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Yale J Biol Med. 1979 May–Jun; 52(3): 257–262. | PMCID: PMC2595457 |
Clinical Comparison of Two Contrast Agents for Oral Cholecystography: Radiologic Efficacy and Drug Safety of Iopanoic Acid and Iopronic Acid 1Laurence Hedlund, Charles E. Putman, and Morton Burrell Abstract Oral doses of either iopronic acid (4.5 g Oravue, Squibb) or iopanoic acid (3 g Telepaque, Winthrop) were given to 98 patients requiring cholecystography. Radiographs were taken 13 to 16 hours after treatment showed good to excellent gallbladder opacification in 44 percent of patients after the first dose of iopronic acid and in an additional 29 percent after a second dose. Similar opacification occurred in 42 percent of patients after the first dose of iopanoic acid and in 34 percent after a second dose. Drug-related abnormalities in blood and urine tests occurred about equally in both groups and one patient in each group exhibited a clinically adverse reaction (diarrhea). Thus, the performance (radiographic efficacy and drug safety) of the new contrast agent, iopronic acid, was similar to a widely used drug, iopanoic acid. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (773K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - Felder E, Tanara CB. Radiopaque contrast media.XXXIII-Oral cholecystography: a review. Farmaco Prat. 1976 Jun;31(6):283–294. [PubMed]
- HEALEY T, GRAINGER RG. A CLINICAL TRIAL OF ORAL CHOLECYSTOGRAPHIC MEDIA: TELEPAQUE, BILOPTIN, OSBIL TABLETS AND OSBIL CAPSULES. Br J Radiol. 1965 Jan;38:57–62. [PubMed]
- Stanley RJ, Melson GL, Cubillo E, Hesker AE. A comparison of three cholecystographic agents. A double-blind study with and without a prior fatty meal. Radiology. 1974 Sep;112(3):513–517. [PubMed]
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- Loeb PM, Berk RN, Janes JO, Perkin L, Moore J. The effect of fasting on gallbladder opacification during oral cholecystography: a controlled study in normal volunteers. Radiology. 1978 Feb;126(2):395–401. [PubMed]
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- Felder E, Pitrè D, Fumagalli L, Lorenzotti E. Radiopaque contrast media. XXXIV - Derivatives of omega-(3-amino-2,4,6-triiodophenoxy)alkoxyalkanoic acids. Farmaco Sci. 1976 May;31(5):349–363. [PubMed]
- Tirone P, Rosati G. Radiopaque contrast media. XXXVII-Iopronic acid, a new contrast medium for oral cholecystography: pharmacologic investigation. Farmaco Prat. 1976 Aug;31(8):397–412. [PubMed]
- Tirone P, Rosati G. Radiopaque contrast media. XXXVIII - Iopronic acid, a new contrast medium for oral cholecystography: toxicologic investigation. Farmaco Prat. 1976 Sep;31(9):437–446. [PubMed]
- Pizzolato NF, Arcomano JP, Baum AE. A new contrast agent for oral cholecystography: iopronic acid (Oravue). AJR Am J Roentgenol. 1978 May;130(5):845–847. [PubMed]
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