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J Virol. Aug 1990; 64(8): 3960–3962.
PMCID: PMC249691

Mutation Frequencies at Defined Single Codon Sites in Vesicular Stomatitis Virus and Poliovirus Can Be Increased Only Slightly by Chemical Mutagenesis

Abstract

Mutagenesis by a variety of chemical mutagens conferred only 1.1- to 2.8-fold increases in mutation frequencies at defined single base sites in vesicular stomatitis virus and poliovirus.

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Selected References

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  • Batschelet E, Domingo E, Weissmann C. The proportion of revertant and mutant phage in a growing population, as a function of mutation and growth rate. Gene. 1976;1(1):27–32. [PubMed]
  • CARP RI, KOPROWSKI H. Mutation of type 3 poliovirus with nitrous acid. Virology. 1962 May;17:99–109. [PubMed]
  • Cupples CG, Miller JH. A set of lacZ mutations in Escherichia coli that allow rapid detection of each of the six base substitutions. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5345–5349. [PMC free article] [PubMed]
  • de la Torre JC, Wimmer E, Holland JJ. Very high frequency of reversion to guanidine resistance in clonal pools of guanidine-dependent type 1 poliovirus. J Virol. 1990 Feb;64(2):664–671. [PMC free article] [PubMed]
  • Domingo E, Flavell RA, Weissmann C. In vitro site-directed mutagenesis: generation and properties of an infectious extracistronic mutant of bacteriophage Qbeta. Gene. 1976;1(1):3–25. [PubMed]
  • Fields BN, Joklik WK. Isolation and preliminary genetic and biochemical characterization of temperature-sensitive mutants of reovirus. Virology. 1969 Mar;37(3):335–342. [PubMed]
  • GRANOFF A. Induction of Newcastle disease virus mutants with nitrous acid. Virology. 1961 Apr;13:402–408. [PubMed]
  • Halle S. 5-Azacytidine as a mutagen for arboviruses. J Virol. 1968 Oct;2(10):1228–1229. [PMC free article] [PubMed]
  • Holland JJ, de la Torre JC, Steinhauer DA, Clarke D, Duarte E, Domingo E. Virus mutation frequencies can be greatly underestimated by monoclonal antibody neutralization of virions. J Virol. 1989 Dec;63(12):5030–5036. [PMC free article] [PubMed]
  • Holland JJ, Villarreal LP, Breindl M. Factors involved in the generation and replication of rhabdovirus defective T particles. J Virol. 1976 Mar;17(3):805–815. [PMC free article] [PubMed]
  • MUNDRY KW, GIERER A. Die Erzeugung von Mutationen des Tabakmosaikvirus durch chemische Behandlung seiner Nucleinsäure in vitro. Z Vererbungsl. 1958;89(4):614–630. [PubMed]
  • Pincus SE, Rohl H, Wimmer E. Guanidine-dependent mutants of poliovirus: identification of three classes with different growth requirements. Virology. 1987 Mar;157(1):83–88. [PubMed]
  • Pringle CR. Genetic characteristics of conditional lethal mutants of vesicular stomatitis virus induced by 5-fluorouracil, 5-azacytidine, and ethyl methane sulfonate. J Virol. 1970 May;5(5):559–567. [PMC free article] [PubMed]
  • Pringle CR, Devine V, Wilkie M, Preston CM, Dolan A, McGeoch DJ. Enhanced mutability associated with a temperature-sensitive mutant of vesicular stomatitis virus. J Virol. 1981 Aug;39(2):377–389. [PMC free article] [PubMed]
  • Radman M, Wagner R. Mismatch repair in Escherichia coli. Annu Rev Genet. 1986;20:523–538. [PubMed]
  • Smith DB, Inglis SC. The mutation rate and variability of eukaryotic viruses: an analytical review. J Gen Virol. 1987 Nov;68(Pt 11):2729–2740. [PubMed]
  • Steinhauer DA, de la Torre JC, Holland JJ. High nucleotide substitution error frequencies in clonal pools of vesicular stomatitis virus. J Virol. 1989 May;63(5):2063–2071. [PMC free article] [PubMed]
  • Steinhauer DA, Holland JJ. Rapid evolution of RNA viruses. Annu Rev Microbiol. 1987;41:409–433. [PubMed]
  • Valcárcel J, Ortín J. Phenotypic hiding: the carryover of mutations in RNA viruses as shown by detection of mar mutants in influenza virus. J Virol. 1989 Sep;63(9):4107–4109. [PMC free article] [PubMed]

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