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Infect Immun. Sep 1986; 53(3): 700–701.
PMCID: PMC260851

Inhibition of cholera toxin production by thiols in Vibrio cholerae.


We found that thiols reduced the amount of cholera toxin produced by Vibrio cholerae 569B in vitro. A sulfhydryl group at least was necessary for the reduction of cholera toxin production by thiols.

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Selected References

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  • Finkelstein RA, Atthasampunna P, Chulasamaya M, Charunmethee P. Pathogenesis of experimental cholera: biologic ativities of purified procholeragen A. J Immunol. 1966 Mar;96(3):440–449. [PubMed]
  • Greenberg RN, Dunn JA, Guerrant RL. Reduction of the secretory response to Escherichia coli heat-stable enterotoxin by thiol and disulfide compounds. Infect Immun. 1983 Jul;41(1):174–180. [PMC free article] [PubMed]
  • Shimamura T, Watanabe S, Sasaki S. Enhancement of enterotoxin production by carbon dioxide in Vibrio cholerae. Infect Immun. 1985 Aug;49(2):455–456. [PMC free article] [PubMed]
  • Toohey JI. Sulfhydryl dependence in primary explant hematopoietic cells. Inhibition of growth in vitro with vitamin B12 compounds. Proc Natl Acad Sci U S A. 1975 Jan;72(1):73–77. [PMC free article] [PubMed]

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