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Table 2
Table 2 Eight Clinical Questions, and Expected Answers
QuestionCorrect Answer
  • Q1 A 58 year old woman with longstanding pain of osteoarthritis in knees, hips and hands asks about the benefits of glucosamine sulfate. Does existing evidence demonstrate that glucosamine has a disease modifying role in osteoarthritis?
Conflicting evidence
  • Q2 What is the best delivery device for effective administration of inhaled medication to a five-year-old child during a moderately severe acute asthma attack?
Spacer (aka holding chamber)
  • Q3 What anaerobic microorganism is most commonly found in osteomyelitis associated with diabetic foot?
Peptrostrepococcus/bacteroides
  • Q4 A man is bitten by a brown snake in Australia and is taken to the hospital emergency department. There is clear evidence of envenoming (poisonous effects of venom). The hospital has run out of brown snake antivenom, so the patient must be given polyvalent snake antivenom (which contains antivenom for all Australian snakes). Should adrenaline be given with the antivenom to prevent anaphylaxis?
Conflicting evidence
  • Q5 A mother brings her 15 month old son who has been seen three times in the past year for glue ear. She has heard that this can lead to learning and developmental problems and thinks her child may need surgery. His hearing is normal. Does current evidence support the need for the insertion of tympanostomy tubes to avoid developmental problems in this child?
No, not indicated
  • Q6 A 37-year-old woman with infertility comes to see you. She asks about the association between IVF and breast and cervical cancer. Do women who undertake IVF have a greater risk of breast or cervical cancer than other women of a similar age?
No evidence of increased risk
  • Q7 A patient staying in hospital had a myocardial infarction two days ago and is now threatening to sign himself out. You suspect this is due to nicotine withdrawal. The patient wishes to stop smoking and seeks your advice on whether he can start nicotine replacement therapy. Is nicotine replacement therapy appropriate for this patient?
No, use is contraindicated
  • Q8 A woman whose first baby died of sudden infant death syndrome (SIDS) comes to see you. She asks about the risk of her next baby dying of SIDS. Is there an increased risk of SIDS for this woman's next baby?
Yes, there is an increased risk
J Am Med Inform Assoc. 2008 Sep–Oct; 15(5): 638–646.
doi: 10.1197/jamia.M2765.