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Infect Immun. Oct 1985; 50(1): 62–65.
PMCID: PMC262135

Lack of correlation between known virulence properties of Aeromonas hydrophila and enteropathogenicity for humans.

Abstract

Five strains of Aeromonas hydrophila were selected for use in volunteer challenge trials. All five strains produced cytotoxin, hemolysin enterotoxin, lysine decarboxylase, acetylmethylcarbinol, and DNase. Two strains hydrolyzed esculin. All strains produced purulent hemorrhagic fluid accumulation in rabbit ileal loops, but failed to induce keratoconjunctivitis in guinea pigs. None of the strains produced mannose-resistant hemagglutinins. In challenge studies, diarrhea was demonstrated in only 2 of 57 human volunteers with doses ranging from 10(4) to 10(10) CFU. One person experienced mild diarrhea with 10(9) CFU of strain 6Y. A second person developed moderate diarrhea with 10(7) CFU of strain 3647. At higher doses, no diarrhea was seen in any of the volunteers. The other three strains (B158, SSU, 3284) failed to cause diarrhea and were not recovered from stools of volunteers. Additional virulence properties of A. hydrophila need to be sought before enteropathogenicity for humans can be established.

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Selected References

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  • Atkinson HM, Trust TJ. Hemagglutination properties and adherence ability of Aeromonas hydrophila. Infect Immun. 1980 Mar;27(3):938–946. [PMC free article] [PubMed]
  • Burke V, Cooper M, Robinson J, Gracey M, Lesmana M, Echeverria P, Janda JM. Hemagglutination patterns of Aeromonas spp. in relation to biotype and source. J Clin Microbiol. 1984 Jan;19(1):39–43. [PMC free article] [PubMed]
  • Burke V, Gracey M, Robinson J, Peck D, Beaman J, Bundell C. The microbiology of childhood gastroenteritis: Aeromonas species and other infective agents. J Infect Dis. 1983 Jul;148(1):68–74. [PubMed]
  • Champsaur H, Adremont A, Mathieu D, Rottman E, Auzepy P. Cholera-like illness due to Aeromonas sobria. J Infect Dis. 1982 Feb;145(2):248–254. [PubMed]
  • Daily OP, Joseph SW, Coolbaugh JC, Walker RI, Merrell BR, Rollins DM, Seidler RJ, Colwell RR, Lissner CR. Association of Aeromonas sobria with human infection. J Clin Microbiol. 1981 Apr;13(4):769–777. [PMC free article] [PubMed]
  • Davis WA, 2nd, Kane JG, Garagusi VF. Human aeromonas infections: a review of the literature and a case report of endocarditis. Medicine (Baltimore) 1978 May;57(3):267–277. [PubMed]
  • DuPont HL, Formal SB, Hornick RB, Snyder MJ, Libonati JP, Sheahan DG, LaBrec EH, Kalas JP. Pathogenesis of Escherichia coli diarrhea. N Engl J Med. 1971 Jul 1;285(1):1–9. [PubMed]
  • DuPont HL, Reves RR, Galindo E, Sullivan PS, Wood LV, Mendiola JG. Treatment of travelers' diarrhea with trimethoprim/sulfamethoxazole and with trimethoprim alone. N Engl J Med. 1982 Sep 30;307(14):841–844. [PubMed]
  • Echeverria P, Blacklow NR, Sanford LB, Cukor GG. Travelers' diarrhea among American Peace Corps volunteers in rural Thailand. J Infect Dis. 1981 Jun;143(6):767–771. [PubMed]
  • Ericsson CD, DuPont HL, Sullivan P, Galindo E, Evans DG, Evans DJ., Jr Bicozamycin, a poorly absorbable antibiotic, effectively treats travelers' diarrhea. Ann Intern Med. 1983 Jan;98(1):20–25. [PubMed]
  • Evans DG, Evans DJ, Jr, Pierce NF. Differences in the response of rabbit small intestine to heat-labile and heat-stable enterotoxins of Escherichia coli. Infect Immun. 1973 Jun;7(6):873–880. [PMC free article] [PubMed]
  • Evans DJ, Jr, Evans DG, Young LS, Pitt J. Hemagglutination typing of Escherichia coli: definition of seven hemagglutination types. J Clin Microbiol. 1980 Aug;12(2):235–242. [PMC free article] [PubMed]
  • Fulghum DD, Linton WR, Taplin D. Fatal Aeromonas hydrophila infection of the skin. South Med J. 1978 Jun;71(6):739–741. [PubMed]
