• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of nihpaAbout Author manuscriptsSubmit a manuscriptNIH Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
Psychooncology. Author manuscript; available in PMC Dec 3, 2008.
Published in final edited form as:
PMCID: PMC2593110




With the established effectiveness of diverse treatments for prostate cancer, identification of the physical and psychosocial consequences of the disease and various treatments becomes critical. We review the literature on the effects of prostate cancer and its treatment on health-related quality of life (HRQoL). Studies show that prostate cancer and its treatment affect both disease-specific HRQoL (i.e. urinary, sexual, and bowel function) as well as general HRQoL (i.e. energy/vitality, performance in physical and social roles). Yet, these effects appear to differ across stage of disease and type of treatment. We outline evidence from three sources: (1) studies that compare men with the disease with an age-matched sample of men without the disease, (2) studies that assess men with the disease across time, and (3) cross-sectional studies that highlight predictors of HRQoL. Future research directions are discussed.


Prostate cancer is the most common solid tumor malignancy and the second leading cause of cancer death in American men (American Cancer Society-ACS, 2001). It is also one of the most common malignancies in European men (Borghede et al., 1997; Curran et al., 1997). While prostate cancer can prove deadly, 93% of men diagnosed with the disease will survive for at least 5 years, and 72.1% will survive for at least 10 years (ACS, 2001). Due to the location of the prostate gland and the delicate nature of treatment, the man with prostate cancer often faces a host of difficulties which can affect health-related quality of life (HRQoL). Thus, concerns about HRQoL are often paramount in the minds of men diagnosed with prostate cancer. This article aims to bring clarity and order to the rapidly growing literature on the effects of prostate cancer and its treatment on men’s HRQoL.

While reviews of HRQoL in men with prostate cancer have been done, most have taken a somewhat narrow view of the term. These reviews often emphasize the disease-specific, physical complications while paying less attention to general domains of HRQoL. Certainly, the symptoms of the disease are critically important to understand, but patients and health-care providers also have many questions about the influence of prostate cancer and its treatment on a man’s everyday existence. To address this shortcoming in prior reviews, we have chosen to define HRQoL widely, as both disease-specific, physical complications and general domains of HRQoL. In the past 5 years, there has been a virtual explosion of research in the HRQoL issues of men with prostate cancer. Thus, there is a pressing need to take stock of this accumulating literature. This review synthesizes the findings of recent research from the fields of medicine and psycho-oncology.

Prostate cancer treatment

Since different treatments for prostate cancer have variable effects, it is important to outline the types of therapies that are currently available. Typically, some form of surgery or radiation is used when the cancer is of low grade and confined to the prostate gland (i.e., localized disease). Hormonal and chemotherapeutic options are ordinarily used when the malignancy has spread from the prostate to other areas of the body (i.e., advanced disease). Treatments for localized prostate cancer can result in cure, but those for advanced disease are mainly used to delay disease progression or palliate symptoms.

Therapeutic options for localized disease include surgical and non-surgical approaches. Surgical approaches include radical prostatectomy, transurethral resection of the prostate, and cryosurgery. Radical prostatectomy, including the nerve-sparing approach, involves surgical removal of the entire prostate and is used mainly when it is believed that the cancer has not spread outside of the gland. Transurethral resection of the prostate involves surgical removal of prostate tissue that surrounds the urethra and is mostly used with men who cannot have radical surgery due to other health complications or advanced age. Cryosurgery, which involves freezing malignant areas of the prostate with cooled metal probes, is used by a small proportion of men who are interested in a less aggressive form of surgery.

Non-surgical options for localized disease include external and internal irradiation and ‘watchful waiting’. Radiation therapy is commonly used when prostate cancer is localized to the prostate and the surrounding region. External beam radiotherapy (EBR) makes use of high-energy X-rays or radioactive particles generated outside of the body and focused on the malignancy. EBR can cover the broad area of the pelvis or be stereotaxically conformed to a specified region, thereby reducing the likelihood of damage to surrounding tissue. Internal irradiation, or brachytherapy, utilizes small radioactive pellets that are implanted directly into the prostate. Finally, for some men with localized disease the appropriate course of action after a prostate cancer diagnosis is observation, or ‘watchful waiting’ (Fleming et al., 1993). That is, no immediate treatment is administered, rather the cancer is observed and monitored for signs of progression. This is often a reasonable choice for older men with early-stage, low-grade disease and few or no complications, because prostate cancer can be a slow-growing malignancy.

At present, there is no consensus about which therapeutic option is best for men with localized prostate cancer. Existing data from non-randomized studies show similar survival rates (Bonney et al., 1982; Chodak et al., 1994; Gerber et al., 1996; Hanks, 1991; Lu-Yao and Yao, 1997) and the results of randomized clinical trials are still some years away. Hence, the selection of a treatment is based on factors other than survival advantage and may include the effect of therapy on HRQoL.

Hormone therapies and chemotherapy are options for men with advanced prostate cancer. Hormone therapies help to reduce the levels of circulating androgens. Androgen can promote the growth of malignant prostate cancer cells. Surgical and non-surgical hormone therapies exist. Orchiectomy involves the surgical removal of the testicles. It physically eliminates the primary source of androgen in the body. Pharmacological hormone therapies can achieve essentially the same end without surgery. Luteinizing hormone-releasing hormone (LHRH) analogs are used to interrupt testosterone production. Another class of drugs, anti-androgens, are used to block the body’s ability to use androgen. Anti-androgens can be combined with either orchiectomy or LHRH analog to completely block androgen activity. Finally, chemotherapy is an option for a select few men who have prostate cancer that has metastasized and for whom hormone therapy has failed. Like hormone therapy, the aim of chemotherapy is to stop the spread of the disease and reduce physical complications such as bone pain.

Prostate cancer and HRQoL

The concept of quality of life has great significance in the health-care arena, because the number of people living with chronic illness is growing rapidly. In weighing options for treating life-threatening diseases, such as cancer, patients and health-care providers are interested in knowing both the number of years a given treatment will add to life and the quality of life in those added years. HRQoL is a multidimensional construct that typically includes four broad categories: physical, functional, social and emotional well-being (Cella and Tulsky, 1993). Cella states that HRQoL refers to the extent to which one’s usual or expected physical, social and emotional well-being are affected by a medical condition or its treatment (Cella, 1995). Thus, the minimum criteria for an appropriate measurement of HRQoL include (a) that measurement incorporates the patient’s perspective and (b) that it captures physical, social and mental well-being. We adopt this definition for the present review.

