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Can Fam Physician. Apr 1998; 44: 799–808.
PMCID: PMC2277821

Benzodiazepine use and motor vehicle accidents. Systematic review of reported association.

Abstract

OBJECTIVE: To examine the relationship between benzodiazepine (BZD) use and motor vehicle accidents (MVAs). DATA SOURCES: MEDLINE was searched from 1980 to 1997 using the key words traffic accidents or motor vehicle accidents and benzodiazepines (and alternative terms and outcomes) in English, German, French, or Italian. STUDY SELECTION: Case-control studies of BZDs and MVAs; police or emergency studies of BZD use among travelers; driving tests with subjects taking BZDs. Outcomes were impaired driving, accidents; mortality; postaccident medical attention, emergency ward care, or hospitalization. Quality criteria were whether all driving BZD users and non-users had an equal chance of entering the study; whether medication dosage and timing were ascertained; whether all kilometres driven by BZD users and non-users were studied; whether all types of accidents were ascertained; and whether medical conditions were controlled for. SYNTHESIS: In case-control studies, the odds ratios for mortality and emergency medical treatment ranged from 1.45 to 2.4 in relation to time of use and quantity of drug taken. In police and emergency ward studies, BZD use was a factor in 1% to 65% of accidents (usually 5% to 10%). In two studies where subjects had blood alcohol concentrations less than the legal limit, BZDs were found in 43% and 65% of subjects. In one study with controls, 5% of drivers and 2% of controls in accidents had used BZDs. CONCLUSIONS: Case-control studies suggest using BZDs approximately doubles the risk of motor vehicle accidents. The risk for drivers older than 65 of being involved in reported motor vehicle collisions is higher when they take longer-acting and larger quantities of BZDs.

