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Br J Cancer. 2000 Sep; 83(5): 577–582.
Published online 2000 Aug 16. doi:  10.1054/bjoc.2000.1337
PMCID: PMC2363517

Long-term quality of life in premenopausal women with node-negative localized breast cancer treated with or without adjuvant chemotherapy


Our purpose was to evaluate the late physical and psychosocial difficulties of premenpausal patients treated for a localized breast cancer and to weigh the impact of chemotherapy on long-term quality of life. Two self-administered questionnaires, the EORTC core QLQ-C30 and the breast module (BR23) were mailed to 179 premenopausal node-negative women continuously disease-free, previously enrolled in a trial testing the efficacy of adjuvant CMF chemotherapy (Espié et al, 1997). The core questionnaire evaluates the physical, role, emotional, cognitive and social functioning and global health status. The breast module includes four functional scales: body image, sexual functioning, sexual enjoyment and future perspective. It also includes symptom scales such as arm or breast symptoms. Some specific professional and social states were added. 119 (68%) patients (mean age 54 years, range 30–69) participated. Mean follow-up time since diagnosis was 9.6 years (4–16). 68% had conservative and 32% radical surgery (with reconstructive surgery in 50%). CMF was given to 77 (65%) patients. Irradiation was administered in 75% of patients irrespective of adjuvant therapy. QLQ-C30 scale scores were similar in patients who had or had not received chemotherapy. Disturbance in body image, sex life and breast symptoms did not differ between patients who had or had not received adjuvant CMF. No major socioprofessional difficulties were reported except problems in borrowing from banks not related to past chemotherapy. With long follow-up, most premenopausal women treated for a localized breast cancer cope with the disease and its treatments. Adjuvant CMF chemotherapy does not appear to impair quality of life nor social and professional life in these patients. © 2000 Cancer Research Campaign

Keywords: localized breast cancer, clinical trial, premenopausal node-negative women, adjuvant chemotherapy, long-term quality of life

