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Microbiol Rev. Sep 1995; 59(3): 423–450.
PMCID: PMC239368

mRNA stability in mammalian cells.

Abstract

This review concerns how cytoplasmic mRNA half-lives are regulated and how mRNA decay rates influence gene expression. mRNA stability influences gene expression in virtually all organisms, from bacteria to mammals, and the abundance of a particular mRNA can fluctuate manyfold following a change in the mRNA half-life, without any change in transcription. The processes that regulate mRNA half-lives can, in turn, affect how cells grow, differentiate, and respond to their environment. Three major questions are addressed. Which sequences in mRNAs determine their half-lives? Which enzymes degrade mRNAs? Which (trans-acting) factors regulate mRNA stability, and how do they function? The following specific topics are discussed: techniques for measuring eukaryotic mRNA stability and for calculating decay constants, mRNA decay pathways, mRNases, proteins that bind to sequences shared among many mRNAs [like poly(A)- and AU-rich-binding proteins] and proteins that bind to specific mRNAs (like the c-myc coding-region determinant-binding protein), how environmental factors like hormones and growth factors affect mRNA stability, and how translation and mRNA stability are linked. Some perspectives and predictions for future research directions are summarized at the end.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Adamou J, Bag J. Alteration of translation and stability of mRNA for the poly(A)-binding protein during myogenesis. Eur J Biochem. 1992 Nov 1;209(3):803–812. [PubMed]
  • Adams CC, Stern DB. Control of mRNA stability in chloroplasts by 3' inverted repeats: effects of stem and loop mutations on degradation of psbA mRNA in vitro. Nucleic Acids Res. 1990 Oct 25;18(20):6003–6010. [PMC free article] [PubMed]
  • Adhya S, Gottesman M. Control of transcription termination. Annu Rev Biochem. 1978;47:967–996. [PubMed]
  • Aharon T, Schneider RJ. Selective destabilization of short-lived mRNAs with the granulocyte-macrophage colony-stimulating factor AU-rich 3' noncoding region is mediated by a cotranslational mechanism. Mol Cell Biol. 1993 Mar;13(3):1971–1980. [PMC free article] [PubMed]
  • Aida K, Negishi M. Posttranscriptional regulation of coumarin 7-hydroxylase induction by xenobiotics in mouse liver: mRNA stabilization by pyrazole. Biochemistry. 1991 Aug 13;30(32):8041–8045. [PubMed]
  • Akashi M, Hachiya M, Koeffler HP, Suzuki G. Irradiation increases levels of GM-CSF through RNA stabilization which requires an AU-rich region in cancer cells. Biochem Biophys Res Commun. 1992 Dec 15;189(2):986–993. [PubMed]
  • Alberta JA, Rundell K, Stiles CD. Identification of an activity that interacts with the 3'-untranslated region of c-myc mRNA and the role of its target sequence in mediating rapid mRNA degradation. J Biol Chem. 1994 Feb 11;269(6):4532–4538. [PubMed]
  • Almendral JM, Sommer D, Macdonald-Bravo H, Burckhardt J, Perera J, Bravo R. Complexity of the early genetic response to growth factors in mouse fibroblasts. Mol Cell Biol. 1988 May;8(5):2140–2148. [PMC free article] [PubMed]
  • Alterman RB, Ganguly S, Schulze DH, Marzluff WF, Schildkraut CL, Skoultchi AI. Cell cycle regulation of mouse H3 histone mRNA metabolism. Mol Cell Biol. 1984 Jan;4(1):123–132. [PMC free article] [PubMed]
  • Altus MS, Nagamine Y. Protein synthesis inhibition stabilizes urokinase-type plasminogen activator mRNA. Studies in vivo and in cell-free decay reactions. J Biol Chem. 1991 Nov 5;266(31):21190–21196. [PubMed]
  • Amara FM, Chen FY, Wright JA. A novel transforming growth factor-beta 1 responsive cytoplasmic trans-acting factor binds selectively to the 3'-untranslated region of mammalian ribonucleotide reductase R2 mRNA: role in message stability. Nucleic Acids Res. 1993 Oct 11;21(20):4803–4809. [PMC free article] [PubMed]
  • Amara FM, Chen FY, Wright JA. Phorbol ester modulation of a novel cytoplasmic protein binding activity at the 3'-untranslated region of mammalian ribonucleotide reductase R2 mRNA and role in message stability. J Biol Chem. 1994 Mar 4;269(9):6709–6715. [PubMed]
  • Amara JF, Lodish HF. Specific mRNA destabilization in Dictyostelium discoideum requires RNA synthesis. Mol Cell Biol. 1987 Dec;7(12):4585–4588. [PMC free article] [PubMed]
  • Aström J, Aström A, Virtanen A. In vitro deadenylation of mammalian mRNA by a HeLa cell 3' exonuclease. EMBO J. 1991 Oct;10(10):3067–3071. [PMC free article] [PubMed]
  • Aström J, Aström A, Virtanen A. Properties of a HeLa cell 3' exonuclease specific for degrading poly(A) tails of mammalian mRNA. J Biol Chem. 1992 Sep 5;267(25):18154–18159. [PubMed]
  • Bachurski CJ, Theodorakis NG, Coulson RM, Cleveland DW. An amino-terminal tetrapeptide specifies cotranslational degradation of beta-tubulin but not alpha-tubulin mRNAs. Mol Cell Biol. 1994 Jun;14(6):4076–4086. [PMC free article] [PubMed]
  • Bagby GC, Jr, Heinrich MC. Vascular endothelial cells and hematopoiesis: regulation of gene expression in human vascular endothelial cells. Hematol Pathol. 1991;5(3):93–99. [PubMed]
  • Baglioni C, De Benedetti A, Williams GJ. Cleavage of nascent reovirus mRNA by localized activation of the 2'-5'-oligoadenylate-dependent endoribonuclease. J Virol. 1984 Dec;52(3):865–871. [PMC free article] [PubMed]
  • Bakker O, Arnberg AC, Noteborn MH, Winter AJ, Ab G. Turnover products of the apo very low density lipoprotein II messenger RNA from chicken liver. Nucleic Acids Res. 1988 Nov 11;16(21):10109–10118. [PMC free article] [PubMed]
  • Bandyopadhyay R, Coutts M, Krowczynska A, Brawerman G. Nuclease activity associated with mammalian mRNA in its native state: possible basis for selectivity in mRNA decay. Mol Cell Biol. 1990 May;10(5):2060–2069. [PMC free article] [PubMed]
  • Bastos RN, Aviv H. Theoretical analysis of a model for globin messenger RNA accumulation during erythropoiesis. J Mol Biol. 1977 Feb 25;110(2):205–218. [PubMed]
  • Bastos RN, Volloch Z, Aviv H. Messenger RNA population analysis during erythroid differentiation: a kinetical approach. J Mol Biol. 1977 Feb 25;110(2):191–203. [PubMed]
  • Baumbach LL, Stein GS, Stein JL. Regulation of human histone gene expression: transcriptional and posttranscriptional control in the coupling of histone messenger RNA stability with DNA replication. Biochemistry. 1987 Sep 22;26(19):6178–6187. [PubMed]
  • Beach LR, Ross J. Cordycepin. An inhibitor of newly synthesized globin messenger RNA. J Biol Chem. 1978 Apr 25;253(8):2628–2632. [PubMed]
  • Becker Y, Tavor E, Asher Y, Berkowitz C, Moyal M. Effect of herpes simplex virus type-1 UL41 gene on the stability of mRNA from the cellular genes: beta-actin, fibronectin, glucose transporter-1, and docking protein, and on virus intraperitoneal pathogenicity to newborn mice. Virus Genes. 1993 Jun;7(2):133–143. [PubMed]
  • Beelman CA, Parker R. Differential effects of translational inhibition in cis and in trans on the decay of the unstable yeast MFA2 mRNA. J Biol Chem. 1994 Apr 1;269(13):9687–9692. [PubMed]
  • Belgrader P, Cheng J, Maquat LE. Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):482–486. [PMC free article] [PubMed]
  • Belgrader P, Cheng J, Zhou X, Stephenson LS, Maquat LE. Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life. Mol Cell Biol. 1994 Dec;14(12):8219–8228. [PMC free article] [PubMed]
  • Bernstein P, Peltz SW, Ross J. The poly(A)-poly(A)-binding protein complex is a major determinant of mRNA stability in vitro. Mol Cell Biol. 1989 Feb;9(2):659–670. [PMC free article] [PubMed]
  • Bernstein P, Ross J. Poly(A), poly(A) binding protein and the regulation of mRNA stability. Trends Biochem Sci. 1989 Sep;14(9):373–377. [PubMed]
  • Bernstein PL, Herrick DJ, Prokipcak RD, Ross J. Control of c-myc mRNA half-life in vitro by a protein capable of binding to a coding region stability determinant. Genes Dev. 1992 Apr;6(4):642–654. [PubMed]
  • Binder R, Horowitz JA, Basilion JP, Koeller DM, Klausner RD, Harford JB. Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3' UTR and does not involve poly(A) tail shortening. EMBO J. 1994 Apr 15;13(8):1969–1980. [PMC free article] [PubMed]
  • Binder R, Hwang SP, Ratnasabapathy R, Williams DL. Degradation of apolipoprotein II mRNA occurs via endonucleolytic cleavage at 5'-AAU-3'/5'-UAA-3' elements in single-stranded loop domains of the 3'-noncoding region. J Biol Chem. 1989 Oct 5;264(28):16910–16918. [PubMed]
  • Blobel GA, Hanafusa H. The v-src inducible gene 9E3/pCEF4 is regulated by both its promoter upstream sequence and its 3' untranslated region. Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1162–1166. [PMC free article] [PubMed]
  • Blume JE, Shapiro DJ. Ribosome loading, but not protein synthesis, is required for estrogen stabilization of Xenopus laevis vitellogenin mRNA. Nucleic Acids Res. 1989 Nov 25;17(22):9003–9014. [PMC free article] [PubMed]
  • Boggaram V, John ME, Simpson ER, Waterman MR. Effect of ACTH on the stability of mRNAs encoding bovine adrenocortical P-450scc, P-45011 beta, P-45017 alpha, P-450C21 and adrenodoxin. Biochem Biophys Res Commun. 1989 May 15;160(3):1227–1232. [PubMed]
  • Bohjanen PR, Petryniak B, June CH, Thompson CB, Lindsten T. An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA. Mol Cell Biol. 1991 Jun;11(6):3288–3295. [PMC free article] [PubMed]
  • Bohjanen PR, Petryniak B, June CH, Thompson CB, Lindsten T. AU RNA-binding factors differ in their binding specificities and affinities. J Biol Chem. 1992 Mar 25;267(9):6302–6309. [PubMed]