We reviewed the literature from English-language empirical studies identified from the MEDLINE (coverage from 1965) and PSYCINFO (coverage from 1887) databases and the reference lists of published articles. To capture the full range of HRQoL outcomes, we used the following descriptor terms for our database searches: prostate cancer, quality of life, mental health, adjustment, sexual function, body image, depression, impotence, incontinence, urogenital disorders, fatigue, well-being, anxiety, psychological distress, and mood. In each search, the term ‘prostate cancer’ was combined with one of the other terms. We used only those articles in which data from subgroups of men with prostate cancer could be clearly identified. Consistent with the operationalization of HRQoL that we have chosen to adopt, this review includes empirical studies that assess both disease-specific, physical parameters as well as general HRQoL parameters. For reviews of just the physical symptoms associated with prostate cancer and its treatments, we refer the reader to several excellent articles (see Altwein et al., 1997; Middleton et al., 1995; Shipley et al., 1994; Wasson et al., 1993). Furthermore, unlike other reviews (see Herr, 1997; Van Andel et al., 1997) we chose to exclude studies that did not use validated measures of HRQoL. Finally, we review here only studies that make inferential statistical comparisons.

We have organized the review into four sections, corresponding to the major HRQoL outcomes related to prostate cancer. We first examine evidence that clarifies the disease-specific sequela of prostate cancer, namely, urinary, sexual, and bowel functioning outcomes. Next, we present the evidence on general HRQoL outcomes. We considered evidence from three types of studies; comparison group (comparisons of men with prostate cancer with an age-matched sample of men without the disease), longitudinal (assessments of men over time), and cross-sectional (assessments of men at one time point). Within each section, we consider the issues of men with localized prostate cancer separately from those of men with advanced prostate cancer, as quality of life concerns are often very different across these two forms of the disease. Whenever possible, we also provide information on the magnitude of HRQoL outcomes.


Localized disease

Comparison group studies show that men treated for localized prostate cancer have more problems with urinary function than men of the same age without the disease (Joly et al., 1998; Litwin et al., 1995). Moreover, treated men seem to have more urinary problems than men who are not treated for the disease (Litwin et al., 1995). Thus, urinary dysfunction appears to be a treatment-related complication (see Table 1). Those suffering the most urinary problems are those who are treated with radical prostatectomy (RP). Litwin et al. (1995) compared three groups of men with localized prostate cancer to a matched comparison group of men without prostate cancer. Those in the diseased group were diagnosed an average of 5–6 years prior to the study and had been treated with either RP (mean time since treatment (TST)=5.3 years) or EBR (mean TST=5.9 years) or were part of an observation-alone group (mean time since diagnosis (TSD)=5.7 years). Across all four groups, men treated with RP had the worst urinary function. Forty percent of men treated with RP reported leaking urine daily (almost twice as often as men treated with EBR). Furthermore, 90% of these men reported using two or fewer absorptive pads per day, while only 30% claimed total urinary control. Men treated with EBR also had worse urinary function than men in the comparison group; however, their problems were not as severe as those of RP-treated men. Among men treated with EBR, 92% claimed total control or occasional leakage, while 23% reported daily mild urinary leakage.

Table 1
Summary of studies of localized prostate cancer

Others have reported elevated rates of urinary problems in men treated with combination radiotherapy. Joly and colleagues (Joly et al., 1998) compared men with localized prostate cancer treated with EBR+brachytherapy with a matched sample of men without the disease. Men in the diseased group had been treated an average of 4 years prior to the study. Treated men reported greater urinary incontinence and more burning upon urination than did men in the comparison group. Overall, 40% of men reported urinary incontinence, while 27% reported mild burning upon urination.

A number of cross-sectional studies have directly compared RP with radiation treatments for localized prostate cancer (see Table 1). Men treated with RP have consistently reported more urinary problems (i.e., dripping and leaking urine, lack of urinary control) than men treated with EBR (Fowler et al., 1996; Lim et al., 1995; Shrader-Bogen et al., 1997; Tefilli et al., 1998; Yarbro and Ferrans, 1998). For example, Fowler et al. (1996) found that 62% of men treated with EBR (TST range=3–5 years) reported no dripping or leaking of urine posttreatment, whereas only 14% of men treated with RP (TST range=2–4 years) reported the same. Similar to comparison group studies, many of these cross-sectional studies assess men several years posttreatment. Overall, the results of comparison group and cross-sectional studies indicate that urinary dysfunction is associated with treatments for localized prostate cancer and that RP leads to the greatest number of problems. Missing from these studies, however, is information about how urinary function changes over time.

Longitudinal studies help to clarify the trajectory of urinary dysfunction in men treated for localized prostate cancer. Recent longitudinal investigations have shown that while declines in urinary function are quite common in the first few months following RP, function improves substantially 1 year after treatment (see Table 1) (Litwin et al., 1999; Lubeck et al., 1999; Potosky et al., 2000; Stanford et al., 2000). In the Litwin et al. (1999) study, 61% of men treated with RP had reportedly recovered pretreatment urinary function at 1 year posttreatment. This finding contrasts with those of earlier cross-sectional studies (i.e. Litwin et al., 1995; Fowler et al., 1996; Shrader-Bogen et al., 1997) showing high levels of urinary dysfunction 1–5 years post-RP. However, RP-treated men in the Litwin et al. (1999) study were younger and had fewer co-morbid conditions than the RP-treated men in the cross-sectional studies. Hence, it may have been easier for them to recover from surgery.

Urinary sequela for men treated non-surgically and those who are observed is quite different. Men treated with EBR, hormone therapy, and those who are observed exhibit few short- or long-term deficits in urinary function (Lubeck et al., 1999; Potosky et al., 2000). Lubeck and colleagues (Lubeck et al., 1999) found few urinary problems in an EBR group, a hormone therapy group or an observation-alone group immediately after treatment or at 1 year and 2 years after treatment. In the large-scale, community-based Prostate Cancer Outcomes Study (PCOS) (Potosky et al., 1999), men who had received RP experienced substantial declines in urinary function in the months after treatment, men treated with EBR declined only slightly (Potosky et al., 2000).

