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Bull World Health Organ. 1997; 75(3): 261–290.
PMCID: PMC2486945

Hypoglycaemia of the newborn: a review.


It is almost a century since hypoglycaemia (a reduction in the glucose concentration of circulating blood) was first described in children, and over 50 years since the condition was first recognized in infants. Nevertheless, controversy still surrounds the definition, significance, and management of neonatal hypoglycaemia. Technological developments such as bedside glucose monitoring have, paradoxically, exacerbated rather than eased the situation. This article reviews the literature on hypoglycaemia of the newborn, and covers the following: historical aspects; glucose homeostasis and metabolic adaptation at birth; the effect of low blood glucose levels on the central nervous system; the definition of hypoglycaemia; screening; prevention; treatment; research needs; and concludes with recommendations for prevention and management.

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  • NORVAL MA. Blood sugar values in premature infants. J Pediatr. 1950 Feb;36(2):177–184. [PubMed]
  • FARQUHAR JW. Control of the blood sugar level in the neonatal period. Arch Dis Child. 1954 Dec;29(148):519–530. [PMC free article] [PubMed]
  • CORNBLATH M, ODELL GB, LEVIN EY. Symptomatic neonatal hypoglycemia associated with toxemia of pregnancy. J Pediatr. 1959 Nov;55:545–562. [PubMed]
  • Fluge G. Clinical aspects of neonatal hypoglycaemia. Acta Paediatr Scand. 1974 Nov;63(6):826–832. [PubMed]
  • Gutberlet RL, Cornblath M. Neonatal hypoglycemia revisited, 1975. Pediatrics. 1976 Jul;58(1):10–17. [PubMed]
  • Lubchenco LO, Bard H. Incidence of hypoglycemia in newborn infants classified by birth weight and gestational age. Pediatrics. 1971 May;47(5):831–838. [PubMed]
  • Anderson S, Shakya KN, Shrestha LN, Costello AM. Hypoglycaemia: a common problem among uncomplicated newborn infants in Nepal. J Trop Pediatr. 1993 Oct;39(5):273–277. [PubMed]
  • Haworth JC, Vidyasagar D. Hypoglycemia in the newborn. Clin Obstet Gynecol. 1971 Sep;14(3):821–839. [PubMed]
  • Griffiths AD, Bryant GM. Assessment of effects of neonatal hypoglycaemia. A study of 41 cases with matched controls. Arch Dis Child. 1971 Dec;46(250):819–827. [PMC free article] [PubMed]
  • Koivisto M, Blanco-Sequeiros M, Krause U. Neonatal symptomatic and asymptomatic hypoglycaemia: a follow-up study of 151 children. Dev Med Child Neurol. 1972 Oct;14(5):603–614. [PubMed]
  • Singh M, Singhal PK, Paul VK, Deorari AK, Sundaram KR, Ghorpade MD, Agadi A. Neurodevelopmental outcome of asymptomatic & symptomatic babies with neonatal hypoglycaemia. Indian J Med Res. 1991 Feb;94:6–10. [PubMed]
  • Pildes RS, Cornblath M, Warren I, Page-El E, Di Menza S, Merritt DM, Peeva A. A prospective controlled study of neonatal hypoglycemia. Pediatrics. 1974 Jul;54(1):5–14. [PubMed]
  • Cornblath M, Schwartz R, Aynsley-Green A, Lloyd JK. Hypoglycemia in infancy: the need for a rational definition. A Ciba Foundation discussion meeting. Pediatrics. 1990 May;85(5):834–837. [PubMed]
  • Lucas A, Morley R, Cole TJ. Adverse neurodevelopmental outcome of moderate neonatal hypoglycaemia. BMJ. 1988 Nov 19;297(6659):1304–1308. [PMC free article] [PubMed]
