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Infect Immun. Jan 1988; 56(1): 60–63.
PMCID: PMC259234

Monoclonal antibodies that recognize a specific surface antigen of Treponema denticola.

Abstract

Spirochetes have been implicated as potential etiologic agents of periodontitis in humans. Murine monoclonal antibodies (MAbs) specific for a serogroup of Treponema denticola, an oral spirochete, were developed and characterized in this study. Antibodies secreted by clone IAA11 were judged to be the most useful, since they were able to detect 8 of 15 T. denticola strains. This MAb consisted of an immunoglobulin G3 heavy chain and a kappa light chain. MAb IAA11 was found to react with an epitope target located on the outer sheath of the cell wall. This MAb should be of diagnostic and scientific value in the study of T. denticola populations in human periodontitis.

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Selected References

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  • Armitage GC, Dickinson WR, Jenderseck RS, Levine SM, Chambers DW. Relationship between the percentage of subgingival spirochetes and the severity of periodontal disease. J Periodontol. 1982 Sep;53(9):550–556. [PubMed]
  • Cheng SL, Chan EC. The routine isolation, growth, and maintenance of the intermediate-size anaerobic oral spirochetes from periodontal pockets. J Periodontal Res. 1983 Jul;18(4):362–368. [PubMed]
  • Cheng SL, Siboo R, Quee TC, Johnson JL, Mayberry WR, Chan EC. Comparative study of six random oral spirochete isolates. Serological heterogeneity of Treponema denticola. J Periodontal Res. 1985 Nov;20(6):602–612. [PubMed]
  • Jacob E, Carter TB, Nauman RK. Immunological relationship among oral anaerobic spirochetes as detected by indirect microhemagglutination. J Clin Microbiol. 1980 Oct;12(4):610–613. [PMC free article] [PubMed]
  • Jacob E, Nauman RK. Common antigens of Treponema denticola: chemical, physical, and serological characterization. Infect Immun. 1982 Aug;37(2):474–480. [PMC free article] [PubMed]
  • Listgarten MA, Levin S. Positive correlation between the proportions of subgingival spirochetes and motile bacteria and susceptibility of human subjects to periodontal deterioration. J Clin Periodontol. 1981 Apr;8(2):122–138. [PubMed]
  • Moore WE, Holdeman LV, Cato EP, Smibert RM, Burmeister JA, Ranney RR. Bacteriology of moderate (chronic) periodontitis in mature adult humans. Infect Immun. 1983 Nov;42(2):510–515. [PMC free article] [PubMed]
  • Moore WE, Holdeman LV, Smibert RM, Hash DE, Burmeister JA, Ranney RR. Bacteriology of severe periodontitis in young adult humans. Infect Immun. 1982 Dec;38(3):1137–1148. [PMC free article] [PubMed]
  • Simonson LG, Merrell BR, Rouse RF, Shklair IL. Production and characterization of monoclonal antibodies to Bacteroides gingivalis. J Dent Res. 1986 Feb;65(2):95–97. [PubMed]

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