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  • Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, Filiberti A, Flechtner H, Fleishman SB, de Haes JC, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993 Mar 3;85(5):365–376. [PubMed]
  • Barni S, Mondin R. Sexual dysfunction in treated breast cancer patients. Ann Oncol. 1997 Feb;8(2):149–153. [PubMed]
  • Berglund G, Bolund C, Fornander T, Rutqvist LE, Sjödén PO. Late effects of adjuvant chemotherapy and postoperative radiotherapy on quality of life among breast cancer patients. Eur J Cancer. 1991;27(9):1075–1081. [PubMed]
  • Bernhard J, Hürny C, Coates AS, Peterson HF, Castiglione-Gertsch M, Gelber RD, Goldhirsch A, Senn HJ, Rudenstam CM. Quality of life assessment in patients receiving adjuvant therapy for breast cancer: the IBCSG approach. The International Breast Cancer Study Group. Ann Oncol. 1997 Sep;8(9):825–835. [PubMed]
  • Craig TJ, Comstock GW, Geiser PB. The quality of survival in breast cancer: a case-control comparison. Cancer. 1974 May;33(5):1451–1457. [PubMed]
  • Dorval M, Maunsell E, Deschênes L, Brisson J, Mâsse B. Long-term quality of life after breast cancer: comparison of 8-year survivors with population controls. J Clin Oncol. 1998 Feb;16(2):487–494. [PubMed]
  • Dow KH, Ferrell BR, Leigh S, Ly J, Gulasekaram P. An evaluation of the quality of life among long-term survivors of breast cancer. Breast Cancer Res Treat. 1996;39(3):261–273. [PubMed]
  • Ganz PA, Coscarelli A, Fred C, Kahn B, Polinsky ML, Petersen L. Breast cancer survivors: psychosocial concerns and quality of life. Breast Cancer Res Treat. 1996;38(2):183–199. [PubMed]
  • Ganz PA, Rowland JH, Meyerowitz BE, Desmond KA. Impact of different adjuvant therapy strategies on quality of life in breast cancer survivors. Recent Results Cancer Res. 1998;152:396–411. [PubMed]
  • Ganz PA, Rowland JH, Desmond K, Meyerowitz BE, Wyatt GE. Life after breast cancer: understanding women's health-related quality of life and sexual functioning. J Clin Oncol. 1998 Feb;16(2):501–514. [PubMed]
  • Ganz PA, Desmond KA, Belin TR, Meyerowitz BE, Rowland JH. Predictors of sexual health in women after a breast cancer diagnosis. J Clin Oncol. 1999 Aug;17(8):2371–2380. [PubMed]
  • Goldhirsch A, Wood WC, Senn HJ, Glick JH, Gelber RD. Fifth International Conference on Adjuvant Therapy of Breast Cancer, St Gallen, March 1995. International Consensus Panel on the Treatment of Primary Breast Cancer. Eur J Cancer. 1995 Oct;31A(11):1754–1759. [PubMed]
  • Halttunen A, Hietanen P, Jallinoja P, Lönnqvist J. Getting free of breast cancer. An eight-year perspective of the relapse-free patients. Acta Oncol. 1992;31(3):307–310. [PubMed]
  • Hébert-Croteau N, Brisson J, Latreille J, Gariépy G, Blanchette C, Deschênes L. Time trends in systemic adjuvant treatment for node-negative breast cancer. J Clin Oncol. 1999 May;17(5):1458–1464. [PubMed]
  • Hietanen PS. Measurement and practical aspects of quality of life in breast cancer. Acta Oncol. 1996;35(1):39–42. [PubMed]
  • Hughson AV, Cooper AF, McArdle CS, Smith DC. Psychological impact of adjuvant chemotherapy in the first two years after mastectomy. Br Med J (Clin Res Ed) 1986 Nov 15;293(6557):1268–1271. [PMC free article] [PubMed]
  • Hürny C, Bernhard J, Coates AS, Castiglione-Gertsch M, Peterson HF, Gelber RD, Forbes JF, Rudenstam CM, Simoncini E, Crivellari D, et al. Impact of adjuvant therapy on quality of life in women with node-positive operable breast cancer. International Breast Cancer Study Group. Lancet. 1996 May 11;347(9011):1279–1284. [PubMed]
  • Joly F, Henry-Amar M, Arveux P, Reman O, Tanguy A, Peny AM, Lebailly P, Macé-Lesec'h J, Vié B, Génot JY, et al. Late psychosocial sequelae in Hodgkin's disease survivors: a French population-based case-control study. J Clin Oncol. 1996 Sep;14(9):2444–2453. [PubMed]
  • Kiebert GM, de Haes JC, van de Velde CJ. The impact of breast-conserving treatment and mastectomy on the quality of life of early-stage breast cancer patients: a review. J Clin Oncol. 1991 Jun;9(6):1059–1070. [PubMed]
  • Knobf MT. Physical and psychologic distress associated with adjuvant chemotherapy in women with breast cancer. J Clin Oncol. 1986 May;4(5):678–684. [PubMed]
  • Lindley C, Vasa S, Sawyer WT, Winer EP. Quality of life and preferences for treatment following systemic adjuvant therapy for early-stage breast cancer. J Clin Oncol. 1998 Apr;16(4):1380–1387. [PubMed]
  • Maguire GP, Tait A, Brooke M, Thomas C, Howat JM, Sellwood RA, Bush H. Psychiatric morbidity and physical toxicity associated with adjuvant chemotherapy after mastectomy. Br Med J. 1980 Nov 1;281(6249):1179–1180. [PMC free article] [PubMed]
  • Maunsell E, Brisson J, Deschênes L. Arm problems and psychological distress after surgery for breast cancer. Can J Surg. 1993 Aug;36(4):315–320. [PubMed]
  • Osoba D, Zee B, Pater J, Warr D, Kaizer L, Latreille J. Psychometric properties and responsiveness of the EORTC quality of Life Questionnaire (QLQ-C30) in patients with breast, ovarian and lung cancer. Qual Life Res. 1994 Oct;3(5):353–364. [PubMed]
  • Palmer BV, Walsh GA, McKinna JA, Greening WP. Adjuvant chemotherapy for breast cancer: side effects and quality of life. Br Med J. 1980 Dec 13;281(6255):1594–1597. [PMC free article] [PubMed]
  • Schover LR, Yetman RJ, Tuason LJ, Meisler E, Esselstyn CB, Hermann RE, Grundfest-Broniatowski S, Dowden RV. Partial mastectomy and breast reconstruction. A comparison of their effects on psychosocial adjustment, body image, and sexuality. Cancer. 1995 Jan 1;75(1):54–64. [PubMed]
  • Sprangers MA, Groenvold M, Arraras JI, Franklin J, te Velde A, Muller M, Franzini L, Williams A, de Haes HC, Hopwood P, et al. The European Organization for Research and Treatment of Cancer breast cancer-specific quality-of-life questionnaire module: first results from a three-country field study. J Clin Oncol. 1996 Oct;14(10):2756–2768. [PubMed]
  • van Dam FS, Schagen SB, Muller MJ, Boogerd W, vd Wall E, Droogleever Fortuyn ME, Rodenhuis S. Impairment of cognitive function in women receiving adjuvant treatment for high-risk breast cancer: high-dose versus standard-dose chemotherapy. J Natl Cancer Inst. 1998 Feb 4;90(3):210–218. [PubMed]

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