  • Bonnieu A, Piechaczyk M, Marty L, Cuny M, Blanchard JM, Fort P, Jeanteur P. Sequence determinants of c-myc mRNA turn-over: influence of 3' and 5' non-coding regions. Oncogene Res. 1988 Sep;3(2):155–166. [PubMed]
  • Bonnieu A, Roux P, Marty L, Jeanteur P, Piechaczyk M. AUUUA motifs are dispensable for rapid degradation of the mouse c-myc RNA. Oncogene. 1990 Oct;5(10):1585–1588. [PubMed]
  • Bouvet P, Paris J, Phillippe M, Osborne HB. Degradation of a developmentally regulated mRNA in Xenopus embryos is controlled by the 3' region and requires the translation of another maternal mRNA. Mol Cell Biol. 1991 Jun;11(6):3115–3124. [PMC free article] [PubMed]
  • Brand K, Fowler BJ, Edgington TS, Mackman N. Tissue factor mRNA in THP-1 monocytic cells is regulated at both transcriptional and posttranscriptional levels in response to lipopolysaccharide. Mol Cell Biol. 1991 Sep;11(9):4732–4738. [PMC free article] [PubMed]
  • Brewer G. An A + U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro. Mol Cell Biol. 1991 May;11(5):2460–2466. [PMC free article] [PubMed]
  • Brewer G, Ross J. Poly(A) shortening and degradation of the 3' A+U-rich sequences of human c-myc mRNA in a cell-free system. Mol Cell Biol. 1988 Apr;8(4):1697–1708. [PMC free article] [PubMed]
  • Brewer G, Ross J. Regulation of c-myc mRNA stability in vitro by a labile destabilizer with an essential nucleic acid component. Mol Cell Biol. 1989 May;9(5):1996–2006. [PMC free article] [PubMed]
  • Brock ML, Shapiro DJ. Estrogen stabilizes vitellogenin mRNA against cytoplasmic degradation. Cell. 1983 Aug;34(1):207–214. [PubMed]
  • Brown BD, Harland RM. Endonucleolytic cleavage of a maternal homeo box mRNA in Xenopus oocytes. Genes Dev. 1990 Nov;4(11):1925–1935. [PubMed]
  • Brown BD, Zipkin ID, Harland RM. Sequence-specific endonucleolytic cleavage and protection of mRNA in Xenopus and Drosophila. Genes Dev. 1993 Aug;7(8):1620–1631. [PubMed]
  • Burd CG, Dreyfuss G. Conserved structures and diversity of functions of RNA-binding proteins. Science. 1994 Jul 29;265(5172):615–621. [PubMed]
  • Capasso O, Bleecker GC, Heintz N. Sequences controlling histone H4 mRNA abundance. EMBO J. 1987 Jun;6(6):1825–1831. [PMC free article] [PubMed]
  • Caput D, Beutler B, Hartog K, Thayer R, Brown-Shimer S, Cerami A. Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators. Proc Natl Acad Sci U S A. 1986 Mar;83(6):1670–1674. [PMC free article] [PubMed]
  • Caron JM, Jones AL, Rall LB, Kirschner MW. Autoregulation of tubulin synthesis in enucleated cells. Nature. 1985 Oct 17;317(6038):648–651. [PubMed]
  • Caruccio N, Ross J. Purification of a human polyribosome-associated 3' to 5' exoribonuclease. J Biol Chem. 1994 Dec 16;269(50):31814–31821. [PubMed]
  • Casey JL, Koeller DM, Ramin VC, Klausner RD, Harford JB. Iron regulation of transferrin receptor mRNA levels requires iron-responsive elements and a rapid turnover determinant in the 3' untranslated region of the mRNA. EMBO J. 1989 Dec 1;8(12):3693–3699. [PMC free article] [PubMed]
  • Chalbos D, Galtier F, Emiliani S, Rochefort H. The anti-progestin RU486 stabilizes the progestin-induced fatty acid synthetase mRNA but does not stimulate its transcription. J Biol Chem. 1991 May 5;266(13):8220–8224. [PubMed]
  • Chandrasekhar A, Rotman M, Kraft B, Soll DR. Developmental mechanisms regulating the rapid decrease in a cohesion glycoprotein mRNA in Dictyostelium function primarily at the level of mRNA degradation. Dev Biol. 1990 Oct;141(2):262–269. [PubMed]
  • Chang JC, Temple GF, Trecartin RF, Kan YW. Suppression of the nonsense mutation in homozygous beta 0 thalassaemia. Nature. 1979 Oct 18;281(5732):602–603. [PubMed]
  • Chen CY, Chen TM, Shyu AB. Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function. Mol Cell Biol. 1994 Jan;14(1):416–426. [PMC free article] [PubMed]
  • Chen CY, You Y, Shyu AB. Two cellular proteins bind specifically to a purine-rich sequence necessary for the destabilization function of a c-fos protein-coding region determinant of mRNA instability. Mol Cell Biol. 1992 Dec;12(12):5748–5757. [PMC free article] [PubMed]
  • Chen CY, Shyu AB. Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements. Mol Cell Biol. 1994 Dec;14(12):8471–8482. [PMC free article] [PubMed]
  • Chen FY, Amara FM, Wright JA. Mammalian ribonucleotide reductase R1 mRNA stability under normal and phorbol ester stimulating conditions: involvement of a cis-trans interaction at the 3' untranslated region. EMBO J. 1993 Oct;12(10):3977–3986. [PMC free article] [PubMed]
  • Chen FY, Amara FM, Wright JA. Defining a novel ribonucleotide reductase r1 mRNA cis element that binds to an unique cytoplasmic trans-acting protein. Nucleic Acids Res. 1994 Nov 11;22(22):4796–4797. [PMC free article] [PubMed]
  • Chen FY, Amara FM, Wright JA. Regulation of mammalian ribonucleotide reductase R1 mRNA stability is mediated by a ribonucleotide reductase R1 mRNA 3'-untranslated region cis-trans interaction through a protein kinase C-controlled pathway. Biochem J. 1994 Aug 15;302(Pt 1):125–132. [PMC free article] [PubMed]
  • Chen Y, Weeks J, Mortin MA, Greenleaf AL. Mapping mutations in genes encoding the two large subunits of Drosophila RNA polymerase II defines domains essential for basic transcription functions and for proper expression of developmental genes. Mol Cell Biol. 1993 Jul;13(7):4214–4222. [PMC free article] [PubMed]
  • Cheng J, Fogel-Petrovic M, Maquat LE. Translation to near the distal end of the penultimate exon is required for normal levels of spliced triosephosphate isomerase mRNA. Mol Cell Biol. 1990 Oct;10(10):5215–5225. [PMC free article] [PubMed]
  • Cheng J, Maquat LE. Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA. Mol Cell Biol. 1993 Mar;13(3):1892–1902. [PMC free article] [PubMed]
  • Choi JK, Holtzer S, Chacko SA, Lin ZX, Hoffman RK, Holtzer H. Phorbol esters selectively and reversibly inhibit a subset of myofibrillar genes responsible for the ongoing differentiation program of chick skeletal myotubes. Mol Cell Biol. 1991 Sep;11(9):4473–4482. [PMC free article] [PubMed]
  • Chu E, Koeller DM, Casey JL, Drake JC, Chabner BA, Elwood PC, Zinn S, Allegra CJ. Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):8977–8981. [PMC free article] [PubMed]
  • Chu E, Takechi T, Jones KL, Voeller DM, Copur SM, Maley GF, Maley F, Segal S, Allegra CJ. Thymidylate synthase binds to c-myc RNA in human colon cancer cells and in vitro. Mol Cell Biol. 1995 Jan;15(1):179–185. [PMC free article] [PubMed]
  • Chu E, Voeller DM, Jones KL, Takechi T, Maley GF, Maley F, Segal S, Allegra CJ. Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells. Mol Cell Biol. 1994 Jan;14(1):207–213. [PMC free article] [PubMed]
  • Chu E, Voeller D, Koeller DM, Drake JC, Takimoto CH, Maley GF, Maley F, Allegra CJ. Identification of an RNA binding site for human thymidylate synthase. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):517–521. [PMC free article] [PubMed]
  • Clerch LB, Iqbal J, Massaro D. Perinatal rat lung catalase gene expression: influence of corticosteroid and hyperoxia. Am J Physiol. 1991 Jun;260(6 Pt 1):L428–L433. [PubMed]
  • Clerch LB, Massaro D. Oxidation-reduction-sensitive binding of lung protein to rat catalase mRNA. J Biol Chem. 1992 Feb 15;267(5):2853–2855. [PubMed]
  • Cleveland DW, Havercroft JC. Is apparent autoregulatory control of tubulin synthesis nontranscriptionally regulated? J Cell Biol. 1983 Sep;97(3):919–924. [PMC free article] [PubMed]
  • Cleveland DW, Lopata MA, Sherline P, Kirschner MW. Unpolymerized tubulin modulates the level of tubulin mRNAs. Cell. 1981 Aug;25(2):537–546. [PubMed]
  • Cleveland DW, Pittenger MF, Feramisco JR. Elevation of tubulin levels by microinjection suppresses new tubulin synthesis. Nature. 1983 Oct 20;305(5936):738–740. [PubMed]
  • Cleveland DW, Yen TJ. Multiple determinants of eukaryotic mRNA stability. New Biol. 1989 Nov;1(2):121–126. [PubMed]
  • Cochrane A, Deeley RG. Detection and characterization of degradative intermediates of avian apo very low density lipoprotein II mRNA present in estrogen-treated birds and following destabilization by hormone withdrawal. J Biol Chem. 1989 Apr 15;264(11):6495–6503. [PubMed]
  • Cochrane AW, Deeley RG. Estrogen-dependent activation of the avian very low density apolipoprotein II and vitellogenin genes. Transient alterations in mRNA polyadenylation and stability early during induction. J Mol Biol. 1988 Oct 5;203(3):555–567. [PubMed]
  • Cole MD. The myc oncogene: its role in transformation and differentiation. Annu Rev Genet. 1986;20:361–384. [PubMed]
  • Collins S, Bouvier M, Bolanowski MA, Caron MG, Lefkowitz RJ. cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure. Proc Natl Acad Sci U S A. 1989 Jul;86(13):4853–4857. [PMC free article] [PubMed]
  • Constable A, Quick S, Gray NK, Hentze MW. Modulation of the RNA-binding activity of a regulatory protein by iron in vitro: switching between enzymatic and genetic function? Proc Natl Acad Sci U S A. 1992 May 15;89(10):4554–4558. [PMC free article] [PubMed]
  • Coutts M, Brawerman G. A 5' exoribonuclease from cytoplasmic extracts of mouse sarcoma 180 ascites cells. Biochim Biophys Acta. 1993 Apr 29;1173(1):57–62. [PubMed]
  • Coutts M, Krowczynska A, Brawerman G. Protection of mRNA against nucleases in cytoplasmic extracts of mouse sarcoma ascites cells. Biochim Biophys Acta. 1993 Apr 29;1173(1):49–56. [PubMed]
