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Infect Immun. Dec 1988; 56(12): 3326–3328.
PMCID: PMC259746

Plasmodium chabaudi malaria: protective immunization with surface membranes of infected erythrocytes.

Abstract

Plasmodium chabaudi-susceptible NMRI and B10.A mice were vaccinated with host cell plasma membranes isolated from P. chabaudi-infected erythrocytes. Most of the mice were protected from the lethal consequences of challenge with the homologous parasite, although protection was unassociated with a reduction in the course or peak of parasitemia. Vaccination also induced the production of antibodies against Pc90, which is the immunodominant protein expressed by parasites in host cell plasma membranes.

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Selected References

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  • Hoffman SL, Oster CN, Plowe CV, Woollett GR, Beier JC, Chulay JD, Wirtz RA, Hollingdale MR, Mugambi M. Naturally acquired antibodies to sporozoites do not prevent malaria: vaccine development implications. Science. 1987 Aug 7;237(4815):639–642. [PubMed]
  • Jensen JB, Boland MT, Akood M. Induction of crisis forms in cultured Plasmodium falciparum with human immune serum from Sudan. Science. 1982 Jun 11;216(4551):1230–1233. [PubMed]
  • Jensen JB, Boland MT, Allan JS, Carlin JM, Vande Waa JA, Divo AA, Akood MA. Association between human serum-induced crisis forms in cultured Plasmodium falciparum and clinical immunity to malaria in Sudan. Infect Immun. 1983 Sep;41(3):1302–1311. [PMC free article] [PubMed]
  • Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970 Aug 15;227(5259):680–685. [PubMed]
  • Sherman IW. Membrane structure and function of malaria parasites and the infected erythrocyte. Parasitology. 1985 Dec;91(Pt 3):609–645. [PubMed]
  • Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A. 1979 Sep;76(9):4350–4354. [PMC free article] [PubMed]
  • Wunderlich F, Helwig M, Schillinger G, Speth V. Cryptic disposition of antigenic parasite proteins in plasma membranes of erythrocytes infected with Plasmodium chabaudi. Mol Biochem Parasitol. 1988 Jul;30(1):55–65. [PubMed]
  • Wunderlich F, Helwig M, Schillinger G, Vial H, Philippot J, Speth V. Isolation and characterization of parasites and host cell ghosts from erythrocytes infected with Plasmodium chabaudi. Mol Biochem Parasitol. 1987 Mar;23(2):103–115. [PubMed]
  • Wunderlich F, Stübig H, Königk E. Development of Plasmodium chabaudi in mouse red blood cells: structural properties of the host and parasite membranes. J Protozool. 1982 Feb;29(1):60–66. [PubMed]

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