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The Alzheimer's disease β-secretase enzyme, BACE1
Sarah L Cole, Robert Vassar
Mol Neurodegener. 2007; 2: 22. Published online 2007 November 15. doi: 10.1186/1750-1326-2-22
PMCID:
PMC2211305
Abstract Full Text PDF–898K

Is Cited by the Following 23 Articles in this Archive:

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease
David M. Holtzman, Joachim Herz, Guojun Bu
Cold Spring Harb Perspect Med. 2012 March; 2(3): a006312. doi: 10.1101/cshperspect.a006312
PMCID:
PMC3282491
Abstract Full Text PDF–1.1M
The precision of axon targeting of mouse olfactory sensory neurons requires the BACE1 protease
Luxiang Cao, Gregory T. Rickenbacher, Steve Rodriguez, Thomas W. Moulia, Mark W. Albers
Sci Rep. 2012; 2: 231. Published online 2012 January 20. doi: 10.1038/srep00231
PMCID:
PMC3262176
Abstract Full Text PDF–1.8M
Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice
Paul J. Meakin, Alex J. Harper, D. Lee Hamilton, Jennifer Gallagher, Alison D. McNeilly, Laura A. Burgess, Lobke M. Vaanholt, Kirsten A. Bannon, Judy Latcham, Ishrut Hussain, John R. Speakman, David R. Howlett, Michael L.J. Ashford
Biochem J. 2012 January 1; 441(Pt 1): 285–296. Prepublished online 2011 August 31. Published online 2011 December 14. doi: 10.1042/BJ20110512
PMCID:
PMC3242510
Abstract Full Text PDF–1.1M Supplementary Material
Salubrinal attenuates β-amyloid-induced neuronal death and microglial activation by inhibition of the NF-κB pathway
Xiumei Huang, Yaomin Chen, Han Zhang, Qilin Ma, Yun-wu Zhang, Huaxi Xu
Neurobiol Aging. Author manuscript; available in PMC 2013 May 1.
Published in final edited form as: Neurobiol Aging. 2012 May; 33(5): 1007.e9–1007.e17. Published online 2011 November 5. doi: 10.1016/j.neurobiolaging.2011.10.007
PMCID:
PMC3294262
Free in PMC on 2013/05/01
The association of diabetes and dementia and possible implications for nondiabetic populations
Ramit Ravona-Springer, Michal Schnaider-Beeri
Expert Rev Neurother. Author manuscript; available in PMC 2012 September 1.
Published in final edited form as: Expert Rev Neurother. 2011 November; 11(11): 1609–1617. doi: 10.1586/ern.11.152
PMCID:
PMC3240939
Free in PMC on 2012/09/01
Prion Protein Interacts with BACE1 Protein and Differentially Regulates Its Activity toward Wild Type and Swedish Mutant Amyloid Precursor Protein
Heledd H. Griffiths, Isobel J. Whitehouse, Herbert Baybutt, Debbie Brown, Katherine A. B. Kellett, Carolyn D. Jackson, Anthony J. Turner, Pedro Piccardo, Jean C. Manson, Nigel M. Hooper
J Biol Chem. 2011 September 23; 286(38): 33489–33500. Published online 2011 July 27. doi: 10.1074/jbc.M111.278556
PMCID:
PMC3190950
Free in PMC on 2012/09/23
Loss of Cleavage at β′-Site Contributes to Apparent Increase in β-Amyloid Peptide (Aβ) Secretion by β-Secretase (BACE1)-Glycosylphosphatidylinositol (GPI) Processing of Amyloid Precursor Protein
Kulandaivelu S. Vetrivel, Arghya Barman, Ying Chen, Phuong D. Nguyen, Steven L. Wagner, Rajeev Prabhakar, Gopal Thinakaran
J Biol Chem. 2011 July 22; 286(29): 26166–26177. Published online 2011 June 3. doi: 10.1074/jbc.M111.260471
PMCID:
PMC3138254
Free in PMC on 2012/07/22
Differential regulation of BACE1 expression by oxidative and nitrosative signals
Young-Don Kwak, Ruishan Wang, Jing Jing Li, Yun-Wu Zhang, Huaxi Xu, Francesca-Fang Liao
Mol Neurodegener. 2011; 6: 17. Published online 2011 March 3. doi: 10.1186/1750-1326-6-17
PMCID:
PMC3059281
Abstract Full Text PDF–567K Supplementary Material
Central Angiotensin II Stimulation Promotes β Amyloid Production in Sprague Dawley Rats
Donglin Zhu, Jingping Shi, Yingdong Zhang, Bianrong Wang, Wei Liu, Zhicong Chen, Qiang Tong
PLoS One. 2011; 6(1): e16037. Published online 2011 January 28. doi: 10.1371/journal.pone.0016037
PMCID:
PMC3030571
Abstract Full Text PDF–529K Supplementary Material
Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit
Manuel T Gersbacher, Doo Yeon Kim, Raja Bhattacharyya, Dora M Kovacs
Mol Neurodegener. 2010; 5: 61. Published online 2010 December 23. doi: 10.1186/1750-1326-5-61
PMCID:
PMC3022600
Abstract Full Text PDF–1.4M
SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer’s disease amyloidosis and improves synaptic function
Bing Gong, Fei Chen, Yong Pan, Isabel Arrieta-Cruz, Yukiko Yoshida, Vahram Haroutunian, Giulio M. Pasinetti
Aging Cell. Author manuscript; available in PMC 2012 March 19.