  • Cremer K, Schlessinger D. Ca2+ ions inhibit messenger ribonucleic acid degradation, but permit messenger ribonucleic acid transcription and translation in deoxyribonucleic acid-coupled systems from Escherichia coli. J Biol Chem. 1974 Aug 10;249(15):4730–4736. [PubMed]
  • Cremer K, Silengo L, Schlessinger D. Polypeptide formation and polyribosomes in Escherichia coli treated with chloramphenicol. J Bacteriol. 1974 May;118(2):582–589. [PMC free article] [PubMed]
  • Crossman DC, Carr DP, Tuddenham EG, Pearson JD, McVey JH. The regulation of tissue factor mRNA in human endothelial cells in response to endotoxin or phorbol ester. J Biol Chem. 1990 Jun 15;265(17):9782–9787. [PubMed]
  • Czyzyk-Krzeska MF, Dominski Z, Kole R, Millhorn DE. Hypoxia stimulates binding of a cytoplasmic protein to a pyrimidine-rich sequence in the 3'-untranslated region of rat tyrosine hydroxylase mRNA. J Biol Chem. 1994 Apr 1;269(13):9940–9945. [PubMed]
  • Czyzyk-Krzeska MF, Furnari BA, Lawson EE, Millhorn DE. Hypoxia increases rate of transcription and stability of tyrosine hydroxylase mRNA in pheochromocytoma (PC12) cells. J Biol Chem. 1994 Jan 7;269(1):760–764. [PubMed]
  • Daar IO, Maquat LE. Premature translation termination mediates triosephosphate isomerase mRNA degradation. Mol Cell Biol. 1988 Feb;8(2):802–813. [PMC free article] [PubMed]
  • Dani C, Blanchard JM, Piechaczyk M, El Sabouty S, Marty L, Jeanteur P. Extreme instability of myc mRNA in normal and transformed human cells. Proc Natl Acad Sci U S A. 1984 Nov;81(22):7046–7050. [PMC free article] [PubMed]
  • Dean DC, Newby RF, Bourgeois S. Regulation of fibronectin biosynthesis by dexamethasone, transforming growth factor beta, and cAMP in human cell lines. J Cell Biol. 1988 Jun;106(6):2159–2170. [PMC free article] [PubMed]
  • Decker CJ, Parker R. A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation. Genes Dev. 1993 Aug;7(8):1632–1643. [PubMed]
  • Decker CJ, Parker R. Mechanisms of mRNA degradation in eukaryotes. Trends Biochem Sci. 1994 Aug;19(8):336–340. [PubMed]
  • Dietz HC, Kendzior RJ., Jr Maintenance of an open reading frame as an additional level of scrutiny during splice site selection. Nat Genet. 1994 Oct;8(2):183–188. [PubMed]
  • Dellavalle RP, Petersen R, Lindquist S. Preferential deadenylation of Hsp70 mRNA plays a key role in regulating Hsp70 expression in Drosophila melanogaster. Mol Cell Biol. 1994 Jun;14(6):3646–3659. [PMC free article] [PubMed]
  • Dhawan J, Lichtler AC, Rowe DW, Farmer SR. Cell adhesion regulates pro-alpha 1(I) collagen mRNA stability and transcription in mouse fibroblasts. J Biol Chem. 1991 May 5;266(13):8470–8475. [PubMed]
  • DiDomenico BJ, Bugaisky GE, Lindquist S. The heat shock response is self-regulated at both the transcriptional and posttranscriptional levels. Cell. 1982 Dec;31(3 Pt 2):593–603. [PubMed]
  • Dodson RE, Shapiro DJ. An estrogen-inducible protein binds specifically to a sequence in the 3' untranslated region of estrogen-stabilized vitellogenin mRNA. Mol Cell Biol. 1994 May;14(5):3130–3138. [PMC free article] [PubMed]
  • Dompenciel RE, Garnepudi VR, Schoenberg DR. Purification and characterization of an estrogen-regulated Xenopus liver polysomal nuclease involved in the selective destabilization of albumin mRNA. J Biol Chem. 1995 Mar 17;270(11):6108–6118. [PubMed]
  • Dozin B, Quarto R, Rossi F, Cancedda R. Stabilization of the mRNA follows transcriptional activation of type II collagen gene in differentiating chicken chondrocyte. J Biol Chem. 1990 May 5;265(13):7216–7220. [PubMed]
  • Duval C, Bouvet P, Omilli F, Roghi C, Dorel C, LeGuellec R, Paris J, Osborne HB. Stability of maternal mRNA in Xenopus embryos: role of transcription and translation. Mol Cell Biol. 1990 Aug;10(8):4123–4129. [PMC free article] [PubMed]
  • Eckner R, Birnstiel ML. Evolutionary conserved multiprotein complexes interact with the 3' untranslated region of histone transcripts. Nucleic Acids Res. 1992 Mar 11;20(5):1023–1030. [PMC free article] [PubMed]
  • Edgar BA, Weir MP, Schubiger G, Kornberg T. Repression and turnover pattern fushi tarazu RNA in the early Drosophila embryo. Cell. 1986 Dec 5;47(5):747–754. [PubMed]
  • Ernest MJ. Regulation of tyrosine aminotransferase messenger ribonucleic acid in rat liver. effect of cycloheximide on messenger ribonucleic acid turnover. Biochemistry. 1982 Dec 21;21(26):6761–6767. [PubMed]
  • Ernst TJ, Ritchie AR, Demetri GD, Griffin JD. Regulation of granulocyte- and monocyte-colony stimulating factor mRNA levels in human blood monocytes is mediated primarily at a post-transcriptional level. J Biol Chem. 1989 Apr 5;264(10):5700–5703. [PubMed]
  • Fazzone H, Wangner A, Clerch LB. Rat lung contains a developmentally regulated manganese superoxide dismutase mRNA-binding protein. J Clin Invest. 1993 Sep;92(3):1278–1281. [PMC free article] [PubMed]
  • Fenwick ML, Everett RD. Inactivation of the shutoff gene (UL41) of herpes simplex virus types 1 and 2. J Gen Virol. 1990 Dec;71(Pt 12):2961–2967. [PubMed]
  • Flores-Riveros JR, McLenithan JC, Ezaki O, Lane MD. Insulin down-regulates expression of the insulin-responsive glucose transporter (GLUT4) gene: effects on transcription and mRNA turnover. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):512–516. [PMC free article] [PubMed]
  • Fort P, Rech J, Vie A, Piechaczyk M, Bonnieu A, Jeanteur P, Blanchard JM. Regulation of c-fos gene expression in hamster fibroblasts: initiation and elongation of transcription and mRNA degradation. Nucleic Acids Res. 1987 Jul 24;15(14):5657–5667. [PMC free article] [PubMed]
  • Fuentes ME, Taylor P. Control of acetylcholinesterase gene expression during myogenesis. Neuron. 1993 Apr;10(4):679–687. [PubMed]
  • Furth PA, St Onge L, Böger H, Gruss P, Gossen M, Kistner A, Bujard H, Hennighausen L. Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9302–9306. [PMC free article] [PubMed]
  • Furuichi Y, LaFiandra A, Shatkin AJ. 5'-Terminal structure and mRNA stability. Nature. 1977 Mar 17;266(5599):235–239. [PubMed]
  • Gay DA, Sisodia SS, Cleveland DW. Autoregulatory control of beta-tubulin mRNA stability is linked to translation elongation. Proc Natl Acad Sci U S A. 1989 Aug;86(15):5763–5767. [PMC free article] [PubMed]
  • Geoghegan TE, McCoy L. Biogenesis and cell cycle relationship of poly(A)- actin mRNA in mouse ascites cells. Exp Cell Res. 1986 Jan;162(1):175–182. [PubMed]
  • Goldberg MA, Gaut CC, Bunn HF. Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events. Blood. 1991 Jan 15;77(2):271–277. [PubMed]
  • Gordon DA, Shelness GS, Nicosia M, Williams DL. Estrogen-induced destabilization of yolk precursor protein mRNAs in avian liver. J Biol Chem. 1988 Feb 25;263(6):2625–2631. [PubMed]
  • Görlach M, Burd CG, Dreyfuss G. The mRNA poly(A)-binding protein: localization, abundance, and RNA-binding specificity. Exp Cell Res. 1994 Apr;211(2):400–407. [PubMed]
  • Gorospe M, Baglioni C. Degradation of unstable interleukin-1 alpha mRNA in a rabbit reticulocyte cell-free system. Localization of an instability determinant to a cluster of AUUUA motifs. J Biol Chem. 1994 Apr 22;269(16):11845–11851. [PubMed]
  • Gorospe M, Kumar S, Baglioni C. Tumor necrosis factor increases stability of interleukin-1 mRNA by activating protein kinase C. J Biol Chem. 1993 Mar 25;268(9):6214–6220. [PubMed]
  • Gossen M, Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5547–5551. [PMC free article] [PubMed]
  • Grafi G, Sela I, Galili G. Translational regulation of human beta interferon mRNA: association of the 3' AU-rich sequence with the poly(A) tail reduces translation efficiency in vitro. Mol Cell Biol. 1993 Jun;13(6):3487–3493. [PMC free article] [PubMed]
  • Graves RA, Pandey NB, Chodchoy N, Marzluff WF. Translation is required for regulation of histone mRNA degradation. Cell. 1987 Feb 27;48(4):615–626. [PubMed]
  • Greenberg JR. High stability of messenger RNA in growing cultured cells. Nature. 1972 Nov 10;240(5376):102–104. [PubMed]
  • Greenberg ME, Ziff EB. Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature. 1984 Oct 4;311(5985):433–438. [PubMed]
  • Gruissem W, Barkan A, Deng XW, Stern D. Transcriptional and post-transcriptional control of plastid mRNA levels in higher plants. Trends Genet. 1988 Sep;4(9):258–263. [PubMed]
  • Hämäläinen L, Oikarinen J, Kivirikko KI. Synthesis and degradation of type I procollagen mRNAs in cultured human skin fibroblasts and the effect of cortisol. J Biol Chem. 1985 Jan 25;260(2):720–725. [PubMed]
  • Hargrove JL, Hulsey MG, Beale EG. The kinetics of mammalian gene expression. Bioessays. 1991 Dec;13(12):667–674. [PubMed]
  • Hargrove JL, Hulsey MG, Summers AO. From genotype to phenotype: computer-based modeling of gene expression with STELLA II. Biotechniques. 1993 Dec;15(6):1096–1101. [PubMed]
  • Hargrove JL, Schmidt FH. The role of mRNA and protein stability in gene expression. FASEB J. 1989 Oct;3(12):2360–2370. [PubMed]
  • Harland R, Misher L. Stability of RNA in developing Xenopus embryos and identification of a destabilizing sequence in TFIIIA messenger RNA. Development. 1988 Apr;102(4):837–852. [PubMed]
  • Harris ME, Böhni R, Schneiderman MH, Ramamurthy L, Schümperli D, Marzluff WF. Regulation of histone mRNA in the unperturbed cell cycle: evidence suggesting control at two posttranscriptional steps. Mol Cell Biol. 1991 May;11(5):2416–2424. [PMC free article] [PubMed]
  • Harrold S, Genovese C, Kobrin B, Morrison SL, Milcarek C. A comparison of apparent mRNA half-life using kinetic labeling techniques vs decay following administration of transcriptional inhibitors. Anal Biochem. 1991 Oct;198(1):19–29. [PubMed]