Advanced disease

Treatments for advanced prostate cancer such as combined androgen blockade (CAB) and orchiectomy do not appear to be associated with urinary dysfunction (see Table 2). Litwin and colleagues (Litwin et al., 1998) measured urinary function every 3 months after treatment initiation in men with newly diagnosed metastatic prostate cancer who were treated with either CAB (using leuprolide+flutamide) or bilateral orchiectomy. Men had been diagnosed between 0 and 24 months prior to the study period. Both treatment groups had good urinary function prior to treatment. One year after treatment initiation, urinary function had modestly improved from pretreatment levels for both groups. These findings have been replicated in an European sample (Da Silva et al., 1996). Importantly, the findings from studies of advanced disease must be cautiously interpreted as many men drop out prior to follow-up. Reasons for dropping out include death and disease progression. Thus, follow-up scores often represent only the healthiest men.

Table 2
Summary of studies of advanced prostate cancer


Localized disease

Results from comparison group studies show that men with localized prostate cancer report more sexual problems than do similarly aged men without prostate cancer (see Table 1) (Helgason et al., 1996, 1997; Litwin et al., 1995). Unlike urinary problems, however, some sexual problems seem linked to the disease, irrespective of the type of treatment used. For instance, recently diagnosed, treated and untreated men with localized prostate cancer are at a higher risk for developing physiological impotence than men of similar age with no disease (Helgason et al., 1996, 1997). Litwin et al. (1995) also found that sexual function was better in a healthy comparison group of older men than in a group of men with localized disease who were being observed (mean TSD=5.7 years). Thus, certain aspects of sexual function dysfunction may be a result of having localized prostate cancer.

Notwithstanding the possible effects of the disease alone, declines in sexual function appear to be exa-cerbated by certain treatments. Men treated with RP show the most sexual problems (see Table 1). Helgason et al. (1997) found that among men recently diagnosed with localized disease (within 1 year), those treated with RP had a higher rate of physiological impotence (86%) then those treated with EBR (57%). Men who were only observed displayed the least impotence (57%). Other cross-sectional comparisons of RP and EBR have replicated this result (Fowler et al., 1996; Lim et al., 1995; Shrader-Bogen et al., 1997; Yarbro and Ferrans, 1998). Once again, conclusions about sexual sequela are difficult to draw from these studies as men are assessed at only one time point, often several years after treatment.

Sexual sequela can be better understood in the context of longitudinal investigations. Results from longitudinal studies reveal that problems in sexual function develop early in men with localized prostate cancer (in both treated and untreated men), and they do not dissipate as rapidly as urinary problems (see Table 1). Men treated with RP develop severe sexual difficulties shortly after treatment (Lubeck et al., 1999; Potosky et al., 2000; Stanford et al., 2000). Furthermore, these men have great difficulty regaining pretreatment levels of sexual function (Litwin et al., 1999; Stanford et al., 2000). Litwin et al. (1999) found that only 31% of the men in their study had recovered pretreatment sexual function by a year after RP. This negative sequela is not unique to those treated with RP. Men treated with radiation and those who are observed only also report experiencing sexual problems (Lubeck et al., 1999; Potosky et al., 2000). Like those who have had a prostatectomy, sexual function in these other groups was poor at baseline and remained poor at one and two year follow-up points (Lubeck et al., 1999). Still, negative sexual sequela appears more characteristic of men treated with RP than of those treated with EBR (Potosky et al., 2000).

Importantly, some studies have shown that sexual problems are a source of psychosocial distress in men with localized prostate cancer. Helgason et al. (1996) have shown that more men with prostate cancer (18%) than without the disease (9%) reported ‘severe distress’ due to reduced erectile capacity. Also, more men with prostate cancer (16%) than without the disease (6%) reported ‘severe distress’ due to reduced orgasm pleasure. Others have shown a relation between erectile dysfunction 1 year after treatment and declines in general HRQoL (general health, vitality, and role-emotional function) (Clark et al., 1999). Since these studies report data aggregated across several treatments, it is difficult to ascertain the potential impact of any one treatment on distress. The recent longitudinal analysis from the PCOS has begun to clarify differences across treatments. Potosky et al. (2000) have shown that sexual ‘bother’ was greater at 2 years posttreatment for men treated with RP than those treated with EBR, especially in younger men (aged 55–59 years).

Nerve-sparing prostatectomy procedures appear to preserve erectile function in certain men (Catalona and Bigg, 1990; Catalona and Dresner, 1985; Eggleston and Walsh, 1985). Stanford et al.’s (2000) recent longitudinal analysis of men from the community-based PCOS seems to support the utility of nerve-sparing prostatectomy over standard prostatectomy in reducing sexual dysfunction. However, definitive conclusions about the nerve-sparing procedure are difficult to draw as men who elect it often constitute a highly selective sample of men. Compared to those who do not elect nerve-sparing RP, those who elect this procedure often have better prognoses, less extensive disease, better pretreatment functional status, and, most importantly, better pretreatment sexual function. Without randomized studies, the superiority of this procedure over standard prostatectomy cannot be definitively determined.

Another promising avenue of coping with reduced sexual function is the use of posttreatment erectile aids (e.g. implants, drugs, and vacuum devices). Perez and colleagues (Perez et al., 1997) found that men who used such aids at least 50% of the time after RP (mean TST=2.2 years) reported sexual function that was indistinguishable from a preoperative group. These researchers found similar function across the two groups in several domains of sexuality including arousal, frequency of contact, erectile capacity, and satisfaction with current sexual function. Furthermore, sexual functioning in the men using aids was significantly better than in men who had been treated with either nerve-sparing (mean TST=1.9 years) or standard prostatectomy (mean TST=2.3 years) alone. Conversely, others have shown no benefit of the use of such aids in men with localized disease 1–5 years after treatment (Shrader-Bogen et al., 1997).

Advanced disease

With no available studies comparing the sexual function of men with advanced prostate cancer to similarly aged men without prostate cancer, it is difficult to precisely identify the effects of advanced disease on sexual function. The evidence that does exist addressing this question comes from longitudinal studies that include HRQoL assessments prior to treatment (see Table 2). Pretreatment sexual function in men with advanced disease has been found to be quite poor (Da Silva et al., 1996; Litwin et al., 1998). For example, Litwin et al. (1998) found that sexual functioning prior to hormone therapy was extremely low in a sample of newly diagnosed men with metastatic prostate cancer. The level of sexual dysfunction reported is comparable to that reported by men with localized prostate cancer treated with RP (see Litwin et al., 1995; Lubeck et al., 1999). Such evidence suggests that advanced disease alone may have a substantial impact on sexual function. Nonetheless, while men with metastases report many sexual problems both before and while they are on treatment, they report only a moderate level of distress associated with these problems (Litwin et al., 1998).

