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Infect Immun. 1992 Aug; 60(8): 3446–3447.
PMCID: PMC257335

Mouse neutrophils lack defensins.


Defensins are broad-spectrum antimicrobial peptides that are abundant in human, rat, and rabbit neutrophils. We now report that neutrophils from nine strains of mice lacked appreciable defensin content. Mice may therefore be imperfect experimental surrogates for humans or rats in models of infection in which neutrophil function is significant.

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Selected References

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