  • Hay WW., Jr The placenta. Not just a conduit for maternal fuels. Diabetes. 1991 Dec;40 (Suppl 2):44–50. [PubMed]
  • Hales CN, Barker DJ. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia. 1992 Jul;35(7):595–601. [PubMed]
  • Gerich JE. Control of glycaemia. Baillieres Clin Endocrinol Metab. 1993 Jul;7(3):551–586. [PubMed]
  • Bier DM, Leake RD, Haymond MW, Arnold KJ, Gruenke LD, Sperling MA, Kipnis DM. Measurement of "true" glucose production rates in infancy and childhood with 6,6-dideuteroglucose. Diabetes. 1977 Nov;26(11):1016–1023. [PubMed]
  • Kalhan SC, Savin SM, Adam PA. Measurement of glucose turnover in the human newborn with glucose-1-13C. J Clin Endocrinol Metab. 1976 Sep;43(3):704–707. [PubMed]
  • Denne SC, Kalhan SC. Glucose carbon recycling and oxidation in human newborns. Am J Physiol. 1986 Jul;251(1 Pt 1):E71–E77. [PubMed]
  • Kalhan SC, Oliven A, King KC, Lucero C. Role of glucose in the regulation of endogenous glucose production in the human newborn. Pediatr Res. 1986 Jan;20(1):49–52. [PubMed]
  • Cowett RM, Oh W, Schwartz R. Persistent glucose production during glucose infusion in the neonate. J Clin Invest. 1983 Mar;71(3):467–475. [PMC free article] [PubMed]
  • Sunehag A, Gustafsson J, Ewald U. Very immature infants (< or = 30 Wk) respond to glucose infusion with incomplete suppression of glucose production. Pediatr Res. 1994 Oct;36(4):550–555. [PubMed]
  • Ktorza A, Bihoreau MT, Nurjhan N, Picon L, Girard J. Insulin and glucagon during the perinatal period: secretion and metabolic effects on the liver. Biol Neonate. 1985;48(4):204–220. [PubMed]
  • Hawdon JM, Aynsley-Green A, Alberti KG, Ward Platt MP. The role of pancreatic insulin secretion in neonatal glucoregulation. I. Healthy term and preterm infants. Arch Dis Child. 1993 Mar;68(3 Spec No):274–279. [PMC free article] [PubMed]
  • Hawdon JM, Hubbard M, Hales CN, Clark PM. Use of specific immunoradiometric assay to determine preterm neonatal insulin-glucose relations. Arch Dis Child Fetal Neonatal Ed. 1995 Nov;73(3):F166–F169. [PMC free article] [PubMed]
  • Beard AG, Panos TC, Marasigan BV, Eminians J, Kennedy HF, Lamb J. Perinatal stress and the premature neonate. II. Effect of fluid and calorie deprivation on blood glucose. J Pediatr. 1966 Mar;68(3):329–343. [PubMed]
  • Melichar V, Drahota Z, Hahn P. Ketone bodies in the blood of full term newborns, premature and dysmature infants and infants of diabetic mothers. Biol Neonat. 1967;11(1):23–28. [PubMed]
  • Persson B, Gentz J. The pattern of blood lipids, glycerol and ketone bodies during the neonatal period, infancy and childhood. Acta Paediatr Scand. 1966 Jul;55(4):353–362. [PubMed]
  • Stanley CA, Anday EK, Baker L, Delivoria-Papadopolous M. Metabolic fuel and hormone responses to fasting in newborn infants. Pediatrics. 1979 Nov;64(5):613–619. [PubMed]
  • Anday EK, Stanley CA, Baker L, Delivoria-Papadopoulos M. Plasma ketones in newborn infants: absence of suckling ketosis. J Pediatr. 1981 Apr;98(4):628–630. [PubMed]
  • Hawdon JM, Ward Platt MP, Aynsley-Green A. Patterns of metabolic adaptation for preterm and term infants in the first neonatal week. Arch Dis Child. 1992 Apr;67(4 Spec No):357–365. [PMC free article] [PubMed]
  • Lucas A, Boyes S, Bloom SR, Aynsley-Green A. Metabolic and endocrine responses to a milk feed in six-day-old term infants: differences between breast and cow's milk formula feeding. Acta Paediatr Scand. 1981 Mar;70(2):195–200. [PubMed]
