An illustration of a hypothetic model of dietary fat promotion of prostate growth and tumerogenesis, and the potential actions of genistein in this process. A high dietary fat intake induces prostate 5α-reductase gene expression and potentiates androgen action by increasing the conversion of testosterone (T) to DHT. The elevated androgen action subsequently stimulates the proliferation and then transformation of prostate cells in concert with other dietary fat actions. These processes could be blocked by the administration of genistein.