine DP, Fromm BS, Reddy BR. Slow response to vancomycin or vancomycin plus rifampin in methicillin-resistant Staphylococcus aureus endocarditis. Ann Intern Med. 1991 Nov 1;115(9):674–680. [PubMed]
  • Soriano A, Martínez JA, Mensa J, Marco F, Almela M, Moreno-Martínez A, Sánchez F, Muñoz I, Jiménez de Anta MT, Soriano E. Pathogenic significance of methicillin resistance for patients with Staphylococcus aureus bacteremia. Clin Infect Dis. 2000 Feb;30(2):368–373. [PubMed]
  • Gentry CA, Rodvold KA, Novak RM, Hershow RC, Naderer OJ. Retrospective evaluation of therapies for Staphylococcus aureus endocarditis. Pharmacotherapy. 1997 Sep-Oct;17(5):990–997. [PubMed]
  • Conterno LO, Wey SB, Castelo A. Risk factors for mortality in Staphylococcus aureus bacteremia. Infect Control Hosp Epidemiol. 1998 Jan;19(1):32–37. [PubMed]

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