  • Hayward LJ, Zhu YY, Schwartz RJ. Cellular localization of muscle and nonmuscle actin mRNAs in chicken primary myogenic cultures: the induction of alpha-skeletal actin mRNA is regulated independently of alpha-cardiac actin gene expression. J Cell Biol. 1988 Jun;106(6):2077–2086. [PMC free article] [PubMed]
  • He F, Peltz SW, Donahue JL, Rosbash M, Jacobson A. Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7034–7038. [PMC free article] [PubMed]
  • Heintz N, Sive HL, Roeder RG. Regulation of human histone gene expression: kinetics of accumulation and changes in the rate of synthesis and in the half-lives of individual histone mRNAs during the HeLa cell cycle. Mol Cell Biol. 1983 Apr;3(4):539–550. [PMC free article] [PubMed]
  • Helms SR, Rottman FM. Characterization of an inducible promoter system to investigate decay of stable mRNA molecules. Nucleic Acids Res. 1990 Jan 25;18(2):255–259. [PMC free article] [PubMed]
  • Henics T, Sanfridson A, Hamilton BJ, Nagy E, Rigby WF. Enhanced stability of interleukin-2 mRNA in MLA 144 cells. Possible role of cytoplasmic AU-rich sequence-binding proteins. J Biol Chem. 1994 Feb 18;269(7):5377–5383. [PubMed]
  • Hentze MW. Enzymes as RNA-binding proteins: a role for (di)nucleotide-binding domains? Trends Biochem Sci. 1994 Mar;19(3):101–103. [PubMed]
  • Hentze MW, Argos P. Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase. Nucleic Acids Res. 1991 Apr 25;19(8):1739–1740. [PMC free article] [PubMed]
  • Hepler JE, Van Wyk JJ, Lund PK. Different half-lives of insulin-like growth factor I mRNAs that differ in length of 3' untranslated sequence. Endocrinology. 1990 Sep;127(3):1550–1552. [PubMed]
  • Herrick DJ, Ross J. The half-life of c-myc mRNA in growing and serum-stimulated cells: influence of the coding and 3' untranslated regions and role of ribosome translocation. Mol Cell Biol. 1994 Mar;14(3):2119–2128. [PMC free article] [PubMed]
  • Hesketh J, Campbell G, Piechaczyk M, Blanchard JM. Targeting of c-myc and beta-globin coding sequences to cytoskeletal-bound polysomes by c-myc 3' untranslated region. Biochem J. 1994 Feb 15;298(Pt 1):143–148. [PMC free article] [PubMed]
  • Hildebrandt M, Nellen W. Differential antisense transcription from the Dictyostelium EB4 gene locus: implications on antisense-mediated regulation of mRNA stability. Cell. 1992 Apr 3;69(1):197–204. [PubMed]
  • Hoffmann I, Birnstiel ML. Cell cycle-dependent regulation of histone precursor mRNA processing by modulation of U7 snRNA accessibility. Nature. 1990 Aug 16;346(6285):665–668. [PubMed]
  • Hsu CL, Stevens A. Yeast cells lacking 5'-->3' exoribonuclease 1 contain mRNA species that are poly(A) deficient and partially lack the 5' cap structure. Mol Cell Biol. 1993 Aug;13(8):4826–4835. [PMC free article] [PubMed]
  • Hua J, Garner R, Paetkau V. An RNasin-resistant ribonuclease selective for interleukin 2 mRNA. Nucleic Acids Res. 1993 Jan 11;21(1):155–162. [PMC free article] [PubMed]
  • Humphries RK, Ley TJ, Anagnou NP, Baur AW, Nienhuis AW. Beta O-39 thalassemia gene: a premature termination codon causes beta-mRNA deficiency without affecting cytoplasmic beta-mRNA stability. Blood. 1984 Jul;64(1):23–32. [PubMed]
  • Iost I, Dreyfus M. mRNAs can be stabilized by DEAD-box proteins. Nature. 1994 Nov 10;372(6502):193–196. [PubMed]
  • Iwai Y, Akahane K, Pluznik DH, Cohen RB. Ca2+ ionophore A23187-dependent stabilization of granulocyte-macrophage colony-stimulating factor messenger RNA in murine thymoma EL-4 cells is mediated through two distinct regions in the 3'-untranslated region. J Immunol. 1993 May 15;150(10):4386–4394. [PubMed]
  • Iwai Y, Bickel M, Pluznik DH, Cohen RB. Identification of sequences within the murine granulocyte-macrophage colony-stimulating factor mRNA 3'-untranslated region that mediate mRNA stabilization induced by mitogen treatment of EL-4 thymoma cells. J Biol Chem. 1991 Sep 25;266(27):17959–17965. [PubMed]
  • Jäck HM, Wabl M. Immunoglobulin mRNA stability varies during B lymphocyte differentiation. EMBO J. 1988 Apr;7(4):1041–1046. [PMC free article] [PubMed]
  • Jeon S, Lambert PF. Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1654–1658. [PMC free article] [PubMed]
  • Johnson TR, Rudin SD, Blossey BK, Ilan J, Ilan J. Newly synthesized RNA: simultaneous measurement in intact cells of transcription rates and RNA stability of insulin-like growth factor I, actin, and albumin in growth hormone-stimulated hepatocytes. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5287–5291. [PMC free article] [PubMed]
  • Johnston JM, Carroll WL. c-myc hypermutation in Burkitt's lymphoma. Leuk Lymphoma. 1992 Dec;8(6):431–439. [PubMed]
  • Jones TR, Cole MD. Rapid cytoplasmic turnover of c-myc mRNA: requirement of the 3' untranslated sequences. Mol Cell Biol. 1987 Dec;7(12):4513–4521. [PMC free article] [PubMed]
  • Kabnick KS, Housman DE. Determinants that contribute to cytoplasmic stability of human c-fos and beta-globin mRNAs are located at several sites in each mRNA. Mol Cell Biol. 1988 Aug;8(8):3244–3250. [PMC free article] [PubMed]
  • Kan YW, Todd D, Dozy AM. Haemoglobin Constant Spring synthesis in red cell precursors. Br J Haematol. 1974 Sep;28(1):103–107. [PubMed]
  • Kanamori H, Kodama T, Matsumoto A, Itakura H, Yazaki Y. Stabilization of interleukin-2 receptor alpha chain mRNA by HTLV-1 Rex in mouse L cells: lower amounts of Rex do not stabilize the mRNA. Biochem Biophys Res Commun. 1994 Jan 14;198(1):243–250. [PubMed]
  • Kanamori H, Suzuki N, Siomi H, Nosaka T, Sato A, Sabe H, Hatanaka M, Honjo T. HTLV-1 p27rex stabilizes human interleukin-2 receptor alpha chain mRNA. EMBO J. 1990 Dec;9(12):4161–4166. [PMC free article] [PubMed]
  • Katz DA, Theodorakis NG, Cleveland DW, Lindsten T, Thompson CB. AU-A, an RNA-binding activity distinct from hnRNP A1, is selective for AUUUA repeats and shuttles between the nucleus and the cytoplasm. Nucleic Acids Res. 1994 Jan 25;22(2):238–246. [PMC free article] [PubMed]
  • Kaufmann Y, Milcarek C, Berissi H, Penman S. HeLa cell poly(A)- mRNA codes for a subset of poly(A)+ mRNA-directed proteins with an actin as a major product. Proc Natl Acad Sci U S A. 1977 Nov;74(11):4801–4805. [PMC free article] [PubMed]
  • Kenna M, Stevens A, McCammon M, Douglas MG. An essential yeast gene with homology to the exonuclease-encoding XRN1/KEM1 gene also encodes a protein with exoribonuclease activity. Mol Cell Biol. 1993 Jan;13(1):341–350. [PMC free article] [PubMed]
  • Kessler O, Jiang Y, Chasin LA. Order of intron removal during splicing of endogenous adenine phosphoribosyltransferase and dihydrofolate reductase pre-mRNA. Mol Cell Biol. 1993 Oct;13(10):6211–6222. [PMC free article] [PubMed]
  • Kimelman D, Kirschner MW. An antisense mRNA directs the covalent modification of the transcript encoding fibroblast growth factor in Xenopus oocytes. Cell. 1989 Nov 17;59(4):687–696. [PubMed]
  • Kindy MS, Sonenshein GE. Regulation of oncogene expression in cultured aortic smooth muscle cells. Post-transcriptional control of c-myc mRNA. J Biol Chem. 1986 Sep 25;261(27):12865–12868. [PubMed]
  • Klausner RD, Rouault TA, Harford JB. Regulating the fate of mRNA: the control of cellular iron metabolism. Cell. 1993 Jan 15;72(1):19–28. [PubMed]
  • Klett C, Nobiling R, Gierschik P, Hackenthal E. Angiotensin II stimulates the synthesis of angiotensinogen in hepatocytes by inhibiting adenylylcyclase activity and stabilizing angiotensinogen mRNA. J Biol Chem. 1993 Nov 25;268(33):25095–25107. [PubMed]
  • Koeller DM, Horowitz JA, Casey JL, Klausner RD, Harford JB. Translation and the stability of mRNAs encoding the transferrin receptor and c-fos. Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7778–7782. [PMC free article] [PubMed]
  • Kowalski J, Denhardt DT. Regulation of the mRNA for monocyte-derived neutrophil-activating peptide in differentiating HL60 promyelocytes. Mol Cell Biol. 1989 May;9(5):1946–1957. [PMC free article] [PubMed]
  • Kren BT, Kumar NM, Wang SQ, Gilula NB, Steer CJ. Differential regulation of multiple gap junction transcripts and proteins during rat liver regeneration. J Cell Biol. 1993 Nov;123(3):707–718. [PMC free article] [PubMed]
  • Krikorian CR, Read GS. Proteins associated with mRNA in cells infected with herpes simplex virus. Biochem Biophys Res Commun. 1989 Oct 16;164(1):355–361. [PubMed]
  • Krikorian CR, Read GS. In vitro mRNA degradation system to study the virion host shutoff function of herpes simplex virus. J Virol. 1991 Jan;65(1):112–122. [PMC free article] [PubMed]
  • Krowczynska A, Yenofsky R, Brawerman G. Regulation of messenger RNA stability in mouse erythroleukemia cells. J Mol Biol. 1985 Jan 20;181(2):231–239. [PubMed]
  • Kruijer W, Cooper JA, Hunter T, Verma IM. Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein. Nature. 1984 Dec 20;312(5996):711–716. [PubMed]
  • Kruys V, Marinx O, Shaw G, Deschamps J, Huez G. Translational blockade imposed by cytokine-derived UA-rich sequences. Science. 1989 Aug 25;245(4920):852–855. [PubMed]
  • Kwong AD, Frenkel N. Herpes simplex virus-infected cells contain a function(s) that destabilizes both host and viral mRNAs. Proc Natl Acad Sci U S A. 1987 Apr;84(7):1926–1930. [PMC free article] [PubMed]
  • Kwong AD, Frenkel N. The herpes simplex virus virion host shutoff function. J Virol. 1989 Nov;63(11):4834–4839. [PMC free article] [PubMed]
  • Lachman HM, Cheng GH, Skoultchi AI. Transfection of mouse erythroleukemia cells with myc sequences changes the rate of induced commitment to differentiate. Proc Natl Acad Sci U S A. 1986 Sep;83(17):6480–6484. [PMC free article] [PubMed]