  • Ginsburg BE, Lindblad BS, Persson B, Zetterström R. Plasma valine and urinary C-peptide in infants. The effect of substituting breast-feeding with formula or formula with human milk. Acta Paediatr Scand. 1985 Jul;74(4):615–616. [PubMed]
  • Hume R, Burchell A. Abnormal expression of glucose-6-phosphatase in preterm infants. Arch Dis Child. 1993 Feb;68(2):202–204. [PMC free article] [PubMed]
  • Lindblad BS. The venous plasma free amino acid levels during the first hours of life. I. After normal and short gestation and gestation complicated by hypertension, with special reference to the "small for dates" syndrome. Acta Paediatr Scand. 1970 Jan;59(1):13–20. [PubMed]
  • Haymond MW, Karl IE, Pagliara AS. Increased gluconeogenic substrates in the small-for-gestational-age infant. N Engl J Med. 1974 Aug 15;291(7):322–328. [PubMed]
  • Mestyán J, Soltész G, Schultz K, Horváth M. Hyperaminoacidemia due to the accumulation of gluconeogenic amino acid precursors in hypoglycemic small-for-gestational age infants. J Pediatr. 1975 Sep;87(3):409–414. [PubMed]
  • Sann L, Ruitton A, Mathieu M, Bourgeois J, Genoud J. Effect of intravenous L-alanine administration on plasma glucose, insulin and glucagon, blood pyruvate, lactate and beta-hydroxybutyrate concentrations in newborn infants. Study in term and preterm newborn infants. Acta Paediatr Scand. 1978 May;67(3):297–302. [PubMed]
  • Hawdon JM, Ward Platt MP. Metabolic adaptation in small for gestational age infants. Arch Dis Child. 1993 Mar;68(3 Spec No):262–268. [PMC free article] [PubMed]
  • Hawdon JM, Ward Platt MP, McPhail S, Cameron H, Walkinshaw SA. Prediction of impaired metabolic adaptation by antenatal Doppler studies in small for gestational age fetuses. Arch Dis Child. 1992 Jul;67(7 Spec No):789–792. [PMC free article] [PubMed]
  • Collins JE, Leonard JV. Hyperinsulinism in asphyxiated and small-for-dates infants with hypoglycaemia. Lancet. 1984 Aug 11;2(8398):311–313. [PubMed]
  • Collins JE, Leonard JV, Teale D, Marks V, Williams DM, Kennedy CR, Hall MA. Hyperinsulinaemic hypoglycaemia in small for dates babies. Arch Dis Child. 1990 Oct;65(10):1118–1120. [PMC free article] [PubMed]
  • Mehta A. Hyperinsulinaemic hypoglycaemia in small for dates babies. Arch Dis Child. 1991 Jun;66(6):749–749. [PMC free article] [PubMed]
  • Mestyán J, Schultz K, Soltész G, Horváth M. The metabolic effects of glucagon infusion in normoglycaemic and hypoglycaemic small-for-gestational-age infants. II. Changes in plasma amino acids. Acta Paediatr Acad Sci Hung. 1976;17(3):245–253. [PubMed]
  • PEDERSEN J, BOJSEN-MØLLER B, POULSEN H. Blood sugar in newborn infants of diabetic mothers. Acta Endocrinol (Copenh) 1954 Jan;15(1):33–52. [PubMed]
  • Milner RD, Ashworth MA, Barson AJ. Insulin release from human foetal pancreas in response to glucose, leucine and arginine. J Endocrinol. 1972 Mar;52(3):497–505. [PubMed]
  • FARQUHAR JW. The significance of hypoglycaemia in the newborn infant of the diabetic woman. Arch Dis Child. 1956 Jun;31(157):203–211. [PMC free article] [PubMed]
  • Kalhan SC, Savin SM, Adam PA. Attenuated glucose production rate in newborn infants of insulin-dependent diabetic mothers. N Engl J Med. 1977 Feb 17;296(7):375–376. [PubMed]