Therapies for advanced disease have also been compared (see Table 2). Both CAB and orchiectomy have resulted in similar levels of sexual dysfunction in the months after treatment initiation (Litwin et al., 1998). In a novel study investigating the potential benefit of non-intervention, Herr et al. (1993) compared men with metastatic prostate cancer who had received hormonal therapy (either diethylstilbestrol or LHRH analog+flutamide) with a group that deferred treatment. These researchers were interested in ascertaining whether the side effects of hormone therapy (e.g. decreased erectile capacity, loss of interest in sex) outweigh the potential benefits of treatment (e.g., reduction in disease progression). At issue here is whether hormone therapy should be started immediately in men with advanced disease or whether it should be deferred, due to its potential negative effects, until disease progression is clearly evident. At 1–2 months after treatment initiation, the hormone therapy group reported lower interest in and enjoyment of sexuality than the deferred treatment group, though both groups reported at least some problems in these areas. By 6 months, the hormone therapy group reported worse erectile function and less interest in and enjoyment of sex than the untreated group. Although absolute rates of these problems were not provided, mean scores indicate that the sexual problems were most pronounced in the hormone therapy group. On average, this group reported at least a ‘moderate’ level of problems in this area. Caution must be exercised in interpreting these findings, however, as baseline differences in sexual function were not statistically controlled. In fact, the authors reported that the untreated group included younger, more sexually active men.

Finally, a few studies have compared the use of the anti-androgen, bicalutamide (Casodex) to castration (either surgical or medical) (see Table 2). Chodak et al. (1995) found that at 6 months after treatment initiation, sexual function had declined from pretreatment levels in a castrated group, but was maintained at pretreatment levels in a group receiving bicalutamide. Further, two cross-sectional studies have shown that in comparison with castration, treatment with bicalutamide resulted in more interest in sexuality 1 year following the initiation of treatment in both advanced, non-metastatic (Iversen et al., 1998) and metastatic men (Tyrrell et al., 1998). Unfortunately, the authors of these studies do not provide absolute rates of function. Albeit preliminary, the findings of such studies suggest that for some men with slowly progressing, advanced prostate cancer, ‘less’ treatment may afford a better HRQoL outcome.


Localized disease

Bowel problems that occur in men with localized prostate cancer are likely the result of treatment. This is supported by evidence from comparison group and cross-sectional studies of treated and untreated men. Bowel function in untreated, observed men with localized disease (mean time since diagnosis=5.7 years) is similar to that of older men without prostate cancer (Litwin et al., 1995). Findings from several studies appear to indicate that bowel problems are more likely to occur after treatment, especially after radiotherapy (see Table 1). Problems such as increased frequency, increased urgency, diarrhea, and bleeding with movements are reported more often by men treated with EBR than by men treated with RP (Fowler et al., 1996; Lim et al., 1995; Shrader-Bogen et al., 1997; Yarbro and Ferrans, 1998). Shrader-Bogen et al. (1997) observed that 34% of men treated with EBR (mean TSD=3.4 years) reported experiencing bowel urgency at least once per week compared to 15% of men treated with RP (mean TSD=2.6 years). Furthermore, Joly et al. found that 21% of men treated with a combination of EBR and brachytherapy (mean TST=4 years) reported digestive complications. Once again, only cross-sectional assessments were made in these studies, limiting conclusions about the sequela of bowel dysfunction.

Recent longitudinal studies shed light on the trajectory of bowel dysfunction over time (see Table 1). Data from the PCOS show that both men treated with EBR and those treated with RP experienced declines in bowel function at 4 months after the completion of treatment (Potosky et al., 2000); however, the declines in the EBR group were greater than those of the RP group. Both groups showed improvements by 10 months posttreatment. This relatively rapid recovery of function within a year of treatment has been observed by others (Litwin et al., 1999; Lubeck et al., 1999).

Advanced disease

Bowel problems are infrequent in men treated for advanced prostate cancer (see Table 2) (Litwin et al., 1998; Moinpour et al., 1998). Castrated men in the Litwin et al. (1998) study of metastatic disease reported a level of bowel function comparable to that of older men without prostate cancer (see Litwin et al., 1995) in the months after treatment initiation. In another study, castrated men with metastases reported ‘none’ to ‘occasional’ bowel problems such as diarrhea in the first 6 months after treatment initiation (Moinpour et al., 1998). When problems do arise, treatments have been associated with improvements in function. Bowel function improved in men with metastases treated with either surgical or medical castration (Litwin et al., 1998). Others have observed decreases in constipation over time in men with advanced hormone-resistant prostate cancer who had responded to palliative chemotherapy (time points not specified) (Stockler et al., 1998).


Localized disease

Although data are sparse, merely having localized prostate cancer does not seem to affect general domains of HRQoL (see Table 1). In the one comparison group study comparing untreated men with localized disease (mean TSD=5.7 years) with an age-matched sample of men without disease, Litwin et al. (1995) found no between-group differences in general physical well-being, role-physical well-being (e.g. limitations in work/ home activities due to physical health), body pain, general health, vitality/energy, social well-being, or emotional well-being. Interestingly, data from both comparison group and cross-sectional studies reveal no general HRQoL differences across treatment groups. Men treated with RP appear to have similar general HRQoL to men who have received EBR (Lim et al., 1995; Litwin et al., 1995; Shrader-Bogen et al., 1997; Tefilli et al., 1998; Yarbro and Ferrans, 1998). Yet, concluding that treatments for localized prostate cancer have no effect on general HRQoL may be premature. In many of these studies, HRQoL assessments were made years after treatment. A slightly different story emerges when the results of longitudinal investigations are considered.

Longitudinal studies have revealed that men with localized disease treated via RP do show problems in some domains of general HRQoL, but these problems diminish over time (see Table 1). Men treated with RP have reported deficits in role-physical well-being and vitality/energy shortly after treatment (Lubeck et al., 1999). Yet these men also reported substantial and clinically significant improvements in these domains at 1 year posttreatment (Lubeck et al., 1999). Others have observed the same recovery trajectory of general HRQoL. Litwin and colleagues (Litwin et al., 1999) found that between 86 and 97% of men who opted for RP regained pretreatment levels of physical well-being, role-physical well-being, general health, body pain, vitality/energy, role-emotional well-being, social well-being, and mental health within one year of treatment. In the latter study, race and marital status moderated recovery. Non-whites were less likely than whites to return to pretreatment levels on physical (55% vs 90%), role-physical (64% vs 96%), and social (72% vs 91%) well-being. Unmarried men were less likely than married men to regain pretreatment levels of general health (50% vs 83%), and social well-being (70% vs 91%).

