• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of pnasPNASInfo for AuthorsSubscriptionsAboutThis Article
Proc Natl Acad Sci U S A. Oct 1968; 61(2): 708–716.
PMCID: PMC225217

The cross-linking of collagen and elastin: enzymatic conversion of lysine in peptide linkage to alpha-aminoadipic-delta-semialdehyde (allysine) by an extract from bone.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (909K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bornstein P, Kang AH, Piez KA. The nature and location of intramolecular cross-links in collagen. Proc Natl Acad Sci U S A. 1966 Feb;55(2):417–424. [PMC free article] [PubMed]
  • Miller EJ, Pinnell SR, Martin GR, Schiffmann E. Investigation of the nature of the intermediates involved in desmosine biosynthesis. Biochem Biophys Res Commun. 1967 Jan 23;26(2):132–137. [PubMed]
  • Partridge SM. Biosynthesis and nature of elastin structures. Fed Proc. 1966 May-Jun;25(3):1023–1029. [PubMed]
  • Bornstein P, Piez KA. The nature of the intramolecular cross-links in collagen. The separation and characterization of peptides from the cross-link region of rat skin collagen. Biochemistry. 1966 Nov;5(11):3460–3473. [PubMed]
  • Pinnell SR, Martin GR, Miller EJ. Desmosine biosynthesis: nature of inhibition by D-penicillamine. Science. 1968 Aug 2;161(3840):475–476. [PubMed]
  • LEVENE CI, GROSS J. Alterations in state of molecular aggregation of collagen induced in chick embryos by beta-aminopropionitrile (lathyrus factor). J Exp Med. 1959 Nov 1;110:771–790. [PMC free article] [PubMed]
  • Miller EJ, Martin GR, Mecca CE, Piez KA. The biosynthesis of elastin cross-links. The effect of copper deficiency and a lathyrogen. J Biol Chem. 1965 Sep;240(9):3623–3627. [PubMed]
  • Higashino K, Fujioka M, Aoki T, Yamamura T. Metabolism of lysine in rat liver. Biochem Biophys Res Commun. 1967 Oct 11;29(1):95–100. [PubMed]
  • Miller EJ, Piez KA. An accelerated single-column procedure for the automatic analysis of amino acids in collagen and elastin hydrolyzates. Anal Biochem. 1966 Aug;16(2):320–326. [PubMed]
  • PIEZ KA. Continuous scintillation counting of carbon-14 and tritium in effluent of the automatic amino acid analyzer. Anal Biochem. 1962 Dec;4:444–458. [PubMed]
  • Popenoe EA, Aronson RB, Van Slyke DD. Hydroxylysine formation from lysine during collagen biosynthesis. Proc Natl Acad Sci U S A. 1966 Feb;55(2):393–397. [PMC free article] [PubMed]
  • Bird DW, Savage JE, O'Dell BL. Effect of copper deficiency and inhibitors on the amine oxidase activity of chick tissues. Proc Soc Exp Biol Med. 1966 Oct;123(1):250–254. [PubMed]
  • Hill CH, Starcher B, Kim C. Role of copper in the formation of elastin. Fed Proc. 1967 Jan-Feb;26(1):129–133. [PubMed]
  • Page RC, Benditt EP. Molecular diseases of connective and vascular tissues. II. Amine oxidase inhibition by the lathyrogen, beta-aminopropionitrile. Biochemistry. 1967 Apr;6(4):1142–1148. [PubMed]
  • Page RC, Benditt EP. Interaction of the lathyrogen beta-aminopropionitrile (BAPN) with a copper-containing amine oxidase. Proc Soc Exp Biol Med. 1967 Feb;124(2):454–459. [PubMed]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • Compound
    PubChem Compound links
  • PubMed
    PubMed citations for these articles
  • Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...