  • Williams PR, Sperling MA, Racasa Z. Blunting of spontaneous and alanine-stimulated glucagon secretion in newborn infants of diabetic mothers. Am J Obstet Gynecol. 1979 Jan 1;133(1):51–56. [PubMed]
  • Lucas A, Adrian TE, Aynsley-Green A, Bloom SR. Iatrogenic hyperinsulinism at birth. Lancet. 1980 Jan 19;1(8160):144–145. [PubMed]
  • Epstein MF, Nicholls E, Stubblefield PG. Neonatal hypoglycemia after beta-sympathomimetic tocolytic therapy. J Pediatr. 1979 Mar;94(3):449–453. [PubMed]
  • Procianoy RS, Pinheiro CE. Neonatal hyperinsulinism after short-term maternal beta sympathomimetic therapy. J Pediatr. 1982 Oct;101(4):612–614. [PubMed]
  • Thomas DJ, Dove AF, Alberti KG. Metabolic effects of salbutamol infusion during premature labour. Br J Obstet Gynaecol. 1977 Jul;84(7):497–499. [PubMed]
  • Jouppila R, Kauppila A, Tuimala R, Pakarinen A, Moilanen K. Maternal, fetal and neonatal effects of beta-adrenergic stimulation in connection with cesarean section. Acta Obstet Gynecol Scand. 1980;59(6):489–493. [PubMed]
  • Vidnes J, Oyasaeter S. Glucagon deficiency causing severe neonatal hypoglycemia in a patient with normal insulin secretion. Pediatr Res. 1977 Sep;11(9 Pt 1):943–949. [PubMed]
  • Kollee LA, Monnens LA, Cecjka V, Wilms RM. Persistent neonatal hypoglycaemia due to glucagon deficiency. Arch Dis Child. 1978 May;53(5):422–424. [PMC free article] [PubMed]
  • Gotlin RW, Silver HK. Neonatal hypoglycaemia, hyperinsulinism, and absence of pancreatic alpha-cells. Lancet. 1970 Jun 20;760(1):1346–1346. [PubMed]
  • Saudubray JM, Narcy C, Lyonnet L, Bonnefont JP, Poll The BT, Munnich A. Clinical approach to inherited metabolic disorders in neonates. Biol Neonate. 1990;58 (Suppl 1):44–53. [PubMed]
  • Aynsley-Green A. Glucose: a fuel for thought! J Paediatr Child Health. 1991 Feb;27(1):21–30. [PubMed]
  • Fernandes J, Berger R. Hypoglycaemia: principles of diagnosis and treatment in children. Baillieres Clin Endocrinol Metab. 1993 Jul;7(3):591–609. [PubMed]
  • Cornblath M, Schwartz R. Hypoglycemia in the neonate. J Pediatr Endocrinol. 1993 Apr-Jun;6(2):113–129. [PubMed]
  • Papagapiou MP, Auer RN. Regional neuroprotective effects of the NMDA receptor antagonist MK-801 (dizocilpine) in hypoglycemic brain damage. J Cereb Blood Flow Metab. 1990 Mar;10(2):270–276. [PubMed]
  • Thurston JH, Hauhart RE, Schiro JA. Lactate reverses insulin-induced hypoglycemic stupor in suckling-weanling mice: biochemical correlates in blood, liver, and brain. J Cereb Blood Flow Metab. 1983 Dec;3(4):498–506. [PubMed]
  • Young RS, Petroff OA, Chen B, Aquila WJ, Jr, Gore JC. Preferential utilization of lactate in neonatal dog brain: in vivo and in vitro proton NMR study. Biol Neonate. 1991;59(1):46–53. [PubMed]
  • Amiel SA. Nutrition of the brain: macronutrient supply. Proc Nutr Soc. 1994 Jul;53(2):401–405. [PubMed]
  • Fernandes J, Berger R, Smit GP. Lactate as a cerebral metabolic fuel for glucose-6-phosphatase deficient children. Pediatr Res. 1984 Apr;18(4):335–339. [PubMed]
  • Bougneres PF, Lemmel C, Ferré P, Bier DM. Ketone body transport in the human neonate and infant. J Clin Invest. 1986 Jan;77(1):42–48. [PMC free article] [PubMed]
  • Dombrowski GJ, Jr, Swiatek KR, Chao KL. Lactate, 3-hydroxybutyrate, and glucose as substrates for the early postnatal rat brain. Neurochem Res. 1989 Jul;14(7):667–675. [PubMed]
