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J Virol. Dec 1997; 71(12): 9764–9769.
PMCID: PMC230286

A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma-associated herpesvirus.

Abstract

A herpesvirus that is related to but distinct from the Kaposi's sarcoma-associated herpesvirus (KSHV, or human herpesvirus 8) was isolated from rhesus monkeys. The sequence of 10.6 kbp from virion DNA revealed the presence of an interleukin-6 homolog similar to what is present in KSHV and a closer relatedness of the DNA polymerase and glycoprotein B reading frames to those of KSHV than to those of any other herpesvirus. This rhesus monkey herpesvirus replicated lytically and to high titers in cultured rhesus monkey fibroblasts. Antibody testing revealed a high prevalence for at least 10 years in our rhesus monkey colony and a high prevalence in two other colonies that were tested. Thus, rhesus monkeys naturally harbor a virus related to KSHV, which we have called RRV, for rhesus monkey rhadinovirus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Albrecht JC, Nicholas J, Biller D, Cameron KR, Biesinger B, Newman C, Wittmann S, Craxton MA, Coleman H, Fleckenstein B, et al. Primary structure of the herpesvirus saimiri genome. J Virol. 1992 Aug;66(8):5047–5058. [PMC free article] [PubMed]
  • Ambroziak JA, Blackbourn DJ, Herndier BG, Glogau RG, Gullett JH, McDonald AR, Lennette ET, Levy JA. Herpes-like sequences in HIV-infected and uninfected Kaposi's sarcoma patients. Science. 1995 Apr 28;268(5210):582–583. [PubMed]
  • Boshoff C, Schulz TF, Kennedy MM, Graham AK, Fisher C, Thomas A, McGee JO, Weiss RA, O'Leary JJ. Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells. Nat Med. 1995 Dec;1(12):1274–1278. [PubMed]
  • Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med. 1995 May 4;332(18):1186–1191. [PubMed]
  • Cesarman E, Moore PS, Rao PH, Inghirami G, Knowles DM, Chang Y. In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences. Blood. 1995 Oct 1;86(7):2708–2714. [PubMed]
  • Chalifoux LV, Simon MA, Pauley DR, MacKey JJ, Wyand MS, Ringler DJ. Arteriopathy in macaques infected with simian immunodeficiency virus. Lab Invest. 1992 Sep;67(3):338–349. [PubMed]
  • Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 1994 Dec 16;266(5192):1865–1869. [PubMed]
  • Daniel MD, Letvin NL, King NW, Kannagi M, Sehgal PK, Hunt RD, Kanki PJ, Essex M, Desrosiers RC. Isolation of T-cell tropic HTLV-III-like retrovirus from macaques. Science. 1985 Jun 7;228(4704):1201–1204. [PubMed]
  • Daniel MD, Letvin NL, Sehgal PK, Schmidt DK, Silva DP, Solomon KR, Hodi FS, Jr, Ringler DJ, Hunt RD, King NW, et al. Prevalence of antibodies to 3 retroviruses in a captive colony of macaque monkeys. Int J Cancer. 1988 Apr 15;41(4):601–608. [PubMed]
  • Desrosiers RC. Safety issues facing development of a live-attenuated, multiply deleted HIV-1 vaccine. AIDS Res Hum Retroviruses. 1994 Apr;10(4):331–332. [PubMed]
  • Desrosiers RC. The value of specific pathogen-free rhesus monkey breeding colonies for AIDS research. AIDS Res Hum Retroviruses. 1997 Jan 1;13(1):5–6. [PubMed]
  • Desrosiers RC, Bakker A, Kamine J, Falk LA, Hunt RD, King NW. A region of the Herpesvirus saimiri genome required for oncogenicity. Science. 1985 Apr 12;228(4696):184–187. [PubMed]
  • Desrosiers RC, Daniel MD, Butler CV, Schmidt DK, Letvin NL, Hunt RD, King NW, Barker CS, Hunter E. Retrovirus D/New England and its relation to Mason-Pfizer monkey virus. J Virol. 1985 May;54(2):552–560. [PMC free article] [PubMed]
  • Duboise SM, Guo J, Desrosiers RC, Jung JU. Use of virion DNA as a cloning vector for the construction of mutant and recombinant herpesviruses. Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11389–11394. [PMC free article] [PubMed]
  • Foreman KE, Friborg J, Jr, Kong WP, Woffendin C, Polverini PJ, Nickoloff BJ, Nabel GJ. Propagation of a human herpesvirus from AIDS-associated Kaposi's sarcoma. N Engl J Med. 1997 Jan 16;336(3):163–171. [PubMed]
  • Gao SJ, Kingsley L, Hoover DR, Spira TJ, Rinaldo CR, Saah A, Phair J, Detels R, Parry P, Chang Y, et al. Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma. N Engl J Med. 1996 Jul 25;335(4):233–241. [PubMed]
  • Giddens WE, Jr, Tsai CC, Morton WR, Ochs HD, Knitter GH, Blakley GA. Retroperitoneal fibromatosis and acquired immunodeficiency syndrome in macaques. Pathologic observations and transmission studies. Am J Pathol. 1985 May;119(2):253–263. [PMC free article] [PubMed]
  • Honess RW, Bodemer W, Cameron KR, Niller HH, Fleckenstein B, Randall RE. The A+T-rich genome of Herpesvirus saimiri contains a highly conserved gene for thymidylate synthase. Proc Natl Acad Sci U S A. 1986 Jun;83(11):3604–3608. [PMC free article] [PubMed]
