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Journal List > Infect Immun > v.49(2); Aug 1985

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Infect Immun. 1985 August; 49(2): 443–446.
PMCID: PMC262038
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Ultrastructural studies of adherence of Staphylococcus aureus in experimental acute hematogenous osteomyelitis.
D J Speers and S M Nade
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Abstract
A model of acute hematogenous osteomyelitis initiated by injection of Staphylococcus aureus into 29-day-old chickens was used. Transmission electron microscopy showed that the bacteria adhered to exposed cartilage matrix in the metaphyseal region of long bones but not to adjacent vascular linings or to erythrocytes. It is proposed that the combination of exposure of growth plate cartilage during normal bone growth and the ability of S. aureus to adhere to this cartilage is the mechanism for initiation of infection which proceeds to an osteomyelitic abscess.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • Deysine M, Rosario E, Isenberg HD. Acute hematogenous osteomyelitis: an experimental model. Surgery. 1976 Jan;79(1):97–99. [PubMed]
  • Emslie KR, Nade S. Acute hematogenous staphylococcal osteomyelitis. A description of the natural history in an avian model. Am J Pathol. 1983 Mar;110(3):333–345. [PubMed]
  • Emslie KR, Ozanne NR, Nade SM. Acute haematogenous osteomyelitis: an experimental model. J Pathol. 1983 Oct;141(2):157–167. [PubMed]
  • Howlett CR. The fine structure of the proximal growth plate of the avian tibia. J Anat. 1979 Mar;128(Pt 2):377–399. [PubMed]
  • Howlett CR. The fine structure of the proximal growth plate and metaphysis of the avian tibia: endochondral osteogenesis. J Anat. 1980 Jun;130(Pt 4):745–768. [PubMed]
  • Norden CW. Experimental osteomyelitis. I. A description of the model. J Infect Dis. 1970 Nov;122(5):410–418. [PubMed]
  • Proctor RA, Hamill RJ, Mosher DF, Textor JA, Olbrantz PJ. Effects of subinhibitory concentrations of antibiotics on Staphylococcus aureus interactions with fibronectin. J Antimicrob Chemother. 1983 Oct;12 Suppl NaN:85–95. [PubMed]
  • Wise DR, Jennings AR. The development and morphology of the growth plates of two long bones of the turkey. Res Vet Sci. 1973 Mar;14(2):161–166. [PubMed]
  • WOLBACH SB, HEGSTED DM. Endochondral bone growth in the chick. AMA Arch Pathol. 1952 Jul;54(1):1–12. [PubMed]
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