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Bull World Health Organ. 1971; 45(4): 457–464.
PMCID: PMC2427941

Studies on vaccination against bacillary dysentery*

6. Protection of children by oral immunization with streptomycin-dependent Shigella strains

Abstract

A field trial of oral streptomycin-dependent mutant Shigella vaccines in five hyperendemic areas of Yugoslavia in 1969 confirmed the findings of earlier studies by demonstrating the effectiveness of these vaccines against dysentery. For the first time, a high degree of protection was demonstrated in children. The vaccines induced serotype-specific immunity against Shigella flexneri 1 and 2a and S. sonnei. Postvaccinal reactions were minor and consisted of vomiting or diarrhoea, or both, in a small proportion of children within several hours of the administration of the vaccine. These reactions, seen mainly after the first dose, were dose-dependent and could be decreased by reducing the number of live organisms. Reactions to subsequent doses were much fewer. Pretreatment with sodium bicarbonate was necessary. Under the conditions of this study, the vaccines proved to be stable with no evidence of reversion of the mutant strains to the virulent parent.

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Selected References

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  • Kostrzewski J, Stypulkowska-Misiurewicz Changes in the epidemiology of dysentery in Poland and the situation in Europe. Arch Immunol Ther Exp (Warsz) 1968;16(3):429–451. [PubMed]
  • Linde K, Koch H. Untersuchungen zur oralen Immunisierung gegen Coli-Enteritis mit Streptomycin-dependenten Coli-Keimen. 3. Vergleich der Wirksankeit von Impfstoffen aus abgetöteten und lebenden Streptomycin-dependenten EC-O111 B4-Bakterien im aktiven Mäuse-schutzversuch sowie auf die Hemmung der Ansiedlung des homologen Streptomycin-resistenten Stammes bei "darmsteilen" Mäusen. Zentralbl Bakteriol Orig. 1969;211(4):476–485. [PubMed]
  • Mel DM, Arsić BL, Nikolić BD, Radovanić ML. Studies on vaccination against bacillary dysentery. 4. Oral immunization with live monotypic and combined vaccines. Bull World Health Organ. 1968;39(3):375–380. [PMC free article] [PubMed]
  • Mel DM, Papo RG, Terzin AL, Vuksić L. Studies on vaccination against bacillary dysentery. 2. Safety tests and reactogenicity studies on a live dysentery vaccine intended for use in field trials. Bull World Health Organ. 1965;32(5):637–645. [PMC free article] [PubMed]
  • Mel DM, Terzin AL, Vuksić L. Studies on vaccination against bacillary dysentery. 3. Effective oral immunization against Shigella flexneri 2a in a field trial. Bull World Health Organ. 1965;32(5):647–655. [PMC free article] [PubMed]

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