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J Virol. Sep 1985; 55(3): 836–839.
PMCID: PMC255070

Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide.


Comparative surface feature analyses of the VP1 sequences of hepatitis A virus (HAV) and poliovirus type 1 allowed an alignment of the two sequences and an identification of probable HAV neutralization antigenic sites. A synthetic peptide containing the HAV-specific amino acid sequence of one of these sites induced anti-HAV-neutralizing antibodies. It is concluded that a structural homology exists between the two viruses, despite minimal primary sequence conservation.

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Selected References

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