  • Nehlig A, Pereira de Vasconcelos A. Glucose and ketone body utilization by the brain of neonatal rats. Prog Neurobiol. 1993 Feb;40(2):163–221. [PubMed]
  • Owen OE, Morgan AP, Kemp HG, Sullivan JM, Herrera MG, Cahill GF., Jr Brain metabolism during fasting. J Clin Invest. 1967 Oct;46(10):1589–1595. [PMC free article] [PubMed]
  • Settergren G, Lindblad BS, Persson B. Cerebral blood flow and exchange of oxygen, glucose, ketone bodies, lactate, pyruvate and amino acids in infants. Acta Paediatr Scand. 1976 May;65(3):343–353. [PubMed]
  • Patel MS, Johnson CA, Rajan R, Owen OE. The metabolism of ketone bodies in developing human brain: development of ketone-body-utilizing enzymes and ketone bodies as precursors for lipid synthesis. J Neurochem. 1975 Dec;25(6):905–908. [PubMed]
  • Adam PA, Räihä N, Rahiala EL, Kekomäki M. Oxidation of glucose and D-B-OH-butyrate by the early human fetal brain. Acta Paediatr Scand. 1975 Jan;64(1):17–24. [PubMed]
  • Kraus H, Schlenker S, Schwedesky D. Developmental changes of cerebral ketone body utilization in human infants. Hoppe Seylers Z Physiol Chem. 1974 Feb;355(2):164–170. [PubMed]
  • Pryds O, Greisen G, Friis-Hansen B. Compensatory increase of CBF in preterm infants during hypoglycaemia. Acta Paediatr Scand. 1988 Sep;77(5):632–637. [PubMed]
  • Pryds O, Christensen NJ, Friis-Hansen B. Increased cerebral blood flow and plasma epinephrine in hypoglycemic, preterm neonates. Pediatrics. 1990 Feb;85(2):172–176. [PubMed]
  • Skov L, Pryds O. Capillary recruitment for preservation of cerebral glucose influx in hypoglycemic, preterm newborns: evidence for a glucose sensor? Pediatrics. 1992 Aug;90(2 Pt 1):193–195. [PubMed]
  • Koh TH, Eyre JA, Aynsley-Green A. Neonatal hypoglycaemia--the controversy regarding definition. Arch Dis Child. 1988 Nov;63(11):1386–1388. [PMC free article] [PubMed]
  • Schwartz R. Neonatal hypoglycemia. Back to basics in diagnosis and treatment. Diabetes. 1991 Dec;40 (Suppl 2):71–73. [PubMed]
  • Chance GW, Bower BD. Hypoglycaemia and temporary hyperglycaemia in infants of low birth weight for materity. Arch Dis Child. 1966 Jun;41(217):279–285. [PMC free article] [PubMed]
  • Sexson WR. Incidence of neonatal hypoglycemia: a matter of definition. J Pediatr. 1984 Jul;105(1):149–150. [PubMed]
  • Srinivasan G, Pildes RS, Cattamanchi G, Voora S, Lilien LD. Plasma glucose values in normal neonates: a new look. J Pediatr. 1986 Jul;109(1):114–117. [PubMed]
  • Heck LJ, Erenberg A. Serum glucose levels in term neonates during the first 48 hours of life. J Pediatr. 1987 Jan;110(1):119–122. [PubMed]
  • Grazaitis DM, Sexson WR. Erroneously high Dextrostix values caused by isopropyl alcohol. Pediatrics. 1980 Aug;66(2):221–223. [PubMed]
  • Togari H, Oda M, Wada Y. Mechanism of erroneous Dextrostix readings. Arch Dis Child. 1987 Apr;62(4):408–409. [PMC free article] [PubMed]
  • Joosten KF, Schellekens AP, Waelkens JJ, Wulffraat NM. Foutieve diagnose 'neonatale hypoglykemie' door onjuist bewaren van bloedmonsters. Ned Tijdschr Geneeskd. 1991 Sep 14;135(37):1691–1694. [PubMed]
  • Kaplan M, Blondheim O, Alon I, Eylath U, Trestian S, Eidelman AI. Screening for hypoglycemia with plasma in neonatal blood of high hematocrit value. Crit Care Med. 1989 Mar;17(3):279–282. [PubMed]