  • Hird DW, Diesch SL, McKinnell RG, Gorham E, Martin FB, Meadows CA, Gasiorowski M. Enterobacteriaceae and Aeromonas hydrophila in Minnesota frogs and tadpoles (Rana pipiens). Appl Environ Microbiol. 1983 Dec;46(6):1423–1425. [PMC free article] [PubMed]
  • Holmberg SD, Farmer JJ., 3rd Aeromonas hydrophila and Plesiomonas shigelloides as causes of intestinal infections. Rev Infect Dis. 1984 Sep-Oct;6(5):633–639. [PubMed]
  • James C, Dibley M, Burke V, Robinson J, Gracey M. Immunological cross-reactivity of enterotoxins of Aeromonas hydrophila and cholera toxin. Clin Exp Immunol. 1982 Jan;47(1):34–42. [PMC free article] [PubMed]
  • Kaper JB, Lockman H, Colwell RR, Joseph SW. Aeromonas hydrophila: ecology and toxigenicity of isolates from an estuary. J Appl Bacteriol. 1981 Apr;50(2):359–377. [PubMed]
  • Ketover BP, Young LS, Armstrong D. Septicemia due to Aeromonas hydrophila: clinical and immunologic aspects. J Infect Dis. 1973 Mar;127(3):284–290. [PubMed]
  • Levine MM, Bergquist EJ, Nalin DR, Waterman DH, Hornick RB, Young CR, Sotman S. Escherichia coli strains that cause diarrhoea but do not produce heat-labile or heat-stable enterotoxins and are non-invasive. Lancet. 1978 May 27;1(8074):1119–1122. [PubMed]
  • Ljungh A, Popoff M, Wadstrom T. Aeromonas hydrophila in acute diarrheal disease: detection of enterotoxin and biotyping of strains. J Clin Microbiol. 1977 Aug;6(2):96–100. [PMC free article] [PubMed]
  • Morgan DR, DuPont HL, Wood LV, Ericsson CD. Comparison of methods to detect Escherichia coli heat-labile enterotoxin in stool and cell-free culture supernatants. J Clin Microbiol. 1983 Oct;18(4):798–802. [PMC free article] [PubMed]
  • Moulsdale MT. Isolation of Aeromonas from faeces. Lancet. 1983 Feb 12;1(8320):351–351. [PubMed]
  • Pickering LK, Evans DG, DuPont HL, Vollet JJ, 3rd, Evans DJ., Jr Diarrhea caused by Shigella, rotavirus, and Giardia in day-care centers: prospective study. J Pediatr. 1981 Jul;99(1):51–56. [PubMed]
  • Pickering LK, Evans DJ, Jr, Muñoz O, DuPont HL, Coello-Ramírez P, Vollet JJ, Conklin RH, Olarte J, Kohl S. Prospective study of enteropathogens in children with diarrhea in Houston and Mexico. J Pediatr. 1978 Sep;93(3):383–388. [PubMed]
  • Pitarangsi C, Echeverria P, Whitmire R, Tirapat C, Formal S, Dammin GJ, Tingtalapong M. Enteropathogenicity of Aeromonas hydrophila and Plesiomonas shigelloides: prevalence among individuals with and without diarrhea in Thailand. Infect Immun. 1982 Feb;35(2):666–673. [PMC free article] [PubMed]
  • Popoff M, Véron M. A taxonomic study of the Aeromonas hydrophila-Aeromonas punctata group. J Gen Microbiol. 1976 May;94(1):11–22. [PubMed]
  • Rahman AF, Willoughby JM. Dysentery-like syndrome associated with Aeromonas hydrophila. Br Med J. 1980 Oct 11;281(6246):976–976. [PMC free article] [PubMed]
  • SERENY B. Experimental shigella keratoconjunctivitis; a preliminary report. Acta Microbiol Acad Sci Hung. 1955;2(3):293–296. [PubMed]
  • Trust TJ, Chipman DC. Clinical involvement of Aeromonas hydrophila. Can Med Assoc J. 1979 Apr 21;120(8):942–946. [PMC free article] [PubMed]
  • Turnbull PC, Lee JV, Miliotis MD, Van de Walle S, Koornhof HJ, Jeffery L, Bryant TN. Enterotoxin production in relation to taxonomic grouping and source of isolation of Aeromonas species. J Clin Microbiol. 1984 Feb;19(2):175–180. [PMC free article] [PubMed]
  • von Graevenitz A, Bucher C. Evaluation of differential and selective media for isolation of Aeromonas and Plesiomonas spp. from human feces. J Clin Microbiol. 1983 Jan;17(1):16–21. [PMC free article] [PubMed]
  • Von Graevenitz A, Mensch AH. The genus aeromonas in human bacteriology report of 30 cases and review of the literature. N Engl J Med. 1968 Feb 1;278(5):245–249. [PubMed]
  • Waltman WD, 2nd, Shotts EB, Hsu TC. Enzymatic characterization of Aeromonas hydrophila complex by the API ZYM system. J Clin Microbiol. 1982 Oct;16(4):692–696. [PMC free article] [PubMed]

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