Men treated with radiation and those who are observed report even fewer of these complications (see Table 1). Lubeck and colleagues (Lubeck et al., 1999) have shown that although men treated with EBR report moderate deficits in role-physical well-being and vitality/energy immediately after treatment, they report no other substantial problems. Men who were observed in this study reported adequate functioning in all domains shortly after diagnosis, providing further evidence that any deficits in general HRQoL are treatment-related. At 1 and 2 years later, baseline levels of general HRQoL were found to persist in both men treated with EBR and those who were observed (Lubeck et al., 1999).

Among men treated with EBR, fatigue appears to be the most common complication. EBR has been associated with increases in fatigue from pretreatment to 3 and 12 month follow-up, particularly in those receiving ‘whole pelvis’ radiation (Beard et al., 1997). Yet a few studies have also shown that increases in fatigue are not associated with poor psychological well-being (e.g., mood disturbance, anxiety, depression) (Beard et al., 1997; Monga et al., 1997). For example, Beard et al. (1997) observed decreases in vitality/energy in men receiving ‘whole pelvis’ radiation from before treatment to 12 months after treatment initiation. However, relatively low levels of depression were indicated at both of these time points. Hence, though fatigue may increase in the year of treatment, it does not appear to be particularly distressing to men with localized disease.

Selected cross-sectional studies of men with localized prostate cancer have revealed correlates of general HRQoL (see Table 1). These studies point to potential predictors of general HRQoL beyond treatment. Schag and colleagues (Schag et al., 1994) have found that the presence of psychiatric co-morbidities is related to poorer quality of life in men with prostate cancer (mean TSD=3.5 years). Having more psychiatric comorbidities (i.e., previous psychiatric history, alcohol abuse, drug abuse) was found to be associated with worse global quality of life. Furthermore, when compared to men with co-morbid heart conditions, those with co-morbid psychiatric conditions show worse physical, role, social, cognitive, and emotional well-being (TSD range=1.5–3.5 years) (Borghede et al., 1997). Others have found that pain is predictive of depression and anxiety in men with non-metastatic cancer (mean TSD=2.1 years) (Heim and Oei, 1993). Finally, Fossa and colleagues (Fossa et al., 1997) have found an association between fatigue and global quality of life. Fatigue was strongly related to lower global quality of life across three treatment groups (EBR, RP, and hormone therapy) and even among diseased men in an observation group. These findings contrast with those mentioned above, showing no relation between fatigue and psychosocial well-being in men treated with EBR. Note, however, that men in the aforementioned studies were assessed within a year of treatment, whereas those in the Fossa study had all been diagnosed at least one year prior to the study period. Perhaps increases in fatigue are expected in the months immediately following treatment and therefore more likely to be tolerated.

Advanced disease

Few studies have been undertaken that clarify whether advanced prostate cancer affects general HRQoL independent of treatment. Currently, only one comparison group study on general HRQoL outcomes has been conducted in men with advanced prostate cancer (see Table 2). Albertsen et al. (1997) compared men in remission and those with progressing disease to age-matched norms on the SF-36. At the time of the study, all men were being treated with CAB for at least 1 month. Men with progressive disease showed significantly more bodily pain, less vitality/energy, and poorer social and emotional well-being than men in remission. Men in remission were no different than the normative group in general domains of HRQoL. This study suggests that progressing, advancedstage disease may negatively impact general HRQoL.

Most studies of general HRQoL in men with advanced prostate cancer are longitudinal and focus on how general HRQoL fluctuates across time and treatment. Studies of castration (both surgical and medical) have shown only minor deficits in general HRQoL after treatment initiation (see Table 2). Most problems seem limited to emotional and social domains. Some have found declines in emotional well-being at 3 and 6 months after castration therapy (Cassileth et al., 1992; Moinpour et al., 1998). Litwin and colleagues found that the biggest improvements in general HRQoL in the year after CAB or orchiectomy were in emotional, role-emotional, and social well-being. What is unclear is which type of castration results in more problems. Moinpour et al. (1998) found that emotional function was worse in a CAB group than a group that was orchiectomized at 3 and 6 months after treatment initiation. However, Cassileth et al. (1992) found that at 6 months after treatment initiation, a group receiving LHRH analog continued to show improvements in mood, whereas an orchiectomized group had fallen back to pretreatment levels. Collectively, these studies do not clarify which treatment is associated with better general HRQoL; however, these mixed results do illustrate the importance of allowing men at least some autonomy in selecting a therapeutic course.

A few studies have compared castration with the use of anti-androgen, a less aggressive form of therapy in men with advanced prostate cancer (see Table 2). Men treated with the anti-androgen bicalutamide have shown greater improvements in overall health, emotional and social well-being 1 month after treatment than men treated with either surgical or medical castration (Chodak et al., 1995). These improvements are not limited to the short term. In both men with advanced, metastatic (Tyrrell et al., 1998) and advanced, nonmetastatic disease (Iversen et al., 1998), those treated with bicalutamide showed better general physical well-being after 1 year than men who were either surgically or medically castrated. These studies support the conclusion that ‘less’ treatment may result in a better general HRQoL outcome. Of course, less aggressive treatment may not be an option for all men, especially those with rapidly progressing disease.

Finally, some studies have examined the effects of palliative treatments on the general HRQoL of men with hormone-resistant disease (see Table 2). In these studies, palliation was achieved through the use of chemotherapy and/or low doses of prednisone. Moore and colleagues (Moore et al., 1994) found improvements in pain, social and emotional well-being after treatment with mitoxantrone (up to 8 cycles) and prednisone. Improvements were observed at 6, 12, and 18 weeks after treatment initiation. Others have demonstrated similar improvements in pain and overall well-being in the months following the initiation of this treatment regimen (Stockler et al., 1998; Tannock et al., 1989). Noteworthy in these and all studies of advanced disease is the potential biasing influence of participant attrition. Sizeable percentages of men are lost over the course of these studies due to death or disease progression. Hence findings may not be easily generalized to all men with advanced disease, as those with poorest functional status are less likely to be represented.


The HRQoL of men with prostate cancer encompasses both disease-specific and general aspects. The disease and its treatments can affect both of these areas; however, effects differ across stage of disease, time, and type of treatment. In men treated for localized prostate cancer, disease-specific domains like urinary, sexual, and bowel function are the most profoundly affected, whereas with some exceptions, general HRQoL is spared. All men with advanced prostate cancer, whether treated or not treated, experience sexual dysfunction, yet it does not appear to be particularly distressing to many men. What may bother these men more are the numerous deficits in general domains of HRQoL. We summarize the evidence for these conclusions below.