  • Lagnado CA, Brown CY, Goodall GJ. AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U/A)(U/A). Mol Cell Biol. 1994 Dec;14(12):7984–7995. [PMC free article] [PubMed]
  • Laird-Offringa IA, de Wit CL, Elfferich P, van der Eb AJ. Poly(A) tail shortening is the translation-dependent step in c-myc mRNA degradation. Mol Cell Biol. 1990 Dec;10(12):6132–6140. [PMC free article] [PubMed]
  • Larimer FW, Hsu CL, Maupin MK, Stevens A. Characterization of the XRN1 gene encoding a 5'-->3' exoribonuclease: sequence data and analysis of disparate protein and mRNA levels of gene-disrupted yeast cells. Gene. 1992 Oct 12;120(1):51–57. [PubMed]
  • Lee FS, Vallee BL. Structure and action of mammalian ribonuclease (angiogenin) inhibitor. Prog Nucleic Acid Res Mol Biol. 1993;44:1–30. [PubMed]
  • Lee NH, Earle-Hughes J, Fraser CM. Agonist-mediated destabilization of m1 muscarinic acetylcholine receptor mRNA. Elements involved in mRNA stability are localized in the 3'-untranslated region. J Biol Chem. 1994 Feb 11;269(6):4291–4298. [PubMed]
  • Lee SW, Tsou AP, Chan H, Thomas J, Petrie K, Eugui EM, Allison AC. Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA. Proc Natl Acad Sci U S A. 1988 Feb;85(4):1204–1208. [PMC free article] [PubMed]
  • Lee WM, Lin C, Curran T. Activation of the transforming potential of the human fos proto-oncogene requires message stabilization and results in increased amounts of partially modified fos protein. Mol Cell Biol. 1988 Dec;8(12):5521–5527. [PMC free article] [PubMed]
  • Leeds P, Peltz SW, Jacobson A, Culbertson MR. The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon. Genes Dev. 1991 Dec;5(12A):2303–2314. [PubMed]
  • Leeds P, Wood JM, Lee BS, Culbertson MR. Gene products that promote mRNA turnover in Saccharomyces cerevisiae. Mol Cell Biol. 1992 May;12(5):2165–2177. [PMC free article] [PubMed]
  • Levine BJ, Chodchoy N, Marzluff WF, Skoultchi AI. Coupling of replication type histone mRNA levels to DNA synthesis requires the stem-loop sequence at the 3' end of the mRNA. Proc Natl Acad Sci U S A. 1987 Sep;84(17):6189–6193. [PMC free article] [PubMed]
  • Levine RA, McCormack JE, Buckler A, Sonenshein GE. Transcriptional and posttranscriptional control of c-myc gene expression in WEHI 231 cells. Mol Cell Biol. 1986 Nov;6(11):4112–4116. [PMC free article] [PubMed]
  • Levis R, Penman S. The metabolism of poly (A)+ and poly(A)-hnRNA in cultured Drosophila cells studied with a rapid uridine pulse-chase. Cell. 1977 May;11(1):105–113. [PubMed]
  • Lieberman AP, Pitha PM, Shin ML. Poly(A) removal is the kinase-regulated step in tumor necrosis factor mRNA decay. J Biol Chem. 1992 Feb 5;267(4):2123–2126. [PubMed]
  • Lim S, Mullins JJ, Chen CM, Gross KW, Maquat LE. Novel metabolism of several beta zero-thalassemic beta-globin mRNAs in the erythroid tissues of transgenic mice. EMBO J. 1989 Sep;8(9):2613–2619. [PMC free article] [PubMed]
  • Lim SK, Maquat LE. Human beta-globin mRNAs that harbor a nonsense codon are degraded in murine erythroid tissues to intermediates lacking regions of exon I or exons I and II that have a cap-like structure at the 5' termini. EMBO J. 1992 Sep;11(9):3271–3278. [PMC free article] [PubMed]
  • Lim SK, Sigmund CD, Gross KW, Maquat LE. Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products. Mol Cell Biol. 1992 Mar;12(3):1149–1161. [PMC free article] [PubMed]
  • Lindholm D, Heumann R, Hengerer B, Thoenen H. Interleukin 1 increases stability and transcription of mRNA encoding nerve growth factor in cultured rat fibroblasts. J Biol Chem. 1988 Nov 5;263(31):16348–16351. [PubMed]
  • Lindstein T, June CH, Ledbetter JA, Stella G, Thompson CB. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science. 1989 Apr 21;244(4902):339–343. [PubMed]
  • Losson R, Lacroute F. Interference of nonsense mutations with eukaryotic messenger RNA stability. Proc Natl Acad Sci U S A. 1979 Oct;76(10):5134–5137. [PMC free article] [PubMed]
  • Love HD, Jr, Allen-Nash A, Zhao QA, Bannon GA. mRNA stability plays a major role in regulating the temperature-specific expression of a Tetrahymena thermophila surface protein. Mol Cell Biol. 1988 Jan;8(1):427–432. [PMC free article] [PubMed]
  • Lowell JE, Rudner DZ, Sachs AB. 3'-UTR-dependent deadenylation by the yeast poly(A) nuclease. Genes Dev. 1992 Nov;6(11):2088–2099. [PubMed]
  • Lozano F, Maertzdorf B, Pannell R, Milstein C. Low cytoplasmic mRNA levels of immunoglobulin kappa light chain genes containing nonsense codons correlate with inefficient splicing. EMBO J. 1994 Oct 3;13(19):4617–4622. [PMC free article] [PubMed]
  • Luo Z, Fuentes ME, Taylor P. Regulation of acetylcholinesterase mRNA stability by calcium during differentiation from myoblasts to myotubes. J Biol Chem. 1994 Nov 4;269(44):27216–27223. [PubMed]
  • Lüscher B, Schümperli D. RNA 3' processing regulates histone mRNA levels in a mammalian cell cycle mutant. A processing factor becomes limiting in G1-arrested cells. EMBO J. 1987 Jun;6(6):1721–1726. [PMC free article] [PubMed]
  • Lüscher B, Stauber C, Schindler R, Schümperli D. Faithful cell-cycle regulation of a recombinant mouse histone H4 gene is controlled by sequences in the 3'-terminal part of the gene. Proc Natl Acad Sci U S A. 1985 Jul;82(13):4389–4393. [PMC free article] [PubMed]
  • Maher F, Harrison LC. Stabilization of glucose transporter mRNA by insulin/IGF-1 and glucose deprivation. Biochem Biophys Res Commun. 1990 Aug 31;171(1):210–215. [PubMed]
  • Malter JS, Hong Y. A redox switch and phosphorylation are involved in the post-translational up-regulation of the adenosine-uridine binding factor by phorbol ester and ionophore. J Biol Chem. 1991 Feb 15;266(5):3167–3171. [PubMed]
  • Maquat LE, Kinniburgh AJ. A beta zero-thalassemic beta-globin RNA that is labile in bone marrow cells is relatively stable in HeLa cells. Nucleic Acids Res. 1985 Apr 25;13(8):2855–2867. [PMC free article] [PubMed]
  • Maquat LE, Kinniburgh AJ, Rachmilewitz EA, Ross J. Unstable beta-globin mRNA in mRNA-deficient beta o thalassemia. Cell. 1981 Dec;27(3 Pt 2):543–553. [PubMed]
  • Marzluff WF, Pandey NB. Multiple regulatory steps control histone mRNA concentrations. Trends Biochem Sci. 1988 Feb;13(2):49–52. [PubMed]
  • Mason JO, Williams GT, Neuberger MS. The half-life of immunoglobulin mRNA increases during B-cell differentiation: a possible role for targeting to membrane-bound polysomes. Genes Dev. 1988 Aug;2(8):1003–1011. [PubMed]
  • McCrae MA, Woodland HR. Stability of non-polyadenylated viral mRNAs injected into frog oocytes. Eur J Biochem. 1981 Jun 1;116(3):467–470. [PubMed]
  • McLaren RS, Ross J. Individual purified core and linker histones induce histone H4 mRNA destabilization in vitro. J Biol Chem. 1993 Jul 15;268(20):14637–14644. [PubMed]
  • McMillan PJ, Tondravi MM, Bannon GA. rseB, a chromosomal locus that affects the stability of a temperature-specific surface protein mRNA in Tetrahymena thermophila. Nucleic Acids Res. 1993 Sep 11;21(18):4356–4362. [PMC free article] [PubMed]
  • Meeks-Wagner D, Hartwell LH. Normal stoichiometry of histone dimer sets is necessary for high fidelity of mitotic chromosome transmission. Cell. 1986 Jan 17;44(1):43–52. [PubMed]
  • Meijlink F, Curran T, Miller AD, Verma IM. Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene. Proc Natl Acad Sci U S A. 1985 Aug;82(15):4987–4991. [PMC free article] [PubMed]
  • Meinsma D, Holthuizen PE, Van den Brande JL, Sussenbach JS. Specific endonucleolytic cleavage of IGF-II mRNAs. Biochem Biophys Res Commun. 1991 Sep 30;179(3):1509–1516. [PubMed]
  • Meinsma D, Scheper W, Holthuizen PE, Van den Brande JL, Sussenbach JS. Site-specific cleavage of IGF-II mRNAs requires sequence elements from two distinct regions of the IGF-II gene. Nucleic Acids Res. 1992 Oct 11;20(19):5003–5009. [PMC free article] [PubMed]
  • Melin L, Soldati D, Mital R, Streit A, Schümperli D. Biochemical demonstration of complex formation of histone pre-mRNA with U7 small nuclear ribonucleoprotein and hairpin binding factors. EMBO J. 1992 Feb;11(2):691–697. [PMC free article] [PubMed]
  • Mercer JF, Wake SA. An analysis of the rate of metallothionein mRNA poly(A)-shortening using RNA blot hybridization. Nucleic Acids Res. 1985 Nov 25;13(22):7929–7943. [PMC free article] [PubMed]
  • Merkel CG, Kwan S, Lingrel JB. Size of the polyadenylic acid region of newly synthesized globin messenger ribonucleic acid. J Biol Chem. 1975 May 25;250(10):3725–3728. [PubMed]
  • Merkel CG, Wood TG, Lingrel JB. Shortening of the poly(A) region of mouse globin messenger RNA. J Biol Chem. 1976 Sep 25;251(18):5512–5515. [PubMed]
  • Mitchelson A, Simonelig M, Williams C, O'Hare K. Homology with Saccharomyces cerevisiae RNA14 suggests that phenotypic suppression in Drosophila melanogaster by suppressor of forked occurs at the level of RNA stability. Genes Dev. 1993 Feb;7(2):241–249. [PubMed]
  • Moore MA, Shenk T. The adenovirus tripartite leader sequence can alter nuclear and cytoplasmic metabolism of a non-adenovirus mRNA within infected cells. Nucleic Acids Res. 1988 Mar 25;16(5):2247–2262. [PMC free article] [PubMed]
  • Morello D, Lavenu A, Pournin S, Babinet C. The 5' and 3' non-coding sequences of the c-myc gene, required in vitro for its post-transcriptional regulation, are dispensable in vivo. Oncogene. 1993 Jul;8(7):1921–1929. [PubMed]
  • Morris TD, Weber LA, Hickey E, Stein GS, Stein JL. Changes in the stability of a human H3 histone mRNA during the HeLa cell cycle. Mol Cell Biol. 1991 Jan;11(1):544–553. [PMC free article] [PubMed]
