National Library of Medicine resource grants provide assistance in developing information services or activities, which are then made available to others. The resource grant program was redefined in 1989 to establish information access grants and information systems grants. The preparation of a resource grant proposal is discussed, with examples included for some sections. All applicants must use the PHS 398 application form, which is geared to research grants. The review process and reapplication are described. Problems with National Institutes of Health grant proposals that have been reported in the literature are discussed.