Logo of brcnresBioMed CentralBiomed Central Web Sitesearchsubmit a manuscriptregisterthis articleBreast Cancer Research : BCR
Breast Cancer Res. 2008; 10(Suppl 4): S2.
Published online Dec 18, 2008. doi:  10.1186/bcr2162
PMCID: PMC2614854

Introduction to sessions on 'What can surgeons do for us (and we for them): radiology, pathology, molecular biology and local therapy'

A number of important issues surrounding local control of breast cancer continue to attract debate. In breast conserving surgery, the balance between excising sufficient tissue to achieve a satisfactory cosmetic outcome while also achieving adequate long-term local control remains an issue of contention. Despite the review by Singletary [1] indicating that wider excisions are unlikely to reduce local recurrence rates, there remains considerable conflict among surgeons and radiation oncologists as to what is the optimum width of clear margin after breast conserving surgery. There has been increasing focus on trying to identify those patients who are at significant risk for local recurrence from radiological, pathological and molecular biology perspectives. The radiological issues have focused on the role played by magnetic resonance imaging and its value in identifying mammographically occult disease. There remain some radiologists who advocate its widespread use, but evidence of its value is limited [2]. Work by Tabar and coworkers [3] suggests there is a group of patients with widespread casting type microcalcification on mammograms; they consider this to represent neoductgenesis, and it was a poor prognostic sign in their series. Using all of the information that we are provided with by radiologists and incorporating mammographic patterns of cancer into prognosis remains challenging and is an area of controversy.

As well as margins, the pathologist assesses a variety of factors that have been shown to influence local recurrence, including histological grade and the presence of lymphatic vascular invasion. Even with accurate pathology, however, it is difficult to identify those who will develop local recurrence with any precision. For this reason, there has been a move to investigate molecular markers. Gene array profiles have been investigated recently but cannot yet accurately identify those patients at risk for local recurrence.

Therefore, the greatest influence on local recurrence after breast conserving surgery is currently the surgeon's ability to reduce the volume of disease within the breast, to a level that can be adequately controlled by radiotherapy. Thus, the art of surgery and the ability of the surgeon to remove diseased tissue while retaining sufficient breast tissue to produce a satisfactory outcome is a major reason why such surgery is best carried out by those with a large volume of clinical experience.

Competing interests

The authors declare that they have no competing interests.

Acknowledgements

This article has been published as part of Breast Cancer Research Volume 10 Supplement 4, 2008: Controversies in Breast Cancer 2008. The full contents of the supplement are available online at http://breast-cancer-research.com/supplements/10/S4

References

  • Singletary SE. Surgical margins in patients with early-stage breast cancer treated with breast conservation therapy. Am J Surg. 2002;184:383–393. doi: 10.1016/S0002-9610(02)01012-7. [PubMed] [Cross Ref]
  • Houssami N, Ciatto S, Macaskill P, Lord SJ, Warren RM, Dixon JM, Irwig L. Accuracy and surgical impact of MRI in breast cancer staging: systematic review and meta-analysis in detection of multifocal and multicentric cancer. J Clin Oncol. 2008;26:3248–3258. doi: 10.1200/JCO.2007.15.2108. [PubMed] [Cross Ref]
  • Tabar L, Tot T, Dean PB. Breast Cancer: Early Detection with Mammography Casting Type Calcifications: Sign of a Subtype with Deceptive Features. New York, NY: Thieme Medical Publishers Inc; 2007.

Articles from Breast Cancer Research : BCR are provided here courtesy of BioMed Central
PubReader format: click here to try

Formats:

Related citations in PubMed

See reviews...See all...

Links

  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...