  • Moschonas N, de Boer E, Grosveld FG, Dahl HH, Wright S, Shewmaker CK, Flavell RA. Structure and expression of a cloned beta o thalassaemic globin gene. Nucleic Acids Res. 1981 Sep 11;9(17):4391–4401. [PMC free article] [PubMed]
  • Mowry KL, Oh R, Steitz JA. Each of the conserved sequence elements flanking the cleavage site of mammalian histone pre-mRNAs has a distinct role in the 3'-end processing reaction. Mol Cell Biol. 1989 Jul;9(7):3105–3108. [PMC free article] [PubMed]
  • Muhlrad D, Decker CJ, Parker R. Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript. Genes Dev. 1994 Apr 1;8(7):855–866. [PubMed]
  • Muhlrad D, Parker R. Premature translational termination triggers mRNA decapping. Nature. 1994 Aug 18;370(6490):578–581. [PubMed]
  • Müller R, Bravo R, Burckhardt J, Curran T. Induction of c-fos gene and protein by growth factors precedes activation of c-myc. Nature. 1984 Dec 20;312(5996):716–720. [PubMed]
  • Müllner EW, Kühn LC. A stem-loop in the 3' untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm. Cell. 1988 Jun 3;53(5):815–825. [PubMed]
  • Murphy W, Attardi G. Stability of cytoplasmic messenger RNA in HeLa cels. Proc Natl Acad Sci U S A. 1973 Jan;70(1):115–119. [PMC free article] [PubMed]
  • Myer VE, Lee SI, Steitz JA. Viral small nuclear ribonucleoproteins bind a protein implicated in messenger RNA destabilization. Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1296–1300. [PMC free article] [PubMed]
  • Naeger LK, Schoborg RV, Zhao Q, Tullis GE, Pintel DJ. Nonsense mutations inhibit splicing of MVM RNA in cis when they interrupt the reading frame of either exon of the final spliced product. Genes Dev. 1992 Jun;6(6):1107–1119. [PubMed]
  • Nagy E, Rigby WF. Glyceraldehyde-3-phosphate dehydrogenase selectively binds AU-rich RNA in the NAD(+)-binding region (Rossmann fold). J Biol Chem. 1995 Feb 10;270(6):2755–2763. [PubMed]
  • Nair AP, Hahn S, Banholzer R, Hirsch HH, Moroni C. Cyclosporin A inhibits growth of autocrine tumour cell lines by destabilizing interleukin-3 mRNA. Nature. 1994 May 19;369(6477):239–242. [PubMed]
  • Nakagawa J, Waldner H, Meyer-Monard S, Hofsteenge J, Jenö P, Moroni C. AUH, a gene encoding an AU-specific RNA binding protein with intrinsic enoyl-CoA hydratase activity. Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2051–2055. [PMC free article] [PubMed]
  • Narayanan CS, Fujimoto J, Geras-Raaka E, Gershengorn MC. Regulation by thyrotropin-releasing hormone (TRH) of TRH receptor mRNA degradation in rat pituitary GH3 cells. J Biol Chem. 1992 Aug 25;267(24):17296–17303. [PubMed]
  • Nielsen DA, Shapiro DJ. Estradiol and estrogen receptor-dependent stabilization of a minivitellogenin mRNA lacking 5,100 nucleotides of coding sequence. Mol Cell Biol. 1990 Jan;10(1):371–376. [PMC free article] [PubMed]
  • Nielsen FC, Christiansen J. Endonucleolysis in the turnover of insulin-like growth factor II mRNA. J Biol Chem. 1992 Sep 25;267(27):19404–19411. [PubMed]
  • Nilsson G, Belasco JG, Cohen SN, von Gabain A. Effect of premature termination of translation on mRNA stability depends on the site of ribosome release. Proc Natl Acad Sci U S A. 1987 Jul;84(14):4890–4894. [PMC free article] [PubMed]
  • Nishizawa K. NGF-induced stabilization of GAP-43 mRNA is mediated by both 3' untranslated region and a segment encoding the carboxy-terminus peptide. Biochem Biophys Res Commun. 1994 Apr 29;200(2):789–796. [PubMed]
  • Nishizawa K, Okamoto H. Mutation analysis of the role for the carboxy-terminus encoding region in NGF-induced stabilization of GAP-43 mRNA. Biochem Biophys Res Commun. 1994 Dec 15;205(2):1380–1385. [PubMed]
  • Ohh M, Takei F. Interferon-gamma- and phorbol myristate acetate-responsive elements involved in intercellular adhesion molecule-1 mRNA stabilization. J Biol Chem. 1994 Dec 2;269(48):30117–30120. [PubMed]
  • Oroskar AA, Read GS. A mutant of herpes simplex virus type 1 exhibits increased stability of immediate-early (alpha) mRNAs. J Virol. 1987 Feb;61(2):604–606. [PMC free article] [PubMed]
  • Oroskar AA, Read GS. Control of mRNA stability by the virion host shutoff function of herpes simplex virus. J Virol. 1989 May;63(5):1897–1906. [PMC free article] [PubMed]
  • Pachter JS, Yen TJ, Cleveland DW. Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs. Cell. 1987 Oct 23;51(2):283–292. [PubMed]
  • Paek I, Axel R. Glucocorticoids enhance stability of human growth hormone mRNA. Mol Cell Biol. 1987 Apr;7(4):1496–1507. [PMC free article] [PubMed]
  • Paillard F, Sterkers G, Vaquero C. Transcriptional and post-transcriptional regulation of TcR, CD4 and CD8 gene expression during activation of normal human T lymphocytes. EMBO J. 1990 Jun;9(6):1867–1872. [PMC free article] [PubMed]
  • Pandey NB, Marzluff WF. The stem-loop structure at the 3' end of histone mRNA is necessary and sufficient for regulation of histone mRNA stability. Mol Cell Biol. 1987 Dec;7(12):4557–4559. [PMC free article] [PubMed]
  • Pandey NB, Sun JH, Marzluff WF. Different complexes are formed on the 3' end of histone mRNA with nuclear and polyribosomal proteins. Nucleic Acids Res. 1991 Oct 25;19(20):5653–5659. [PMC free article] [PubMed]
  • Pandey NB, Williams AS, Sun JH, Brown VD, Bond U, Marzluff WF. Point mutations in the stem-loop at the 3' end of mouse histone mRNA reduce expression by reducing the efficiency of 3' end formation. Mol Cell Biol. 1994 Mar;14(3):1709–1720. [PMC free article] [PubMed]
  • Pastori RL, Moskaitis JE, Buzek SW, Schoenberg DR. Coordinate estrogen-regulated instability of serum protein-coding messenger RNAs in Xenopus laevis. Mol Endocrinol. 1991 Apr;5(4):461–468. [PubMed]
  • Pastori RL, Moskaitis JE, Schoenberg DR. Estrogen-induced ribonuclease activity in Xenopus liver. Biochemistry. 1991 Oct 29;30(43):10490–10498. [PubMed]
  • Pastori RL, Schoenberg DR. The nuclease that selectively degrades albumin mRNA in vitro associates with Xenopus liver polysomes through the 80S ribosome complex. Arch Biochem Biophys. 1993 Sep;305(2):313–319. [PubMed]
  • Patel D, Butler JS. Conditional defect in mRNA 3' end processing caused by a mutation in the gene for poly(A) polymerase. Mol Cell Biol. 1992 Jul;12(7):3297–3304. [PMC free article] [PubMed]
  • Pei R, Calame K. Differential stability of c-myc mRNAS in a cell-free system. Mol Cell Biol. 1988 Jul;8(7):2860–2868. [PMC free article] [PubMed]
  • Peltz SW, Brewer G, Bernstein P, Hart PA, Ross J. Regulation of mRNA turnover in eukaryotic cells. Crit Rev Eukaryot Gene Expr. 1991;1(2):99–126. [PubMed]
  • Peltz SW, Brewer G, Kobs G, Ross J. Substrate specificity of the exonuclease activity that degrades H4 histone mRNA. J Biol Chem. 1987 Jul 5;262(19):9382–9388. [PubMed]
  • Peltz SW, He F, Welch E, Jacobson A. Nonsense-mediated mRNA decay in yeast. Prog Nucleic Acid Res Mol Biol. 1994;47:271–298. [PubMed]
  • Peltz SW, Jacobson A. mRNA stability: in trans-it. Curr Opin Cell Biol. 1992 Dec;4(6):979–983. [PubMed]
  • Peltz SW, Ross J. Autogenous regulation of histone mRNA decay by histone proteins in a cell-free system. Mol Cell Biol. 1987 Dec;7(12):4345–4356. [PMC free article] [PubMed]
  • Peppel K, Baglioni C. Deadenylation and turnover of interferon-beta mRNA. J Biol Chem. 1991 Apr 15;266(11):6663–6666. [PubMed]
  • Peppel K, Vinci JM, Baglioni C. The AU-rich sequences in the 3' untranslated region mediate the increased turnover of interferon mRNA induced by glucocorticoids. J Exp Med. 1991 Feb 1;173(2):349–355. [PMC free article] [PubMed]
  • Petersen RB, Lindquist S. Regulation of HSP70 synthesis by messenger RNA degradation. Cell Regul. 1989 Nov;1(1):135–149. [PMC free article] [PubMed]
  • Piechaczyk M, Yang JQ, Blanchard JM, Jeanteur P, Marcu KB. Posttranscriptional mechanisms are responsible for accumulation of truncated c-myc RNAs in murine plasma cell tumors. Cell. 1985 Sep;42(2):589–597. [PubMed]
  • Pittenger MF, Cleveland DW. Retention of autoregulatory control of tubulin synthesis in cytoplasts: demonstration of a cytoplasmic mechanism that regulates the level of tubulin expression. J Cell Biol. 1985 Nov;101(5 Pt 1):1941–1952. [PMC free article] [PubMed]
  • Pontecorvi A, Tata JR, Phyillaier M, Robbins J. Selective degradation of mRNA: the role of short-lived proteins in differential destabilization of insulin-induced creatine phosphokinase and myosin heavy chain mRNAs during rat skeletal muscle L6 cell differentiation. EMBO J. 1988 May;7(5):1489–1495. [PMC free article] [PubMed]
  • Port JD, Huang LY, Malbon CC. Beta-adrenergic agonists that down-regulate receptor mRNA up-regulate a M(r) 35,000 protein(s) that selectively binds to beta-adrenergic receptor mRNAs. J Biol Chem. 1992 Nov 25;267(33):24103–24108. [PubMed]
  • Prokipcak RD, Herrick DJ, Ross J. Purification and properties of a protein that binds to the C-terminal coding region of human c-myc mRNA. J Biol Chem. 1994 Mar 25;269(12):9261–9269. [PubMed]
  • Proweller A, Butler S. Efficient translation of poly(A)-deficient mRNAs in Saccharomyces cerevisiae. Genes Dev. 1994 Nov 1;8(21):2629–2640. [PubMed]
  • Pulak R, Anderson P. mRNA surveillance by the Caenorhabditis elegans smg genes. Genes Dev. 1993 Oct;7(10):1885–1897. [PubMed]
  • Rabbitts PH, Forster A, Stinson MA, Rabbitts TH. Truncation of exon 1 from the c-myc gene results in prolonged c-myc mRNa stability. EMBO J. 1985 Dec 30;4(13B):3727–3733. [PMC free article] [PubMed]
  • Rahmsdorf HJ, Schönthal A, Angel P, Litfin M, Rüther U, Herrlich P. Posttranscriptional regulation of c-fos mRNA expression. Nucleic Acids Res. 1987 Feb 25;15(4):1643–1659. [PMC free article] [PubMed]
