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Journal List > Postgrad Med J > v.73(861); Jul 1997

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Postgrad Med J. 1997 July; 73(861): 391–394.
PMCID: PMC2431404
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Langerhans cell histiocytosis (histiocytosis X).
K. Y. Lam
Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong.
Abstract
There has been a renewed interest in Langerhans cell histiocytosis in recent years due both to advances in basic research and to improvements in diagnostic and treatment approaches. In this article, we review the various aspects of the disease and the potential implications of these recent scientific researches for our understanding and management of the disorder.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • LICHTENSTEIN L. Histiocytosis X; integration of eosinophilic granuloma of bone, Letterer-Siwe disease, and Schüller-Christian disease as related manifestations of a single nosologic entity. AMA Arch Pathol. 1953 Jul;56(1):84–102. [PubMed]
  • Osband ME. Histiocytosis X. Langerhans' cell histiocytosis. Hematol Oncol Clin North Am. 1987 Dec;1(4):737–751. [PubMed]
  • Cline MJ. Histiocytes and histiocytosis. Blood. 1994 Nov 1;84(9):2840–2853. [PubMed]
  • Pritchard J, Broadbent V. Histiocytosis--an introduction. Br J Cancer Suppl. 1994 Sep;23:S1–S3. [PubMed]
  • Mierau GW, Wills EJ, Steele PO. Ultrastructural studies in Langerhans cell histiocytosis: a search for evidence of viral etiology. Pediatr Pathol. 1994 Sep–Oct;14(5):895–904. [PubMed]
  • McClain K, Jin H, Gresik V, Favara B. Langerhans cell histiocytosis: lack of a viral etiology. Am J Hematol. 1994 Sep;47(1):16–20. [PubMed]
  • Leahy MA, Krejci SM, Friednash M, Stockert SS, Wilson H, Huff JC, Weston WL, Brice SL. Human herpesvirus 6 is present in lesions of Langerhans cell histiocytosis. J Invest Dermatol. 1993 Nov;101(5):642–645. [PubMed]
  • Kannourakis G, Abbas A. The role of cytokines in the pathogenesis of Langerhans cell histiocytosis. Br J Cancer Suppl. 1994 Sep;23:S37–S40. [PubMed]
  • Ruco LP, Stoppacciaro A, Vitolo D, Uccini S, Baroni CD. Expression of adhesion molecules in Langerhans' cell histiocytosis. Histopathology. 1993 Jul;23(1):29–37. [PubMed]
  • de Graaf JH, Tamminga RY, Kamps WA, Timens W. Langerhans' cell histiocytosis: expression of leukocyte cellular adhesion molecules suggests abnormal homing and differentiation. Am J Pathol. 1994 Mar;144(3):466–472. [PubMed]
  • de Graaf JH, Tamminga RY, Kamps WA, Timens W. Expression of cellular adhesion molecules in Langerhans cell histiocytosis and normal Langerhans cells. Am J Pathol. 1995 Oct;147(4):1161–1171. [PubMed]
  • Katz AM, Rosenthal D, Jakubovic HR, Pai RK, Quinonez GE, Sauder DN. Langerhans cell histiocytosis in monozygotic twins. J Am Acad Dermatol. 1991 Jan;24(1):32–37. [PubMed]
  • Willman CL, Busque L, Griffith BB, Favara BE, McClain KL, Duncan MH, Gilliland DG. Langerhans'-cell histiocytosis (histiocytosis X)--a clonal proliferative disease. N Engl J Med. 1994 Jul 21;331(3):154–160. [PubMed]
  • Yu RC, Chu C, Buluwela L, Chu AC. Clonal proliferation of Langerhans cells in Langerhans cell histiocytosis. Lancet. 1994 Mar 26;343(8900):767–768. [PubMed]
  • Hage C, Willman CL, Favara BE, Isaacson PG. Langerhans' cell histiocytosis (histiocytosis X): immunophenotype and growth fraction. Hum Pathol. 1993 Aug;24(8):840–845. [PubMed]
  • Ornvold K, Carstensen H, Larsen JK, Christensen IJ, Ralfkiaer E. Flow cytometric DNA analysis of lesions from 18 children with langerhans cell histiocytosis (histiocytosis x). Am J Pathol. 1990 Jun;136(6):1301–1307. [PubMed]
  • Yu RC, Chu AC. Lack of T-cell receptor gene rearrangements in cells involved in Langerhans cell histiocytosis. Cancer. 1995 Mar 1;75(5):1162–1166. [PubMed]
  • Broadbent V, Egeler RM, Nesbit ME., Jr Langerhans cell histiocytosis--clinical and epidemiological aspects. Br J Cancer Suppl. 1994 Sep;23:S11–S16. [PubMed]
  • Leavey P, Varughese M, Breatnach F, O'Meara A. Langerhans cell histiocytosis--a 31 year review. Ir J Med Sci. 1991 Sep;160(9):271–274. [PubMed]
  • Chen BF, Liang DC. A clinicopathological study of Langerhans cell histiocytosis. Zhonghua Yi Xue Za Zhi (Taipei). 1994 Aug;54(2):116–121. [PubMed]
  • Longaker MA, Frieden IJ, LeBoit PE, Sherertz EF. Congenital "self-healing" Langerhans cell histiocytosis: the need for long-term follow-up. J Am Acad Dermatol. 1994 Nov;31(5 Pt 2):910–916. [PubMed]