Urinary and sexual function are the most common disease-specific domains of HRQoL affected by localized prostate cancer and its treatments. Comparison group (e.g., Litwin et al., 1995), longitudinal (e.g., Stanford et al., 2000), and cross-sectional (e.g., Shrader-Bogen et al., 1997) studies all illustrate that urinary and sexual problems are prevalent in men treated for localized disease. Comparison group studies (e.g., Helgason et al., 1996) show that sexual problems can also occur in untreated men with localized disease. However, urinary and sexual problems are the worst in treated men, especially those treated via a surgical removal of the prostate gland. Longitudinal studies (e.g., Lubeck et al., 1999) show that while urinary problems like incontinence and urgency dissipate over time, sexual problems like poor erection quality and low desire tend to persist. Bowel problems are less frequently reported in men treated for localized disease, although several longitudinal (e.g., Potosky et al., 2000) and cross-sectional (e.g., Shrader-Bogen et al., 1997) studies have shown that they are more prevalent in men treated with EBR than in men treated with RP. These problems dissipate within a year of treatment.

Only longitudinal studies (e.g., Lubeck et al., 1999) have uncovered any problems in general HRQoL in men with localized disease. These problems, restricted to men treated with either RP or EBR, are limited to a loss of energy and some inability to perform daily activities. However, these problems appear to be temporary, lasting less than one year after treatment.

Health-related quality of life issues in men with more advanced stage disease are quite different. Longitudinal studies (e.g., Litwin et al., 1998) have indicated that few urinary and bowel problems occur for these men either before or after treatment. Furthermore, results of longitudinal studies (e.g., Da Silva et al., 1996) indicate that men treated for advanced disease have heightened sexual dysfunction both before and after treatment, indicating that some sexual problems are disease-related. These problems are reported to be only moderately distressing, however (e.g., Litwin et al., 1998). Since men with more advanced disease are faced with the possibility that death could occur within a year of diagnosis, sexual function may be less of a priority. Finally, evidence from both longitudinal (e.g., Chodak et al., 1995) and cross-sectional (e.g., Iversen et al., 1998) studies indicates that less aggressive forms of treatment (i.e., anti-androgen therapy) are associated with better sexual function than more aggressive therapies (i.e., surgical or medical castration). However, it is important to recognize that less aggressive treatment may not be an option for all men, especially those with rapidly progressing disease.

In contrast to men with localized disease, general HRQoL deficits are observed in men with advanced disease. One comparison group study (e.g., Albertsen et al., 1997) suggests that irrespective of treatment, progressing disease is related to more bodily pain, less vitality/energy, and poorer social and emotional well-being than disease in remission. Longitudinal studies (e.g., Litwin et al., 1998) show that deficits in social and emotional well-being occur in men treated with either surgical or medical castration in the first 6 months after treatment. Yet substantial improvements occur in these domains after 1 year. Notably, this may be an artifact of survival. Those advanced patients still alive at 1 year follow-up are most likely those with the best functional status. In comparison, anti-androgen therapy seems to result in fewer immediate declines in general HRQoL (e.g., Chodak et al., 1995). Finally, for advanced patients with hormone-resistant disease, palliative chemotherapy is associated with improvements in pain, social, and emotional well-being (e.g., Stockler et al., 1998).

Clearly, additional studies of prostate cancer and HRQoL are needed. There is a particularly pressing need for more research of men with advanced disease. Advanced prostate cancer seems to affect numerous areas of HRQoL. Studies of medical treatments like hormone therapy often target response to treatment and time to disease progression as a primary endpoint. While unargu-ably important, these are not the only indicators of treatment efficacy. It is also important to determine the varied effects of treatment on HRQoL. Thus, future research should address not only what treatments result in a clinical response or delay time to progression, but also which ones have the best chance of maximizing HRQoL. Also, an understanding of the interrelations among HRQoL domains will be critical. For example, are pain and fatigue equally associated with mental health?

Related to issues of treatment impact on HRQoL is the issue of decision-making about treatment. Since all treatments for prostate cancer involve a risk/benefit tradeoff it will be important to clarify how patients make treatment decisions. Does quality of life information enter into this decision? If so, how heavily is it weighted? Do men with prostate cancer feel they have adequate information about HRQoL prior to choosing a treatment? Is this information presented to them clearly? Are there useful methodologies for determining treatment preferences? A relatively recent addition to HRQoL measurement, the preference-based utilities approach, may provide an avenue for understanding decisions about treatment. Utility-based approaches like the Quality of Well-Being Scale (Kaplan and Anderson, 1996) and time-tradeoff (Albertsen et al., 1998; Bennett et al., 1997; Chapman et al., 1998) have been used to assess the cost-effectiveness of various medical technologies. These methods are often used to determine quality-adjusted life years, which presumably provide a measure of survival time adjusting for declines in HRQoL. Albeit promising, the usefulness of such approaches in the area of prostate cancer has yet to be fully determined.

Finally, interest has grown recently in the identification and treatment of psychological distress in men with prostate cancer. A study by Roth and colleagues (Roth et al., 1998) suggests that many distressed prostate cancer patients go untreated because there are no suitable means available for identifying their distress. They piloted a rapid screening procedure that uses two pencil-and-paper self-report measures to detect distress: the Hospital Anxiety and Depression Scale (Zigmond and Snaith, 1983) and a ‘Distress Thermometer’. The approach was successful in identifying patients in need of psychological intervention. Others (see Lepore and Helgeson, 1999) have piloted a psychoeducational support group intervention that has successfully reduced psychological distress in men treated for localized prostate cancer. At present, these novel approaches to psychological screening and treatment have the potential of reducing some of the quality of life burden of this disease; however, they await larger-scale empirical tests.

As the number of new cases of prostate cancer grows, it will be important for clinical investigators and health-care professionals to work collaboratively to educate men and their families about the consequences of the disease and its treatments for HRQoL. This is particularly important given that several options for treatment exist. Knowledge of the potential risks and benefits of therapeutic choices will help men and their families make informed decisions about their illness. Ultimately, any course of therapy must meet both the physical and psychosocial needs of both the man with prostate cancer and his family.


We thank Vicki S. Helgeson for comments on an earlier draft of this manuscript, David Cella for his advice and support and three anonymous reviewers for their comments.


Preparation of this manuscript was partially supported by a training grant from the National Institute of Mental Health (T32 MH19953) and a grant from the National Cancer Institute (RO1 CA68354).