  • Rajagopalan LE, Malter JS. Modulation of granulocyte-macrophage colony-stimulating factor mRNA stability in vitro by the adenosine-uridine binding factor. J Biol Chem. 1994 Sep 30;269(39):23882–23888. [PubMed]
  • Ratnasabapathy R, Hwang SP, Williams DL. The 3'-untranslated region of apolipoprotein II mRNA contains two independent domains that bind distinct cytosolic factors. J Biol Chem. 1990 Aug 15;265(23):14050–14055. [PubMed]
  • Ray D, Meneceur P, Tavitian A, Robert-Lezenes J. Presence of a c-myc transcript initiated in intron 1 in Friend erythroleukemia cells and in other murine cell types with no evidence of c-myc gene rearrangement. Mol Cell Biol. 1987 Feb;7(2):940–945. [PMC free article] [PubMed]
  • Read GS, Frenkel N. Herpes simplex virus mutants defective in the virion-associated shutoff of host polypeptide synthesis and exhibiting abnormal synthesis of alpha (immediate early) viral polypeptides. J Virol. 1983 May;46(2):498–512. [PMC free article] [PubMed]
  • Read GS, Karr BM, Knight K. Isolation of a herpes simplex virus type 1 mutant with a deletion in the virion host shutoff gene and identification of multiple forms of the vhs (UL41) polypeptide. J Virol. 1993 Dec;67(12):7149–7160. [PMC free article] [PubMed]
  • Ross J, Kobs G. H4 histone messenger RNA decay in cell-free extracts initiates at or near the 3' terminus and proceeds 3' to 5'. J Mol Biol. 1986 Apr 20;188(4):579–593. [PubMed]
  • Ross J, Kobs G, Brewer G, Peltz SW. Properties of the exonuclease activity that degrades H4 histone mRNA. J Biol Chem. 1987 Jul 5;262(19):9374–9381. [PubMed]
  • Ross J, Peltz SW, Kobs G, Brewer G. Histone mRNA degradation in vivo: the first detectable step occurs at or near the 3' terminus. Mol Cell Biol. 1986 Dec;6(12):4362–4371. [PMC free article] [PubMed]
  • Ross J, Pizarro A. Human beta and delta globin messenger RNAs turn over at different rates. J Mol Biol. 1983 Jul 5;167(3):607–617. [PubMed]
  • Ross J, Sullivan TD. Half-lives of beta and gamma globin messenger RNAs and of protein synthetic capacity in cultured human reticulocytes. Blood. 1985 Nov;66(5):1149–1154. [PubMed]
  • Roy N, Laflamme G, Raymond V. 5' untranslated sequences modulate rapid mRNA degradation mediated by 3' AU-rich element in v-/c-fos recombinants. Nucleic Acids Res. 1992 Nov 11;20(21):5753–5762. [PMC free article] [PubMed]
  • Ruckman J, Parma D, Tuerk C, Hall DH, Gold L. Identification of a T4 gene required for bacteriophage mRNA processing. New Biol. 1989 Oct;1(1):54–65. [PubMed]
  • Rüther U, Komitowski D, Schubert FR, Wagner EF. c-fos expression induces bone tumors in transgenic mice. Oncogene. 1989 Jul;4(7):861–865. [PubMed]
  • Saceda M, Knabbe C, Dickson RB, Lippman ME, Bronzert D, Lindsey RK, Gottardis MM, Martin MB. Post-transcriptional destabilization of estrogen receptor mRNA in MCF-7 cells by 12-O-tetradecanoylphorbol-13-acetate. J Biol Chem. 1991 Sep 25;266(27):17809–17814. [PubMed]
  • Sachs A. The role of poly(A) in the translation and stability of mRNA. Curr Opin Cell Biol. 1990 Dec;2(6):1092–1098. [PubMed]
  • Sachs AB. Messenger RNA degradation in eukaryotes. Cell. 1993 Aug 13;74(3):413–421. [PubMed]
  • Sachs AB, Bond MW, Kornberg RD. A single gene from yeast for both nuclear and cytoplasmic polyadenylate-binding proteins: domain structure and expression. Cell. 1986 Jun 20;45(6):827–835. [PubMed]
  • Sachs AB, Davis RW. The poly(A) binding protein is required for poly(A) shortening and 60S ribosomal subunit-dependent translation initiation. Cell. 1989 Sep 8;58(5):857–867. [PubMed]
  • Sachs AB, Davis RW. Translation initiation and ribosomal biogenesis: involvement of a putative rRNA helicase and RPL46. Science. 1990 Mar 2;247(4946):1077–1079. [PubMed]
  • Sachs AB, Davis RW, Kornberg RD. A single domain of yeast poly(A)-binding protein is necessary and sufficient for RNA binding and cell viability. Mol Cell Biol. 1987 Sep;7(9):3268–3276. [PMC free article] [PubMed]
  • Sachs AB, Deardorff JA. Translation initiation requires the PAB-dependent poly(A) ribonuclease in yeast. Cell. 1992 Sep 18;70(6):961–973. [PubMed]
  • Savant-Bhonsale S, Cleveland DW. Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex. Genes Dev. 1992 Oct;6(10):1927–1939. [PubMed]
  • Scarpati EM, Sadler JE. Regulation of endothelial cell coagulant properties. Modulation of tissue factor, plasminogen activator inhibitors, and thrombomodulin by phorbol 12-myristate 13-acetate and tumor necrosis factor. J Biol Chem. 1989 Dec 5;264(34):20705–20713. [PubMed]
  • Schek N, Bachenheimer SL. Degradation of cellular mRNAs induced by a virion-associated factor during herpes simplex virus infection of Vero cells. J Virol. 1985 Sep;55(3):601–610. [PMC free article] [PubMed]
  • Scheper W, Meinsma D, Holthuizen PE, Sussenbach JS. Long-range RNA interaction of two sequence elements required for endonucleolytic cleavage of human insulin-like growth factor II mRNAs. Mol Cell Biol. 1995 Jan;15(1):235–245. [PMC free article] [PubMed]
  • Schiavi SC, Wellington CL, Shyu AB, Chen CY, Greenberg ME, Belasco JG. Multiple elements in the c-fos protein-coding region facilitate mRNA deadenylation and decay by a mechanism coupled to translation. J Biol Chem. 1994 Feb 4;269(5):3441–3448. [PubMed]
  • Schneider E, Blundell M, Kennell D. Translation and mRNA decay. Mol Gen Genet. 1978 Apr 6;160(2):121–129. [PubMed]
  • Schoenberg DR, Moskaitis JE, Smith LH, Jr, Pastori RL. Extranuclear estrogen-regulated destabilization of Xenopus laevis serum albumin mRNA. Mol Endocrinol. 1989 May;3(5):805–814. [PubMed]
  • Schümperli D. Multilevel regulation of replication-dependent histone genes. Trends Genet. 1988 Jul;4(7):187–191. [PubMed]
  • Schwartz RJ. Control of glutamine synthetase synthesis in the embryonic chick neural retina. A caution in the use of actinomycin D. J Biol Chem. 1973 Sep 25;248(18):6426–6435. [PubMed]
  • Seeley KA, Byrne DH, Colbert JT. Red Light-Independent Instability of Oat Phytochrome mRNA in Vivo. Plant Cell. 1992 Jan;4(1):29–38. [PMC free article] [PubMed]
  • Sehgal PB, Tamm I, Vilcek J. Human interferon production: superinduction by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole. Science. 1975 Oct 17;190(4211):282–284. [PubMed]
  • Semenkovich CF, Coleman T, Goforth R. Physiologic concentrations of glucose regulate fatty acid synthase activity in HepG2 cells by mediating fatty acid synthase mRNA stability. J Biol Chem. 1993 Apr 5;268(10):6961–6970. [PubMed]
  • Shaw G, Kamen R. A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell. 1986 Aug 29;46(5):659–667. [PubMed]
  • Sheiness D, Darnell JE. Polyadenylic acid segment in mRNA becomes shorter with age. Nat New Biol. 1973 Feb 28;241(113):265–268. [PubMed]
  • Shimotohno K, Kodama Y, Hashimoto J, Miura KI. Importance of 5'-terminal blocking structure to stabilize mRNA in eukaryotic protein synthesis. Proc Natl Acad Sci U S A. 1977 Jul;74(7):2734–2738. [PMC free article] [PubMed]
  • Shyu AB, Belasco JG, Greenberg ME. Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay. Genes Dev. 1991 Feb;5(2):221–231. [PubMed]
  • Shyu AB, Greenberg ME, Belasco JG. The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways. Genes Dev. 1989 Jan;3(1):60–72. [PubMed]
  • Simonet WS, Ness GC. Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl-CoA reductase mRNA in rat liver. Glucocorticoids block the stabilization caused by thyroid hormones. J Biol Chem. 1989 Jan 5;264(1):569–573. [PubMed]
  • Singer RH, Penman S. Stability of HeLa cell mRNA in actinomycin. Nature. 1972 Nov 10;240(5376):100–102. [PubMed]
  • Singer RH, Penman S. Messenger RNA in HeLa cells: kinetics of formation and decay. J Mol Biol. 1973 Aug 5;78(2):321–334. [PubMed]
  • Singh R, Green MR. Sequence-specific binding of transfer RNA by glyceraldehyde-3-phosphate dehydrogenase. Science. 1993 Jan 15;259(5093):365–368. [PubMed]
  • Smibert CA, Popova B, Xiao P, Capone JP, Smiley JR. Herpes simplex virus VP16 forms a complex with the virion host shutoff protein vhs. J Virol. 1994 Apr;68(4):2339–2346. [PMC free article] [PubMed]
  • Smibert CA, Smiley JR. Differential regulation of endogenous and transduced beta-globin genes during infection of erythroid cells with a herpes simplex virus type 1 recombinant. J Virol. 1990 Aug;64(8):3882–3894. [PMC free article] [PubMed]
  • Sorenson CM, Hart PA, Ross J. Analysis of herpes simplex virus-induced mRNA destabilizing activity using an in vitro mRNA decay system. Nucleic Acids Res. 1991 Aug 25;19(16):4459–4465. [PMC free article] [PubMed]
  • Stauber C, Lüscher B, Eckner R, Lötscher E, Schümperli D. A signal regulating mouse histone H4 mRNA levels in a mammalian cell cycle mutant and sequences controlling RNA 3' processing are both contained within the same 80-bp fragment. EMBO J. 1986 Dec 1;5(12):3297–3303. [PMC free article] [PubMed]
  • Stein GS, Stein JL. Is human histone gene expression autogenously regulated? Mol Cell Biochem. 1984 Sep;64(2):105–110. [PubMed]
  • Stephens JM, Carter BZ, Pekala PH, Malter JS. Tumor necrosis factor alpha-induced glucose transporter (GLUT-1) mRNA stabilization in 3T3-L1 preadipocytes. Regulation by the adenosine-uridine binding factor. J Biol Chem. 1992 Apr 25;267(12):8336–8341. [PubMed]
  • Stevens A. An exoribonuclease from Saccharomyces cerevisiae: effect of modifications of 5' end groups on the hydrolysis of substrates to 5' mononucleotides. Biochem Biophys Res Commun. 1978 Mar 30;81(2):656–661. [PubMed]