  • Jung JU, Desrosiers RC. Distinct functional domains of STP-C488 of herpesvirus saimiri. Virology. 1994 Nov 1;204(2):751–758. [PubMed]
  • Kaur A, Daniel MD, Hempel D, Lee-Parritz D, Hirsch MS, Johnson RP. Cytotoxic T-lymphocyte responses to cytomegalovirus in normal and simian immunodeficiency virus-infected rhesus macaques. J Virol. 1996 Nov;70(11):7725–7733. [PMC free article] [PubMed]
  • Kedes DH, Operskalski E, Busch M, Kohn R, Flood J, Ganem D. The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission. Nat Med. 1996 Aug;2(8):918–924. [PubMed]
  • Kodama T, Silva DP, Daniel MD, Phillips-Conroy JE, Jolly CJ, Rogers J, Desrosiers RC. Prevalence of antibodies to SIV in baboons in their native habitat. AIDS Res Hum Retroviruses. 1989 Jun;5(3):337–343. [PubMed]
  • Moore PS, Boshoff C, Weiss RA, Chang Y. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science. 1996 Dec 6;274(5293):1739–1744. [PubMed]
  • Moore PS, Chang Y. Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and without HIV infection. N Engl J Med. 1995 May 4;332(18):1181–1185. [PubMed]
  • Murthy SC, Trimble JJ, Desrosiers RC. Deletion mutants of herpesvirus saimiri define an open reading frame necessary for transformation. J Virol. 1989 Aug;63(8):3307–3314. [PMC free article] [PubMed]
  • Naidu YM, Kestler HW, 3rd, Li Y, Butler CV, Silva DP, Schmidt DK, Troup CD, Sehgal PK, Sonigo P, Daniel MD, et al. Characterization of infectious molecular clones of simian immunodeficiency virus (SIVmac) and human immunodeficiency virus type 2: persistent infection of rhesus monkeys with molecularly cloned SIVmac. J Virol. 1988 Dec;62(12):4691–4696. [PMC free article] [PubMed]
  • Neipel F, Albrecht JC, Ensser A, Huang YQ, Li JJ, Friedman-Kien AE, Fleckenstein B. Human herpesvirus 8 encodes a homolog of interleukin-6. J Virol. 1997 Jan;71(1):839–842. [PMC free article] [PubMed]
  • Renne R, Zhong W, Herndier B, McGrath M, Abbey N, Kedes D, Ganem D. Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat Med. 1996 Mar;2(3):342–346. [PubMed]
  • REYNOLDS ES. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol. 1963 Apr;17:208–212. [PMC free article] [PubMed]
  • Roizmann B, Desrosiers RC, Fleckenstein B, Lopez C, Minson AC, Studdert MJ. The family Herpesviridae: an update. The Herpesvirus Study Group of the International Committee on Taxonomy of Viruses. Arch Virol. 1992;123(3-4):425–449. [PubMed]
  • Rose TM, Strand KB, Schultz ER, Schaefer G, Rankin GW, Jr, Thouless ME, Tsai CC, Bosch ML. Identification of two homologs of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in retroperitoneal fibromatosis of different macaque species. J Virol. 1997 May;71(5):4138–4144. [PMC free article] [PubMed]
  • Russo JJ, Bohenzky RA, Chien MC, Chen J, Yan M, Maddalena D, Parry JP, Peruzzi D, Edelman IS, Chang Y, et al. Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14862–14867. [PMC free article] [PubMed]
  • Said W, Chien K, Takeuchi S, Tasaka T, Asou H, Cho SK, de Vos S, Cesarman E, Knowles DM, Koeffler HP. Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8) in primary effusion lymphoma: ultrastructural demonstration of herpesvirus in lymphoma cells. Blood. 1996 Jun 15;87(12):4937–4943. [PubMed]
  • Soulier J, Grollet L, Oksenhendler E, Cacoub P, Cazals-Hatem D, Babinet P, d'Agay MF, Clauvel JP, Raphael M, Degos L, et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood. 1995 Aug 15;86(4):1276–1280. [PubMed]
  • Staskus KA, Zhong W, Gebhard K, Herndier B, Wang H, Renne R, Beneke J, Pudney J, Anderson DJ, Ganem D, et al. Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol. 1997 Jan;71(1):715–719. [PMC free article] [PubMed]
  • Thompson R, Honess RW, Taylor L, Morran J, Davison AJ. Varicella-zoster virus specifies a thymidylate synthetase. J Gen Virol. 1987 May;68(Pt 5):1449–1455. [PubMed]
  • Trimble JJ, Murthy SC, Bakker A, Grassmann R, Desrosiers RC. A gene for dihydrofolate reductase in a herpesvirus. Science. 1988 Mar 4;239(4844):1145–1147. [PubMed]
  • Tsai CC, Giddens WE, Jr, Morton WR, Rosenkranz SL, Ochs HD, Benveniste RE. Retroperitoneal fibromatosis and acquired immunodeficiency syndrome in macaques: epidemiologic studies. Lab Anim Sci. 1985 Oct;35(5):460–464. [PubMed]
  • Tsai CC, Warner TF, Uno H, Giddens WE, Jr, Ochs HD. Subcutaneous fibromatosis associated with an acquired immune deficiency syndrome in pig-tailed macaques. Am J Pathol. 1985 Jul;120(1):30–37. [PMC free article] [PubMed]
  • Whitby D, Howard MR, Tenant-Flowers M, Brink NS, Copas A, Boshoff C, Hatzioannou T, Suggett FE, Aldam DM, Denton AS, et al. Detection of Kaposi sarcoma associated herpesvirus in peripheral blood of HIV-infected individuals and progression to Kaposi's sarcoma. Lancet. 1995 Sep 23;346(8978):799–802. [PubMed]

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