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Bull World Health Organ. 1992; 70(4): 457–460.
PMCID: PMC2393376

Low seroconversion rates to measles vaccine among children in Nigeria.


The Nigerian Expanded Programme on Immunization (EPI) was assessed with particular reference to measles immunization. Of 150 children who received measles vaccine at the Institute of Child Health, University of Ibadan, Nigeria, 82 (54.7%) seroconverted. The immune response was directly related to the titre of the vaccines used. Vaccines whose titres were 10(-1) to 10(1.7) stimulated immune responses in 0-25% of vaccinees, those with titres in the range 10(-2.1) to 10(-2.5) stimulated responses in 12-47.6%, while those with titres of 10(-2.7) to 10(-3.4) stimulated responses in 87.5-100% of vaccinees. Only one of the vaccines used had a titre that met the minimum WHO required standard of log 10(-3) TCID50 at the point of vaccination.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Nakano JH, Miller DL, Foster SO, Brink EW. Microtiter determination of measles hemagglutination inhibition antibody with filter papers. J Clin Microbiol. 1983 May;17(5):860–863. [PMC free article] [PubMed]
  • Munube GM. Measles sero-immunity in rural non-vaccinated children of Busoga District, Uganda. East Afr Med J. 1979 Jul;56(7):335–338. [PubMed]
  • Albrecht P, Ennis FA, Saltzman EJ, Krugman S. Persistence of maternal antibody in infants beyond 12 months: mechanism of measles vaccine failure. J Pediatr. 1977 Nov;91(5):715–718. [PubMed]
  • Abdurrahman MB, Greenwood BM, Olafimihan O, Whitle HC. Measles antibody levels from birth to 9 months of age in Nigerian infants. Afr J Med Med Sci. 1982 Sep;11(3):113–115. [PubMed]

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