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J Virol. Sep 1985; 55(3): 836–839.
PMCID: PMC255070

Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide.

Abstract

Comparative surface feature analyses of the VP1 sequences of hepatitis A virus (HAV) and poliovirus type 1 allowed an alignment of the two sequences and an identification of probable HAV neutralization antigenic sites. A synthetic peptide containing the HAV-specific amino acid sequence of one of these sites induced anti-HAV-neutralizing antibodies. It is concluded that a structural homology exists between the two viruses, despite minimal primary sequence conservation.

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Selected References

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  • Chou PY, Fasman GD. Prediction of the secondary structure of proteins from their amino acid sequence. Adv Enzymol Relat Areas Mol Biol. 1978;47:45–148. [PubMed]
  • Coulepis AG, Locarnini SA, Westaway EG, Tannock GA, Gust ID. Biophysical and biochemical characterization of hepatitis A virus. Intervirology. 1982;18(3):107–127. [PubMed]
  • Emini EA, Jameson BA, Lewis AJ, Larsen GR, Wimmer E. Poliovirus neutralization epitopes: analysis and localization with neutralizing monoclonal antibodies. J Virol. 1982 Sep;43(3):997–1005. [PMC free article] [PubMed]
  • Emini EA, Jameson BA, Wimmer E. Priming for and induction of anti-poliovirus neutralizing antibodies by synthetic peptides. Nature. 1983 Aug 25;304(5928):699–703. [PubMed]
  • Garnier J, Osguthorpe DJ, Robson B. Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Mol Biol. 1978 Mar 25;120(1):97–120. [PubMed]
  • Gust ID, Coulepis AG, Feinstone SM, Locarnini SA, Moritsugu Y, Najera R, Siegl G. Taxonomic classification of hepatitis A virus. Intervirology. 1983;20(1):1–7. [PubMed]
  • Hopp TP, Woods KR. Prediction of protein antigenic determinants from amino acid sequences. Proc Natl Acad Sci U S A. 1981 Jun;78(6):3824–3828. [PMC free article] [PubMed]
  • Hughes JV, Stanton LW, Tomassini JE, Long WJ, Scolnick EM. Neutralizing monoclonal antibodies to hepatitis A virus: partial localization of a neutralizing antigenic site. J Virol. 1984 Nov;52(2):465–473. [PMC free article] [PubMed]
  • Janin J, Wodak S. Conformation of amino acid side-chains in proteins. J Mol Biol. 1978 Nov 5;125(3):357–386. [PubMed]
  • Kitamura N, Semler BL, Rothberg PG, Larsen GR, Adler CJ, Dorner AJ, Emini EA, Hanecak R, Lee JJ, van der Werf S, et al. Primary structure, gene organization and polypeptide expression of poliovirus RNA. Nature. 1981 Jun 18;291(5816):547–553. [PubMed]
  • Krugman S, Giles JP, Hammond J. Infectious hepatitis. Evidence for two distinctive clinical, epidemiological, and immunological types of infection. JAMA. 1967 May 1;200(5):365–373. [PubMed]
  • Linemeyer DL, Menke JG, Martin-Gallardo A, Hughes JV, Young A, Mitra SW. Molecular cloning and partial sequencing of hepatitis A viral cDNA. J Virol. 1985 May;54(2):247–255. [PMC free article] [PubMed]
  • Liu FT, Zinnecker M, Hamaoka T, Katz DH. New procedures for preparation and isolation of conjugates of proteins and a synthetic copolymer of D-amino acids and immunochemical characterization of such conjugates. Biochemistry. 1979 Feb 20;18(4):690–693. [PubMed]
  • Melnick JL. Classification of hepatitis A virus as enterovirus type 72 and of hepatitis B virus as hepadnavirus type 1. Intervirology. 1982;18(3):105–106. [PubMed]
  • Provost PJ, Wolanski BS, Miller WJ, Ittensohn OL, McAleer WJ, Hilleman MR. Physical, chemical and morphologic dimensions of human hepatitis A virus strain CR326 (38578). Proc Soc Exp Biol Med. 1975 Feb;148(2):532–539. [PubMed]
  • Racaniello VR, Baltimore D. Molecular cloning of poliovirus cDNA and determination of the complete nucleotide sequence of the viral genome. Proc Natl Acad Sci U S A. 1981 Aug;78(8):4887–4891. [PMC free article] [PubMed]
  • Siegl G, Frösner GG, Gauss-Müller V, Tratschin JD, Deinhardt F. The physicochemical properties of infectious hepatitis A virions. J Gen Virol. 1981 Dec;57(Pt 2):331–341. [PubMed]
  • Ticehurst JR, Racaniello VR, Baroudy BM, Baltimore D, Purcell RH, Feinstone SM. Molecular cloning and characterization of hepatitis A virus cDNA. Proc Natl Acad Sci U S A. 1983 Oct;80(19):5885–5889. [PMC free article] [PubMed]
  • Walter G, Scheidtmann KH, Carbone A, Laudano AP, Doolittle RF. Antibodies specific for the carboxy- and amino-terminal regions of simian virus 40 large tumor antigen. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5197–5200. [PMC free article] [PubMed]

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