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J Bacteriol. Oct 1975; 124(1): 573–575.
PMCID: PMC235931

Formation of indoleacetic acid by intestinal anaerobes.

Abstract

Indoleacetic acid was produced from tryptophan by only three of 23 intestinal anaerobes studied. Evidence is presented to show that the formation of indoleacetic acid proceeds through the intermediate, indolepyruvic acid, via transamination with alpha-ketoglutarate rather than by tryptamine pathway.

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Selected References

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  • Anderson GM. Quantitation of tryptophan metabolites in rat feces by thin-layer chromatography. J Chromatogr. 1975 Feb 26;105(2):323–328. [PubMed]
  • BARON DN, DENT CE, HARRIS H, HART EW, JEPSON JB. Hereditary pellagra-like skin rash with temporary cerebellar ataxia, constant renal amino-aciduria, and other bizarre biochemical features. Lancet. 1956 Sep 1;271(6940):421–428. [PubMed]
  • Carlson JR, Yokoyama MT, Dickinson EO. Induction of pulmonary edema and emphysema in cattle and goats with 3-methylindole. Science. 1972 Apr 21;176(4032):298–299. [PubMed]
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  • DUNNING WF, CURTIS MR. The role of indole in incidence of 2-acetylamino-fluorene-induced bladder cancer in rats. Proc Soc Exp Biol Med. 1958 Oct;99(1):91–95. [PubMed]
  • RAUSCHENBACH MO, JAROVA EI, PROTASOVA TG. BLASTOMOGENIC PROPERTIES OF CERTAIN METABOLITES OF TRYPTOPHANE. Acta Unio Int Contra Cancrum. 1963;19:660–662. [PubMed]
  • WEISSBACH H, KING W, SJOERDSMA A, UDENFRIEND S. Formation of indole-3-acetic acid and tryptamine in animals: a method for estimation of indole-3-acetic acid in tissues. J Biol Chem. 1959 Jan;234(1):81–86. [PubMed]

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