  • Fox RE, Redstone D. Sources of error in glucose determinations in neonatal blood by glucose oxidase methods, including Dextrostix. Am J Clin Pathol. 1976 Oct;66(4):658–666. [PubMed]
  • Chantler C, Baum JD, Norman DA. Dextrostix in the diagnosis of neonatal hypoglycaemia. Lancet. 1967 Dec 30;2(7531):1395–1396. [PubMed]
  • Reynolds GJ, Davies S. A clinical audit of cotside blood glucose measurement in the detection of neonatal hypoglycaemia. J Paediatr Child Health. 1993 Aug;29(4):289–291. [PubMed]
  • Holtrop PC, Madison KA, Kiechle FL, Karcher RE, Batton DG. A comparison of chromogen test strip (Chemstrip bG) and serum glucose values in newborns. Am J Dis Child. 1990 Feb;144(2):183–185. [PubMed]
  • Perelman RH, Gutcher GR, Engle MJ, MacDonald MJ. Comparative analysis of four methods for rapid glucose determination in neonates. Am J Dis Child. 1982 Dec;136(12):1051–1053. [PubMed]
  • Herrera AJ, Hsiang YH. Comparison of various methods of blood sugar screening in newborn infants. J Pediatr. 1983 May;102(5):769–772. [PubMed]
  • Hay WW, Jr, Osberg IM. The "eyetone" blood glucose reflectance colorimeter evaluated for in vitro and in vivo accuracy and clinical efficacy. Clin Chem. 1983 Mar;29(3):558–560. [PubMed]
  • Lin HC, Maguire C, Oh W, Cowett R. Accuracy and reliability of glucose reflectance meters in the high-risk neonate. J Pediatr. 1989 Dec;115(6):998–1000. [PubMed]
  • Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986 Feb 8;1(8476):307–310. [PubMed]
  • Vadasdi E, Jacobs E. HemoCue beta-glucose photometer evaluated for use in a neonatal intensive care unit. Clin Chem. 1993 Nov;39(11 Pt 1):2329–2332. [PubMed]
  • Hall DM, Michel JM. Screening in infancy. Arch Dis Child. 1995 Jan;72(1):93–96. [PMC free article] [PubMed]
  • Ho KL, Loke HL, Tan KW. Accuracy and reliability of two methods of screening for hypoglycemia in neonates. J Singapore Paediatr Soc. 1991;33(3-4):156–158. [PubMed]
  • Holtrop PC. The frequency of hypoglycemia in full-term large and small for gestational age newborns. Am J Perinatol. 1993 Mar;10(2):150–154. [PubMed]
  • Jones RA, Roberton NR. Small for dates babies: are they really a problem? Arch Dis Child. 1986 Sep;61(9):877–880. [PMC free article] [PubMed]
  • van den Bosch CA, Bullough CH. Effect of early suckling on term neonates' core body temperature. Ann Trop Paediatr. 1990;10(4):347–353. [PubMed]
  • Anderson DM, Kliegman RM. The relationship of neonatal alimentation practices to the occurrence of endemic necrotizing enterocolitis. Am J Perinatol. 1991 Jan;8(1):62–67. [PubMed]
  • McKeown RE, Marsh TD, Amarnath U, Garrison CZ, Addy CL, Thompson SJ, Austin JL. Role of delayed feeding and of feeding increments in necrotizing enterocolitis. J Pediatr. 1992 Nov;121(5 Pt 1):764–770. [PubMed]
  • Brown EG, Sweet AY. Preventing necrotizing enterocolitis in neonates. JAMA. 1978 Nov 24;240(22):2452–2454. [PubMed]
  • Goldman HI. Feeding and necrotizing enterocolitis. Am J Dis Child. 1980 Jun;134(6):553–555. [PubMed]
  • Book LS, Herbst JJ, Jung AL. Comparison of fast- and slow-feeding rate schedules to the development of necrotizing enterocolitis. J Pediatr. 1976 Sep;89(3):463–466. [PubMed]
  • Lucas A, Cole TJ. Breast milk and neonatal necrotising enterocolitis. Lancet. 1990 Dec 22;336(8730):1519–1523. [PubMed]
