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J Gen Physiol. 1972 Dec 1; 60(6): 698–719.
PMCID: PMC2226100

Adaptation in Skate Photoreceptors


Receptor potentials were recorded extracellularly from the all-rod retina of the skate after the application of sodium aspartate. This agent suppresses the responses of proximal elements, but leaves relatively unaffected the electrical activity of the photoreceptors (a-wave) and pigment epithelium (c-wave). Since the latter develops too slowly to interfere with the receptor response, it was possible to isolate receptor potentials and to compare their behavior in light and dark adaptation with earlier observations on the S-potential, b-wave, and ganglion cell discharge. The results show that the photoreceptors display the full complement of adaptational changes exhibited by cells proximal to the receptors. Thus, it appears that visual adaptation in the skate is governed primarily by the photoreceptors themselves. Of particular interest was the recovery of sensitivity in the presence of background fields that initially saturate the receptor potential. Analysis of this recovery phase indicates that a gain-control mechanism operates within the receptors, at a distal stage of the visual process.

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Selected References

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  • Alpern M, Rushton WA, Torii S. Signals from cones. J Physiol. 1970 Apr;207(2):463–475. [PMC free article] [PubMed]
  • Arden GB, Ernst W. A comparison of the behaviour to ions of the P3 component of the pigeon cone and rat rod electroretinogram. J Physiol. 1972 Jan;220(2):479–497. [PMC free article] [PubMed]
  • Boynton RM, Whitten DN. Visual adaptation in monkey cones: recordings of late receptor potentials. Science. 1970 Dec 25;170(3965):1423–1426. [PubMed]
  • BROWN KT, WATANABE K. Isolation and identification of a receptor potential from the pure cone fovea of the monkey retina. Nature. 1962 Mar 10;193:958–passim. [PubMed]
  • BROWN KT, WATANABE K. Rod receptor potential from the retina of the night monkey. Nature. 1962 Nov 10;196:547–550. [PubMed]
  • Daw NW, Pearlman AL. Cat colour vision: one cone process or several? J Physiol. 1969 May;201(3):745–764. [PMC free article] [PubMed]
  • DODT E, ECHTE K. Dark and light adaptation in pigmented and white rat as measured by electroretinogram threshold. J Neurophysiol. 1961 Jul;24:427–445. [PubMed]
  • DOWLING JE. Chemistry of visual adaptation in the rat. Nature. 1960 Oct 8;188:114–118. [PubMed]
  • Dowling JE, Ripps H. Visual adaptation in the retina of the skate. J Gen Physiol. 1970 Oct;56(4):491–520. [PMC free article] [PubMed]
  • Dowling JE, Ripps H. S-potentials in the skate retina. Intracellular recordings during light and dark adaptation. J Gen Physiol. 1971 Aug;58(2):163–189. [PMC free article] [PubMed]
  • Frank RN. Properties of "neural" adaptation in components of the frog electroretinogram. Vision Res. 1971 Oct;11(10):1113–1123. [PubMed]
  • Green DG. Light adaptation in the rat retina: evidence for two receptor mechanisms. Science. 1971 Nov 5;174(4009):598–600. [PubMed]
  • Hagins WA, Penn RD, Yoshikami S. Dark current and photocurrent in retinal rods. Biophys J. 1970 May;10(5):380–412. [PMC free article] [PubMed]
  • Kishida K, Naka KI. Amino acids and the spikes from the retinal ganglion cells. Science. 1967 May 5;156(3775):648–650. [PubMed]
  • Miller RF, Dowling JE. Intracellular responses of the Müller (glial) cells of mudpuppy retina: their relation to b-wave of the electroretinogram. J Neurophysiol. 1970 May;33(3):323–341. [PubMed]
  • Murakami M, Kaneko A. Differentiation of P 3 subcomponents in cold-blooded vertebrate retinas. Vision Res. 1966 Dec;6(12):627–636. [PubMed]
  • Naka KI, Rushton WA. S-potentials from luminosity units in the retina of fish (Cyprinidae). J Physiol. 1966 Aug;185(3):587–599. [PMC free article] [PubMed]
  • Penn RD, Hagins WA. Signal transmission along retinal rods and the origin of the electroretinographic a-wave. Nature. 1969 Jul 12;223(5202):201–204. [PubMed]
  • RUSHTON WA. Rhodopsin measurement and dark-adaptation in a subject deficient in cone vision. J Physiol. 1961 Apr;156:193–205. [PMC free article] [PubMed]
  • RUSHTON WA. VISUAL ADAPTATION. Proc R Soc Lond B Biol Sci. 1965 Mar 16;162:20–46. [PubMed]
  • Sillman AJ, Ito H, Tomita T. Studies on the mass receptor potential of the isolated frog retina. I. General properties of the response. Vision Res. 1969 Dec;9(12):1435–1442. [PubMed]
  • Steinberg RH, Schmidt R, Brown KT. Intracellular responses to light from cat pigment epithelium: origin of the electroretinogram c-wave. Nature. 1970 Aug 15;227(5259):728–730. [PubMed]
  • Stiles WS. COLOR VISION: THE APPROACH THROUGH INCREMENT-THRESHOLD SENSITIVITY. Proc Natl Acad Sci U S A. 1959 Jan;45(1):100–114. [PMC free article]
  • Werblin FS. Adaptation in a vertebrate retina: intracellular recording in Necturus. J Neurophysiol. 1971 Mar;34(2):228–241. [PubMed]
  • WALD F, DE ROBERTIS E. The action of glutamate and the problem of the "extracellular space" in the retina. An electron microscope study. Z Zellforsch Mikrosk Anat. 1961;55:649–661. [PubMed]

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