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Comp Funct Genomics. 2004 Aug-Oct; 5(6-7): 501–508.
PMCID: PMC2447428

Biomedical Informatics and Granularity


An explicit formal-ontological representation of entities existing at multiple levels of granularity is an urgent requirement for biomedical information processing. We discuss some fundamental principles which can form a basis for such a representation. We also comment on some of the implicit treatments of granularity in currently available ontologies and terminologies (GO, FMA, SNOMED CT).

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Selected References

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  • Mejino José V, Jr, Agoncillo Augusto V, Rickard Kurt L, Rosse Cornelius. Representing complexity in part-whole relationships within the Foundational Model of Anatomy. AMIA Annu Symp Proc. 2003:450–454. [PMC free article] [PubMed]
  • Rosse Cornelius, Mejino José L V., Jr A reference ontology for biomedical informatics: the Foundational Model of Anatomy. J Biomed Inform. 2003 Dec;36(6):478–500. [PubMed]
  • Smith Barry, Rosse Cornelius. The role of foundational relations in the alignment of biomedical ontologies. Stud Health Technol Inform. 2004;107(Pt 1):444–448. [PubMed]
  • Smith Barry, Williams Jennifer, Schulze-Kremer Steffen. The ontology of the gene ontology. AMIA Annu Symp Proc. 2003:609–613. [PMC free article] [PubMed]

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