  • Stimac E, Groppi VE, Coffino P. Increased histone mRNA levels during inhibition of protein synthesis. Biochem Biophys Res Commun. 1983 Jul 18;114(1):131–137. [PubMed]
  • Stoeckle MY. Post-transcriptional regulation of gro alpha, beta, gamma, and IL-8 mRNAs by IL-1 beta. Nucleic Acids Res. 1991 Feb 25;19(4):917–920. [PMC free article] [PubMed]
  • Stoeckle MY. Removal of a 3' non-coding sequence is an initial step in degradation of gro alpha mRNA and is regulated by interleukin-1. Nucleic Acids Res. 1992 Mar 11;20(5):1123–1127. [PMC free article] [PubMed]
  • Stoeckle MY, Guan L. High-resolution analysis of gro alpha mRNA poly(A) shortening: regulation by interleukin-1 beta. Nucleic Acids Res. 1993 Apr 11;21(7):1613–1617. [PMC free article] [PubMed]
  • Stoeckle MY, Hanafusa H. Processing of 9E3 mRNA and regulation of its stability in normal and Rous sarcoma virus-transformed cells. Mol Cell Biol. 1989 Nov;9(11):4738–4745. [PMC free article] [PubMed]
  • Stoecklin G, Hahn S, Moroni C. Functional hierarchy of AUUUA motifs in mediating rapid interleukin-3 mRNA decay. J Biol Chem. 1994 Nov 18;269(46):28591–28597. [PubMed]
  • Sullivan ML, Green PJ. Post-transcriptional regulation of nuclear-encoded genes in higher plants: the roles of mRNA stability and translation. Plant Mol Biol. 1993 Dec;23(6):1091–1104. [PubMed]
  • Sun J, Pilch DR, Marzluff WF. The histone mRNA 3' end is required for localization of histone mRNA to polyribosomes. Nucleic Acids Res. 1992 Nov 25;20(22):6057–6066. [PMC free article] [PubMed]
  • Sunitha I, Slobin LI. An in vitro system derived from Friend erythroleukemia cells to study messenger RNA stability. Biochem Biophys Res Commun. 1987 Apr 29;144(2):560–568. [PubMed]
  • Swartwout SG, Kinniburgh AJ. c-myc RNA degradation in growing and differentiating cells: possible alternate pathways. Mol Cell Biol. 1989 Jan;9(1):288–295. [PMC free article] [PubMed]
  • Swartwout SG, Preisler H, Guan WD, Kinniburgh AJ. Relatively stable population of c-myc RNA that lacks long poly(A). Mol Cell Biol. 1987 Jun;7(6):2052–2058. [PMC free article] [PubMed]
  • Theodorakis NG, Cleveland DW. Physical evidence for cotranslational regulation of beta-tubulin mRNA degradation. Mol Cell Biol. 1992 Feb;12(2):791–799. [PMC free article] [PubMed]
  • Theodorakis NG, Morimoto RI. Posttranscriptional regulation of hsp70 expression in human cells: effects of heat shock, inhibition of protein synthesis, and adenovirus infection on translation and mRNA stability. Mol Cell Biol. 1987 Dec;7(12):4357–4368. [PMC free article] [PubMed]
  • Thompson CB, Challoner PB, Neiman PE, Groudine M. Expression of the c-myb proto-oncogene during cellular proliferation. Nature. 319(6052):374–380. [PubMed]
  • Treisman R. Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5' element and c-fos 3' sequences. Cell. 1985 Oct;42(3):889–902. [PubMed]
  • Trembley JH, Kren BT, Steer CJ. Posttranscriptional regulation of cyclin B messenger RNA expression in the regenerating rat liver. Cell Growth Differ. 1994 Jan;5(1):99–108. [PubMed]
  • Urlaub G, Mitchell PJ, Ciudad CJ, Chasin LA. Nonsense mutations in the dihydrofolate reductase gene affect RNA processing. Mol Cell Biol. 1989 Jul;9(7):2868–2880. [PMC free article] [PubMed]
  • Uzan M, Favre R, Brody E. A nuclease that cuts specifically in the ribosome binding site of some T4 mRNAs. Proc Natl Acad Sci U S A. 1988 Dec;85(23):8895–8899. [PMC free article] [PubMed]
  • Verma IM, Sassone-Corsi P. Proto-oncogene fos: complex but versatile regulation. Cell. 1987 Nov 20;51(4):513–514. [PubMed]
  • Volloch V, Schweitzer B, Rits S. Messenger RNA changes during differentiation of murine erythroleukemia cells. Exp Cell Res. 1987 Nov;173(1):38–48. [PubMed]
  • Wager RE, Assoian RK. A phorbol ester-regulated ribonuclease system controlling transforming growth factor beta 1 gene expression in hematopoietic cells. Mol Cell Biol. 1990 Nov;10(11):5983–5990. [PMC free article] [PubMed]
  • Wager RE, Scotto L, Assoian RK. Analysis of transforming growth factor beta 1 messenger RNA degradation by the transcript-selective, 12-O-tetradecanoylphorbol-13-acetate-regulated ribonuclease system from U937 promonocytes. Cell Growth Differ. 1994 Feb;5(2):117–124. [PubMed]
  • Wang X, Kiledjian M, Weiss IM, Liebhaber SA. Detection and characterization of a 3' untranslated region ribonucleoprotein complex associated with human alpha-globin mRNA stability. Mol Cell Biol. 1995 Mar;15(3):1769–1777. [PMC free article] [PubMed]
  • Weiss IM, Liebhaber SA. Erythroid cell-specific determinants of alpha-globin mRNA stability. Mol Cell Biol. 1994 Dec;14(12):8123–8132. [PMC free article] [PubMed]
  • Wek RC, Sameshima JH, Hatfield GW. Rho-dependent transcriptional polarity in the ilvGMEDA operon of wild-type Escherichia coli K12. J Biol Chem. 1987 Nov 5;262(31):15256–15261. [PubMed]
  • Wellington CL, Greenberg ME, Belasco JG. The destabilizing elements in the coding region of c-fos mRNA are recognized as RNA. Mol Cell Biol. 1993 Aug;13(8):5034–5042. [PMC free article] [PubMed]
  • White KN, Nosaka T, Kanamori H, Hatanaka M, Honjo T. The nucleolar localisation signal of the HTLV-I protein p27rex is important for stabilisation of IL-2 receptor alpha subunit mRNA by p27rex. Biochem Biophys Res Commun. 1991 Feb 28;175(1):98–103. [PubMed]
  • Whitfield TT, Sharpe CR, Wylie CC. Nonsense-mediated mRNA decay in Xenopus oocytes and embryos. Dev Biol. 1994 Oct;165(2):731–734. [PubMed]
  • Whitley RJ. Herpes simplex virus infections of women and their offspring: implications for a developed society. Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2441–2447. [PMC free article] [PubMed]
  • Wilhelm JE, Vale RD. RNA on the move: the mRNA localization pathway. J Cell Biol. 1993 Oct;123(2):269–274. [PMC free article] [PubMed]
  • Williams AS, Ingledue TC, 3rd, Kay BK, Marzluff WF. Changes in the stem-loop at the 3' terminus of histone mRNA affects its nucleocytoplasmic transport and cytoplasmic regulation. Nucleic Acids Res. 1994 Nov 11;22(22):4660–4666. [PMC free article] [PubMed]
  • Wilson T, Treisman R. Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3' AU-rich sequences. Nature. 1988 Nov 24;336(6197):396–399. [PubMed]
  • Winkles JA, Grainger RM. Differential stability of Drosophila embryonic mRNAs during subsequent larval development. J Cell Biol. 1985 Nov;101(5 Pt 1):1808–1816. [PMC free article] [PubMed]
  • Wisdom R, Lee W. Translation of c-myc mRNA is required for its post-transcriptional regulation during myogenesis. J Biol Chem. 1990 Nov 5;265(31):19015–19021. [PubMed]
  • Wisdom R, Lee W. The protein-coding region of c-myc mRNA contains a sequence that specifies rapid mRNA turnover and induction by protein synthesis inhibitors. Genes Dev. 1991 Feb;5(2):232–243. [PubMed]
  • Wodnar-Filipowicz A, Moroni C. Regulation of interleukin 3 mRNA expression in mast cells occurs at the posttranscriptional level and is mediated by calcium ions. Proc Natl Acad Sci U S A. 1990 Jan;87(2):777–781. [PMC free article] [PubMed]
  • Wolffe AP, Glover JF, Martin SC, Tenniswood MP, Williams JL, Tata JR. Deinduction of transcription of Xenopus 74-kDa albumin genes and destabilization of mRNA by estrogen in vivo and in hepatocyte cultures. Eur J Biochem. 1985 Feb 1;146(3):489–496. [PubMed]
  • Wreschner DH, Rechavi G. Differential mRNA stability to reticulocyte ribonucleases correlates with 3' non-coding (U)nA sequences. Eur J Biochem. 1988 Mar 1;172(2):333–340. [PubMed]
  • Wright JJ, Hayward RS. Transcriptional termination at a fully rho-independent site in Escherichia coli is prevented by uninterrupted translation of the nascent RNA. EMBO J. 1987 Apr;6(4):1115–1119. [PMC free article] [PubMed]
  • Yen TJ, Gay DA, Pachter JS, Cleveland DW. Autoregulated changes in stability of polyribosome-bound beta-tubulin mRNAs are specified by the first 13 translated nucleotides. Mol Cell Biol. 1988 Mar;8(3):1224–1235. [PMC free article] [PubMed]
  • Yen TJ, Machlin PS, Cleveland DW. Autoregulated instability of beta-tubulin mRNAs by recognition of the nascent amino terminus of beta-tubulin. Nature. 1988 Aug 18;334(6183):580–585. [PubMed]
  • Yost HJ, Petersen RB, Lindquist S. RNA metabolism: strategies for regulation in the heat shock response. Trends Genet. 1990 Jul;6(7):223–227. [PubMed]
  • Zaidi SH, Malter JS. Amyloid precursor protein mRNA stability is controlled by a 29-base element in the 3'-untranslated region. J Biol Chem. 1994 Sep 30;269(39):24007–24013. [PubMed]
  • Zambetti G, Stein J, Stein G. Targeting of a chimeric human histone fusion mRNA to membrane-bound polysomes in HeLa cells. Proc Natl Acad Sci U S A. 1987 May;84(9):2683–2687. [PMC free article] [PubMed]
  • Zambetti G, Stein J, Stein G. Role of messenger RNA subcellular localization in the posttranscriptional regulation of human histone gene expression. J Cell Physiol. 1990 Jul;144(1):175–182. [PubMed]
  • Zhang W, Wagner BJ, Ehrenman K, Schaefer AW, DeMaria CT, Crater D, DeHaven K, Long L, Brewer G. Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1. Mol Cell Biol. 1993 Dec;13(12):7652–7665. [PMC free article] [PubMed]
  • Zhu YY, Schwartz RJ, Crow MT. Phorbol esters selectively downregulate contractile protein gene expression in terminally differentiated myotubes through transcriptional repression and message destabilization. J Cell Biol. 1991 Nov;115(3):745–754. [PMC free article] [PubMed]
  • Zubiaga AM, Belasco JG, Greenberg ME. The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation. Mol Cell Biol. 1995 Apr;15(4):2219–2230. [PMC free article] [PubMed]

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