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Selected References

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  • Mason AP, McBay AJ. Ethanol, marijuana, and other drug use in 600 drivers killed in single-vehicle crashes in North Carolina, 1978-1981. J Forensic Sci. 1984 Oct;29(4):987–1026. [PubMed]
  • Koepsell TD, Wolf ME, McCloskey L, Buchner DM, Louie D, Wagner EH, Thompson RS. Medical conditions and motor vehicle collision injuries in older adults. J Am Geriatr Soc. 1994 Jul;42(7):695–700. [PubMed]
  • Hansotia P, Broste SK. The effect of epilepsy or diabetes mellitus on the risk of automobile accidents. N Engl J Med. 1991 Jan 3;324(1):22–26. [PubMed]
  • Oster G, Russell MW, Huse DM, Adams SF, Imbimbo J. Accident- and injury-related health-care utilization among benzodiazepine users and nonusers. J Clin Psychiatry. 1987 Dec;48 (Suppl):17–21. [PubMed]
  • Hemmelgarn B, Suissa S, Huang A, Boivin JF, Pinard G. Benzodiazepine use and the risk of motor vehicle crash in the elderly. JAMA. 1997 Jul 2;278(1):27–31. [PubMed]
  • Ray WA, Fought RL, Decker MD. Psychoactive drugs and the risk of injurious motor vehicle crashes in elderly drivers. Am J Epidemiol. 1992 Oct 1;136(7):873–883. [PubMed]
  • Christensen LQ, Nielsen LM, Nielsen SL. Traffic accidents and drivers suspected for drug influence. Forensic Sci Int. 1990 Apr;45(3):273–280. [PubMed]
  • White JM, Clardy DO, Graves MH, Kuo MC, MacDonald BJ, Wiersema SJ, Fitzpatrick G, Pearce DS. Testing for sedative-hypnotic drugs in the impaired driver: a survey of 72,000 arrests. Clin Toxicol. 1981 Aug;18(8):945–957. [PubMed]
  • Augsburger M, Rivier L. Drugs and alcohol among suspected impaired drivers in Canton de Vaud (Switzerland). Forensic Sci Int. 1997 Feb 28;85(2):95–104. [PubMed]
  • Binnie GA. Psychotropic drugs and accidents in a general practice. Br Med J (Clin Res Ed) 1983 Nov 5;287(6402):1349–1350. [PMC free article] [PubMed]
  • Honkanen R, Ertama L, Linnoila M, Alha A, Lukkari I, Karlsson M, Kiviluoto O, Puro M. Role of drugs in traffic accidents. Br Med J. 1980 Nov 15;281(6251):1309–1312. [PMC free article] [PubMed]
  • Currie D, Hashemi K, Fothergill J, Findlay A, Harris A, Hindmarch I. The use of anti-depressants and benzodiazepines in the perpetrators and victims of accidents. Occup Med (Lond) 1995 Dec;45(6):323–325. [PubMed]
  • Merlin G, Lepoittevin L, Turcant A, Mylonas J, Cavellat JF. Responsabilité des neuropsychotropes dans les accidents de la voie publique. Presse Med. 1991 Mar 9;20(9):409–412. [PubMed]
  • Gjerde H, Kinn G. Impairment in drivers due to cannabis in combination with other drugs. Forensic Sci Int. 1991 Jul-Aug;50(1):57–60. [PubMed]
  • Gjerde H, Beylich KM, Mørland J. Incidence of alcohol and drugs in fatally injured car drivers in Norway. Accid Anal Prev. 1993 Aug;25(4):479–483. [PubMed]
  • Ulrich L, Rudin O, Amsler A, Zink P. Häufigkeit von Medikamenten im Strassenverkehr. Eine Pilotstudie an Verkehrsteilnehmern in der Schweiz (Region Bern). Z Rechtsmed. 1984;93(2):95–110. [PubMed]
  • Cimbura G, Lucas DM, Bennett RC, Warren RA, Simpson HM. Incidence and toxicological aspects of drugs detected in 484 fatally injured drivers and pedestrians in Ontario. J Forensic Sci. 1982 Oct;27(4):855–867. [PubMed]
  • Fortenberry JC, Brown DB, Shevlin LT. Analysis of drug involvement in traffic fatalities in Alabama. Am J Drug Alcohol Abuse. 1986;12(3):257–267. [PubMed]
  • Logan BK, Schwilke EW. Drug and alcohol use in fatally injured drivers in Washington State. J Forensic Sci. 1996 May;41(3):505–510. [PubMed]
  • Sugrue M, Seger M, Dredge G, Davies DJ, Ieraci S, Bauman A, Deane SA, Sloane D. Evaluation of the prevalence of drug and alcohol abuse in motor vehicle trauma in south western Sydney. Aust N Z J Surg. 1995 Dec;65(12):853–856. [PubMed]
  • Crouch DJ, Birky MM, Gust SW, Rollins DE, Walsh JM, Moulden JV, Quinlan KE, Beckel RW. The prevalence of drugs and alcohol in fatally injured truck drivers. J Forensic Sci. 1993 Nov;38(6):1342–1353. [PubMed]
  • Stoduto G, Vingilis E, Kapur BM, Sheu WJ, McLellan BA, Liban CB. Alcohol and drug use among motor vehicle collision victims admitted to a regional trauma unit: demographic, injury, and crash characteristics. Accid Anal Prev. 1993 Aug;25(4):411–420. [PubMed]
  • Holmgren P, Loch E, Schuberth J. Drugs in motorists traveling Swedish roads: on-the-road-detection of intoxicated drivers and screening for drugs in these offenders. Forensic Sci Int. 1985 Jan;27(1):57–65. [PubMed]
  • Girre C, Facy F, Lagier G, Dally S. Présence de benzodiazépines dans le sérum de sujets accidentés. Relation avec l'alcoolisme. Presse Med. 1988 Jun 4;17(22):1135–1138. [PubMed]
  • Staub C, Lacalle H, Fryc O. Présence de psychotropes dans le sang de conducteurs responsables d'accidents de la route ayant consommé en même temps de l'alcool. Soz Praventivmed. 1994;39(3):143–149. [PubMed]
  • Arditti J, Bourdon JH, David JM, Lanze L, Thirion X, Jouglard J. Imprégnation en benzodiazépines de conducteurs impliqués dans des accidents de la circulation. Presse Med. 1993 May 1;22(16):765–766. [PubMed]
  • Steentoft A, Worm K, Christensen H. Hyppigheden af benzodiazepiner i blodprøver indsendt til alkohol- og/eller medikamentundersøgelse på Retskemisk Institut i København. Ugeskr Laeger. 1988 Oct 3;150(40):2383–2386. [PubMed]
  • Lillsunde P, Korte T, Michelson L, Portman M, Pikkarainen J, Seppälä T. Drugs usage of drivers suspected of driving under the influence of alcohol and/or drugs. A study of one week's samples in 1979 and 1993 in Finland. Forensic Sci Int. 1996 Jan 12;77(1-2):119–129. [PubMed]
  • Rivara FP, Mueller BA, Fligner CL, Luna G, Raisys VA, Copass M, Reay DT. Drug use in trauma victims. J Trauma. 1989 Apr;29(4):462–470. [PubMed]
  • Orsay EM, Doan-Wiggins L, Lewis R, Lucke R, RamaKrishnan V. The impaired driver: hospital and police detection of alcohol and other drugs of abuse in motor vehicle crashes. Ann Emerg Med. 1994 Jul;24(1):51–55. [PubMed]
  • McLinden VJ. Experiences in relation to drugs/driving offences. J Forensic Sci Soc. 1987 Mar-Apr;27(2):73–80. [PubMed]
  • de Gier JJ, 't Hart BJ, Nelemans FA, Bergman H. Psychomotor performance and real driving performance of outpatients receiving diazepam. Psychopharmacology (Berl) 1981;73(4):340–344. [PubMed]
  • O'Hanlon JF, Vermeeren A, Uiterwijk MM, van Veggel LM, Swijgman HF. Anxiolytics' effects on the actual driving performance of patients and healthy volunteers in a standardized test. An integration of three studies. Neuropsychobiology. 1995;31(2):81–88. [PubMed]
  • O'Hanlon JF, Volkerts ER. Hypnotics and actual driving performance. Acta Psychiatr Scand Suppl. 1986;332:95–104. [PubMed]
  • van Laar MW, Volkerts ER, van Willigenburg AP. Therapeutic effects and effects on actual driving performance of chronically administered buspirone and diazepam in anxious outpatients. J Clin Psychopharmacol. 1992 Apr;12(2):86–95. [PubMed]
  • Biehl B. Studies of clobazam and car-driving. Br J Clin Pharmacol. 1979;7 (Suppl 1):85S–90S. [PMC free article] [PubMed]
  • Irving A, Jones W. Methods for testing impairment of driving due to drugs. Eur J Clin Pharmacol. 1992;43(1):61–66. [PubMed]

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