Published in final edited form as: Aging Cell. 2010 December; 9(6): 1018–1031. Published online 2010 October 29. doi: 10.1111/j.1474-9726.2010.00632.x
PMCID:
PMC3307224
Abstract Full Text PDF–2.0M Supplementary Material
Phospho-eIF2α Level Is Important for Determining Abilities of BACE1 Reduction to Rescue Cholinergic Neurodegeneration and Memory Defects in 5XFAD Mice
Latha Devi, Masuo Ohno
PLoS One. 2010; 5(9): e12974. Published online 2010 September 23. doi: 10.1371/journal.pone.0012974
PMCID:
PMC2944882
Abstract Full Text PDF–4.2M
Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer’s disease transgenic mice
Ryoichi Kimura, Latha Devi, Masuo Ohno
J Neurochem. Author manuscript; available in PMC 2011 April 1.
Published in final edited form as: J Neurochem. 2010 April; 113(1): 248–261. Published online 2010 January 20. doi: 10.1111/j.1471-4159.2010.06608.x
PMCID:
PMC2921968
Abstract Full Text PDF–1.2M
Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics
Matthew L. Hemming, Joshua E. Elias, Steven P. Gygi, Dennis J. Selkoe
PLoS One. 2009; 4(12): e8477. Published online 2009 December 29. doi: 10.1371/journal.pone.0008477
PMCID:
PMC2793532
Abstract Full Text PDF–1.2M Supplementary Material
Overexpression of Low Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance
Jungsu Kim, Joseph M. Castellano, Hong Jiang, Jacob M. Basak, Maia Parsadanian, Vi Pham, Stephanie M. Mason, Steven M. Paul, David M. Holtzman
Neuron. Author manuscript; available in PMC 2010 August 13.
Published in final edited form as: Neuron. 2009 December 10; 64(5): 632–644. doi: 10.1016/j.neuron.2009.11.013
PMCID:
PMC2787195
Abstract Full Text PDF–1.6M Supplementary Material
Receptor-associated Protein Interacts with Amyloid-β Peptide and Promotes Its Cellular Uptake
Takahisa Kanekiyo, Guojun Bu
J Biol Chem. 2009 November 27; 284(48): 33352–33359. Published online 2009 October 13. doi: 10.1074/jbc.M109.015032
PMCID:
PMC2785178
Abstract Full Text Supplementary Material
Maturation of BRI2 generates a specific inhibitor that reduces APP processing at the plasma membrane and in endocytic vesicles
Shuji Matsuda, Yukiko Matsuda, Erik L. Snapp, Luciano D’Adamio
Neurobiol Aging. Author manuscript; available in PMC 2011 August 1.
Published in final edited form as: Neurobiol Aging. 2011 August; 32(8): 1400–1408. Published online 2009 September 12. doi: 10.1016/j.neurobiolaging.2009.08.005
PMCID:
PMC2932834
Abstract Full Text PDF–2.4M
Signaling Effect of Amyloid-β42 on the Processing of AβPP
Massimo Tabaton, Xiongwei Zhu, George Perry, Mark A. Smith, Luca Giliberto
Exp Neurol. Author manuscript; available in PMC 2011 January 1.
Published in final edited form as: Exp Neurol. 2010 January; 221(1): 18–25. Published online 2009 September 9. doi: 10.1016/j.expneurol.2009.09.002
PMCID:
PMC2812589
Abstract Full Text PDF–703K
Apolipoprotein E4 (1–272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells
Toshiyuki Nakamura, Atsushi Watanabe, Takahiro Fujino, Takashi Hosono, Makoto Michikawa
Mol Neurodegener. 2009; 4: 35. Published online 2009 August 20. doi: 10.1186/1750-1326-4-35
PMCID:
PMC2739857
Abstract Full Text PDF–969K
Apolipoprotein E and its receptors in Alzheimer’s disease: pathways, pathogenesis and therapy
Guojun Bu
Nat Rev Neurosci. Author manuscript; available in PMC 2010 July 22.
Published in final edited form as: Nat Rev Neurosci. 2009 May; 10(5): 333–344. Published online 2009 April 2. doi: 10.1038/nrn2620
PMCID:
PMC2908393
Abstract Full Text PDF–528K Supplementary Material
Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription
Yaomin Chen, Kun Zhou, Ruishan Wang, Yun Liu, Young-Don Kwak, Tao Ma, Robert C. Thompson, Yongbo Zhao, Layton Smith, Laura Gasparini, Zhijun Luo, Huaxi Xu, Francesca-Fang Liao
Proc Natl Acad Sci U S A. 2009 March 10; 106(10): 3907–3912. Published online 2009 February 23. doi: 10.1073/pnas.0807991106
PMCID:
PMC2656178
Abstract Full Text PDF–630K Supplementary Material
The Role of Amyloid Precursor Protein Processing by BACE1, the β-Secretase, in Alzheimer Disease Pathophysiology
Sarah L. Cole, Robert Vassar
J Biol Chem. 2008 October 31; 283(44): 29621–29625. doi: 10.1074/jbc.R800015200
PMCID:
PMC2662048
Abstract Full Text Supplementary Material
Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer’s disease
Maria-Paz Marzolo, Guojun Bu
Semin Cell Dev Biol. Author manuscript; available in PMC 2010 April 1.
Published in final edited form as: Semin Cell Dev Biol. 2009 April; 20(2): 191–200. Published online 2008 October 17. doi: 10.1016/j.semcdb.2008.10.005
PMCID:
PMC2691858
Abstract Full Text PDF–660K
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