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Br J Cancer. 1989 Jan; 59(1): 92–96.
PMCID: PMC2246960

Dietary factors and epithelial ovarian cancer.


Dietary data from a population-based case-control study of 172 epithelial ovarian cancer cases and 172 controls were analysed. A significant (P less than 0.01) dose-response relationship was found between intake of fat from animal sources and risk of ovarian cancer, but plant fat was not associated. Although the effect of animal fat was confounded by education, an adjusted odds ratio of 1.8 persisted for those in the upper quartile compared to the lower quartile of consumption (P for trend = 0.03). After adjustment for animal fat intake, calorific and protein intake had minimal effects on risk. Total vegetables were found to be somewhat protective, but the mechanism of action was unclear. Weight, height and relative weight (weight/height2) were not related to risk of ovarian cancer.

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  • Armstrong BK, Brown JB, Clarke HT, Crooke DK, Hähnel R, Masarei JR, Ratajczak T. Diet and reproductive hormones: a study of vegetarian and nonvegetarian postmenopausal women. J Natl Cancer Inst. 1981 Oct;67(4):761–767. [PubMed]
  • Armstrong B, Doll R. Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer. 1975 Apr 15;15(4):617–631. [PubMed]
  • Block G. A review of validations of dietary assessment methods. Am J Epidemiol. 1982 Apr;115(4):492–505. [PubMed]
  • Byers T, Marshall J, Graham S, Mettlin C, Swanson M. A case-control study of dietary and nondietary factors in ovarian cancer. J Natl Cancer Inst. 1983 Oct;71(4):681–686. [PubMed]
  • Carroll KK. Neutral fats and cancer. Cancer Res. 1981 Sep;41(9 Pt 2):3695–3699. [PubMed]
  • Cramer DW, Welch WR, Hutchison GB, Willett W, Scully RE. Dietary animal fat in relation to ovarian cancer risk. Obstet Gynecol. 1984 Jun;63(6):833–838. [PubMed]
  • Friberg LG, Kullander S, Persijn JP, Korsten CB. On receptors for estrogens (E2) and androgens (DHT) in human endometrial carcinoma and ovarian tumours. Acta Obstet Gynecol Scand. 1978;57(3):261–264. [PubMed]
  • Galli MC, De Giovanni C, Nicoletti G, Grilli S, Nanni P, Prodi G, Gola G, Rocchetta R, Orlandi C. The occurrence of multiple steroid hormone receptors in disease-free and neoplastic human ovary. Cancer. 1981 Mar 15;47(6):1297–1302. [PubMed]
  • Goldin BR, Adlercreutz H, Dwyer JT, Swenson L, Warram JH, Gorbach SL. Effect of diet on excretion of estrogens in pre- and postmenopausal women. Cancer Res. 1981 Sep;41(9 Pt 2):3771–3773. [PubMed]
  • Haenszel W, Kurihara M. Studies of Japanese migrants. I. Mortality from cancer and other diseases among Japanese in the United States. J Natl Cancer Inst. 1968 Jan;40(1):43–68. [PubMed]
  • Hill MJ, Goddard P, Williams RE. Gut bacteria and aetiology of cancer of the breast. Lancet. 1971 Aug 28;2(7722):472–473. [PubMed]
  • Holt JA, Caputo TA, Kelly KM, Greenwald P, Chorost S. Estrogen and progestin binding in cytosols of ovarian adenocarcinomas. Obstet Gynecol. 1979 Jan;53(1):50–58. [PubMed]
  • Kinlen LJ. Meat and fat consumption and cancer mortality: A study of strict religious orders in Britain. Lancet. 1982 Apr 24;1(8278):946–949. [PubMed]
  • La Vecchia C, Decarli A, Negri E, Parazzini F, Gentile A, Cecchetti G, Fasoli M, Franceschi S. Dietary factors and the risk of epithelial ovarian cancer. J Natl Cancer Inst. 1987 Oct;79(4):663–669. [PubMed]
  • Lubin JH. A computer program for the analysis of matched case-control studies. Comput Biomed Res. 1981 Apr;14(2):138–143. [PubMed]
  • Phillips RL, Garfinkel L, Kuzma JW, Beeson WL, Lotz T, Brin B. Mortality among California Seventh-Day Adventists for selected cancer sites. J Natl Cancer Inst. 1980 Nov;65(5):1097–1107. [PubMed]
  • Rose DP, Boyar AP. Diet and ovarian cancer. JAMA. 1985 Nov 8;254(18):2553–2553. [PubMed]
  • Rose DP, Boyar AP, Wynder EL. International comparisons of mortality rates for cancer of the breast, ovary, prostate, and colon, and per capita food consumption. Cancer. 1986 Dec 1;58(11):2363–2371. [PubMed]
  • Snowdon DA. Diet and ovarian cancer. JAMA. 1985 Jul 19;254(3):356–357. [PubMed]
  • Willett WC, MacMahon B. Diet and cancer--an overview. N Engl J Med. 1984 Mar 8;310(10):633–638. [PubMed]
  • Willett WC, MacMahon B. Diet and cancer--an overview (second of two parts). N Engl J Med. 1984 Mar 15;310(11):697–703. [PubMed]
  • Williams GM, Weisburger JH. Food and cancer: cause and effect? Surg Clin North Am. 1986 Oct;66(5):873–889. [PubMed]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK


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