  • Albertsen PC, Aaronson NK, Muller MJ, Keller SD, Ware JE. Health-related quality of life among patients with metastatic prostate cancer. Urology. 1997;49:207–216. [PubMed]
  • Albertsen PC, Nease RF, Potosky AL. Assessment of patient preferences among men with prostate cancer. J Urol. 1998;159:158–163. [PubMed]
  • Altwein J, Ekman P, Barry M, et al. How is quality of life in prostate cancer patients influenced by modern treatment? The Wallenberg Symposium. Urology. 1997;49:66–76. [PubMed]
  • American Cancer Society . Cancer Facts & Figures. 2001. ACS; Atlanta, GA: 2001.
  • Beard CJ, Propert KJ, Rieker PP, et al. Complications after treatment with external-beam irradiation in early-stage prostate cancer patients: A prospective multiinstitutional outcomes study. J Clin Oncol. 1997;15:223–229. [PubMed]
  • Bennett CL, Chapman G, Elstein AS, et al. A comparison of perspectives on prostate cancer: Analysis of utility assessments of patients and physicians. Eur Urol. 1997;32:86–88. [PubMed]
  • Bonney WW, Fallon B, Gerber WL, et al. Cryosurgery in prostatic cancer: Survival. Urology. 1982;19:37–42. [PubMed]
  • Borghede G, Karlsson J, Sullivan M. Quality of life in patients with prostatic cancer: Results from a Swedish population study. J Urol. 1997;158:1477–1485. [PubMed]
  • Cassileth BR, Soloway MS, Vogelzang NJ, et al. Quality of life and psychosocial status in stage D prostate cancer. Zoladex Prostate Cancer Study Group. Qual Life Res. 1992;1:323–329. [PubMed]
  • Catalona W, Bigg S. Nerve-sparing radical prostatectomy: Evaluation of results after 250 patients. J Urol. 1990;143:538–544. [PubMed]
  • Catalona W, Dresner S. Nerve-sparing radical prostatectomy: Extraprostatic tumor extension and preservation of erectile function. J Urol. 1985;134:1149–1151. [PubMed]
  • Cella DF. Measuring quality of life in palliative care. Semin Oncol. 1995;22:73–81. [PubMed]
  • Cella DF, Tulsky DS. Quality of life in cancer: Definition, purpose, and method of measurement. Cancer Invest. 1993;11:327–336. [PubMed]
  • Chapman GB, Elstein AS, Kuzel TM, et al. Med Decis Making. 1998;18:278–286. [PubMed]
  • Chodak G, Sharifi R, Kasimis B, Block NL, Macramalla E, Kennealey GT. Single-agent therapy with bicalutamide: A comparison with medical or surgical castration in the treatment of advanced prostate carcinoma. Urology. 1995;46:849–855. [PubMed]
  • Chodak GW, Thisted RA, Gerber GS, et al. Results of conservative management of clinically localized prostate cancer. N Engl J Med. 1994;330:242–248. [PubMed]
  • Clark JA, Rieker P, Propert KJ, Talcott JA. Changes in quality of life following treatment for early prostate cancer. Urology. 1999;53:161–168. [PubMed]
  • Curran D, Fossa S, Aaronson N, Kiebert G, Keuppens E, Hall R. Baseline quality of life of patients with advanced prostate cancer. European Organization for Research and Treatment of Cancer (EORTC), Genito-Urinary Tract Cancer Cooperative Group (GUT-CCG) Eur J Cancer. 1997;33:1809–1814. [PubMed]
  • Da Silva FC, Fossa SD, Aaronson NK, et al. The quality of life of patients with newly diagnosed M1 prostate cancer: Experience with EORTC clinical trial 30853. Eur J Cancer. 1996;32A:72–77. [PubMed]
  • Eggleston J, Walsh P. Radical prostatectomy with preservation of sexual function: Pathological findings in the first 100 cases. J Urol. 1985;134:1146–1148. [PubMed]
  • Fleming G, Wasson JH, Albertsen PC, Barry MJ, Wennberg JE. A decision analysis of alternative treatment strategies for clinically localized prostate cancer. J Am Med Assoc. 1993;269:2650–2658. [PubMed]
  • Fossa SD, Woehre H, Kurth KH, et al. Influence of urological morbidity on quality of life in patients with prostate cancer. Eur Urol. 1997;31:3–8. [PubMed]
  • Fowler FJ, Barry MJ, Lu-Yao G, Wasson JH, Bin L. Outcomes of external-beam radiation therapy for prostate cancer: A study of Medicare beneficiaries in three Surveillance, Epidemiology, and End Results areas. J Clin Oncol. 1996;14:2258–2265. [PubMed]
  • Gerber GS, Thisted RA, Scardino PT, et al. Results of radical prostatectomy in men with clinically localized prostate cancer: Multi-institutional pooled analysis. J Am Med Asso. 1996;276:615–619. [PubMed]
  • Hanks GE. Radiotherapy or surgery for prostate cancer? Ten and fifteen-year results of external beam therapy. Acta Oncol. 1991;30:231–237. [PubMed]
  • Heim HM, Oei TP. Comparison of prostate cancer patients with and without pain. Pain. 1993;53:159–162. [PubMed]
  • Helgason AR, Adolfsson J, Dickman P, Arver S, Fredrikson M, Steineck G. Factors associated with waning sexual function among elderly men and prostate cancer patients. J Urol. 1997;158:155–159. [PubMed]
  • Helgason AR, Adolfsson J, Dickman P, Fredrikson M, Arver S, Steineck G. Waning sexual function—the most important disease-specific distress for patients with prostate cancer. Br J Cancer. 1996;73:1417–1421. [PMC free article] [PubMed]
  • Herr HW. Quality of life in prostate cancer patients. CA Cancer J Clin. 1997;47:207–217. [PubMed]
  • Herr HW, Kornblith AB, Ofman U. A comparison of the quality of life of patients with metastatic prostate cancer who received or did not receive hormonal therapy. Cancer. 1993;71:1143–1150. [PubMed]
  • Iversen P, Tyrrell CJ, Kaisary AV, et al. Casodex (bicalutamide) 150-mg monotherapy compared with castration in patients with previously untreated nonmetastatic prostate cancer: Results from two multicenter randomized trials at a median follow-up of 4 years. Urology. 1998;51:389–396. [PubMed]
  • Joly F, Brune D, Couette JE, et al. Health-related quality of life and sequelae in patients treated with brachytherapy and external beam irradiation for localized prostate cancer. Ann Oncol. 1999;9:751–757. [PubMed]
