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Infect Immun. Aug 1992; 60(8): 3446–3447.
PMCID: PMC257335

Mouse neutrophils lack defensins.

Abstract

Defensins are broad-spectrum antimicrobial peptides that are abundant in human, rat, and rabbit neutrophils. We now report that neutrophils from nine strains of mice lacked appreciable defensin content. Mice may therefore be imperfect experimental surrogates for humans or rats in models of infection in which neutrophil function is significant.

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Selected References

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  • Daher KA, Lehrer RI, Ganz T, Kronenberg M. Isolation and characterization of human defensin cDNA clones. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7327–7331. [PMC free article] [PubMed]
  • Eisenhauer P, Harwig SS, Szklarek D, Ganz T, Lehrer RI. Polymorphic expression of defensins in neutrophils from outbred rats. Infect Immun. 1990 Dec;58(12):3899–3902. [PMC free article] [PubMed]
  • Eisenhauer PB, Harwig SS, Szklarek D, Ganz T, Selsted ME, Lehrer RI. Purification and antimicrobial properties of three defensins from rat neutrophils. Infect Immun. 1989 Jul;57(7):2021–2027. [PMC free article] [PubMed]
  • Ganz T, Rayner JR, Valore EV, Tumolo A, Talmadge K, Fuller F. The structure of the rabbit macrophage defensin genes and their organ-specific expression. J Immunol. 1989 Aug 15;143(4):1358–1365. [PubMed]
  • Ganz T, Selsted ME, Lehrer RI. Defensins. Eur J Haematol. 1990 Jan;44(1):1–8. [PubMed]
  • Lehrer RI, Ganz T. Antimicrobial polypeptides of human neutrophils. Blood. 1990 Dec 1;76(11):2169–2181. [PubMed]
  • Ouellette AJ, Greco RM, James M, Frederick D, Naftilan J, Fallon JT. Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium. J Cell Biol. 1989 May;108(5):1687–1695. [PMC free article] [PubMed]
  • Ouellette AJ, Lualdi JC. A novel mouse gene family coding for cationic, cysteine-rich peptides. Regulation in small intestine and cells of myeloid origin. J Biol Chem. 1990 Jun 15;265(17):9831–9837. [PubMed]
  • Selsted ME, Harwig SS. Purification, primary structure, and antimicrobial activities of a guinea pig neutrophil defensin. Infect Immun. 1987 Sep;55(9):2281–2286. [PMC free article] [PubMed]
  • Selsted ME, Szklarek D, Lehrer RI. Purification and antibacterial activity of antimicrobial peptides of rabbit granulocytes. Infect Immun. 1984 Jul;45(1):150–154. [PMC free article] [PubMed]
  • Valore EV, Ganz T. Posttranslational processing of defensins in immature human myeloid cells. Blood. 1992 Mar 15;79(6):1538–1544. [PubMed]
  • Wray W, Boulikas T, Wray VP, Hancock R. Silver staining of proteins in polyacrylamide gels. Anal Biochem. 1981 Nov 15;118(1):197–203. [PubMed]

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