  • Goldberg-Stern H, Weitz R, Zaizov R, Gornish M, Gadoth N. Progressive spinocerebellar degeneration "plus" associated with Langerhans cell histiocytosis: a new paraneoplastic syndrome? J Neurol Neurosurg Psychiatry. 1995 Feb;58(2):180–183. [PubMed]
  • Broadbent V, Williams M, Dossetor J. Ruptured spleen as a cause of death in an infant with Langerhans cell histiocytosis (histiocytosis X). Pediatr Hematol Oncol. 1990;7(3):297–299. [PubMed]
  • Tsang WY, Lau MF, Chan JK. Incidental Langerhans' cell histiocytosis of the thyroid. Histopathology. 1994 Apr;24(4):397–399. [PubMed]
  • Montine TJ, Hollensead SC, Ellis WG, Martin JS, Moffat EJ, Burger PC. Solitary eosinophilic granuloma of the temporal lobe: a case report and long-term follow-up of previously reported cases. Clin Neuropathol. 1994 Jul–Aug;13(4):225–228. [PubMed]
  • Lam KY, Chan AC, Wat MS. Langerhans cell histiocytosis forming an asymptomatic solitary nodule in the spleen. J Clin Pathol. 1996 Mar;49(3):262–264. [PubMed]
  • Axiotis CA, Merino MJ, Duray PH. Langerhans cell histiocytosis of the female genital tract. Cancer. 1991 Mar 15;67(6):1650–1660. [PubMed]
  • Grois N, Tsunematsu Y, Barkovich AJ, Favara BE. Central nervous system disease in Langerhans cell histiocytosis. Br J Cancer Suppl. 1994 Sep;23:S24–S28. [PubMed]
  • Travis WD, Borok Z, Roum JH, Zhang J, Feuerstein I, Ferrans VJ, Crystal RG. Pulmonary Langerhans cell granulomatosis (histiocytosis X). A clinicopathologic study of 48 cases. Am J Surg Pathol. 1993 Oct;17(10):971–986. [PubMed]
  • DiMaggio LA, Lippes HA, Lee RV. Histiocytosis X and pregnancy. Obstet Gynecol. 1995 May;85(5 Pt 2):806–809. [PubMed]
  • Scherbaum WA, Seif FJ. Spontaneous transient remission of disseminated histiocytosis X during pregnancy. J Cancer Res Clin Oncol. 1995;121(1):57–60. [PubMed]
  • Broadbent V, Gadner H, Komp DM, Ladisch S. Histiocytosis syndromes in children: II. Approach to the clinical and laboratory evaluation of children with Langerhans cell histiocytosis. Clinical Writing Group of the Histiocyte Society. Med Pediatr Oncol. 1989;17(6):492–495. [PubMed]
  • Akhtar M, Ali MA, Bakry M, Sackey K, Sabbah R. Fine-needle aspiration biopsy of Langerhans histiocytosis (histiocytosis-X). Diagn Cytopathol. 1993 Oct;9(5):527–533. [PubMed]
  • Favara BE, Jaffe R. The histopathology of Langerhans cell histiocytosis. Br J Cancer Suppl. 1994 Sep;23:S17–S23. [PubMed]
  • Ben-Ezra JM, Koo CH. Langerhans' cell histiocytosis and malignancies of the M-PIRE system. Am J Clin Pathol. 1993 Apr;99(4):464–471. [PubMed]
  • Chu T, Jaffe R. The normal Langerhans cell and the LCH cell. Br J Cancer Suppl. 1994 Sep;23:S4–10. [PubMed]
  • Emile JF, Wechsler J, Brousse N, Boulland ML, Cologon R, Fraitag S, Voisin MC, Gaulard P, Boumsell L, Zafrani ES. Langerhans' cell histiocytosis. Definitive diagnosis with the use of monoclonal antibody O10 on routinely paraffin-embedded samples. Am J Surg Pathol. 1995 Jun;19(6):636–641. [PubMed]
  • Egeler RM, Neglia JP, Puccetti DM, Brennan CA, Nesbit ME. Association of Langerhans cell histiocytosis with malignant neoplasms. Cancer. 1993 Feb 1;71(3):865–873. [PubMed]
  • de Camargo B, Alves AC, Gorender EF, Bianchi A. Association of malignancy and Langerhans' cell histiocytosis: report of three cases. Med Pediatr Oncol. 1993;21(6):451–453. [PubMed]
  • Ng WK, Lam KY, Ng IO. Langerhans' cell histiocytosis: possible association with malignant germ cell tumour. J Clin Pathol. 1995 Oct;48(10):963–965. [PubMed]
  • Ladisch S, Gadner H. Treatment of Langerhans cell histiocytosis--evolution and current approaches. Br J Cancer Suppl. 1994 Sep;23:S41–S46. [PubMed]
  • Aricò M, Colella R, Conter V, Indolfi P, Pession A, Santoro N, Burgio GR. Cyclosporine therapy for refractory Langerhans cell histiocytosis. Med Pediatr Oncol. 1995 Jul;25(1):12–16. [PubMed]
  • Thomas L, Ducros B, Secchi T, Balme B, Moulin G. Successful treatment of adult's Langerhans cell histiocytosis with thalidomide. Report of two cases and literature review. Arch Dermatol. 1993 Oct;129(10):1261–1264. [PubMed]
  • Zandi P, Panis Y, Debray D, Bernard O, Houssin D. Pediatric liver transplantation for Langerhans' cell histiocytosis. Hepatology. 1995 Jan;21(1):129–133. [PubMed]
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