  • Kaplan RM, Anderson JP. The general health policy model: An integrated approach. In: Spilker B, editor. Quality of Life and Pharmacoeconomics in Clinical Trials. Lippincott-Raven; Philadelphia, PA: 1996. pp. 309–322.
  • Lepore SJ, Helgeson VS. Psychoeducational support group enhances quality of life after prostate cancer. Cancer Res Ther Control. 1999;8:81–91.
  • Lim AJ, Brandon AH, Fiedler J, et al. Quality of life: Radical prostatectomy versus radiation therapy for prostate cancer. J Urol. 1995;154:1420–1425. [PubMed]
  • Litwin MS, Hays RD, Fink, et al. Quality-of-life outcomes in men treated for localized prostate cancer. J Am Med Assoc. 1995;273:129–135. [PubMed]
  • Litwin MS, McGuigan KA, Shpall AI, Dhanani N. Recovery of health related quality of life in the year after radical prostatectomy: Early experience. J Urol. 1999;161:515–519. [PubMed]
  • Litwin MS, Shpall AI, Dorey F, Nguyen TH. Quality-of-life outcomes in long-term survivors of advanced prostate cancer. Am J Clin Oncol. 1998;21:327–332. [PubMed]
  • Lubeck DP, Litwin MS, Henning JM, Stoddard ML, Flanders SC, Carroll PR. Changes in health-related quality of life in the first year after treatment for prostate cancer: Results from CaPSURE. Urology. 1999;53:180–186. [PubMed]
  • Lu-Yao GL, Yao S-L. Population-based study of long-term survival in patients with clinically localised prostate cancer. Lancet. 1997;349:906–910. [PubMed]
  • Middleton RG, Thompson IM, Austenfeld MS, et al. Prostate cancer clinical guidelines panel summary report on the management of clinically localized prostate cancer. J Urol. 1995;154:2144–2148. [PubMed]
  • Moinpour CM, Savage MJ, Troxel A, et al. Quality of life in advanced prostate cancer: Results of a randomized therapeutic trial. J Natl Cancer Inst. 1998;90:1537–1544. [PubMed]
  • Monga U, Jaweed M, Kerrigan AJ, et al. Neuromuscular fatigue in prostate cancer patients undergoing radiation therapy. Arch Phys Med Rehabil. 1997;78:961–966. [PubMed]
  • Moore MJ, Osoba D, Murphy K, et al. Use of palliative end points to evaluate the effects of mitoxantrone and low-dose prednisone in patients with hormonally resistant prostate cancer. J Clin Oncol. 1994;12:689–694. [PubMed]
  • Perez MA, Meyerowitz BE, Lieskovsky G, Skinner DG, Reynolds B, Skinner EC. Quality of life and sexuality following radical prostatectomy in patients with prostate cancer who use or do not use erectile aids. Urology. 1997;50:740–746. [PubMed]
  • Potosky A, Harlan L, Stanford J, et al. Prostate cancer practice patterns and quality of life: The Prostate Cancer Outcomes Study. J Natl Cancer Inst. 1999;91:1719–1724. [PubMed]
  • Potosky A, Legler J, Albertsen P, et al. Health outcomes after prostatectomy or radiotherapy for prostate cancer: Results from the Prostate Cancer Outcomes Study. J Natl Cancer Inst. 2000;92:1582–1592. [PubMed]
  • Roth AJ, Kornblith AB, Batel-Copel L, Peabody E, Scher HI, Holland JC. Rapid screening for psychologic distress in men with prostate carcinoma. Cancer. 1998;82:1904–1908. [PubMed]
  • Schag CA, Ganz PA, Wing DS, Sim MS, Lee JJ. Quality of life in adult survivors of lung, colon and prostate cancer. Qual Life Res. 1994;3:127–141. [PubMed]
  • Shipley WU, Zietman GE, Hanks GE, et al. Treatment related sequelae following external beam radiation for prostate cancer: A review with an update in patients with stages T1 and T2 tumor. J Urol. 1994;152:1799–1805. [PubMed]
  • Shrader-Bogen CL, Kjellberg JL, McPherson CP, Murray CL. Quality of life and treatment outcomes: Prostate carcinoma patients’ perspectives after prostatectomy or radiation therapy. Cancer. 1997;79:1977–1986. [PubMed]
  • Stanford JL, Feng Z, Hamilton AS, et al. Urinary and sexual function after radical prostatectomy for clinically localized prostate cancer: The prostate cancer outcomes study. J Am Med Assoc. 2000;283:354–360. [PubMed]
  • Stockler MR, Osoba D, Goodwin P, Corey P, Tannock IF. Responsiveness to change in health-related quality of life in a randomized clinical trial: A comparison of the Prostate Cancer Specific Quality of Life Instrument (PROSQOLI) with analogous scales from the EORTC QLQ-C30 and a trial specific module. European Organization for Research and Treatment of Cancer. J Clin Epidemiol. 1998;51:137–145. [PubMed]
  • Tannock I, Gospodarowicz M, Meakin W, Panzarella T, Stewart L, Rider W. Treatment of metastatic prostatic cancer with low-dose prednisone: evaluation of pain and quality of life as pragmatic indices of response. J Clin Oncol. 1989;7:590–597. [PubMed]
  • Tefilli MV, Gheiler EL, Tiguert R, et al. Quality of life in patients undergoing salvage procedures for locally recurrent prostate cancer. J Surg Oncol. 1998;69:156–161. [PubMed]
  • Tyrrell CJ, Kaisary AV, Iversen P, et al. A randomised comparison of ‘Casodex’ (bicalutamide) 150 mg monotherapy versus castration in the treatment of metastatic and locally advanced prostate cancer. Eur Urol. 1998;33:447–456. [PubMed]
  • Van Andel G, Kurth KH, De Haes JC. Quality of life in patients with prostatic carcinoma: A review and results of a study in N+disease. Prostate-specific antigen as predictor of quality of life. Urol Res. 1997;25:S79–88. [PubMed]
  • Wasson JH, Cushman CC, Bruskewitz RC, Littenberg B, Mulley AG, Wennberg JE. A structured literature review of treatment for localized prostate cancer. Arch Fam Med. 1993;2:487–493. [PubMed]
  • Yarbro CH, Ferrans CE. Quality of life of patients with prostate cancer treated with surgery or radiation therapy. Oncol Nurs Forum. 1998;25:685–693. [PubMed]
  • Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67:361–370. [PubMed]
PubReader format: click here to try


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...