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J Clin Microbiol. Feb 1994; 32(2): 525–527.
PMCID: PMC263067

Suppression of fungal growth exhibited by Pseudomonas aeruginosa.


Three surgery patients were monitored postoperatively, with particular reference to lung infection. In each case there was a clinical impression that Pseudomonas aeruginosa suppressed the growth of Candida albicans in patients with clinically significant lung infections from whom both of these organisms were isolated from serial sputum samples. Regrowth of C. albicans after P. aeruginosa eradication occurred in two patients, despite fluconazole therapy, to which both C. albicans isolates were susceptible. In all three patients, the strain of P. aeruginosa was found to inhibit the growth of the corresponding C. albicans strain in vitro. Further in vitro susceptibility studies revealed significant inhibition by 10 strains of P. aeruginosa of 11 strains of fungi known to infect humans; these were Candida krusei, Candida keyfr, Candida guillermondii, Candida tropicalis, Candida lusitaniae, Candida parapsilosis, Candida pseudotropicalis, Candida albicans, Torulopsis glabrata, Saccharomyces cerevisiae, and Aspergillus fumigatus.

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  • Arima K, Imanaka H, Kousaka M, Fukuda A, Tamura G. Studies on pyrrolnitrin, a new antibiotic. I. Isolation and properties of pyrrolnitrin. J Antibiot (Tokyo) 1965 Sep;18(5):201–204. [PubMed]
  • Cohen R, Roth FJ, Delgado E, Ahearn DG, Kalser MH. Fungal flora of the normal human small and large intestine. N Engl J Med. 1969 Mar 20;280(12):638–641. [PubMed]
  • Edwards JE., Jr Invasive candida infections--evolution of a fungal pathogen. N Engl J Med. 1991 Apr 11;324(15):1060–1062. [PubMed]
  • Elander RP, Mabe JA, Hamill RH, Gorman M. Metabolism of tryptophans by Pseudomonas aureofaciens. VI. Production of pyrrolnitrin by selected Pseudomonas species. Appl Microbiol. 1968 May;16(5):753–758. [PMC free article] [PubMed]
  • Evans LR, Linker A. Production and characterization of the slime polysaccharide of Pseudomonas aeruginosa. J Bacteriol. 1973 Nov;116(2):915–924. [PMC free article] [PubMed]
  • Gillies RR, Govan JR. Typing of Pseudomonas pyocyanea by pyocine production. J Pathol Bacteriol. 1966 Apr;91(2):339–345. [PubMed]
  • Gordee RS, Matthews TR. Evaluation of the in vitro and in vivo antifungal activity of pyrrolnitrin. Antimicrob Agents Chemother (Bethesda) 1967;7:378–387. [PubMed]
  • Gordee RS, Matthews TR. Systemic antifungal activity of pyrrolnitrin. Appl Microbiol. 1969 May;17(5):690–694. [PMC free article] [PubMed]
  • Govan JR, Fyfe JA, McMillan C. The instability of mucoid Pseudomonas aeruginosa: fluctuation test and improved stability of the mucoid form in shaken culture. J Gen Microbiol. 1979 Jan;110(1):229–232. [PubMed]
  • Jayaswal RK, Fernandez MA, Schroeder RG. Isolation and characterization of a pseudomonas strain that restricts growth of various phytopathogenic fungi. Appl Environ Microbiol. 1990 Apr;56(4):1053–1058. [PMC free article] [PubMed]
  • Leisinger T, Margraff R. Secondary metabolites of the fluorescent pseudomonads. Microbiol Rev. 1979 Sep;43(3):422–442. [PMC free article] [PubMed]
  • Meunier F. Candidiasis. Eur J Clin Microbiol Infect Dis. 1989 May;8(5):438–447. [PubMed]
  • Tripathi RK, Gottlieb D. Mechanism of action of the antifungal antibiotic pyrrolnitrin. J Bacteriol. 1969 Oct;100(1):310–318. [PMC free article] [PubMed]
  • Upadhyay RS, Visintin L, Jayaswal RK. Environmental factors affecting the antagonism of Pseudomonas cepacia against Trichoderma viride. Can J Microbiol. 1991 Nov;37(11):880–884. [PubMed]
  • Zhou P, Mocek U, Siesel B, Floss HG. Biosynthesis of pyrrolnitrin. Incorporation of 13C, 15N double-labelled D- and L-tryptophan. J Basic Microbiol. 1992;32(3):209–214. [PubMed]

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