  • Beeby PJ, Jeffery H. Risk factors for necrotising enterocolitis: the influence of gestational age. Arch Dis Child. 1992 Apr;67(4 Spec No):432–435. [PMC free article] [PubMed]
  • Lang S, Lawrence CJ, Orme RL. Cup feeding: an alternative method of infant feeding. Arch Dis Child. 1994 Oct;71(4):365–369. [PMC free article] [PubMed]
  • Pearce JL, Buchanan LF. Breast milk and breast feeding in very low birthweight infants. Arch Dis Child. 1979 Nov;54(11):897–899. [PMC free article] [PubMed]
  • Lucas A. AIDS and human milk bank closures. Lancet. 1987 May 9;1(8541):1092–1093. [PubMed]
  • Altman DG, Coles EC. Nomograms for precise determination of birth weight for dates. Br J Obstet Gynaecol. 1980 Feb;87(2):81–86. [PubMed]
  • Gardosi J, Chang A, Kalyan B, Sahota D, Symonds EM. Customised antenatal growth charts. Lancet. 1992 Feb 1;339(8788):283–287. [PubMed]
  • Whitby C, de Cates CR, Roberton NR. Infants weighing 1.8-2.5 kg: should they be cared for in neonatal units or postnatal wards? Lancet. 1982 Feb 6;1(8267):322–325. [PubMed]
  • Singhal PK, Singh M, Paul VK, Malhotra AK, Deorari AK, Ghorpade MD. A controlled study of sugar-fortified milk feeding for prevention of neonatal hypoglycaemia. Indian J Med Res. 1991 Oct;94:342–345. [PubMed]
  • Sann L, Mousson B, Rousson M, Maire I, Bethenod M. Prevention of neonatal hypoglycaemia by oral lipid supplementation in low birth weight infants. Eur J Pediatr. 1988 Feb;147(2):158–161. [PubMed]
  • Sann L, Mathieu M, Lasne Y, Ruitton A. Effect of oral administration of lipids with 67% medium chain triglycerides on glucose homeostasis in preterm neonates. Metabolism. 1981 Jul;30(7):712–716. [PubMed]
  • Sann L, Divry P, Lasne Y, Ruitton A. Effect of oral lipid administration on glucose homeostasis in small-for-gestational-age infants. Acta Paediatr Scand. 1982 Nov;71(6):923–927. [PubMed]
  • Hawdon JM, Aynsley-Green A, Ward Platt MP. Neonatal blood glucose concentrations: metabolic effects of intravenous glucagon and intragastric medium chain triglyceride. Arch Dis Child. 1993 Mar;68(3 Spec No):255–261. [PMC free article] [PubMed]
  • Lilien LD, Pildes RS, Srinivasan G, Voora S, Yeh TF. Treatment of neonatal hypoglycemia with minibolus and intraveous glucose infusion. J Pediatr. 1980 Aug;97(2):295–298. [PubMed]
  • Hawdon JM, Ward Platt MP, Aynsley-Green A. Prevention and management of neonatal hypoglycaemia. Arch Dis Child Fetal Neonatal Ed. 1994 Jan;70(1):F60–F65. [PMC free article] [PubMed]
  • Shah A, Stanhope R, Matthew D. Hazards of pharmacological tests of growth hormone secretion in childhood. BMJ. 1992 Jan 18;304(6820):173–174. [PMC free article] [PubMed]
  • Mehta A, Wootton R, Cheng KN, Penfold P, Halliday D, Stacey TE. Effect of diazoxide or glucagon on hepatic glucose production rate during extreme neonatal hypoglycaemia. Arch Dis Child. 1987 Sep;62(9):924–930. [PMC free article] [PubMed]
  • Carter PE, Lloyd DJ, Duffty P. Glucagon for hypoglycaemia in infants small for gestational age. Arch Dis Child. 1988 Oct;63(10):1264–1266. [PMC free article] [PubMed]
  • Hawdon JM, Weddell A, Aynsley-Green A, Ward Platt MP. Hormonal and metabolic response to hypoglycaemia in small for gestational age infants. Arch Dis Child. 1993 Mar;68(3 Spec No):269–273. [PMC free article] [PubMed]

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