• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of jvirolPermissionsJournals.ASM.orgJournalJV ArticleJournal InfoAuthorsReviewers
J Virol. Nov 1991; 65(11): 6260–6265.
PMCID: PMC250327

Human herpesvirus 7: antigenic properties and prevalence in children and adults.

Abstract

The recent isolation of human herpesvirus 7 (HHV-7) from activated CD4+ T lymphocytes of a healthy individual raises questions regarding the prevalence of this virus in humans and its immunological relationship to previously characterized human herpesviruses. We report that HHV-7 is a ubiquitous virus which is immunologically distinct from the highly prevalent T-lymphotropic HHV-6. Thus, (i) only two of six monoclonal antibodies to HHV-6 cross-reacted with HHV-7-infected cells, (ii) Western immunoblot analyses of viral proteins revealed different patterns for HHV-6- and HHV-7-infected cells, (iii) tests of sequential serum samples from children revealed seroconversion to HHV-6 without concomitant seroconversion to HHV-7, and (iv) in some instances HHV-7 infection occurred in the presence of high titers of HHV-6 antibodies, suggesting the lack of apparent protection of children seropositive for HHV-6 against subsequent infection with HHV-7. On the basis of the analyses of sera from children and adults it can be concluded that HHV-7 is a prevalent human herpesvirus which, like other human herpesviruses, infects during childhood. The age of infection appears to be somewhat later than the very early age documented for HHV-6.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.0M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Balachandra K, Ayuthaya PI, Auwanit W, Jayavasu C, Okuno T, Yamanishi K, Takahashi M. Prevalence of antibody to human herpesvirus 6 in women and children. Microbiol Immunol. 1989;33(6):515–518. [PubMed]
  • Balachandran N, Amelse RE, Zhou WW, Chang CK. Identification of proteins specific for human herpesvirus 6-infected human T cells. J Virol. 1989 Jun;63(6):2835–2840. [PMC free article] [PubMed]
  • Briggs M, Fox J, Tedder RS. Age prevalence of antibody to human herpesvirus 6. Lancet. 1988 May 7;1(8593):1058–1059. [PubMed]
  • Di Luca D, Katsafanas G, Schirmer EC, Balachandran N, Frenkel N. The replication of viral and cellular DNA in human herpesvirus 6-infected cells. Virology. 1990 Mar;175(1):199–210. [PubMed]
  • Downing RG, Sewankambo N, Serwadda D, Honess R, Crawford D, Jarrett R, Griffin BE. Isolation of human lymphotropic herpesviruses from Uganda. Lancet. 1987 Aug 15;2(8555):390–390. [PubMed]
  • Frenkel N, Schirmer EC, Wyatt LS, Katsafanas G, Roffman E, Danovich RM, June CH. Isolation of a new herpesvirus from human CD4+ T cells. Proc Natl Acad Sci U S A. 1990 Jan;87(2):748–752. [PMC free article] [PubMed]
  • Levy JA, Ferro F, Greenspan D, Lennette ET. Frequent isolation of HHV-6 from saliva and high seroprevalence of the virus in the population. Lancet. 1990 May 5;335(8697):1047–1050. [PubMed]
  • Lopez C, Pellett P, Stewart J, Goldsmith C, Sanderlin K, Black J, Warfield D, Feorino P. Characteristics of human herpesvirus-6. J Infect Dis. 1988 Jun;157(6):1271–1273. [PubMed]
  • Okuno T, Takahashi K, Balachandra K, Shiraki K, Yamanishi K, Takahashi M, Baba K. Seroepidemiology of human herpesvirus 6 infection in normal children and adults. J Clin Microbiol. 1989 Apr;27(4):651–653. [PMC free article] [PubMed]
  • Salahuddin SZ, Ablashi DV, Markham PD, Josephs SF, Sturzenegger S, Kaplan M, Halligan G, Biberfeld P, Wong-Staal F, Kramarsky B, et al. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science. 1986 Oct 31;234(4776):596–601. [PubMed]
  • Saxinger C, Polesky H, Eby N, Grufferman S, Murphy R, Tegtmeir G, Parekh V, Memon S, Hung C. Antibody reactivity with HBLV (HHV-6) in U.S. populations. J Virol Methods. 1988 Sep;21(1-4):199–208. [PubMed]
  • Schirmer EC, Wyatt LS, Yamanishi K, Rodriguez WJ, Frenkel N. Differentiation between two distinct classes of viruses now classified as human herpesvirus 6. Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5922–5926. [PMC free article] [PubMed]
  • Suga S, Yoshikawa T, Asano Y, Yazaki T, Ozaki T. Neutralizing antibody assay for human herpesvirus-6. J Med Virol. 1990 Jan;30(1):14–19. [PubMed]
  • Tedder RS, Briggs M, Cameron CH, Honess R, Robertson D, Whittle H. A novel lymphotropic herpesvirus. Lancet. 1987 Aug 15;2(8555):390–392. [PubMed]
  • Ueda K, Kusuhara K, Hirose M, Okada K, Miyazaki C, Tokugawa K, Nakayama M, Yamanishi K. Exanthem subitum and antibody to human herpesvirus-6. J Infect Dis. 1989 Apr;159(4):750–752. [PubMed]
  • Wyatt LS, Balachandran N, Frenkel N. Variations in the replication and antigenic properties of human herpesvirus 6 strains. J Infect Dis. 1990 Oct;162(4):852–857. [PubMed]
  • Yamamoto M, Black JB, Stewart JA, Lopez C, Pellett PE. Identification of a nucleocapsid protein as a specific serological marker of human herpesvirus 6 infection. J Clin Microbiol. 1990 Sep;28(9):1957–1962. [PMC free article] [PubMed]
  • Yamanishi K, Okuno T, Shiraki K, Takahashi M, Kondo T, Asano Y, Kurata T. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet. 1988 May 14;1(8594):1065–1067. [PubMed]
  • Yoshikawa T, Suga S, Asano Y, Yazaki T, Kodama H, Ozaki T. Distribution of antibodies to a causative agent of exanthem subitum (human herpesvirus-6) in healthy individuals. Pediatrics. 1989 Oct;84(4):675–677. [PubMed]
  • Yoshikawa T, Suga S, Asano Y, Yazaki T, Ozaki T. Neutralizing antibodies to human herpesvirus-6 in healthy individuals. Pediatr Infect Dis J. 1990 Aug;9(8):589–590. [PubMed]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...