• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of bullwhoWHO Home PageBulletin Home PageBulletin Home PageAbout Bulletine-mail AlertSubmissions
Bull World Health Organ. 1990; 68(5): 571–576.
PMCID: PMC2393202

Serodiagnostic tests for tuberculosis: a need for assessment of their operational predictive accuracy and acceptability.

Abstract

There have been numerous unsuccessful attempts to develop clinically useful serodiagnostic tests for tuberculosis. Although the large number of published reports clearly show that antibody levels are significantly higher in patients, as a group, than in a control population, little consideration is given to the value of the tests in various operational situations. In this paper we review the criteria generally used to assess the usefulness of a diagnostic test and introduce two new concepts--namely, operational predictive accuracy and operational acceptability.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (945K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • French GL, Chan CY, Cheung SW, Oo KT. Diagnosis of pulmonary tuberculosis by detection of tuberculostearic acid in sputum by using gas chromatography-mass spectrometry with selected ion monitoring. J Infect Dis. 1987 Aug;156(2):356–362. [PubMed]
  • Pao CC, Lin SS, Wu SY, Juang WM, Chang CH, Lin JY. The detection of mycobacterial DNA sequences in uncultured clinical specimens with cloned Mycobacterium tuberculosis DNA as probes. Tubercle. 1988 Mar;69(1):27–36. [PubMed]
  • Daniel TM, Debanne SM. The serodiagnosis of tuberculosis and other mycobacterial diseases by enzyme-linked immunosorbent assay. Am Rev Respir Dis. 1987 May;135(5):1137–1151. [PubMed]
  • Stanford JL, Grange JM. The meaning and structure of species as applied to mycobacteria. Tubercle. 1974 Jun;55(2):143–152. [PubMed]
  • Daniel TM, Janicki BW. Mycobacterial antigens: a review of their isolation, chemistry, and immunological properties. Microbiol Rev. 1978 Mar;42(1):84–113. [PMC free article] [PubMed]
  • Grange JM, Gibson J, Nassau E, Kardjito T. Enzyme-linked immunosorbent assay (ELISA): a study of antibodies to Mycobacterium tuberculosis in the IgG, IgA and IgM classes in tuberculosis, sarcoidosis and Crohn's disease. Tubercle. 1980 Sep;61(3):145–152. [PubMed]
  • Gibson JA, Grange JM, Beck JS, Kardjito T. Specific antibody in the subclasses of immunoglobulin G in patients with smear-positive pulmonary tuberculosis. Eur J Respir Dis. 1987 Jan;70(1):29–34. [PubMed]
  • Young RA, Bloom BR, Grosskinsky CM, Ivanyi J, Thomas D, Davis RW. Dissection of Mycobacterium tuberculosis antigens using recombinant DNA. Proc Natl Acad Sci U S A. 1985 May;82(9):2583–2587. [PMC free article] [PubMed]
  • Chanteau S, Cartel JL, Roux J, Plichart R, Bach MA. Comparison of synthetic antigens for detecting antibodies to phenolic glycolipid I in patients with leprosy and their household contacts. J Infect Dis. 1988 Apr;157(4):770–776. [PubMed]
  • Van Vooren JP, Farber CM, Motte S, De Bruyn J, Legros F, Yernault JC. Assay of specific antibody response to mycobacterial antigen for the diagnosis of a pleural effusion in a patient with AIDS. Tubercle. 1988 Dec;69(4):303–305. [PubMed]
  • Grange JM, Gibson J, Batty A, Kardjito T. The specificity of the humoral immune response to soluble mycobacterial antigens in tuberculosis. Tubercle. 1980 Sep;61(3):153–156. [PubMed]
  • Kadival GV, Mazarelo TB, Chaparas SD. Sensitivity and specificity of enzyme-linked immunosorbent assay in the detection of antigen in tuberculous meningitis cerebrospinal fluids. J Clin Microbiol. 1986 May;23(5):901–904. [PMC free article] [PubMed]

Articles from Bulletin of the World Health Organization are provided here courtesy of World Health Organization

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...